LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HFZ3_LEIBR
TriTrypDb:
LbrM.27.2340 , LBRM2903_270030400
Length:
376

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFZ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFZ3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.676
CLV_NRD_NRD_1 23 25 PF00675 0.631
CLV_NRD_NRD_1 309 311 PF00675 0.458
CLV_NRD_NRD_1 346 348 PF00675 0.524
CLV_NRD_NRD_1 357 359 PF00675 0.651
CLV_PCSK_KEX2_1 2 4 PF00082 0.676
CLV_PCSK_KEX2_1 309 311 PF00082 0.537
CLV_PCSK_KEX2_1 346 348 PF00082 0.524
CLV_PCSK_SKI1_1 27 31 PF00082 0.568
CLV_PCSK_SKI1_1 76 80 PF00082 0.371
DEG_COP1_1 238 246 PF00400 0.380
DEG_Nend_UBRbox_1 1 4 PF02207 0.657
DOC_CYCLIN_yCln2_LP_2 317 323 PF00134 0.501
DOC_MAPK_gen_1 235 243 PF00069 0.438
DOC_MAPK_gen_1 290 297 PF00069 0.559
DOC_MAPK_gen_1 346 353 PF00069 0.446
DOC_MAPK_MEF2A_6 346 353 PF00069 0.446
DOC_PP2B_LxvP_1 283 286 PF13499 0.445
DOC_USP7_MATH_1 236 240 PF00917 0.523
DOC_WW_Pin1_4 149 154 PF00397 0.329
DOC_WW_Pin1_4 84 89 PF00397 0.393
LIG_14-3-3_CanoR_1 127 133 PF00244 0.341
LIG_14-3-3_CanoR_1 142 147 PF00244 0.349
LIG_14-3-3_CanoR_1 2 6 PF00244 0.642
LIG_14-3-3_CanoR_1 27 36 PF00244 0.630
LIG_14-3-3_CanoR_1 309 314 PF00244 0.517
LIG_Actin_RPEL_3 66 85 PF02755 0.354
LIG_Actin_WH2_2 59 75 PF00022 0.372
LIG_APCC_ABBA_1 16 21 PF00400 0.584
LIG_APCC_ABBA_1 284 289 PF00400 0.541
LIG_BIR_III_2 251 255 PF00653 0.338
LIG_BRCT_BRCA1_1 106 110 PF00533 0.439
LIG_BRCT_BRCA1_1 89 93 PF00533 0.444
LIG_FHA_1 139 145 PF00498 0.370
LIG_FHA_1 150 156 PF00498 0.338
LIG_FHA_1 61 67 PF00498 0.493
LIG_FHA_1 84 90 PF00498 0.449
LIG_FHA_2 261 267 PF00498 0.476
LIG_LIR_Apic_2 101 106 PF02991 0.476
LIG_LIR_Gen_1 90 99 PF02991 0.319
LIG_LIR_Nem_3 148 154 PF02991 0.336
LIG_LIR_Nem_3 203 209 PF02991 0.320
LIG_LIR_Nem_3 266 270 PF02991 0.478
LIG_LIR_Nem_3 90 96 PF02991 0.316
LIG_MYND_1 244 248 PF01753 0.322
LIG_MYND_3 253 257 PF01753 0.388
LIG_Pex14_2 201 205 PF04695 0.461
LIG_REV1ctd_RIR_1 203 211 PF16727 0.448
LIG_REV1ctd_RIR_1 231 241 PF16727 0.414
LIG_REV1ctd_RIR_1 285 294 PF16727 0.505
LIG_REV1ctd_RIR_1 326 335 PF16727 0.375
LIG_SH2_CRK 103 107 PF00017 0.509
LIG_SH2_CRK 57 61 PF00017 0.486
LIG_SH2_NCK_1 103 107 PF00017 0.509
LIG_SH2_NCK_1 270 274 PF00017 0.324
LIG_SH2_STAP1 270 274 PF00017 0.324
LIG_SH2_STAT5 151 154 PF00017 0.329
LIG_SH2_STAT5 157 160 PF00017 0.306
