Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG01_LEIBR

TriTrypDb:

LbrM.27.2420 , LBRM2903_270031300

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	1
GO:0005768	endosome	7	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG01

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0035493	SNARE complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.604
CLV_NRD_NRD_1	470	472	PF00675	0.583
CLV_PCSK_KEX2_1	219	221	PF00082	0.432
CLV_PCSK_KEX2_1	470	472	PF00082	0.583
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.432
CLV_PCSK_SKI1_1	211	215	PF00082	0.475
CLV_PCSK_SKI1_1	345	349	PF00082	0.534
CLV_PCSK_SKI1_1	470	474	PF00082	0.619
DEG_APCC_DBOX_1	82	90	PF00400	0.685
DOC_CYCLIN_RxL_1	309	321	PF00134	0.517
DOC_CYCLIN_RxL_1	48	56	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.675
DOC_MAPK_gen_1	201	209	PF00069	0.612
DOC_MAPK_gen_1	309	318	PF00069	0.605
DOC_MAPK_MEF2A_6	170	178	PF00069	0.515
DOC_MAPK_MEF2A_6	201	209	PF00069	0.428
DOC_MAPK_MEF2A_6	345	352	PF00069	0.599
DOC_MAPK_MEF2A_6	478	487	PF00069	0.475
DOC_MAPK_MEF2A_6	64	73	PF00069	0.745
DOC_PP1_RVXF_1	66	73	PF00149	0.719
DOC_PP2B_LxvP_1	422	425	PF13499	0.668
DOC_PP4_FxxP_1	108	111	PF00568	0.731
DOC_USP7_MATH_1	13	17	PF00917	0.555
DOC_USP7_MATH_1	200	204	PF00917	0.423
DOC_USP7_UBL2_3	463	467	PF12436	0.588
DOC_WW_Pin1_4	11	16	PF00397	0.666
DOC_WW_Pin1_4	118	123	PF00397	0.641
DOC_WW_Pin1_4	410	415	PF00397	0.551
DOC_WW_Pin1_4	5	10	PF00397	0.741
LIG_14-3-3_CanoR_1	104	109	PF00244	0.777
LIG_14-3-3_CanoR_1	154	160	PF00244	0.780
LIG_14-3-3_CanoR_1	175	179	PF00244	0.494
LIG_14-3-3_CanoR_1	230	240	PF00244	0.633
LIG_14-3-3_CanoR_1	74	82	PF00244	0.565
LIG_Actin_WH2_2	475	490	PF00022	0.318
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_FHA_1	164	170	PF00498	0.535
LIG_FHA_1	319	325	PF00498	0.588
LIG_FHA_1	65	71	PF00498	0.735
LIG_FHA_1	74	80	PF00498	0.532
LIG_FHA_1	92	98	PF00498	0.685
LIG_FHA_2	111	117	PF00498	0.774
LIG_FHA_2	143	149	PF00498	0.511
LIG_FHA_2	175	181	PF00498	0.641
LIG_FHA_2	288	294	PF00498	0.668
LIG_FHA_2	366	372	PF00498	0.658
LIG_FHA_2	39	45	PF00498	0.606
LIG_FHA_2	425	431	PF00498	0.670
LIG_LIR_Apic_2	105	111	PF02991	0.727
LIG_LIR_Apic_2	158	164	PF02991	0.786
LIG_LIR_Gen_1	188	197	PF02991	0.583
LIG_LIR_Nem_3	188	194	PF02991	0.592
LIG_LIR_Nem_3	273	277	PF02991	0.665
LIG_LYPXL_yS_3	399	402	PF13949	0.555
LIG_LYPXL_yS_3	434	437	PF13949	0.311
LIG_NRBOX	478	484	PF00104	0.464
LIG_PCNA_yPIPBox_3	27	36	PF02747	0.735
LIG_RPA_C_Fungi	295	307	PF08784	0.648
LIG_SH2_GRB2like	328	331	PF00017	0.728
