Putative acyl-CoA oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA oxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HG06_LEIBR

TriTrypDb:

LbrM.27.2470 , LBRM2903_270031800 , LBRM2903_270031900

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	11
GO:0042579	microbody	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HG06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG06

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006631	fatty acid metabolic process	4	11
GO:0006635	fatty acid beta-oxidation	6	10
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	10
GO:0009062	fatty acid catabolic process	5	10
GO:0009987	cellular process	1	11
GO:0016042	lipid catabolic process	4	10
GO:0016054	organic acid catabolic process	4	10
GO:0019395	fatty acid oxidation	5	10
GO:0019752	carboxylic acid metabolic process	5	11
GO:0030258	lipid modification	4	10
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0034440	lipid oxidation	5	10
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044242	cellular lipid catabolic process	4	10
GO:0044248	cellular catabolic process	3	10
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	10
GO:0046395	carboxylic acid catabolic process	5	10
GO:0071704	organic substance metabolic process	2	11
GO:0072329	monocarboxylic acid catabolic process	6	10
GO:1901575	organic substance catabolic process	3	10
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	7	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003997	acyl-CoA oxidase activity	5	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0071949	FAD binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0005504	fatty acid binding	3	1
GO:0008289	lipid binding	2	1
GO:0031406	carboxylic acid binding	4	1
GO:0033293	monocarboxylic acid binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.398
CLV_C14_Caspase3-7	429	433	PF00656	0.506
CLV_C14_Caspase3-7	612	616	PF00656	0.315
CLV_NRD_NRD_1	111	113	PF00675	0.309
CLV_NRD_NRD_1	12	14	PF00675	0.663
CLV_NRD_NRD_1	313	315	PF00675	0.391
CLV_NRD_NRD_1	525	527	PF00675	0.297
CLV_NRD_NRD_1	573	575	PF00675	0.287
CLV_NRD_NRD_1	715	717	PF00675	0.702
CLV_NRD_NRD_1	97	99	PF00675	0.295
CLV_PCSK_FUR_1	310	314	PF00082	0.467
CLV_PCSK_KEX2_1	111	113	PF00082	0.438
CLV_PCSK_KEX2_1	12	14	PF00082	0.663
CLV_PCSK_KEX2_1	312	314	PF00082	0.381
CLV_PCSK_KEX2_1	515	517	PF00082	0.383
CLV_PCSK_KEX2_1	525	527	PF00082	0.288
CLV_PCSK_KEX2_1	715	717	PF00082	0.693
CLV_PCSK_KEX2_1	97	99	PF00082	0.346
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.390
CLV_PCSK_PC7_1	521	527	PF00082	0.271
CLV_PCSK_PC7_1	93	99	PF00082	0.262
CLV_PCSK_SKI1_1	252	256	PF00082	0.521
CLV_PCSK_SKI1_1	314	318	PF00082	0.310
CLV_PCSK_SKI1_1	326	330	PF00082	0.270
CLV_PCSK_SKI1_1	485	489	PF00082	0.438
CLV_PCSK_SKI1_1	574	578	PF00082	0.307
CLV_PCSK_SKI1_1	60	64	PF00082	0.368
CLV_Separin_Metazoa	307	311	PF03568	0.488
DEG_APCC_DBOX_1	573	581	PF00400	0.290
DEG_APCC_DBOX_1	59	67	PF00400	0.377
DEG_ODPH_VHL_1	621	634	PF01847	0.315
DOC_CKS1_1	8	13	PF01111	0.435
DOC_CYCLIN_RxL_1	495	507	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.529
DOC_MAPK_gen_1	97	103	PF00069	0.253
DOC_MAPK_MEF2A_6	348	355	PF00069	0.497
DOC_PP1_RVXF_1	450	457	PF00149	0.321
DOC_PP1_RVXF_1	499	506	PF00149	0.331
DOC_PP1_RVXF_1	576	583	PF00149	0.315
DOC_PP1_RVXF_1	590	596	PF00149	0.315
DOC_PP2B_LxvP_1	239	242	PF13499	0.355
DOC_PP2B_LxvP_1	5	8	PF13499	0.432
DOC_PP2B_LxvP_1	83	86	PF13499	0.572
DOC_PP4_FxxP_1	383	386	PF00568	0.436
DOC_PP4_FxxP_1	39	42	PF00568	0.346
DOC_USP7_MATH_1	145	149	PF00917	0.475
DOC_USP7_MATH_1	210	214	PF00917	0.456
DOC_USP7_MATH_1	361	365	PF00917	0.423
DOC_USP7_MATH_1	455	459	PF00917	0.328
DOC_USP7_MATH_1	641	645	PF00917	0.504
DOC_USP7_MATH_1	673	677	PF00917	0.670
DOC_USP7_MATH_1	69	73	PF00917	0.554
DOC_USP7_MATH_1	91	95	PF00917	0.418
DOC_USP7_UBL2_3	563	567	PF12436	0.374
DOC_WW_Pin1_4	106	111	PF00397	0.354
DOC_WW_Pin1_4	121	126	PF00397	0.308
DOC_WW_Pin1_4	357	362	PF00397	0.319
DOC_WW_Pin1_4	490	495	PF00397	0.454
DOC_WW_Pin1_4	67	72	PF00397	0.555
DOC_WW_Pin1_4	7	12	PF00397	0.516
LIG_14-3-3_CanoR_1	111	117	PF00244	0.349
LIG_14-3-3_CanoR_1	17	21	PF00244	0.584
LIG_14-3-3_CanoR_1	246	252	PF00244	0.462
LIG_14-3-3_CanoR_1	4	8	PF00244	0.692
LIG_14-3-3_CanoR_1	541	546	PF00244	0.399
LIG_14-3-3_CanoR_1	666	670	PF00244	0.650
LIG_14-3-3_CanoR_1	98	104	PF00244	0.307
LIG_APCC_ABBA_1	380	385	PF00400	0.427
LIG_APCC_ABBAyCdc20_2	643	649	PF00400	0.357
LIG_deltaCOP1_diTrp_1	40	46	PF00928	0.242
LIG_deltaCOP1_diTrp_1	531	540	PF00928	0.271
LIG_FHA_1	213	219	PF00498	0.355
LIG_FHA_1	304	310	PF00498	0.468
LIG_FHA_1	315	321	PF00498	0.251
LIG_FHA_1	328	334	PF00498	0.267
LIG_FHA_1	417	423	PF00498	0.496
LIG_FHA_1	445	451	PF00498	0.460
LIG_FHA_1	458	464	PF00498	0.305
LIG_FHA_1	471	477	PF00498	0.466
LIG_FHA_2	412	418	PF00498	0.472
LIG_FHA_2	427	433	PF00498	0.265
LIG_FHA_2	657	663	PF00498	0.530
LIG_FHA_2	73	79	PF00498	0.601
LIG_HP1_1	361	365	PF01393	0.423
LIG_Integrin_RGD_1	663	665	PF01839	0.569
LIG_KLC1_Yacidic_2	554	559	PF13176	0.399
LIG_LIR_Apic_2	36	42	PF02991	0.356
LIG_LIR_Apic_2	649	655	PF02991	0.620
LIG_LIR_Gen_1	102	110	PF02991	0.346
LIG_LIR_Gen_1	115	125	PF02991	0.301
LIG_LIR_Gen_1	369	375	PF02991	0.316
LIG_LIR_Gen_1	453	463	PF02991	0.267
LIG_LIR_Gen_1	536	545	PF02991	0.285
LIG_LIR_Gen_1	554	562	PF02991	0.274
