Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG09_LEIBR

TriTrypDb:

LbrM.27.2500 , LBRM2903_270032200

Length:

247

Annotations

LeishMANIAdb annotations

A conserved but unique protein in Kinetoplastids (can also be organellar)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HG09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.704
CLV_NRD_NRD_1	15	17	PF00675	0.566
CLV_NRD_NRD_1	66	68	PF00675	0.490
CLV_PCSK_KEX2_1	17	19	PF00082	0.559
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.559
DEG_Nend_UBRbox_2	1	3	PF02207	0.758
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.724
DOC_MAPK_gen_1	118	127	PF00069	0.703
DOC_MAPK_gen_1	234	243	PF00069	0.677
DOC_PP2B_LxvP_1	131	134	PF13499	0.691
DOC_PP2B_LxvP_1	84	87	PF13499	0.714
DOC_PP4_FxxP_1	139	142	PF00568	0.401
DOC_PP4_FxxP_1	209	212	PF00568	0.527
DOC_USP7_MATH_1	212	216	PF00917	0.401
DOC_USP7_MATH_1	30	34	PF00917	0.742
LIG_14-3-3_CanoR_1	234	240	PF00244	0.615
LIG_14-3-3_CanoR_1	80	85	PF00244	0.690
LIG_BRCT_BRCA1_1	214	218	PF00533	0.240
LIG_Clathr_ClatBox_1	100	104	PF01394	0.780
LIG_deltaCOP1_diTrp_1	8	15	PF00928	0.753
LIG_FHA_1	192	198	PF00498	0.444
LIG_FHA_1	224	230	PF00498	0.432
LIG_FHA_1	27	33	PF00498	0.743
LIG_LIR_Gen_1	237	246	PF02991	0.655
LIG_LIR_Gen_1	7	15	PF02991	0.684
LIG_LIR_Nem_3	237	243	PF02991	0.629
LIG_LIR_Nem_3	7	12	PF02991	0.667
LIG_NRP_CendR_1	245	247	PF00754	0.485
LIG_Pex14_2	139	143	PF04695	0.339
LIG_Pex14_2	209	213	PF04695	0.365
LIG_Pex14_2	218	222	PF04695	0.342
LIG_SH2_STAT5	191	194	PF00017	0.476
LIG_SH2_STAT5	231	234	PF00017	0.540
LIG_SH3_1	18	24	PF00018	0.713
LIG_SH3_3	100	106	PF00018	0.674
LIG_SH3_3	171	177	PF00018	0.387
LIG_SH3_3	18	24	PF00018	0.713
LIG_SUMO_SIM_anti_2	149	154	PF11976	0.444
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.294
LIG_SUMO_SIM_par_1	123	129	PF11976	0.681
LIG_SUMO_SIM_par_1	172	178	PF11976	0.364
LIG_SUMO_SIM_par_1	41	49	PF11976	0.687
LIG_UBA3_1	182	187	PF00899	0.485
LIG_UBA3_1	46	54	PF00899	0.596
LIG_WRC_WIRS_1	12	17	PF05994	0.758
LIG_WRC_WIRS_1	240	245	PF05994	0.668
LIG_WW_3	85	89	PF00397	0.762
MOD_CK1_1	110	116	PF00069	0.765
MOD_CK1_1	156	162	PF00069	0.434
MOD_CK1_1	89	95	PF00069	0.617
MOD_GlcNHglycan	109	112	PF01048	0.466
MOD_GSK3_1	235	242	PF00069	0.606
MOD_GSK3_1	26	33	PF00069	0.741
MOD_GSK3_1	34	41	PF00069	0.742
MOD_GSK3_1	89	96	PF00069	0.654
MOD_NEK2_1	153	158	PF00069	0.511
MOD_NEK2_1	222	227	PF00069	0.366
MOD_PKA_2	107	113	PF00069	0.686
MOD_PKA_2	235	241	PF00069	0.619
MOD_PKA_2	87	93	PF00069	0.638
MOD_Plk_4	126	132	PF00069	0.655
MOD_Plk_4	212	218	PF00069	0.401
MOD_Plk_4	223	229	PF00069	0.372
MOD_Plk_4	235	241	PF00069	0.566
TRG_DiLeu_BaEn_2	97	103	PF01217	0.713
TRG_ENDOCYTIC_2	240	243	PF00928	0.665
TRG_ER_diArg_1	15	18	PF00400	0.764
TRG_ER_diArg_1	233	236	PF00400	0.624
TRG_ER_diArg_1	244	247	PF00400	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI2	Leptomonas seymouri	65%	100%
A0A1X0NSH8	Trypanosomatidae	36%	100%
A0A3Q8IAR5	Leishmania donovani	83%	100%
A0A3R7NGU7	Trypanosoma rangeli	34%	100%
A4I328	Leishmania infantum	84%	100%
E9ACU9	Leishmania major	82%	100%
E9AZD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5B3U0	Trypanosoma cruzi	32%	100%