Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HG13_LEIBR

TriTrypDb:

LbrM.27.2540

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.340
CLV_NRD_NRD_1	101	103	PF00675	0.463
CLV_NRD_NRD_1	177	179	PF00675	0.473
CLV_NRD_NRD_1	204	206	PF00675	0.532
CLV_NRD_NRD_1	214	216	PF00675	0.404
CLV_NRD_NRD_1	295	297	PF00675	0.390
CLV_NRD_NRD_1	324	326	PF00675	0.524
CLV_NRD_NRD_1	69	71	PF00675	0.576
CLV_PCSK_FUR_1	99	103	PF00082	0.584
CLV_PCSK_KEX2_1	101	103	PF00082	0.568
CLV_PCSK_KEX2_1	177	179	PF00082	0.473
CLV_PCSK_KEX2_1	203	205	PF00082	0.519
CLV_PCSK_KEX2_1	214	216	PF00082	0.402
CLV_PCSK_KEX2_1	295	297	PF00082	0.391
CLV_PCSK_KEX2_1	69	71	PF00082	0.576
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.519
CLV_PCSK_SKI1_1	101	105	PF00082	0.593
CLV_PCSK_SKI1_1	178	182	PF00082	0.622
CLV_PCSK_SKI1_1	20	24	PF00082	0.447
CLV_PCSK_SKI1_1	245	249	PF00082	0.445
CLV_PCSK_SKI1_1	341	345	PF00082	0.644
CLV_PCSK_SKI1_1	399	403	PF00082	0.421
CLV_PCSK_SKI1_1	48	52	PF00082	0.382
DEG_Nend_UBRbox_2	1	3	PF02207	0.571
DOC_CYCLIN_RxL_1	36	47	PF00134	0.377
DOC_CYCLIN_RxL_1	99	107	PF00134	0.597
DOC_MAPK_DCC_7	120	130	PF00069	0.508
DOC_MAPK_gen_1	177	183	PF00069	0.468
DOC_MAPK_gen_1	189	197	PF00069	0.369
DOC_MAPK_gen_1	45	55	PF00069	0.396
DOC_MAPK_gen_1	69	76	PF00069	0.385
DOC_MAPK_gen_1	99	106	PF00069	0.593
DOC_MAPK_MEF2A_6	69	78	PF00069	0.388
DOC_MAPK_MEF2A_6	99	108	PF00069	0.602
DOC_MAPK_NFAT4_5	101	109	PF00069	0.613
DOC_PP1_RVXF_1	270	277	PF00149	0.421
DOC_PP1_RVXF_1	90	96	PF00149	0.528
DOC_PP2B_LxvP_1	106	109	PF13499	0.478
DOC_PP4_FxxP_1	183	186	PF00568	0.522
DOC_USP7_MATH_1	321	325	PF00917	0.574
DOC_USP7_MATH_1	332	336	PF00917	0.536
DOC_USP7_MATH_1	339	343	PF00917	0.473
DOC_USP7_UBL2_3	151	155	PF12436	0.604
LIG_14-3-3_CanoR_1	105	109	PF00244	0.487
LIG_14-3-3_CanoR_1	14	18	PF00244	0.459
LIG_14-3-3_CanoR_1	20	30	PF00244	0.571
LIG_14-3-3_CanoR_1	204	209	PF00244	0.619
LIG_14-3-3_CanoR_1	264	268	PF00244	0.519
LIG_14-3-3_CanoR_1	275	279	PF00244	0.381
LIG_14-3-3_CanoR_1	299	309	PF00244	0.462
LIG_14-3-3_CanoR_1	325	332	PF00244	0.585
LIG_14-3-3_CanoR_1	369	373	PF00244	0.528
LIG_14-3-3_CanoR_1	48	53	PF00244	0.419
LIG_Actin_WH2_2	232	250	PF00022	0.493
LIG_AP2alpha_1	282	286	PF02296	0.443
LIG_BRCT_BRCA1_1	26	30	PF00533	0.525
LIG_BRCT_BRCA1_1	282	286	PF00533	0.384
LIG_CaM_IQ_9	196	211	PF13499	0.460
LIG_deltaCOP1_diTrp_1	284	287	PF00928	0.398
LIG_FHA_1	110	116	PF00498	0.478
LIG_FHA_1	197	203	PF00498	0.426
LIG_FHA_1	310	316	PF00498	0.487
LIG_FHA_1	326	332	PF00498	0.568
LIG_FHA_1	47	53	PF00498	0.525
LIG_FHA_1	98	104	PF00498	0.440
LIG_FHA_2	228	234	PF00498	0.326
LIG_FHA_2	27	33	PF00498	0.475
LIG_FHA_2	275	281	PF00498	0.487
LIG_FHA_2	66	72	PF00498	0.560
LIG_LIR_Apic_2	182	186	PF02991	0.530
LIG_LIR_Gen_1	10	19	PF02991	0.436
LIG_LIR_Gen_1	273	282	PF02991	0.426
LIG_LIR_Gen_1	54	62	PF02991	0.337
LIG_LIR_Gen_1	71	79	PF02991	0.331
LIG_LIR_Nem_3	10	15	PF02991	0.420
LIG_LIR_Nem_3	273	279	PF02991	0.437
LIG_LIR_Nem_3	283	289	PF02991	0.385
LIG_LIR_Nem_3	397	401	PF02991	0.408
LIG_LIR_Nem_3	54	58	PF02991	0.331
LIG_LIR_Nem_3	71	76	PF02991	0.329
LIG_NRBOX	372	378	PF00104	0.441
LIG_NRBOX	410	416	PF00104	0.432
