Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG04_LEIBR

TriTrypDb:

LbrM.27.2450 , LBRM2903_270031600

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.640
CLV_C14_Caspase3-7	280	284	PF00656	0.633
CLV_C14_Caspase3-7	402	406	PF00656	0.709
CLV_C14_Caspase3-7	542	546	PF00656	0.453
CLV_C14_Caspase3-7	82	86	PF00656	0.634
CLV_NRD_NRD_1	160	162	PF00675	0.634
CLV_NRD_NRD_1	274	276	PF00675	0.622
CLV_NRD_NRD_1	3	5	PF00675	0.576
CLV_NRD_NRD_1	361	363	PF00675	0.789
CLV_NRD_NRD_1	380	382	PF00675	0.526
CLV_NRD_NRD_1	419	421	PF00675	0.697
CLV_PCSK_FUR_1	272	276	PF00082	0.620
CLV_PCSK_KEX2_1	160	162	PF00082	0.827
CLV_PCSK_KEX2_1	2	4	PF00082	0.584
CLV_PCSK_KEX2_1	203	205	PF00082	0.556
CLV_PCSK_KEX2_1	274	276	PF00082	0.622
CLV_PCSK_KEX2_1	380	382	PF00082	0.645
CLV_PCSK_KEX2_1	419	421	PF00082	0.697
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.620
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.556
CLV_PCSK_SKI1_1	203	207	PF00082	0.552
CLV_PCSK_SKI1_1	458	462	PF00082	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DEG_SPOP_SBC_1	470	474	PF00917	0.666
DOC_MAPK_gen_1	362	370	PF00069	0.686
DOC_MAPK_gen_1	416	426	PF00069	0.729
DOC_MAPK_MEF2A_6	362	370	PF00069	0.686
DOC_MAPK_MEF2A_6	419	428	PF00069	0.679
DOC_MAPK_MEF2A_6	651	660	PF00069	0.500
DOC_PP2B_LxvP_1	452	455	PF13499	0.572
DOC_PP4_FxxP_1	14	17	PF00568	0.514
DOC_USP7_MATH_1	136	140	PF00917	0.696
DOC_USP7_MATH_1	162	166	PF00917	0.584
DOC_USP7_MATH_1	257	261	PF00917	0.685
DOC_USP7_MATH_1	282	286	PF00917	0.717
DOC_USP7_MATH_1	366	370	PF00917	0.633
DOC_USP7_MATH_1	383	387	PF00917	0.734
DOC_USP7_MATH_1	414	418	PF00917	0.553
DOC_WW_Pin1_4	153	158	PF00397	0.650
DOC_WW_Pin1_4	160	165	PF00397	0.633
DOC_WW_Pin1_4	18	23	PF00397	0.599
DOC_WW_Pin1_4	189	194	PF00397	0.640
DOC_WW_Pin1_4	228	233	PF00397	0.608
DOC_WW_Pin1_4	235	240	PF00397	0.699
DOC_WW_Pin1_4	290	295	PF00397	0.601
DOC_WW_Pin1_4	386	391	PF00397	0.604
DOC_WW_Pin1_4	40	45	PF00397	0.591
DOC_WW_Pin1_4	440	445	PF00397	0.741
DOC_WW_Pin1_4	447	452	PF00397	0.681
DOC_WW_Pin1_4	471	476	PF00397	0.611
DOC_WW_Pin1_4	557	562	PF00397	0.601
DOC_WW_Pin1_4	617	622	PF00397	0.613
DOC_WW_Pin1_4	626	631	PF00397	0.617
DOC_WW_Pin1_4	652	657	PF00397	0.568
DOC_WW_Pin1_4	87	92	PF00397	0.633
DOC_WW_Pin1_4	99	104	PF00397	0.512
LIG_14-3-3_CanoR_1	122	131	PF00244	0.532
LIG_14-3-3_CanoR_1	153	157	PF00244	0.609
LIG_14-3-3_CanoR_1	204	208	PF00244	0.592
LIG_14-3-3_CanoR_1	259	263	PF00244	0.682
LIG_14-3-3_CanoR_1	272	278	PF00244	0.626
LIG_14-3-3_CanoR_1	3	11	PF00244	0.540
LIG_14-3-3_CanoR_1	309	317	PF00244	0.531
LIG_14-3-3_CanoR_1	322	327	PF00244	0.635
LIG_14-3-3_CanoR_1	365	371	PF00244	0.635
LIG_14-3-3_CanoR_1	385	391	PF00244	0.520
LIG_14-3-3_CanoR_1	419	426	PF00244	0.650
LIG_14-3-3_CanoR_1	437	444	PF00244	0.579
LIG_14-3-3_CanoR_1	445	451	PF00244	0.552
LIG_14-3-3_CanoR_1	533	541	PF00244	0.380
LIG_BIR_III_2	85	89	PF00653	0.527
LIG_BIR_III_4	405	409	PF00653	0.649
LIG_deltaCOP1_diTrp_1	304	314	PF00928	0.489
LIG_FHA_1	103	109	PF00498	0.618
LIG_FHA_1	209	215	PF00498	0.612
LIG_FHA_1	216	222	PF00498	0.555
LIG_FHA_1	419	425	PF00498	0.703
LIG_FHA_1	447	453	PF00498	0.537
LIG_FHA_1	471	477	PF00498	0.657
LIG_FHA_1	570	576	PF00498	0.547
LIG_FHA_2	238	244	PF00498	0.625
LIG_FHA_2	494	500	PF00498	0.430
LIG_FHA_2	595	601	PF00498	0.689
LIG_FHA_2	80	86	PF00498	0.693
LIG_LIR_Gen_1	59	68	PF02991	0.468
LIG_LIR_Nem_3	311	317	PF02991	0.504
LIG_LIR_Nem_3	59	65	PF02991	0.590
LIG_NRBOX	508	514	PF00104	0.436
LIG_PTAP_UEV_1	432	437	PF05743	0.563
LIG_SH3_1	236	242	PF00018	0.564
LIG_SH3_1	651	657	PF00018	0.489
LIG_SH3_3	151	157	PF00018	0.568
LIG_SH3_3	236	242	PF00018	0.740
LIG_SH3_3	365	371	PF00018	0.610
LIG_SH3_3	38	44	PF00018	0.583
LIG_SH3_3	430	436	PF00018	0.560
LIG_SH3_3	445	451	PF00018	0.675
LIG_SH3_3	620	626	PF00018	0.624
LIG_SH3_3	647	653	PF00018	0.640
LIG_SH3_3	85	91	PF00018	0.525
LIG_TRAF2_1	294	297	PF00917	0.579
LIG_TRAF2_1	553	556	PF00917	0.574
LIG_TRAF2_1	598	601	PF00917	0.654
LIG_TRAF2_2	294	299	PF00917	0.523
LIG_WRC_WIRS_1	303	308	PF05994	0.622
MOD_CDK_SPK_2	440	445	PF00069	0.568
MOD_CDK_SPxK_1	628	634	PF00069	0.622
MOD_CDK_SPxxK_3	153	160	PF00069	0.640
MOD_CDK_SPxxK_3	238	245	PF00069	0.633
MOD_CDK_SPxxK_3	40	47	PF00069	0.509
MOD_CK1_1	102	108	PF00069	0.479
MOD_CK1_1	126	132	PF00069	0.665
MOD_CK1_1	135	141	PF00069	0.716
MOD_CK1_1	194	200	PF00069	0.665
MOD_CK1_1	237	243	PF00069	0.627
MOD_CK1_1	265	271	PF00069	0.586
MOD_CK1_1	305	311	PF00069	0.552
MOD_CK1_1	384	390	PF00069	0.627
MOD_CK1_1	410	416	PF00069	0.567
MOD_CK1_1	450	456	PF00069	0.581
MOD_CK1_1	483	489	PF00069	0.398
MOD_CK1_1	503	509	PF00069	0.354
MOD_CK1_1	53	59	PF00069	0.545
MOD_CK1_1	568	574	PF00069	0.679
MOD_CK1_1	637	643	PF00069	0.529
MOD_CK2_1	136	142	PF00069	0.636
MOD_CK2_1	471	477	PF00069	0.551
MOD_CK2_1	493	499	PF00069	0.433
MOD_CK2_1	533	539	PF00069	0.559
MOD_CK2_1	594	600	PF00069	0.689
MOD_CK2_1	63	69	PF00069	0.465
MOD_CMANNOS	46	49	PF00535	0.615
MOD_Cter_Amidation	272	275	PF01082	0.621
MOD_Cter_Amidation	378	381	PF01082	0.555
MOD_DYRK1A_RPxSP_1	153	157	PF00069	0.562
MOD_DYRK1A_RPxSP_1	189	193	PF00069	0.563
MOD_GlcNHglycan	133	137	PF01048	0.654
MOD_GlcNHglycan	164	167	PF01048	0.642
MOD_GlcNHglycan	196	199	PF01048	0.710
MOD_GlcNHglycan	267	270	PF01048	0.626
MOD_GlcNHglycan	277	280	PF01048	0.665
MOD_GlcNHglycan	326	329	PF01048	0.810
MOD_GlcNHglycan	377	380	PF01048	0.690
MOD_GlcNHglycan	412	415	PF01048	0.685
MOD_GlcNHglycan	455	458	PF01048	0.566
MOD_GlcNHglycan	5	8	PF01048	0.545
MOD_GlcNHglycan	52	55	PF01048	0.661
MOD_GlcNHglycan	541	544	PF01048	0.497
MOD_GlcNHglycan	611	614	PF01048	0.680
MOD_GlcNHglycan	615	618	PF01048	0.616
MOD_GlcNHglycan	636	639	PF01048	0.618
MOD_GlcNHglycan	645	648	PF01048	0.591
MOD_GlcNHglycan	75	78	PF01048	0.567
MOD_GSK3_1	132	139	PF00069	0.657
MOD_GSK3_1	142	149	PF00069	0.564
MOD_GSK3_1	170	177	PF00069	0.683
MOD_GSK3_1	181	188	PF00069	0.540
MOD_GSK3_1	234	241	PF00069	0.667
MOD_GSK3_1	258	265	PF00069	0.568
MOD_GSK3_1	308	315	PF00069	0.548
MOD_GSK3_1	324	331	PF00069	0.651
MOD_GSK3_1	366	373	PF00069	0.642
MOD_GSK3_1	410	417	PF00069	0.716
MOD_GSK3_1	418	425	PF00069	0.731
MOD_GSK3_1	436	443	PF00069	0.724
MOD_GSK3_1	446	453	PF00069	0.815
MOD_GSK3_1	465	472	PF00069	0.566
MOD_GSK3_1	479	486	PF00069	0.545
MOD_GSK3_1	551	558	PF00069	0.701
MOD_GSK3_1	565	572	PF00069	0.757
MOD_GSK3_1	573	580	PF00069	0.546
MOD_GSK3_1	582	589	PF00069	0.479
MOD_GSK3_1	609	616	PF00069	0.668
MOD_GSK3_1	75	82	PF00069	0.661
MOD_GSK3_1	98	105	PF00069	0.578
MOD_N-GLC_1	609	614	PF02516	0.683
MOD_N-GLC_1	643	648	PF02516	0.600
MOD_NEK2_1	169	174	PF00069	0.548
MOD_NEK2_1	185	190	PF00069	0.701
MOD_NEK2_1	251	256	PF00069	0.681
MOD_NEK2_1	258	263	PF00069	0.608
MOD_NEK2_1	418	423	PF00069	0.569
MOD_NEK2_1	460	465	PF00069	0.478
MOD_NEK2_1	68	73	PF00069	0.688
MOD_NEK2_1	79	84	PF00069	0.627
MOD_NEK2_2	414	419	PF00069	0.549
MOD_NEK2_2	422	427	PF00069	0.516
MOD_PIKK_1	203	209	PF00454	0.558
MOD_PIKK_1	370	376	PF00454	0.576
MOD_PIKK_1	493	499	PF00454	0.510
MOD_PIKK_1	551	557	PF00454	0.588
MOD_PIKK_1	570	576	PF00454	0.499
MOD_PIKK_1	63	69	PF00454	0.673
MOD_PK_1	330	336	PF00069	0.705
MOD_PK_1	420	426	PF00069	0.547
MOD_PK_1	500	506	PF00069	0.358
