Vitamin-K-epoxide reductase (warfarin-sensitive)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin K epoxide reductase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HFZ6_LEIBR

TriTrypDb:

LbrM.27.2370 , LBRM2903_270030700

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HFZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006766	vitamin metabolic process	3	11
GO:0006775	fat-soluble vitamin metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11
GO:0042373	vitamin K metabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901661	quinone metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	1
GO:0017187	peptidyl-glutamic acid carboxylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0018214	protein carboxylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	11
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	3	11
GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	4	11
GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor	4	11
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	5	11
GO:0048038	quinone binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	151	155	PF00917	0.436
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.220
DOC_PP2B_LxvP_1	35	38	PF13499	0.220
DOC_PP2B_PxIxI_1	98	104	PF00149	0.321
DOC_PP4_FxxP_1	65	68	PF00568	0.284
DOC_USP7_MATH_1	151	155	PF00917	0.430
LIG_14-3-3_CanoR_1	141	148	PF00244	0.288
LIG_APCC_ABBA_1	25	30	PF00400	0.333
LIG_BRCT_BRCA1_1	54	58	PF00533	0.299
LIG_EH1_1	78	86	PF00400	0.263
LIG_FHA_1	110	116	PF00498	0.305
LIG_FHA_1	123	129	PF00498	0.277
LIG_FHA_1	130	136	PF00498	0.303
LIG_FHA_1	59	65	PF00498	0.257
LIG_FHA_1	89	95	PF00498	0.327
LIG_IRF3_LxIS_1	90	97	PF10401	0.296
LIG_LIR_Apic_2	62	68	PF02991	0.284
LIG_LIR_Gen_1	104	115	PF02991	0.441
LIG_LIR_Nem_3	104	110	PF02991	0.441
LIG_LIR_Nem_3	131	137	PF02991	0.286
LIG_Pex14_2	54	58	PF04695	0.299
LIG_SH2_SRC	21	24	PF00017	0.451
LIG_SH2_STAP1	21	25	PF00017	0.307
LIG_SH2_STAT5	126	129	PF00017	0.345
LIG_SH2_STAT5	134	137	PF00017	0.326
LIG_SH2_STAT5	42	45	PF00017	0.258
LIG_SH3_3	65	71	PF00018	0.250
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.352
LIG_SUMO_SIM_par_1	111	117	PF11976	0.344
LIG_SUMO_SIM_par_1	91	97	PF11976	0.376
LIG_UBA3_1	64	69	PF00899	0.176
MOD_CK1_1	153	159	PF00069	0.395
MOD_CK1_1	56	62	PF00069	0.350
MOD_CK2_1	46	52	PF00069	0.176
MOD_GlcNHglycan	96	99	PF01048	0.307
MOD_GSK3_1	151	158	PF00069	0.408
MOD_GSK3_1	17	24	PF00069	0.451
MOD_GSK3_1	48	55	PF00069	0.267
MOD_N-GLC_1	128	133	PF02516	0.418
MOD_N-GLC_1	4	9	PF02516	0.450
MOD_NEK2_1	109	114	PF00069	0.192
MOD_NEK2_1	152	157	PF00069	0.424
MOD_NEK2_1	16	21	PF00069	0.281
MOD_NEK2_1	4	9	PF00069	0.375
MOD_NEK2_1	58	63	PF00069	0.262
MOD_NEK2_1	94	99	PF00069	0.316
MOD_OFUCOSY	43	50	PF10250	0.453
MOD_PKA_2	140	146	PF00069	0.254
MOD_Plk_1	128	134	PF00069	0.418
MOD_Plk_1	4	10	PF00069	0.460
MOD_Plk_4	109	115	PF00069	0.286
MOD_Plk_4	122	128	PF00069	0.360
MOD_Plk_4	129	135	PF00069	0.315
MOD_Plk_4	4	10	PF00069	0.460
MOD_Plk_4	88	94	PF00069	0.260
TRG_ENDOCYTIC_2	42	45	PF00928	0.255
TRG_ENDOCYTIC_2	79	82	PF00928	0.362
TRG_ER_diLys_1	157	162	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB97	Leptomonas seymouri	67%	100%
A0A0S4J6N8	Bodo saltans	49%	100%
A0A1X0NR17	Trypanosomatidae	55%	94%
A0A3R7K875	Trypanosoma rangeli	49%	100%
A0A3S7X0Y5	Leishmania donovani	80%	100%
A4I315	Leishmania infantum	80%	100%
C9ZJI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ACT6	Leishmania major	78%	100%
E9AZC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q6B4J2	Bos taurus	34%	99%
Q6TEK3	Rattus norvegicus	31%	92%
Q6TEK4	Rattus norvegicus	29%	100%
Q6TEK5	Mus musculus	31%	92%
Q8N0U8	Homo sapiens	32%	92%
Q9BQB6	Homo sapiens	34%	99%
Q9CRC0	Mus musculus	31%	100%