CPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG16_LEIBR

TriTrypDb:

LbrM.27.2570 , LBRM2903_270032900

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.495
CLV_NRD_NRD_1	11	13	PF00675	0.550
CLV_NRD_NRD_1	305	307	PF00675	0.496
CLV_PCSK_KEX2_1	329	331	PF00082	0.628
CLV_PCSK_KEX2_1	337	339	PF00082	0.578
CLV_PCSK_KEX2_1	381	383	PF00082	0.618
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.575
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.504
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.618
CLV_PCSK_SKI1_1	107	111	PF00082	0.548
CLV_PCSK_SKI1_1	132	136	PF00082	0.451
CLV_PCSK_SKI1_1	139	143	PF00082	0.463
CLV_PCSK_SKI1_1	158	162	PF00082	0.286
CLV_PCSK_SKI1_1	33	37	PF00082	0.449
CLV_PCSK_SKI1_1	353	357	PF00082	0.437
CLV_PCSK_SKI1_1	359	363	PF00082	0.380
DEG_APCC_DBOX_1	358	366	PF00400	0.374
DOC_PP4_FxxP_1	151	154	PF00568	0.478
DOC_USP7_MATH_1	319	323	PF00917	0.504
DOC_USP7_MATH_1	372	376	PF00917	0.453
DOC_USP7_MATH_1	53	57	PF00917	0.528
DOC_USP7_UBL2_3	107	111	PF12436	0.562
DOC_USP7_UBL2_3	139	143	PF12436	0.547
DOC_USP7_UBL2_3	222	226	PF12436	0.569
DOC_WW_Pin1_4	146	151	PF00397	0.409
LIG_14-3-3_CanoR_1	330	339	PF00244	0.578
LIG_14-3-3_CanoR_1	369	376	PF00244	0.554
LIG_14-3-3_CanoR_1	77	87	PF00244	0.541
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.527
LIG_EH1_1	269	277	PF00400	0.521
LIG_FHA_1	108	114	PF00498	0.533
LIG_FHA_1	154	160	PF00498	0.392
LIG_FHA_1	334	340	PF00498	0.552
LIG_FHA_1	34	40	PF00498	0.479
LIG_FHA_1	355	361	PF00498	0.419
LIG_FHA_1	371	377	PF00498	0.643
LIG_FHA_1	4	10	PF00498	0.558
LIG_FHA_1	71	77	PF00498	0.381
LIG_FHA_1	79	85	PF00498	0.374
LIG_FHA_1	86	92	PF00498	0.349
LIG_FHA_2	15	21	PF00498	0.501
LIG_FHA_2	256	262	PF00498	0.559
LIG_LIR_Apic_2	148	154	PF02991	0.497
LIG_LIR_Gen_1	266	276	PF02991	0.398
LIG_LIR_Nem_3	211	217	PF02991	0.421
LIG_LIR_Nem_3	266	271	PF02991	0.406
LIG_NRBOX	112	118	PF00104	0.488
LIG_PCNA_yPIPBox_3	283	293	PF02747	0.546
LIG_SH2_SRC	268	271	PF00017	0.516
LIG_SH2_STAP1	268	272	PF00017	0.401
LIG_SH2_STAP1	323	327	PF00017	0.543
LIG_SH3_3	41	47	PF00018	0.558
LIG_SH3_4	222	229	PF00018	0.329
LIG_SUMO_SIM_par_1	5	10	PF11976	0.487
LIG_TRAF2_1	17	20	PF00917	0.312
LIG_UBA3_1	134	143	PF00899	0.430
LIG_UBA3_1	313	320	PF00899	0.434
LIG_UBA3_1	361	367	PF00899	0.535
LIG_WRC_WIRS_1	98	103	PF05994	0.521
MOD_CK1_1	149	155	PF00069	0.474
MOD_CK1_1	28	34	PF00069	0.414
MOD_CK1_1	3	9	PF00069	0.586
MOD_CK1_1	370	376	PF00069	0.596
MOD_CK1_1	40	46	PF00069	0.476
MOD_CK1_1	70	76	PF00069	0.396
MOD_CK2_1	14	20	PF00069	0.382
MOD_CK2_1	169	175	PF00069	0.516
MOD_GlcNHglycan	2	5	PF01048	0.673
MOD_GlcNHglycan	250	253	PF01048	0.482
MOD_GlcNHglycan	27	30	PF01048	0.426
MOD_GSK3_1	107	114	PF00069	0.529
MOD_GSK3_1	145	152	PF00069	0.425
MOD_GSK3_1	315	322	PF00069	0.484
MOD_GSK3_1	33	40	PF00069	0.461
MOD_GSK3_1	367	374	PF00069	0.516
MOD_N-GLC_1	33	38	PF02516	0.509
MOD_N-GLC_1	347	352	PF02516	0.531
MOD_NEK2_1	134	139	PF00069	0.414
MOD_NEK2_1	180	185	PF00069	0.458
MOD_NEK2_1	217	222	PF00069	0.462
MOD_NEK2_1	236	241	PF00069	0.225
MOD_NEK2_1	331	336	PF00069	0.570
MOD_NEK2_1	368	373	PF00069	0.610
MOD_NEK2_1	62	67	PF00069	0.429
MOD_PIKK_1	111	117	PF00454	0.480
MOD_PIKK_1	291	297	PF00454	0.462
MOD_PIKK_1	331	337	PF00454	0.574
MOD_PIKK_1	347	353	PF00454	0.481
MOD_PIKK_1	354	360	PF00454	0.609
MOD_PKA_2	264	270	PF00069	0.447
MOD_PKA_2	368	374	PF00069	0.415
MOD_Plk_1	33	39	PF00069	0.487
MOD_Plk_4	67	73	PF00069	0.409
MOD_ProDKin_1	146	152	PF00069	0.406
MOD_SUMO_for_1	105	108	PF00179	0.546
MOD_SUMO_rev_2	220	227	PF00179	0.528
TRG_ENDOCYTIC_2	268	271	PF00928	0.385
TRG_NLS_MonoExtN_4	364	370	PF00514	0.382
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A8	Leptomonas seymouri	64%	100%
A0A0S4J8X0	Bodo saltans	31%	100%
A0A1X0NG17	Trypanosomatidae	36%	99%
A0A3S7X117	Leishmania donovani	83%	100%
A0A422NDW9	Trypanosoma rangeli	36%	99%
A4I338	Leishmania infantum	83%	100%
C9ZJL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9ACV6	Leishmania major	84%	100%
E9AZE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BB08	Trypanosoma cruzi	36%	99%