PI3K/PI4K catalytic domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol 3- and 4-kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFZ1_LEIBR

TriTrypDb:

LbrM.27.2320 , LBRM2903_270030300

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	319	321	PF00675	0.706
CLV_NRD_NRD_1	461	463	PF00675	0.399
CLV_NRD_NRD_1	602	604	PF00675	0.368
CLV_NRD_NRD_1	818	820	PF00675	0.494
CLV_NRD_NRD_1	92	94	PF00675	0.609
CLV_PCSK_KEX2_1	319	321	PF00082	0.706
CLV_PCSK_KEX2_1	461	463	PF00082	0.399
CLV_PCSK_KEX2_1	602	604	PF00082	0.343
CLV_PCSK_KEX2_1	818	820	PF00082	0.494
CLV_PCSK_KEX2_1	92	94	PF00082	0.609
CLV_PCSK_PC7_1	598	604	PF00082	0.249
CLV_PCSK_SKI1_1	200	204	PF00082	0.561
CLV_PCSK_SKI1_1	462	466	PF00082	0.399
CLV_PCSK_SKI1_1	706	710	PF00082	0.388
CLV_Separin_Metazoa	703	707	PF03568	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DEG_SCF_TRCP1_1	123	129	PF00400	0.530
DEG_SPOP_SBC_1	228	232	PF00917	0.546
DEG_SPOP_SBC_1	33	37	PF00917	0.627
DEG_SPOP_SBC_1	396	400	PF00917	0.582
DEG_SPOP_SBC_1	405	409	PF00917	0.565
DEG_SPOP_SBC_1	411	415	PF00917	0.538
DEG_SPOP_SBC_1	752	756	PF00917	0.650
DOC_MAPK_gen_1	338	347	PF00069	0.344
DOC_MAPK_MEF2A_6	389	397	PF00069	0.436
DOC_PP2B_LxvP_1	393	396	PF13499	0.497
DOC_PP2B_LxvP_1	549	552	PF13499	0.399
DOC_PP2B_LxvP_1	71	74	PF13499	0.668
DOC_PP2B_LxvP_1	76	79	PF13499	0.509
DOC_PP4_FxxP_1	539	542	PF00568	0.249
DOC_PP4_MxPP_1	223	226	PF00568	0.709
DOC_USP7_MATH_1	127	131	PF00917	0.648
DOC_USP7_MATH_1	228	232	PF00917	0.581
DOC_USP7_MATH_1	34	38	PF00917	0.677
DOC_USP7_MATH_1	350	354	PF00917	0.588
DOC_USP7_MATH_1	396	400	PF00917	0.670
DOC_USP7_MATH_1	403	407	PF00917	0.598
DOC_USP7_MATH_1	411	415	PF00917	0.538
DOC_USP7_MATH_1	610	614	PF00917	0.339
DOC_USP7_MATH_1	618	622	PF00917	0.381
DOC_USP7_MATH_1	628	632	PF00917	0.287
DOC_USP7_MATH_1	748	752	PF00917	0.628
DOC_USP7_MATH_1	823	827	PF00917	0.366
DOC_WW_Pin1_4	104	109	PF00397	0.562
DOC_WW_Pin1_4	191	196	PF00397	0.575
DOC_WW_Pin1_4	215	220	PF00397	0.665
DOC_WW_Pin1_4	221	226	PF00397	0.594
DOC_WW_Pin1_4	245	250	PF00397	0.594
DOC_WW_Pin1_4	281	286	PF00397	0.644
DOC_WW_Pin1_4	288	293	PF00397	0.539
DOC_WW_Pin1_4	325	330	PF00397	0.468
DOC_WW_Pin1_4	397	402	PF00397	0.651
DOC_WW_Pin1_4	624	629	PF00397	0.434
DOC_WW_Pin1_4	635	640	PF00397	0.402
DOC_WW_Pin1_4	66	71	PF00397	0.794
DOC_WW_Pin1_4	741	746	PF00397	0.648
DOC_WW_Pin1_4	87	92	PF00397	0.645
LIG_14-3-3_CanoR_1	244	249	PF00244	0.622