LIG_LIR_Gen_1	698	708	PF02991	0.546
LIG_LIR_Nem_3	102	106	PF02991	0.332
LIG_LIR_Nem_3	115	120	PF02991	0.294
LIG_LIR_Nem_3	136	140	PF02991	0.369
LIG_LIR_Nem_3	196	202	PF02991	0.343
LIG_LIR_Nem_3	369	373	PF02991	0.322
LIG_LIR_Nem_3	40	44	PF02991	0.356
LIG_LIR_Nem_3	453	459	PF02991	0.319
LIG_LIR_Nem_3	478	483	PF02991	0.365
LIG_LIR_Nem_3	536	540	PF02991	0.285
LIG_LIR_Nem_3	554	560	PF02991	0.350
LIG_LIR_Nem_3	649	654	PF02991	0.460
LIG_LIR_Nem_3	698	704	PF02991	0.547
LIG_LYPXL_yS_3	350	353	PF13949	0.482
LIG_NRBOX	471	477	PF00104	0.500
LIG_NRBOX	592	598	PF00104	0.370
LIG_OCRL_FandH_1	505	517	PF00620	0.455
LIG_PCNA_yPIPBox_3	359	368	PF02747	0.420
LIG_PTB_Apo_2	486	493	PF02174	0.438
LIG_PTB_Phospho_1	486	492	PF10480	0.435
LIG_REV1ctd_RIR_1	503	513	PF16727	0.320
LIG_RPA_C_Fungi	308	320	PF08784	0.447
LIG_SH2_PTP2	370	373	PF00017	0.322
LIG_SH2_SRC	184	187	PF00017	0.263
LIG_SH2_SRC	392	395	PF00017	0.415
LIG_SH2_SRC	557	560	PF00017	0.399
LIG_SH2_STAP1	117	121	PF00017	0.336
LIG_SH2_STAP1	392	396	PF00017	0.381
LIG_SH2_STAP1	535	539	PF00017	0.290
LIG_SH2_STAT5	135	138	PF00017	0.415
LIG_SH2_STAT5	285	288	PF00017	0.479
LIG_SH2_STAT5	295	298	PF00017	0.575
LIG_SH2_STAT5	321	324	PF00017	0.330
LIG_SH2_STAT5	33	36	PF00017	0.540
LIG_SH2_STAT5	335	338	PF00017	0.320
LIG_SH2_STAT5	340	343	PF00017	0.258
LIG_SH2_STAT5	370	373	PF00017	0.298
LIG_SH2_STAT5	557	560	PF00017	0.417
LIG_SH3_2	8	13	PF14604	0.435
LIG_SH3_3	271	277	PF00018	0.408
LIG_SH3_3	338	344	PF00018	0.430
LIG_SH3_3	5	11	PF00018	0.600
LIG_SH3_3	617	623	PF00018	0.271
LIG_SH3_3	63	69	PF00018	0.448
LIG_SUMO_SIM_par_1	407	414	PF11976	0.436
LIG_TRAF2_1	167	170	PF00917	0.459
LIG_TRAF2_1	297	300	PF00917	0.525
LIG_TRAF2_1	689	692	PF00917	0.587
LIG_TRAF2_1	697	700	PF00917	0.546
LIG_WRC_WIRS_1	100	105	PF05994	0.350
LIG_WRC_WIRS_1	412	417	PF05994	0.392
MOD_CDK_SPK_2	106	111	PF00069	0.432
MOD_CDK_SPK_2	490	495	PF00069	0.454
MOD_CDK_SPK_2	7	12	PF00069	0.591
MOD_CDK_SPxK_1	106	112	PF00069	0.450
MOD_CDK_SPxK_1	7	13	PF00069	0.436
MOD_CK1_1	159	165	PF00069	0.448
MOD_CK1_1	425	431	PF00069	0.359
MOD_CK1_1	72	78	PF00069	0.569
MOD_CK2_1	112	118	PF00069	0.369
MOD_CK2_1	656	662	PF00069	0.517
MOD_CK2_1	694	700	PF00069	0.585
MOD_CK2_1	72	78	PF00069	0.641
MOD_CMANNOS	468	471	PF00535	0.452
MOD_CMANNOS	534	537	PF00535	0.271
MOD_Cter_Amidation	572	575	PF01082	0.315
MOD_GlcNHglycan	158	161	PF01048	0.466
MOD_GlcNHglycan	212	215	PF01048	0.415
MOD_GlcNHglycan	385	389	PF01048	0.504
MOD_GlcNHglycan	446	450	PF01048	0.456
MOD_GlcNHglycan	603	606	PF01048	0.173
MOD_GlcNHglycan	643	646	PF01048	0.549
MOD_GlcNHglycan	670	673	PF01048	0.662
MOD_GlcNHglycan	685	688	PF01048	0.622
MOD_GSK3_1	112	119	PF00069	0.259
