Putative dual specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFZ8_LEIBR

TriTrypDb:

LbrM.27.2390 , LBRM2903_270030900

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFZ8

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0007165	signal transduction	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0004725	protein tyrosine phosphatase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.573
CLV_NRD_NRD_1	152	154	PF00675	0.491
CLV_NRD_NRD_1	289	291	PF00675	0.393
CLV_NRD_NRD_1	337	339	PF00675	0.724
CLV_NRD_NRD_1	352	354	PF00675	0.372
CLV_NRD_NRD_1	73	75	PF00675	0.617
CLV_PCSK_KEX2_1	337	339	PF00082	0.575
CLV_PCSK_SKI1_1	146	150	PF00082	0.658
CLV_PCSK_SKI1_1	44	48	PF00082	0.444
DEG_SPOP_SBC_1	156	160	PF00917	0.507
DEG_SPOP_SBC_1	64	68	PF00917	0.496
DOC_CKS1_1	61	66	PF01111	0.502
DOC_CYCLIN_RxL_1	141	152	PF00134	0.500
DOC_CYCLIN_RxL_1	26	36	PF00134	0.495
DOC_CYCLIN_RxL_1	287	297	PF00134	0.360
DOC_MAPK_gen_1	227	237	PF00069	0.189
DOC_MAPK_MEF2A_6	307	316	PF00069	0.200
DOC_PP1_RVXF_1	27	34	PF00149	0.490
DOC_PP4_FxxP_1	61	64	PF00568	0.505
DOC_USP7_MATH_1	156	160	PF00917	0.797
DOC_USP7_MATH_1	165	169	PF00917	0.733
DOC_USP7_MATH_1	174	178	PF00917	0.629
DOC_USP7_MATH_1	341	345	PF00917	0.515
DOC_USP7_MATH_1	64	68	PF00917	0.580
DOC_WW_Pin1_4	152	157	PF00397	0.603
DOC_WW_Pin1_4	308	313	PF00397	0.266
DOC_WW_Pin1_4	53	58	PF00397	0.773
DOC_WW_Pin1_4	60	65	PF00397	0.730
LIG_14-3-3_CanoR_1	212	222	PF00244	0.296
LIG_14-3-3_CanoR_1	293	303	PF00244	0.335
LIG_14-3-3_CanoR_1	32	38	PF00244	0.444
LIG_BH_BH3_1	119	135	PF00452	0.271
LIG_BRCT_BRCA1_1	177	181	PF00533	0.411
LIG_BRCT_BRCA1_1	247	251	PF00533	0.200
LIG_BRCT_BRCA1_1	341	345	PF00533	0.372
LIG_EH1_1	186	194	PF00400	0.267
LIG_EVH1_2	57	61	PF00568	0.499
LIG_FHA_1	138	144	PF00498	0.577
LIG_GBD_Chelix_1	122	130	PF00786	0.257
LIG_LIR_Apic_2	59	64	PF02991	0.506
LIG_LIR_Gen_1	231	239	PF02991	0.269
LIG_LIR_Gen_1	254	263	PF02991	0.303
LIG_LIR_Nem_3	231	237	PF02991	0.268
LIG_LIR_Nem_3	25	31	PF02991	0.336
LIG_LIR_Nem_3	254	258	PF02991	0.303
LIG_LIR_Nem_3	35	40	PF02991	0.357
LIG_Pex14_1	197	201	PF04695	0.331
LIG_Pex14_2	228	232	PF04695	0.281
LIG_Pex14_2	251	255	PF04695	0.325
LIG_REV1ctd_RIR_1	25	33	PF16727	0.495
LIG_RPA_C_Fungi	115	127	PF08784	0.494
LIG_SH2_CRK	234	238	PF00017	0.280
LIG_SH2_STAT3	323	326	PF00017	0.189
LIG_SH2_STAT5	287	290	PF00017	0.281
LIG_SH3_3	2	8	PF00018	0.483
LIG_SH3_3	223	229	PF00018	0.266
LIG_WW_3	7	11	PF00397	0.473
MOD_CK1_1	158	164	PF00069	0.679
MOD_CK1_1	56	62	PF00069	0.701
MOD_CK1_1	66	72	PF00069	0.680
MOD_CK2_1	165	171	PF00069	0.593
MOD_GlcNHglycan	13	16	PF01048	0.536
MOD_GlcNHglycan	161	164	PF01048	0.648
MOD_GlcNHglycan	167	170	PF01048	0.555
MOD_GlcNHglycan	237	240	PF01048	0.411
MOD_GlcNHglycan	284	287	PF01048	0.479
MOD_GlcNHglycan	296	299	PF01048	0.350
MOD_GlcNHglycan	68	71	PF01048	0.691
MOD_GSK3_1	152	159	PF00069	0.752
MOD_GSK3_1	275	282	PF00069	0.300
MOD_GSK3_1	339	346	PF00069	0.383
MOD_GSK3_1	49	56	PF00069	0.658
MOD_GSK3_1	59	66	PF00069	0.684
MOD_GSK3_1	76	83	PF00069	0.745
MOD_NEK2_1	104	109	PF00069	0.450
MOD_NEK2_1	196	201	PF00069	0.325
MOD_NEK2_1	292	297	PF00069	0.283
MOD_NEK2_1	33	38	PF00069	0.510
MOD_NEK2_2	182	187	PF00069	0.337
MOD_PIKK_1	221	227	PF00454	0.240
MOD_PIKK_1	322	328	PF00454	0.189
MOD_PKA_1	44	50	PF00069	0.458
MOD_PKA_2	11	17	PF00069	0.693
MOD_PKA_2	292	298	PF00069	0.215
MOD_Plk_4	279	285	PF00069	0.358
MOD_ProDKin_1	152	158	PF00069	0.605
MOD_ProDKin_1	308	314	PF00069	0.266
MOD_ProDKin_1	53	59	PF00069	0.774
MOD_ProDKin_1	60	66	PF00069	0.728
MOD_SUMO_rev_2	67	77	PF00179	0.507
TRG_ENDOCYTIC_2	234	237	PF00928	0.272
TRG_ENDOCYTIC_2	37	40	PF00928	0.283
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.189
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK0	Leptomonas seymouri	45%	100%
A0A0S4J521	Bodo saltans	39%	100%
A0A1X0NRN9	Trypanosomatidae	49%	100%
A0A3S7X0Z1	Leishmania donovani	73%	100%
A0A422N807	Trypanosoma rangeli	37%	100%
A4I317	Leishmania infantum	73%	100%
C9ZJI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ACT8	Leishmania major	72%	99%
E9AZC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
V5BIV4	Trypanosoma cruzi	39%	100%