LIG_14-3-3_CanoR_1	251	260	PF00244	0.474
LIG_14-3-3_CanoR_1	349	359	PF00244	0.427
LIG_14-3-3_CanoR_1	494	499	PF00244	0.249
LIG_14-3-3_CanoR_1	535	542	PF00244	0.390
LIG_14-3-3_CanoR_1	611	616	PF00244	0.380
LIG_14-3-3_CanoR_1	62	67	PF00244	0.664
LIG_14-3-3_CanoR_1	724	732	PF00244	0.617
LIG_14-3-3_CanoR_1	773	780	PF00244	0.464
LIG_14-3-3_CanoR_1	81	87	PF00244	0.641
LIG_Actin_WH2_2	25	41	PF00022	0.544
LIG_BRCT_BRCA1_1	625	629	PF00533	0.299
LIG_Clathr_ClatBox_1	372	376	PF01394	0.488
LIG_Clathr_ClatBox_1	655	659	PF01394	0.399
LIG_deltaCOP1_diTrp_1	672	678	PF00928	0.399
LIG_deltaCOP1_diTrp_1	837	848	PF00928	0.508
LIG_DLG_GKlike_1	602	609	PF00625	0.249
LIG_FHA_1	176	182	PF00498	0.617
LIG_FHA_1	27	33	PF00498	0.535
LIG_FHA_1	270	276	PF00498	0.646
LIG_FHA_1	278	284	PF00498	0.686
LIG_FHA_1	285	291	PF00498	0.670
LIG_FHA_1	383	389	PF00498	0.502
LIG_FHA_1	478	484	PF00498	0.418
LIG_FHA_1	6	12	PF00498	0.614
LIG_FHA_1	645	651	PF00498	0.249
LIG_FHA_1	793	799	PF00498	0.556
LIG_FHA_2	10	16	PF00498	0.542
LIG_FHA_2	293	299	PF00498	0.493
LIG_FHA_2	306	312	PF00498	0.458
LIG_FHA_2	807	813	PF00498	0.449
LIG_HCF-1_HBM_1	659	662	PF13415	0.399
LIG_LIR_Apic_2	235	240	PF02991	0.534
LIG_LIR_Apic_2	536	542	PF02991	0.249
LIG_LIR_Apic_2	659	665	PF02991	0.399
LIG_LIR_Apic_2	666	671	PF02991	0.329
LIG_LIR_Gen_1	154	164	PF02991	0.549
LIG_LIR_Gen_1	670	681	PF02991	0.399
LIG_LIR_Gen_1	726	737	PF02991	0.533
LIG_LIR_Gen_1	760	768	PF02991	0.525
LIG_LIR_Gen_1	842	852	PF02991	0.414
LIG_LIR_Nem_3	154	159	PF02991	0.555
LIG_LIR_Nem_3	291	296	PF02991	0.490
LIG_LIR_Nem_3	44	50	PF02991	0.636
LIG_LIR_Nem_3	485	491	PF02991	0.337
LIG_LIR_Nem_3	670	676	PF02991	0.399
LIG_LIR_Nem_3	726	732	PF02991	0.579
LIG_LIR_Nem_3	760	766	PF02991	0.527
LIG_LIR_Nem_3	838	844	PF02991	0.522
LIG_LIR_Nem_3	846	851	PF02991	0.395
LIG_LYPXL_SIV_4	195	203	PF13949	0.553
LIG_MYND_1	653	657	PF01753	0.399
LIG_SH2_CRK	237	241	PF00017	0.533
LIG_SH2_GRB2like	277	280	PF00017	0.514
LIG_SH2_NCK_1	237	241	PF00017	0.533
LIG_SH2_NCK_1	668	672	PF00017	0.399
LIG_SH2_PTP2	662	665	PF00017	0.399
LIG_SH2_SRC	196	199	PF00017	0.559
LIG_SH2_SRC	668	671	PF00017	0.399
LIG_SH2_SRC	811	814	PF00017	0.451
LIG_SH2_STAP1	277	281	PF00017	0.524
LIG_SH2_STAP1	293	297	PF00017	0.498
LIG_SH2_STAP1	780	784	PF00017	0.523
LIG_SH2_STAT3	201	204	PF00017	0.559
LIG_SH2_STAT5	201	204	PF00017	0.578
LIG_SH2_STAT5	277	280	PF00017	0.523
LIG_SH2_STAT5	293	296	PF00017	0.530
LIG_SH2_STAT5	321	324	PF00017	0.475
LIG_SH2_STAT5	662	665	PF00017	0.399
LIG_SH2_STAT5	692	695	PF00017	0.399
LIG_SH3_1	636	642	PF00018	0.312
LIG_SH3_1	64	70	PF00018	0.533
LIG_SH3_3	222	228	PF00018	0.579
LIG_SH3_3	425	431	PF00018	0.403
LIG_SH3_3	636	642	PF00018	0.351
LIG_SH3_3	64	70	PF00018	0.711
LIG_SH3_3	647	653	PF00018	0.250
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.546
LIG_SUMO_SIM_anti_2	480	485	PF11976	0.249
LIG_SUMO_SIM_par_1	278	284	PF11976	0.564
LIG_SUMO_SIM_par_1	479	485	PF11976	0.399
LIG_SUMO_SIM_par_1	7	13	PF11976	0.598
LIG_WRC_WIRS_1	138	143	PF05994	0.555
MOD_CDC14_SPxK_1	248	251	PF00782	0.510
MOD_CDK_SPK_2	87	92	PF00069	0.632
MOD_CDK_SPxK_1	245	251	PF00069	0.519
MOD_CDK_SPxK_1	87	93	PF00069	0.573
MOD_CK1_1	129	135	PF00069	0.676
MOD_CK1_1	137	143	PF00069	0.552
MOD_CK1_1	190	196	PF00069	0.688
MOD_CK1_1	227	233	PF00069	0.762
MOD_CK1_1	291	297	PF00069	0.513
MOD_CK1_1	306	312	PF00069	0.567
MOD_CK1_1	325	331	PF00069	0.602
MOD_CK1_1	399	405	PF00069	0.686
MOD_CK1_1	406	412	PF00069	0.631
MOD_CK1_1	414	420	PF00069	0.500
MOD_CK1_1	448	454	PF00069	0.375
MOD_CK1_1	5	11	PF00069	0.749
MOD_CK1_1	614	620	PF00069	0.412
MOD_CK1_1	632	638	PF00069	0.293
MOD_CK1_1	65	71	PF00069	0.683
MOD_CK1_1	723	729	PF00069	0.616
MOD_CK1_1	751	757	PF00069	0.623
MOD_CK1_1	759	765	PF00069	0.702
MOD_CK2_1	10	16	PF00069	0.667
MOD_CK2_1	129	135	PF00069	0.534
MOD_CK2_1	137	143	PF00069	0.565
MOD_CK2_1	292	298	PF00069	0.486
MOD_CK2_1	325	331	PF00069	0.478
MOD_CK2_1	34	40	PF00069	0.648
MOD_CK2_1	457	463	PF00069	0.524
MOD_CK2_1	494	500	PF00069	0.299
MOD_CK2_1	614	620	PF00069	0.249
MOD_CK2_1	806	812	PF00069	0.452
MOD_CK2_1	823	829	PF00069	0.485
MOD_CMANNOS	675	678	PF00535	0.399
MOD_Cter_Amidation	600	603	PF01082	0.399
MOD_GlcNHglycan	123	126	PF01048	0.652
MOD_GlcNHglycan	143	146	PF01048	0.645
MOD_GlcNHglycan	210	213	PF01048	0.566
MOD_GlcNHglycan	307	311	PF01048	0.524
MOD_GlcNHglycan	380	383	PF01048	0.610
MOD_GlcNHglycan	421	424	PF01048	0.433
MOD_GlcNHglycan	457	460	PF01048	0.406
MOD_GlcNHglycan	523	526	PF01048	0.390
MOD_GlcNHglycan	616	619	PF01048	0.274
MOD_GlcNHglycan	665	668	PF01048	0.519
MOD_GlcNHglycan	685	688	PF01048	0.367
MOD_GlcNHglycan	706	709	PF01048	0.456
MOD_GlcNHglycan	725	728	PF01048	0.681
MOD_GlcNHglycan	750	753	PF01048	0.686
MOD_GlcNHglycan	774	777	PF01048	0.447
MOD_GlcNHglycan	96	99	PF01048	0.602
MOD_GSK3_1	100	107	PF00069	0.718
MOD_GSK3_1	126	133	PF00069	0.580
MOD_GSK3_1	137	144	PF00069	0.553