MOD_PK_1	533	539	PF00069	0.518
MOD_PK_1	89	95	PF00069	0.668
MOD_PKA_1	203	209	PF00069	0.549
MOD_PKA_1	3	9	PF00069	0.544
MOD_PKA_2	123	129	PF00069	0.521
MOD_PKA_2	152	158	PF00069	0.694
MOD_PKA_2	175	181	PF00069	0.641
MOD_PKA_2	203	209	PF00069	0.571
MOD_PKA_2	258	264	PF00069	0.590
MOD_PKA_2	265	271	PF00069	0.596
MOD_PKA_2	273	279	PF00069	0.628
MOD_PKA_2	3	9	PF00069	0.581
MOD_PKA_2	308	314	PF00069	0.544
MOD_PKA_2	384	390	PF00069	0.597
MOD_PKA_2	418	424	PF00069	0.649
MOD_PKA_2	436	442	PF00069	0.723
MOD_PKA_2	479	485	PF00069	0.534
MOD_PKA_2	493	499	PF00069	0.418
MOD_PKA_2	532	538	PF00069	0.360
MOD_PKB_1	322	330	PF00069	0.549
MOD_Plk_1	170	176	PF00069	0.547
MOD_Plk_1	414	420	PF00069	0.550
MOD_Plk_1	480	486	PF00069	0.406
MOD_Plk_1	518	524	PF00069	0.410
MOD_Plk_1	63	69	PF00069	0.510
MOD_Plk_4	197	203	PF00069	0.752
MOD_Plk_4	217	223	PF00069	0.531
MOD_Plk_4	302	308	PF00069	0.762
MOD_Plk_4	500	506	PF00069	0.358
MOD_Plk_4	89	95	PF00069	0.691
MOD_ProDKin_1	153	159	PF00069	0.648
MOD_ProDKin_1	160	166	PF00069	0.633
MOD_ProDKin_1	18	24	PF00069	0.595
MOD_ProDKin_1	189	195	PF00069	0.637
MOD_ProDKin_1	228	234	PF00069	0.611
MOD_ProDKin_1	235	241	PF00069	0.697
MOD_ProDKin_1	290	296	PF00069	0.598
MOD_ProDKin_1	386	392	PF00069	0.605
MOD_ProDKin_1	40	46	PF00069	0.594
MOD_ProDKin_1	440	446	PF00069	0.739
MOD_ProDKin_1	447	453	PF00069	0.675
MOD_ProDKin_1	471	477	PF00069	0.605
MOD_ProDKin_1	557	563	PF00069	0.602
MOD_ProDKin_1	617	623	PF00069	0.609
MOD_ProDKin_1	626	632	PF00069	0.616
MOD_ProDKin_1	652	658	PF00069	0.572
MOD_ProDKin_1	87	93	PF00069	0.635
MOD_ProDKin_1	99	105	PF00069	0.504
MOD_SUMO_for_1	428	431	PF00179	0.690
MOD_SUMO_rev_2	293	303	PF00179	0.521
MOD_SUMO_rev_2	401	406	PF00179	0.594
MOD_SUMO_rev_2	53	61	PF00179	0.745
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.651
TRG_ENDOCYTIC_2	62	65	PF00928	0.532
TRG_ER_diArg_1	159	161	PF00400	0.604
TRG_ER_diArg_1	272	275	PF00400	0.625
TRG_ER_diArg_1	3	5	PF00400	0.556
TRG_ER_diArg_1	418	420	PF00400	0.705
TRG_NLS_MonoExtC_3	361	366	PF00514	0.603
TRG_NLS_MonoExtN_4	360	366	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	275	280	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I823	Leptomonas seymouri	42%	95%
A0A3S7X108	Leishmania donovani	72%	100%
A4I323	Leishmania infantum	71%	100%
E9ACU4	Leishmania major	71%	100%
E9AZD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%