LIG_SH2_STAP1	320	324	PF00017	0.584
LIG_SH2_STAP1	328	332	PF00017	0.599
LIG_SH2_STAP1	393	397	PF00017	0.479
LIG_SH2_STAT5	277	280	PF00017	0.660
LIG_SH2_STAT5	320	323	PF00017	0.579
LIG_SH2_STAT5	426	429	PF00017	0.585
LIG_Sin3_3	93	100	PF02671	0.538
LIG_SUMO_SIM_par_1	320	326	PF11976	0.599
LIG_SUMO_SIM_par_1	384	390	PF11976	0.544
LIG_SUMO_SIM_par_1	399	405	PF11976	0.306
LIG_TRAF2_1	146	149	PF00917	0.769
LIG_TRAF2_1	235	238	PF00917	0.367
LIG_TRAF2_1	291	294	PF00917	0.514
LIG_TRAF2_1	41	44	PF00917	0.675
LIG_TYR_ITIM	397	402	PF00017	0.557
LIG_Vh1_VBS_1	472	490	PF01044	0.574
MOD_CK1_1	405	411	PF00069	0.588
MOD_CK1_1	5	11	PF00069	0.757
MOD_CK1_1	87	93	PF00069	0.690
MOD_CK2_1	110	116	PF00069	0.776
MOD_CK2_1	142	148	PF00069	0.505
MOD_CK2_1	240	246	PF00069	0.566
MOD_CK2_1	287	293	PF00069	0.593
MOD_CK2_1	364	370	PF00069	0.584
MOD_CK2_1	37	43	PF00069	0.711
MOD_CK2_1	424	430	PF00069	0.426
MOD_GlcNHglycan	15	18	PF01048	0.551
MOD_GlcNHglycan	233	236	PF01048	0.515
MOD_GlcNHglycan	242	245	PF01048	0.453
MOD_GlcNHglycan	404	407	PF01048	0.573
MOD_GlcNHglycan	416	419	PF01048	0.574
MOD_GlcNHglycan	88	92	PF01048	0.606
MOD_GSK3_1	127	134	PF00069	0.688
MOD_GSK3_1	150	157	PF00069	0.774
MOD_GSK3_1	318	325	PF00069	0.520
MOD_GSK3_1	355	362	PF00069	0.507
MOD_GSK3_1	387	394	PF00069	0.481
MOD_GSK3_1	4	11	PF00069	0.804
MOD_GSK3_1	405	412	PF00069	0.266
MOD_GSK3_1	87	94	PF00069	0.691
MOD_LATS_1	268	274	PF00433	0.399
MOD_N-GLC_1	414	419	PF02516	0.663
MOD_N-GLC_2	344	346	PF02516	0.601
MOD_NEK2_1	127	132	PF00069	0.533
MOD_NEK2_1	174	179	PF00069	0.750
MOD_NEK2_1	240	245	PF00069	0.618
MOD_NEK2_1	305	310	PF00069	0.498
MOD_NEK2_1	364	369	PF00069	0.672
MOD_NEK2_1	402	407	PF00069	0.593
MOD_PIKK_1	323	329	PF00454	0.571
MOD_PKA_2	174	180	PF00069	0.747
MOD_PKA_2	200	206	PF00069	0.542
MOD_PKA_2	287	293	PF00069	0.623
MOD_PKA_2	73	79	PF00069	0.687
MOD_Plk_1	45	51	PF00069	0.694
MOD_Plk_4	387	393	PF00069	0.462
MOD_ProDKin_1	118	124	PF00069	0.642
MOD_ProDKin_1	410	416	PF00069	0.551
MOD_ProDKin_1	5	11	PF00069	0.742
TRG_DiLeu_BaEn_4	374	380	PF01217	0.571
TRG_ENDOCYTIC_2	399	402	PF00928	0.555
TRG_ENDOCYTIC_2	434	437	PF00928	0.311
TRG_ER_diArg_1	298	301	PF00400	0.602
TRG_ER_diArg_1	470	472	PF00400	0.607
TRG_NES_CRM1_1	315	327	PF08389	0.608
TRG_NES_CRM1_1	477	491	PF08389	0.577
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X103	Leishmania donovani	83%	88%
A4I320	Leishmania infantum	83%	88%
E9ACU1	Leishmania major	83%	100%
E9AZD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	88%
V5ANH3	Trypanosoma cruzi	27%	90%