TBPIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG22_LEIBR

TriTrypDb:

LbrM.27.2630 , LBRM2903_270033500

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0000228	nuclear chromosome	6	1
GO:0000793	condensed chromosome	6	1
GO:0000794	condensed nuclear chromosome	7	1
GO:0005694	chromosome	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	3
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0120231	DNA recombinase auxiliary factor complex	3	1
GO:0150005	enzyme activator complex	2	1
GO:0000502	proteasome complex	3	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

A4HG22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG22

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006310	DNA recombination	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007131	reciprocal meiotic recombination	3	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0022402	cell cycle process	2	12
GO:0022414	reproductive process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0035825	homologous recombination	6	11
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0140527	reciprocal homologous recombination	7	11
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1903046	meiotic cell cycle process	2	12
GO:0000708	meiotic strand invasion	4	1
GO:0000709	meiotic joint molecule formation	3	1
GO:0006996	organelle organization	4	1
GO:0007129	homologous chromosome pairing at meiosis	4	1
GO:0010774	meiotic strand invasion involved in reciprocal meiotic recombination	5	1
GO:0016043	cellular component organization	3	1
GO:0042148	strand invasion	5	1
GO:0051276	chromosome organization	5	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0070192	chromosome organization involved in meiotic cell cycle	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0120230	recombinase activator activity	4	1
GO:0140677	molecular function activator activity	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.527
CLV_C14_Caspase3-7	285	289	PF00656	0.626
CLV_C14_Caspase3-7	88	92	PF00656	0.281
CLV_NRD_NRD_1	201	203	PF00675	0.532
CLV_NRD_NRD_1	24	26	PF00675	0.454
CLV_NRD_NRD_1	265	267	PF00675	0.375
CLV_NRD_NRD_1	268	270	PF00675	0.354
CLV_NRD_NRD_1	27	29	PF00675	0.463
CLV_NRD_NRD_1	273	275	PF00675	0.331
CLV_NRD_NRD_1	34	36	PF00675	0.478
CLV_PCSK_FUR_1	199	203	PF00082	0.382
CLV_PCSK_FUR_1	25	29	PF00082	0.453
CLV_PCSK_FUR_1	263	267	PF00082	0.400
CLV_PCSK_KEX2_1	201	203	PF00082	0.477
CLV_PCSK_KEX2_1	24	26	PF00082	0.454
CLV_PCSK_KEX2_1	265	267	PF00082	0.375
CLV_PCSK_KEX2_1	268	270	PF00082	0.358
CLV_PCSK_KEX2_1	27	29	PF00082	0.463
CLV_PCSK_KEX2_1	34	36	PF00082	0.478
CLV_PCSK_KEX2_1	61	63	PF00082	0.364
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.362
CLV_PCSK_SKI1_1	118	122	PF00082	0.266
CLV_PCSK_SKI1_1	182	186	PF00082	0.290
CLV_PCSK_SKI1_1	215	219	PF00082	0.494
CLV_PCSK_SKI1_1	61	65	PF00082	0.420
CLV_PCSK_SKI1_1	82	86	PF00082	0.360
CLV_PCSK_SKI1_1	96	100	PF00082	0.360
DEG_APCC_DBOX_1	229	237	PF00400	0.524
DOC_CDC14_PxL_1	128	136	PF14671	0.521
DOC_CKS1_1	83	88	PF01111	0.411
DOC_CYCLIN_RxL_1	124	137	PF00134	0.476
DOC_MAPK_gen_1	121	130	PF00069	0.399
DOC_MAPK_gen_1	274	281	PF00069	0.459
DOC_MAPK_MEF2A_6	11	20	PF00069	0.487
DOC_PP1_RVXF_1	119	126	PF00149	0.312
DOC_USP7_MATH_1	241	245	PF00917	0.657
DOC_USP7_MATH_1	307	311	PF00917	0.484
DOC_USP7_MATH_1	36	40	PF00917	0.468
DOC_USP7_MATH_1	41	45	PF00917	0.438
DOC_USP7_MATH_1	92	96	PF00917	0.266
DOC_USP7_UBL2_3	114	118	PF12436	0.275
DOC_USP7_UBL2_3	57	61	PF12436	0.489
DOC_WW_Pin1_4	288	293	PF00397	0.608
DOC_WW_Pin1_4	82	87	PF00397	0.411
LIG_14-3-3_CanoR_1	34	42	PF00244	0.534
LIG_BIR_III_4	91	95	PF00653	0.266
LIG_CaM_IQ_9	191	207	PF13499	0.438
LIG_FHA_1	312	318	PF00498	0.445
LIG_FHA_1	68	74	PF00498	0.303
LIG_FHA_1	88	94	PF00498	0.242
LIG_FHA_2	283	289	PF00498	0.553
LIG_FHA_2	300	306	PF00498	0.546
LIG_GBD_Chelix_1	225	233	PF00786	0.279
LIG_MYND_1	132	136	PF01753	0.413
LIG_NRBOX	12	18	PF00104	0.376
LIG_SH2_STAT5	127	130	PF00017	0.381
LIG_SH3_3	313	319	PF00018	0.628
LIG_SH3_3	80	86	PF00018	0.416
LIG_SH3_3	94	100	PF00018	0.287
LIG_SH3_4	99	106	PF00018	0.393
LIG_UBA3_1	105	114	PF00899	0.331
MOD_CK1_1	197	203	PF00069	0.451
MOD_CK1_1	23	29	PF00069	0.512
MOD_CK1_1	67	73	PF00069	0.435
MOD_CK2_1	160	166	PF00069	0.502
MOD_CK2_1	208	214	PF00069	0.589
MOD_CK2_1	288	294	PF00069	0.483
MOD_CK2_1	299	305	PF00069	0.448
MOD_CMANNOS	206	209	PF00535	0.559
MOD_GlcNHglycan	162	165	PF01048	0.673
MOD_GlcNHglycan	191	194	PF01048	0.548
MOD_GlcNHglycan	242	246	PF01048	0.528
MOD_GlcNHglycan	38	41	PF01048	0.608
MOD_GSK3_1	307	314	PF00069	0.471
MOD_GSK3_1	36	43	PF00069	0.466
MOD_GSK3_1	48	55	PF00069	0.425
MOD_N-GLC_1	249	254	PF02516	0.519
MOD_NEK2_1	18	23	PF00069	0.474
MOD_NEK2_1	282	287	PF00069	0.493
MOD_NEK2_1	311	316	PF00069	0.439
MOD_OFUCOSY	50	56	PF10250	0.440
MOD_PIKK_1	326	332	PF00454	0.453
MOD_PKA_1	34	40	PF00069	0.476
MOD_PKA_2	23	29	PF00069	0.501
MOD_PKA_2	34	40	PF00069	0.463
MOD_Plk_1	67	73	PF00069	0.411
MOD_Plk_4	318	324	PF00069	0.358
MOD_ProDKin_1	288	294	PF00069	0.609
MOD_ProDKin_1	82	88	PF00069	0.411
MOD_SUMO_rev_2	107	115	PF00179	0.360
TRG_DiLeu_BaEn_1	294	299	PF01217	0.439
TRG_DiLeu_BaEn_1	68	73	PF01217	0.411
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.381
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.402
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.287
TRG_ENDOCYTIC_2	127	130	PF00928	0.457
TRG_ER_diArg_1	199	202	PF00400	0.556
TRG_ER_diArg_1	2	5	PF00400	0.433
TRG_ER_diArg_1	24	27	PF00400	0.457
TRG_ER_diArg_1	264	266	PF00400	0.395
TRG_NLS_MonoExtN_4	118	125	PF00514	0.266
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.189

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9H7	Leptomonas seymouri	49%	100%
A0A0S4J6Z3	Bodo saltans	30%	100%
A0A1X0NFH4	Trypanosomatidae	33%	100%
A0A3R7MDB5	Trypanosoma rangeli	33%	100%
A0A3S7X109	Leishmania donovani	78%	100%
A4I343	Leishmania infantum	78%	100%
C9ZJL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ACW2	Leishmania major	75%	100%
E9AZF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5D720	Trypanosoma cruzi	29%	100%