LIG_SH2_STAT5 186 189 PF00017 0.415
LIG_SH2_STAT5 267 270 PF00017 0.330
LIG_SH2_STAT5 344 347 PF00017 0.381
LIG_SH3_3 71 77 PF00018 0.491
LIG_SUMO_SIM_par_1 141 149 PF11976 0.264
LIG_TRAF2_1 145 148 PF00917 0.395
LIG_TRAF2_1 291 294 PF00917 0.428
LIG_WRC_WIRS_1 42 47 PF05994 0.373
MOD_CK1_1 128 134 PF00069 0.427
MOD_CK1_1 149 155 PF00069 0.324
MOD_CK1_1 260 266 PF00069 0.416
MOD_CK1_1 87 93 PF00069 0.397
MOD_CK2_1 142 148 PF00069 0.385
MOD_CK2_1 260 266 PF00069 0.452
MOD_CK2_1 288 294 PF00069 0.517
MOD_GlcNHglycan 127 130 PF01048 0.455
MOD_GlcNHglycan 147 151 PF01048 0.279
MOD_GlcNHglycan 177 182 PF01048 0.508
MOD_GlcNHglycan 89 92 PF01048 0.446
MOD_GSK3_1 138 145 PF00069 0.387
MOD_GSK3_1 185 192 PF00069 0.428
MOD_GSK3_1 27 34 PF00069 0.617
MOD_GSK3_1 305 312 PF00069 0.557
MOD_GSK3_1 83 90 PF00069 0.332
MOD_NEK2_1 1 6 PF00069 0.633
MOD_NEK2_1 125 130 PF00069 0.414
MOD_NEK2_1 146 151 PF00069 0.377
MOD_NEK2_1 159 164 PF00069 0.313
MOD_NEK2_1 295 300 PF00069 0.551
MOD_NEK2_1 62 67 PF00069 0.551
MOD_NEK2_1 72 77 PF00069 0.424
MOD_PIKK_1 213 219 PF00454 0.469
MOD_PIKK_1 295 301 PF00454 0.508
MOD_PK_1 309 315 PF00069 0.351
MOD_PKA_1 309 315 PF00069 0.351
MOD_PKA_1 38 44 PF00069 0.432
MOD_PKA_2 1 7 PF00069 0.645
MOD_PKA_2 19 25 PF00069 0.440
MOD_PKA_2 309 315 PF00069 0.509
MOD_PKA_2 72 78 PF00069 0.442
MOD_Plk_1 146 152 PF00069 0.373
MOD_Plk_4 242 248 PF00069 0.350
MOD_Plk_4 260 266 PF00069 0.357
MOD_Plk_4 31 37 PF00069 0.426
MOD_ProDKin_1 149 155 PF00069 0.327
MOD_ProDKin_1 84 90 PF00069 0.398
TRG_DiLeu_BaEn_1 366 371 PF01217 0.580
TRG_DiLeu_BaEn_2 120 126 PF01217 0.395
TRG_DiLeu_BaEn_4 178 184 PF01217 0.586
TRG_DiLeu_LyEn_5 366 371 PF01217 0.666
TRG_ENDOCYTIC_2 270 273 PF00928 0.515
TRG_ENDOCYTIC_2 57 60 PF00928 0.476
TRG_ER_diArg_1 1 3 PF00400 0.683
TRG_ER_diArg_1 309 311 PF00400 0.547
TRG_ER_diArg_1 345 347 PF00400 0.489
TRG_NLS_MonoCore_2 23 28 PF00514 0.602
TRG_Pf-PMV_PEXEL_1 369 374 PF00026 0.615

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2W1 Leptomonas seymouri 73% 100%
A0A0S4ISK5 Bodo saltans 46% 100%
A0A1X0NRI0 Trypanosomatidae 55% 100%
A0A3Q8ICV5 Leishmania donovani 89% 100%
A4I312 Leishmania infantum 89% 100%
C9ZJH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9ADJ6 Leishmania major 88% 100%
E9AZC2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
V5BNB6 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS