LeishMANIAdb
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Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin motor domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HG12_LEIBR
TriTrypDb:
LbrM.27.2530
Length:
159

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG12
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 97 101 PF00656 0.644
CLV_NRD_NRD_1 115 117 PF00675 0.585
CLV_NRD_NRD_1 20 22 PF00675 0.548
CLV_PCSK_FUR_1 116 120 PF00082 0.491
CLV_PCSK_KEX2_1 118 120 PF00082 0.570
CLV_PCSK_KEX2_1 20 22 PF00082 0.548
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.570
CLV_PCSK_SKI1_1 104 108 PF00082 0.586
LIG_14-3-3_CanoR_1 20 27 PF00244 0.560
LIG_14-3-3_CterR_2 156 159 PF00244 0.499
LIG_BIR_II_1 1 5 PF00653 0.715
LIG_FHA_1 29 35 PF00498 0.612
LIG_LIR_Gen_1 50 57 PF02991 0.608
LIG_LIR_Nem_3 50 56 PF02991 0.613
LIG_PCNA_yPIPBox_3 59 68 PF02747 0.512
LIG_PDZ_Class_2 154 159 PF00595 0.755
LIG_SH2_PTP2 53 56 PF00017 0.621
LIG_SH2_STAT5 53 56 PF00017 0.606
LIG_SH2_STAT5 67 70 PF00017 0.405
LIG_SUMO_SIM_par_1 86 91 PF11976 0.769
LIG_TRAF2_1 106 109 PF00917 0.625
LIG_TRAF2_1 76 79 PF00917 0.762
MOD_CK1_1 152 158 PF00069 0.579
MOD_CK1_1 74 80 PF00069 0.554
MOD_CK2_1 73 79 PF00069 0.735
MOD_GlcNHglycan 28 31 PF01048 0.725
MOD_GlcNHglycan 90 93 PF01048 0.579
MOD_GSK3_1 133 140 PF00069 0.756
MOD_GSK3_1 146 153 PF00069 0.653
MOD_N-GLC_1 98 103 PF02516 0.489
MOD_NEK2_1 34 39 PF00069 0.535
MOD_NEK2_1 57 62 PF00069 0.539
MOD_PIKK_1 137 143 PF00454 0.757
MOD_PKA_1 20 26 PF00069 0.555
MOD_PKA_2 19 25 PF00069 0.620
MOD_PKA_2 71 77 PF00069 0.755
MOD_Plk_1 34 40 PF00069 0.488
MOD_Plk_1 98 104 PF00069 0.466
MOD_Plk_4 63 69 PF00069 0.545
MOD_Plk_4 83 89 PF00069 0.755
MOD_Plk_4 98 104 PF00069 0.482
TRG_DiLeu_BaEn_1 108 113 PF01217 0.586
TRG_ENDOCYTIC_2 53 56 PF00928 0.621
TRG_ER_diArg_1 19 21 PF00400 0.542
TRG_Pf-PMV_PEXEL_1 119 123 PF00026 0.525

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NQZ0 Trypanosomatidae 34% 82%
A0A3R7K6D4 Trypanosoma rangeli 31% 98%
A0A3S7X104 Leishmania donovani 74% 99%
A4I331 Leishmania infantum 74% 99%
E9ACV2 Leishmania major 78% 100%
E9AZE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 99%
V5B8D3 Trypanosoma cruzi 37% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS