Transcription elongation regulator-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation regulator-like protein

Species:

Leishmania braziliensis

UniProt:

A4HG07_LEIBR

TriTrypDb:

LbrM.27.2480 , LBRM2903_270032000

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0008023	transcription elongation factor complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032044	DSIF complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HG07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG07

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0032784	regulation of DNA-templated transcription elongation	7	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006354	DNA-templated transcription elongation	6	1
GO:0006368	transcription elongation by RNA polymerase II	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.658
CLV_C14_Caspase3-7	401	405	PF00656	0.551
CLV_C14_Caspase3-7	74	78	PF00656	0.687
CLV_C14_Caspase3-7	83	87	PF00656	0.679
CLV_NRD_NRD_1	152	154	PF00675	0.621
CLV_NRD_NRD_1	224	226	PF00675	0.321
CLV_NRD_NRD_1	37	39	PF00675	0.619
CLV_NRD_NRD_1	44	46	PF00675	0.570
CLV_NRD_NRD_1	639	641	PF00675	0.648
CLV_NRD_NRD_1	644	646	PF00675	0.718
CLV_PCSK_FUR_1	104	108	PF00082	0.471
CLV_PCSK_KEX2_1	106	108	PF00082	0.585
CLV_PCSK_KEX2_1	152	154	PF00082	0.588
CLV_PCSK_KEX2_1	226	228	PF00082	0.426
CLV_PCSK_KEX2_1	315	317	PF00082	0.518
CLV_PCSK_KEX2_1	44	46	PF00082	0.671
CLV_PCSK_KEX2_1	48	50	PF00082	0.707
CLV_PCSK_KEX2_1	62	64	PF00082	0.530
CLV_PCSK_KEX2_1	644	646	PF00082	0.718
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.597
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.426
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.518
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.704
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.530
CLV_PCSK_PC7_1	44	50	PF00082	0.637
CLV_PCSK_PC7_1	640	646	PF00082	0.696
CLV_PCSK_SKI1_1	107	111	PF00082	0.664
CLV_PCSK_SKI1_1	250	254	PF00082	0.426
CLV_PCSK_SKI1_1	320	324	PF00082	0.540
CLV_PCSK_SKI1_1	611	615	PF00082	0.404
CLV_PCSK_SKI1_1	67	71	PF00082	0.724
DEG_APCC_DBOX_1	278	286	PF00400	0.402
DOC_CKS1_1	321	326	PF01111	0.563
DOC_CKS1_1	592	597	PF01111	0.495
DOC_MAPK_gen_1	173	181	PF00069	0.321
DOC_MAPK_gen_1	200	206	PF00069	0.305
DOC_MAPK_gen_1	264	273	PF00069	0.417
DOC_MAPK_gen_1	539	547	PF00069	0.407
DOC_MAPK_MEF2A_6	439	447	PF00069	0.437
DOC_MAPK_MEF2A_6	478	487	PF00069	0.511
DOC_PP4_FxxP_1	321	324	PF00568	0.414
DOC_SPAK_OSR1_1	241	245	PF12202	0.426
DOC_USP7_MATH_1	174	178	PF00917	0.426
DOC_USP7_MATH_1	470	474	PF00917	0.434
DOC_USP7_MATH_1	56	60	PF00917	0.716
DOC_USP7_MATH_1	670	674	PF00917	0.663
DOC_USP7_MATH_1	72	76	PF00917	0.499
DOC_USP7_UBL2_3	308	312	PF12436	0.446
DOC_WW_Pin1_4	320	325	PF00397	0.565
DOC_WW_Pin1_4	591	596	PF00397	0.474
DOC_WW_Pin1_4	617	622	PF00397	0.504
LIG_14-3-3_CanoR_1	152	160	PF00244	0.487
LIG_14-3-3_CanoR_1	259	267	PF00244	0.570
LIG_14-3-3_CanoR_1	407	413	PF00244	0.522
LIG_14-3-3_CanoR_1	539	548	PF00244	0.514
LIG_14-3-3_CanoR_1	555	560	PF00244	0.468
LIG_14-3-3_CanoR_1	640	648	PF00244	0.639
LIG_Actin_WH2_2	399	416	PF00022	0.499
LIG_APCC_ABBA_1	484	489	PF00400	0.396
LIG_APCC_ABBAyCdc20_2	106	112	PF00400	0.447
LIG_APCC_ABBAyCdc20_2	216	222	PF00400	0.306
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_CSL_BTD_1	592	595	PF09270	0.594
LIG_FHA_1	180	186	PF00498	0.426
LIG_FHA_1	260	266	PF00498	0.619
LIG_FHA_1	294	300	PF00498	0.365
LIG_FHA_1	312	318	PF00498	0.365
LIG_FHA_1	354	360	PF00498	0.473
LIG_FHA_1	408	414	PF00498	0.466
LIG_FHA_1	427	433	PF00498	0.435
LIG_FHA_1	600	606	PF00498	0.401
LIG_FHA_1	610	616	PF00498	0.379
LIG_FHA_2	143	149	PF00498	0.665
LIG_Integrin_RGD_1	279	281	PF01839	0.513
LIG_KLC1_Yacidic_2	217	222	PF13176	0.306
LIG_LIR_Apic_2	318	324	PF02991	0.562
LIG_LIR_Gen_1	217	223	PF02991	0.307
LIG_LIR_Gen_1	269	278	PF02991	0.374
LIG_LIR_Gen_1	4	14	PF02991	0.707
LIG_LIR_Gen_1	556	565	PF02991	0.538
LIG_LIR_Nem_3	217	221	PF02991	0.307
LIG_LIR_Nem_3	269	273	PF02991	0.359
LIG_LIR_Nem_3	336	342	PF02991	0.463
LIG_LIR_Nem_3	4	10	PF02991	0.704
LIG_LIR_Nem_3	479	483	PF02991	0.519
LIG_LIR_Nem_3	556	562	PF02991	0.534
LIG_NRBOX	9	15	PF00104	0.608
LIG_PTB_Apo_2	183	190	PF02174	0.306
LIG_PTB_Phospho_1	183	189	PF10480	0.306
LIG_SH2_CRK	559	563	PF00017	0.546
LIG_SH2_NCK_1	126	130	PF00017	0.620
LIG_SH2_NCK_1	559	563	PF00017	0.573
LIG_SH2_NCK_1	661	665	PF00017	0.729
LIG_SH2_PTP2	218	221	PF00017	0.306
LIG_SH2_PTP2	270	273	PF00017	0.496
LIG_SH2_SRC	126	129	PF00017	0.615
LIG_SH2_SRC	218	221	PF00017	0.306
LIG_SH2_STAP1	189	193	PF00017	0.321
LIG_SH2_STAP1	661	665	PF00017	0.729
LIG_SH2_STAP1	7	11	PF00017	0.706
LIG_SH2_STAT3	377	380	PF00017	0.577
LIG_SH2_STAT5	218	221	PF00017	0.306
LIG_SH2_STAT5	270	273	PF00017	0.496
LIG_SH2_STAT5	337	340	PF00017	0.411
LIG_SH2_STAT5	349	352	PF00017	0.196
LIG_SH2_STAT5	68	71	PF00017	0.620
LIG_SH3_3	243	249	PF00018	0.426
LIG_SH3_3	303	309	PF00018	0.481
LIG_SH3_3	589	595	PF00018	0.480
LIG_SH3_4	308	315	PF00018	0.503
LIG_SUMO_SIM_anti_2	482	487	PF11976	0.495
LIG_SUMO_SIM_anti_2	543	550	PF11976	0.463
LIG_SUMO_SIM_anti_2	632	638	PF11976	0.447
LIG_SUMO_SIM_par_1	398	405	PF11976	0.457
LIG_SUMO_SIM_par_1	524	530	PF11976	0.403
LIG_TRAF2_1	369	372	PF00917	0.430
LIG_TRAF2_1	50	53	PF00917	0.530
LIG_TRAF2_1	648	651	PF00917	0.760
LIG_TRAF2_2	324	329	PF00917	0.323
LIG_TYR_ITIM	5	10	PF00017	0.697
LIG_TYR_ITIM	557	562	PF00017	0.535
MOD_CDK_SPK_2	320	325	PF00069	0.565
MOD_CK1_1	147	153	PF00069	0.684
MOD_CK1_1	450	456	PF00069	0.517
MOD_CK1_1	479	485	PF00069	0.507
MOD_CK1_1	513	519	PF00069	0.544
MOD_CK1_1	673	679	PF00069	0.708
MOD_CK1_1	75	81	PF00069	0.625
MOD_CK2_1	115	121	PF00069	0.507
MOD_CK2_1	366	372	PF00069	0.429
MOD_CK2_1	47	53	PF00069	0.549
MOD_CK2_1	524	530	PF00069	0.489
MOD_CK2_1	75	81	PF00069	0.530
MOD_Cter_Amidation	638	641	PF01082	0.635
MOD_GlcNHglycan	360	363	PF01048	0.461
MOD_GlcNHglycan	448	452	PF01048	0.546
MOD_GlcNHglycan	472	475	PF01048	0.438
MOD_GlcNHglycan	656	659	PF01048	0.704
MOD_GlcNHglycan	668	671	PF01048	0.704
MOD_GlcNHglycan	689	692	PF01048	0.599
MOD_GlcNHglycan	74	77	PF01048	0.622
MOD_GSK3_1	144	151	PF00069	0.679
MOD_GSK3_1	255	262	PF00069	0.634
MOD_GSK3_1	398	405	PF00069	0.524
MOD_GSK3_1	422	429	PF00069	0.458
MOD_GSK3_1	450	457	PF00069	0.465
MOD_GSK3_1	472	479	PF00069	0.460
MOD_GSK3_1	504	511	PF00069	0.553
MOD_GSK3_1	566	573	PF00069	0.570
MOD_GSK3_1	639	646	PF00069	0.708
MOD_GSK3_1	666	673	PF00069	0.693
MOD_N-GLC_1	540	545	PF02516	0.295
MOD_N-GLC_1	687	692	PF02516	0.691
MOD_N-GLC_2	186	188	PF02516	0.306
MOD_N-GLC_2	502	504	PF02516	0.506
MOD_NEK2_1	13	18	PF00069	0.563
MOD_NEK2_1	179	184	PF00069	0.344
MOD_NEK2_1	333	338	PF00069	0.516
MOD_NEK2_1	350	355	PF00069	0.379
MOD_NEK2_1	358	363	PF00069	0.433
MOD_NEK2_1	413	418	PF00069	0.429
MOD_NEK2_1	424	429	PF00069	0.438
MOD_NEK2_1	432	437	PF00069	0.398
MOD_NEK2_1	609	614	PF00069	0.378
MOD_NEK2_2	205	210	PF00069	0.306
MOD_NEK2_2	510	515	PF00069	0.665
MOD_PIKK_1	153	159	PF00454	0.640
MOD_PIKK_1	259	265	PF00454	0.631
MOD_PK_1	508	514	PF00069	0.647
MOD_PKA_1	47	53	PF00069	0.571
MOD_PKA_1	640	646	PF00069	0.722
MOD_PKA_2	174	180	PF00069	0.426
MOD_PKA_2	258	264	PF00069	0.585
MOD_PKA_2	406	412	PF00069	0.484
MOD_PKA_2	413	419	PF00069	0.403
MOD_PKA_2	566	572	PF00069	0.500
MOD_PKA_2	639	645	PF00069	0.593
MOD_PKA_2	666	672	PF00069	0.667
MOD_PKA_2	673	679	PF00069	0.613
MOD_Plk_1	333	339	PF00069	0.483
MOD_Plk_1	576	582	PF00069	0.566
MOD_Plk_1	679	685	PF00069	0.682
MOD_Plk_1	687	693	PF00069	0.692
MOD_Plk_2-3	115	121	PF00069	0.621
MOD_Plk_2-3	366	372	PF00069	0.345
MOD_Plk_2-3	524	530	PF00069	0.516
MOD_Plk_2-3	680	686	PF00069	0.711
MOD_Plk_2-3	82	88	PF00069	0.683
MOD_Plk_4	333	339	PF00069	0.515
MOD_Plk_4	472	478	PF00069	0.408
MOD_Plk_4	479	485	PF00069	0.386
MOD_Plk_4	680	686	PF00069	0.711
MOD_ProDKin_1	320	326	PF00069	0.565
MOD_ProDKin_1	591	597	PF00069	0.477
MOD_ProDKin_1	617	623	PF00069	0.503
MOD_SUMO_for_1	497	500	PF00179	0.529
MOD_SUMO_for_1	629	632	PF00179	0.511
MOD_SUMO_rev_2	112	119	PF00179	0.661
MOD_SUMO_rev_2	162	168	PF00179	0.455
MOD_SUMO_rev_2	54	64	PF00179	0.659
TRG_DiLeu_BaEn_1	632	637	PF01217	0.457
TRG_DiLeu_BaEn_1	9	14	PF01217	0.608
TRG_ENDOCYTIC_2	126	129	PF00928	0.470
TRG_ENDOCYTIC_2	218	221	PF00928	0.306
TRG_ENDOCYTIC_2	270	273	PF00928	0.496
TRG_ENDOCYTIC_2	559	562	PF00928	0.543
TRG_ENDOCYTIC_2	7	10	PF00928	0.704
TRG_ER_diArg_1	152	154	PF00400	0.644
TRG_ER_diArg_1	173	176	PF00400	0.321
TRG_ER_diArg_1	225	228	PF00400	0.426
TRG_ER_diArg_1	271	274	PF00400	0.370
TRG_ER_diArg_1	615	618	PF00400	0.373
TRG_NES_CRM1_1	203	213	PF08389	0.321
TRG_NLS_MonoExtC_3	224	230	PF00514	0.426
TRG_NLS_MonoExtC_3	37	42	PF00514	0.635
TRG_NLS_MonoExtN_4	36	42	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I1	Leptomonas seymouri	82%	100%
A0A0S4IUW1	Bodo saltans	41%	94%
A0A1X0NRB9	Trypanosomatidae	50%	95%
A0A3Q8IDN1	Leishmania donovani	90%	99%
A0A422NAL6	Trypanosoma rangeli	51%	98%
A4I326	Leishmania infantum	90%	99%
C9ZJK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9ACU7	Leishmania major	91%	100%
E9AZD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
O13936	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	70%
O80770	Arabidopsis thaliana	24%	70%
Q4I5I4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	67%
Q4PIC4	Ustilago maydis (strain 521 / FGSC 9021)	23%	73%
Q5ALX3	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	72%
Q5BCN2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	68%
Q6BZG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	72%
Q6CC84	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	71%
Q6CWW9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	67%
Q6FRZ5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	69%
Q759T6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	72%
Q9STN3	Arabidopsis thaliana	24%	67%
V5D465	Trypanosoma cruzi	51%	96%