MOD_GSK3_1	210	217	PF00069	0.321
MOD_GSK3_1	3	10	PF00069	0.496
MOD_GSK3_1	357	364	PF00069	0.438
MOD_GSK3_1	384	391	PF00069	0.486
MOD_GSK3_1	422	429	PF00069	0.413
MOD_GSK3_1	471	478	PF00069	0.420
MOD_GSK3_1	562	569	PF00069	0.290
MOD_GSK3_1	596	603	PF00069	0.334
MOD_GSK3_1	650	657	PF00069	0.468
MOD_N-GLC_1	223	228	PF02516	0.482
MOD_N-GLC_1	673	678	PF02516	0.605
MOD_N-GLC_1	72	77	PF02516	0.505
MOD_NEK2_1	193	198	PF00069	0.375
MOD_NEK2_1	398	403	PF00069	0.295
MOD_NEK2_1	422	427	PF00069	0.444
MOD_NEK2_1	445	450	PF00069	0.457
MOD_NEK2_1	475	480	PF00069	0.336
MOD_NEK2_1	595	600	PF00069	0.374
MOD_NEK2_1	601	606	PF00069	0.387
MOD_NEK2_2	145	150	PF00069	0.476
MOD_PIKK_1	72	78	PF00454	0.545
MOD_PKA_2	16	22	PF00069	0.607
MOD_PKA_2	193	199	PF00069	0.377
MOD_PKA_2	29	35	PF00069	0.654
MOD_PKA_2	3	9	PF00069	0.696
MOD_PKA_2	517	523	PF00069	0.409
MOD_PKA_2	665	671	PF00069	0.646
MOD_PKA_2	694	700	PF00069	0.549
MOD_PKB_1	312	320	PF00069	0.382
MOD_Plk_1	416	422	PF00069	0.507
MOD_Plk_1	445	451	PF00069	0.332
MOD_Plk_2-3	411	417	PF00069	0.445
MOD_Plk_4	112	118	PF00069	0.348
MOD_Plk_4	29	35	PF00069	0.563
MOD_Plk_4	361	367	PF00069	0.319
MOD_Plk_4	433	439	PF00069	0.381
MOD_Plk_4	471	477	PF00069	0.492
MOD_Plk_4	616	622	PF00069	0.264
MOD_Plk_4	647	653	PF00069	0.486
MOD_ProDKin_1	106	112	PF00069	0.354
MOD_ProDKin_1	121	127	PF00069	0.305
MOD_ProDKin_1	357	363	PF00069	0.313
MOD_ProDKin_1	490	496	PF00069	0.455
MOD_ProDKin_1	67	73	PF00069	0.547
MOD_ProDKin_1	7	13	PF00069	0.514
MOD_SUMO_for_1	687	690	PF00179	0.550
MOD_SUMO_rev_2	289	293	PF00179	0.527
TRG_DiLeu_BaEn_4	78	84	PF01217	0.568
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.422
TRG_ENDOCYTIC_2	117	120	PF00928	0.404
TRG_ENDOCYTIC_2	350	353	PF00928	0.373
TRG_ENDOCYTIC_2	370	373	PF00928	0.135
TRG_ENDOCYTIC_2	557	560	PF00928	0.416
TRG_ENDOCYTIC_2	651	654	PF00928	0.463
TRG_ER_diArg_1	11	13	PF00400	0.663
TRG_ER_diArg_1	110	112	PF00400	0.353
TRG_ER_diArg_1	309	312	PF00400	0.435
TRG_ER_diArg_1	313	315	PF00400	0.383
TRG_ER_diArg_1	540	543	PF00400	0.354
TRG_ER_diArg_1	571	574	PF00400	0.291
TRG_NES_CRM1_1	608	624	PF08389	0.387
TRG_NLS_MonoExtC_3	513	518	PF00514	0.422
TRG_NLS_MonoExtN_4	514	519	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V2	Leptomonas seymouri	76%	92%
A0A0S4IUE9	Bodo saltans	45%	99%
A0A1X0NR05	Trypanosomatidae	55%	99%
A0A3S7X102	Leishmania donovani	90%	100%
A4I325	Leishmania infantum	90%	100%
C9ZJJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9ACU6	Leishmania major	90%	100%
E9AZD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O64894	Cucurbita maxima	22%	100%
O65201	Arabidopsis thaliana	23%	100%
V5ANG8	Trypanosoma cruzi	58%	98%