Putative TPR-repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HG19_LEIBR

TriTrypDb:

LbrM.27.2600 , LBRM2903_270033200

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0101031	protein folding chaperone complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A4HG19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.649
CLV_NRD_NRD_1	165	167	PF00675	0.281
CLV_NRD_NRD_1	169	171	PF00675	0.281
CLV_NRD_NRD_1	270	272	PF00675	0.522
CLV_NRD_NRD_1	299	301	PF00675	0.616
CLV_NRD_NRD_1	379	381	PF00675	0.330
CLV_NRD_NRD_1	39	41	PF00675	0.558
CLV_NRD_NRD_1	442	444	PF00675	0.171
CLV_NRD_NRD_1	481	483	PF00675	0.481
CLV_PCSK_FUR_1	297	301	PF00082	0.583
CLV_PCSK_KEX2_1	165	167	PF00082	0.281
CLV_PCSK_KEX2_1	210	212	PF00082	0.569
CLV_PCSK_KEX2_1	227	229	PF00082	0.384
CLV_PCSK_KEX2_1	270	272	PF00082	0.527
CLV_PCSK_KEX2_1	299	301	PF00082	0.574
CLV_PCSK_KEX2_1	379	381	PF00082	0.330
CLV_PCSK_KEX2_1	442	444	PF00082	0.178
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.569
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.384
CLV_PCSK_SKI1_1	147	151	PF00082	0.453
CLV_PCSK_SKI1_1	482	486	PF00082	0.443
DEG_APCC_DBOX_1	16	24	PF00400	0.573
DEG_APCC_DBOX_1	169	177	PF00400	0.289
DEG_APCC_DBOX_1	179	187	PF00400	0.268
DEG_Nend_UBRbox_2	1	3	PF02207	0.569
DEG_SPOP_SBC_1	343	347	PF00917	0.759
DOC_MAPK_gen_1	297	306	PF00069	0.539
DOC_MAPK_gen_1	442	449	PF00069	0.378
DOC_MAPK_MEF2A_6	442	451	PF00069	0.458
DOC_PP2B_LxvP_1	368	371	PF13499	0.392
DOC_USP7_MATH_1	212	216	PF00917	0.568
DOC_USP7_MATH_1	221	225	PF00917	0.633
DOC_USP7_MATH_1	246	250	PF00917	0.676
DOC_USP7_MATH_1	275	279	PF00917	0.359
DOC_USP7_MATH_1	343	347	PF00917	0.695
DOC_USP7_MATH_1	359	363	PF00917	0.570
DOC_USP7_MATH_1	364	368	PF00917	0.639
DOC_USP7_UBL2_3	171	175	PF12436	0.372
DOC_WW_Pin1_4	320	325	PF00397	0.640
DOC_WW_Pin1_4	331	336	PF00397	0.606
DOC_WW_Pin1_4	338	343	PF00397	0.651
DOC_WW_Pin1_4	344	349	PF00397	0.732
DOC_WW_Pin1_4	409	414	PF00397	0.447
LIG_Actin_WH2_2	246	263	PF00022	0.421
LIG_FHA_1	111	117	PF00498	0.443
LIG_FHA_1	122	128	PF00498	0.457
LIG_FHA_1	148	154	PF00498	0.450
LIG_FHA_1	155	161	PF00498	0.470
LIG_FHA_1	202	208	PF00498	0.396
LIG_FHA_1	326	332	PF00498	0.689
LIG_FHA_1	427	433	PF00498	0.517
LIG_FHA_1	446	452	PF00498	0.459
LIG_FHA_2	141	147	PF00498	0.498
LIG_FHA_2	253	259	PF00498	0.612
LIG_LIR_Gen_1	373	381	PF02991	0.436
LIG_LIR_Nem_3	373	377	PF02991	0.436
LIG_LIR_Nem_3	378	384	PF02991	0.434
LIG_PCNA_PIPBox_1	387	396	PF02747	0.533
LIG_PCNA_yPIPBox_3	380	394	PF02747	0.371
LIG_Pex14_2	377	381	PF04695	0.447
LIG_SH2_GRB2like	129	132	PF00017	0.409
LIG_SH2_STAP1	129	133	PF00017	0.410
LIG_SH2_STAT3	394	397	PF00017	0.396
LIG_SH2_STAT5	104	107	PF00017	0.428
LIG_SH2_STAT5	112	115	PF00017	0.445
LIG_SH2_STAT5	136	139	PF00017	0.385
LIG_SH2_STAT5	159	162	PF00017	0.269
LIG_SH2_STAT5	394	397	PF00017	0.447
LIG_SH3_1	467	473	PF00018	0.536
LIG_SH3_2	470	475	PF14604	0.555
LIG_SH3_3	467	473	PF00018	0.557
LIG_SH3_3	82	88	PF00018	0.420
LIG_SUMO_SIM_anti_2	302	311	PF11976	0.628
LIG_SUMO_SIM_anti_2	461	468	PF11976	0.425
LIG_TRAF2_1	196	199	PF00917	0.521
LIG_TRAF2_1	254	257	PF00917	0.617
LIG_TRAF2_1	283	286	PF00917	0.590
LIG_TRAF2_1	314	317	PF00917	0.747
LIG_UBA3_1	415	424	PF00899	0.435
LIG_WRC_WIRS_1	423	428	PF05994	0.533
MOD_CDK_SPxxK_3	325	332	PF00069	0.529
MOD_CK1_1	122	128	PF00069	0.457
MOD_CK1_1	215	221	PF00069	0.647
MOD_CK1_1	251	257	PF00069	0.627
MOD_CK1_1	336	342	PF00069	0.683
MOD_CK1_1	346	352	PF00069	0.648
MOD_CK1_1	409	415	PF00069	0.500
MOD_CK2_1	1	7	PF00069	0.619
MOD_CK2_1	140	146	PF00069	0.445
MOD_CK2_1	251	257	PF00069	0.550
MOD_CK2_1	310	316	PF00069	0.713
MOD_CK2_1	370	376	PF00069	0.436
MOD_GlcNHglycan	101	104	PF01048	0.523
MOD_GlcNHglycan	121	124	PF01048	0.341
MOD_GlcNHglycan	193	197	PF01048	0.406
MOD_GlcNHglycan	217	220	PF01048	0.517
MOD_GlcNHglycan	223	226	PF01048	0.567
MOD_GlcNHglycan	351	354	PF01048	0.701
MOD_GlcNHglycan	44	47	PF01048	0.693
MOD_GlcNHglycan	467	470	PF01048	0.494
MOD_GSK3_1	217	224	PF00069	0.586
MOD_GSK3_1	248	255	PF00069	0.562
MOD_GSK3_1	333	340	PF00069	0.686
MOD_GSK3_1	342	349	PF00069	0.692
MOD_GSK3_1	366	373	PF00069	0.486
MOD_GSK3_1	422	429	PF00069	0.505
MOD_GSK3_1	99	106	PF00069	0.428
MOD_N-GLC_1	409	414	PF02516	0.247
MOD_NEK2_1	1	6	PF00069	0.625
MOD_NEK2_1	406	411	PF00069	0.481
MOD_NEK2_1	426	431	PF00069	0.338
MOD_NEK2_1	465	470	PF00069	0.424
MOD_NEK2_1	99	104	PF00069	0.472
MOD_NEK2_2	422	427	PF00069	0.474
MOD_PIKK_1	212	218	PF00454	0.556
MOD_PIKK_1	35	41	PF00454	0.568
MOD_PKA_2	275	281	PF00069	0.566
MOD_PKA_2	359	365	PF00069	0.529
MOD_PKA_2	55	61	PF00069	0.558
MOD_Plk_1	1	7	PF00069	0.619
MOD_Plk_1	445	451	PF00069	0.392
MOD_Plk_2-3	233	239	PF00069	0.698
MOD_Plk_4	445	451	PF00069	0.461
MOD_ProDKin_1	320	326	PF00069	0.641
MOD_ProDKin_1	331	337	PF00069	0.606
MOD_ProDKin_1	338	344	PF00069	0.654
MOD_ProDKin_1	346	352	PF00069	0.725
MOD_ProDKin_1	409	415	PF00069	0.447
MOD_SUMO_rev_2	13	23	PF00179	0.467
MOD_SUMO_rev_2	305	314	PF00179	0.642
MOD_SUMO_rev_2	316	321	PF00179	0.699
MOD_SUMO_rev_2	476	484	PF00179	0.518
TRG_ENDOCYTIC_2	136	139	PF00928	0.409
TRG_ER_diArg_1	164	166	PF00400	0.281
TRG_ER_diArg_1	269	271	PF00400	0.584
TRG_ER_diArg_1	297	300	PF00400	0.564
TRG_ER_diArg_1	356	359	PF00400	0.729
TRG_ER_diArg_1	379	381	PF00400	0.530
TRG_ER_diArg_1	441	443	PF00400	0.371
TRG_ER_diLys_1	483	487	PF00400	0.544
TRG_NLS_Bipartite_1	210	230	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.171

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF88	Leptomonas seymouri	61%	99%
A0A0S4J9Z5	Bodo saltans	40%	100%
A0A1X0NH58	Trypanosomatidae	40%	100%
A0A3Q8IHU4	Leishmania donovani	82%	100%
A0A3R7KY85	Trypanosoma rangeli	40%	100%
A4I340	Leishmania infantum	83%	100%
C9ZJL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ACV9	Leishmania major	82%	100%
E9AZE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q28IV3	Xenopus tropicalis	27%	74%
Q5ZKQ3	Gallus gallus	26%	73%
Q6NU95	Xenopus laevis	25%	74%
Q9D706	Mus musculus	25%	74%
Q9H6T3	Homo sapiens	24%	73%
V5AR46	Trypanosoma cruzi	41%	100%