Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4HFZ7_LEIBR

TriTrypDb:

LbrM.27.2380 , LBRM2903_270030800

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HFZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFZ7

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.586
CLV_NRD_NRD_1	96	98	PF00675	0.565
CLV_PCSK_KEX2_1	49	51	PF00082	0.581
CLV_PCSK_KEX2_1	96	98	PF00082	0.590
CLV_PCSK_SKI1_1	167	171	PF00082	0.272
CLV_PCSK_SKI1_1	173	177	PF00082	0.239
DEG_APCC_DBOX_1	96	104	PF00400	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.566
DOC_MAPK_gen_1	228	237	PF00069	0.566
DOC_MAPK_MEF2A_6	167	174	PF00069	0.328
DOC_PP1_RVXF_1	206	213	PF00149	0.404
DOC_WW_Pin1_4	179	184	PF00397	0.275
LIG_14-3-3_CanoR_1	160	169	PF00244	0.320
LIG_14-3-3_CanoR_1	188	198	PF00244	0.325
LIG_14-3-3_CanoR_1	230	236	PF00244	0.500
LIG_FHA_1	152	158	PF00498	0.281
LIG_FHA_1	22	28	PF00498	0.553
LIG_FHA_1	232	238	PF00498	0.685
LIG_FHA_2	103	109	PF00498	0.449
LIG_LIR_Gen_1	127	134	PF02991	0.328
LIG_LIR_Nem_3	120	124	PF02991	0.550
LIG_LIR_Nem_3	127	133	PF02991	0.317
LIG_SH2_NCK_1	64	68	PF00017	0.540
LIG_SH2_SRC	64	67	PF00017	0.571
LIG_SH2_STAT5	161	164	PF00017	0.349
LIG_TRAF2_1	105	108	PF00917	0.682
LIG_TRAF2_1	51	54	PF00917	0.477
MOD_CK1_1	163	169	PF00069	0.459
MOD_CK1_1	4	10	PF00069	0.546
MOD_CK2_1	102	108	PF00069	0.675
MOD_GlcNHglycan	3	6	PF01048	0.557
MOD_GlcNHglycan	7	10	PF01048	0.540
MOD_GSK3_1	1	8	PF00069	0.557
MOD_N-GLC_1	21	26	PF02516	0.547
MOD_NEK2_1	1	6	PF00069	0.554
MOD_NEK2_1	165	170	PF00069	0.324
MOD_NEK2_1	189	194	PF00069	0.404
MOD_PIKK_1	122	128	PF00454	0.294
MOD_PKA_2	35	41	PF00069	0.699
MOD_ProDKin_1	179	185	PF00069	0.275
MOD_SUMO_for_1	235	238	PF00179	0.402
TRG_DiLeu_BaEn_1	88	93	PF01217	0.498
TRG_DiLeu_BaEn_2	179	185	PF01217	0.260
TRG_ENDOCYTIC_2	121	124	PF00928	0.554
TRG_ER_diArg_1	49	51	PF00400	0.703
TRG_ER_diArg_1	95	97	PF00400	0.527
TRG_NES_CRM1_1	91	101	PF08389	0.670
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI4	Leptomonas seymouri	80%	100%
A0A0S4J4Q7	Bodo saltans	58%	98%
A0A1X0NR32	Trypanosomatidae	63%	99%
A0A3R7KUG1	Trypanosoma rangeli	64%	98%
A0A3S7X0Z3	Leishmania donovani	91%	100%
A0A3S7X612	Leishmania donovani	30%	100%
A4I316	Leishmania infantum	91%	100%
A4I8C0	Leishmania infantum	30%	100%
C9ZJI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	96%
E9ACT7	Leishmania major	89%	99%
E9AZC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B379	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O14095	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	86%
Q9U1D8	Leishmania major	31%	100%
V5DF31	Trypanosoma cruzi	67%	98%