LIG_PCNA_TLS_4	178	185	PF02747	0.460
LIG_Pex14_2	282	286	PF04695	0.443
LIG_Pex14_2	73	77	PF04695	0.369
LIG_REV1ctd_RIR_1	284	294	PF16727	0.501
LIG_SH2_CRK	398	402	PF00017	0.418
LIG_SH3_4	134	141	PF00018	0.493
LIG_SUMO_SIM_par_1	4	11	PF11976	0.495
LIG_SxIP_EBH_1	324	333	PF03271	0.511
LIG_TYR_ITIM	396	401	PF00017	0.409
LIG_UBA3_1	83	92	PF00899	0.468
LIG_WRC_WIRS_1	110	115	PF05994	0.490
LIG_WRC_WIRS_1	34	39	PF05994	0.511
LIG_WRC_WIRS_1	354	359	PF05994	0.455
LIG_WRC_WIRS_1	52	57	PF05994	0.286
LIG_WRC_WIRS_1	9	14	PF05994	0.421
MOD_CK1_1	207	213	PF00069	0.343
MOD_CK1_1	24	30	PF00069	0.585
MOD_CK1_1	270	276	PF00069	0.524
MOD_CK1_1	324	330	PF00069	0.650
MOD_CK1_1	356	362	PF00069	0.426
MOD_CK1_1	397	403	PF00069	0.477
MOD_CK1_1	60	66	PF00069	0.444
MOD_CK1_1	8	14	PF00069	0.350
MOD_CK2_1	274	280	PF00069	0.493
MOD_CK2_1	383	389	PF00069	0.467
MOD_CK2_1	41	47	PF00069	0.557
MOD_CK2_1	65	71	PF00069	0.490
MOD_CMANNOS	298	301	PF00535	0.522
MOD_GlcNHglycan	148	151	PF01048	0.549
MOD_GlcNHglycan	163	166	PF01048	0.537
MOD_GlcNHglycan	358	361	PF01048	0.425
MOD_GlcNHglycan	385	388	PF01048	0.473
MOD_GlcNHglycan	62	65	PF01048	0.374
MOD_GSK3_1	104	111	PF00069	0.550
MOD_GSK3_1	22	29	PF00069	0.613
MOD_GSK3_1	263	270	PF00069	0.516
MOD_GSK3_1	320	327	PF00069	0.613
MOD_GSK3_1	397	404	PF00069	0.591
MOD_N-GLC_1	280	285	PF02516	0.392
MOD_NEK2_1	104	109	PF00069	0.465
MOD_NEK2_1	146	151	PF00069	0.650
MOD_NEK2_1	196	201	PF00069	0.379
MOD_NEK2_1	247	252	PF00069	0.333
MOD_NEK2_1	274	279	PF00069	0.495
MOD_NEK2_1	309	314	PF00069	0.446
MOD_NEK2_1	394	399	PF00069	0.419
MOD_NEK2_1	41	46	PF00069	0.400
MOD_NEK2_1	5	10	PF00069	0.507
MOD_PIKK_1	196	202	PF00454	0.452
MOD_PIKK_1	302	308	PF00454	0.497
MOD_PK_1	118	124	PF00069	0.585
MOD_PKA_1	204	210	PF00069	0.403
MOD_PKA_1	325	331	PF00069	0.532
MOD_PKA_2	104	110	PF00069	0.543
MOD_PKA_2	13	19	PF00069	0.361
MOD_PKA_2	204	210	PF00069	0.403
MOD_PKA_2	263	269	PF00069	0.521
MOD_PKA_2	274	280	PF00069	0.381
MOD_PKA_2	324	330	PF00069	0.670
MOD_PKA_2	332	338	PF00069	0.580
MOD_PKA_2	368	374	PF00069	0.476
MOD_PKB_1	318	326	PF00069	0.505
MOD_Plk_1	118	124	PF00069	0.599
MOD_Plk_1	270	276	PF00069	0.524
MOD_Plk_1	46	52	PF00069	0.465
MOD_Plk_4	141	147	PF00069	0.511
MOD_Plk_4	247	253	PF00069	0.326
MOD_Plk_4	33	39	PF00069	0.475
MOD_Plk_4	339	345	PF00069	0.487
MOD_Plk_4	368	374	PF00069	0.476
MOD_Plk_4	397	403	PF00069	0.440
MOD_Plk_4	48	54	PF00069	0.438
MOD_SUMO_rev_2	182	191	PF00179	0.558
TRG_DiLeu_BaEn_1	2	7	PF01217	0.380
TRG_DiLeu_BaEn_3	389	395	PF01217	0.457
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.431
TRG_ENDOCYTIC_2	398	401	PF00928	0.413
TRG_ER_diArg_1	176	178	PF00400	0.497
TRG_ER_diArg_1	213	215	PF00400	0.474
TRG_ER_diArg_1	295	297	PF00400	0.386
TRG_ER_diArg_1	315	318	PF00400	0.518
TRG_ER_diArg_1	99	102	PF00400	0.549
TRG_NES_CRM1_1	175	187	PF08389	0.465
TRG_NES_CRM1_1	72	85	PF08389	0.524
TRG_NLS_MonoCore_2	202	207	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T5	Leptomonas seymouri	29%	99%
A0A3Q8IEE0	Leishmania donovani	66%	100%
E9ACV3	Leishmania major	64%	100%
E9AHG2	Leishmania infantum	66%	100%
E9AZE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%