MOD_GSK3_1	162	169	PF00069	0.671
MOD_GSK3_1	170	177	PF00069	0.750
MOD_GSK3_1	179	186	PF00069	0.675
MOD_GSK3_1	187	194	PF00069	0.600
MOD_GSK3_1	208	215	PF00069	0.607
MOD_GSK3_1	224	231	PF00069	0.695
MOD_GSK3_1	24	31	PF00069	0.653
MOD_GSK3_1	275	282	PF00069	0.600
MOD_GSK3_1	284	291	PF00069	0.643
MOD_GSK3_1	306	313	PF00069	0.595
MOD_GSK3_1	378	385	PF00069	0.619
MOD_GSK3_1	391	398	PF00069	0.520
MOD_GSK3_1	399	406	PF00069	0.651
MOD_GSK3_1	410	417	PF00069	0.555
MOD_GSK3_1	482	489	PF00069	0.432
MOD_GSK3_1	5	12	PF00069	0.652
MOD_GSK3_1	503	510	PF00069	0.328
MOD_GSK3_1	529	536	PF00069	0.324
MOD_GSK3_1	610	617	PF00069	0.286
MOD_GSK3_1	618	625	PF00069	0.344
MOD_GSK3_1	62	69	PF00069	0.782
MOD_GSK3_1	628	635	PF00069	0.414
MOD_GSK3_1	714	721	PF00069	0.640
MOD_GSK3_1	748	755	PF00069	0.671
MOD_N-GLC_1	104	109	PF02516	0.517
MOD_N-GLC_1	507	512	PF02516	0.312
MOD_N-GLC_1	87	92	PF02516	0.695
MOD_N-GLC_2	597	599	PF02516	0.249
MOD_NEK2_1	162	167	PF00069	0.752
MOD_NEK2_1	275	280	PF00069	0.512
MOD_NEK2_1	322	327	PF00069	0.476
MOD_NEK2_1	629	634	PF00069	0.299
MOD_NEK2_1	704	709	PF00069	0.399
MOD_NEK2_1	720	725	PF00069	0.582
MOD_NEK2_1	792	797	PF00069	0.399
MOD_NEK2_1	806	811	PF00069	0.478
MOD_NEK2_2	34	39	PF00069	0.556
MOD_PK_1	62	68	PF00069	0.665
MOD_PKA_1	602	608	PF00069	0.249
MOD_PKA_2	151	157	PF00069	0.771
MOD_PKA_2	17	23	PF00069	0.546
MOD_PKA_2	170	176	PF00069	0.686
MOD_PKA_2	186	192	PF00069	0.565
MOD_PKA_2	269	275	PF00069	0.645
MOD_PKA_2	348	354	PF00069	0.523
MOD_PKA_2	445	451	PF00069	0.424
MOD_PKA_2	534	540	PF00069	0.274
MOD_PKA_2	602	608	PF00069	0.249
MOD_PKA_2	610	616	PF00069	0.214
MOD_PKA_2	723	729	PF00069	0.609
MOD_PKA_2	772	778	PF00069	0.478
MOD_PKB_1	185	193	PF00069	0.561
MOD_Plk_1	134	140	PF00069	0.544
MOD_Plk_1	162	168	PF00069	0.556
MOD_Plk_1	310	316	PF00069	0.630
MOD_Plk_1	391	397	PF00069	0.489
MOD_Plk_1	529	535	PF00069	0.273
MOD_Plk_1	658	664	PF00069	0.291
MOD_Plk_1	837	843	PF00069	0.521
MOD_Plk_2-3	837	843	PF00069	0.521
MOD_Plk_4	134	140	PF00069	0.544
MOD_Plk_4	238	244	PF00069	0.534
MOD_Plk_4	292	298	PF00069	0.561
MOD_Plk_4	382	388	PF00069	0.376
MOD_Plk_4	482	488	PF00069	0.368
MOD_Plk_4	629	635	PF00069	0.249
MOD_Plk_4	658	664	PF00069	0.375
MOD_Plk_4	823	829	PF00069	0.579
MOD_ProDKin_1	104	110	PF00069	0.560
MOD_ProDKin_1	191	197	PF00069	0.576
MOD_ProDKin_1	215	221	PF00069	0.665
MOD_ProDKin_1	224	230	PF00069	0.550
MOD_ProDKin_1	245	251	PF00069	0.594
MOD_ProDKin_1	281	287	PF00069	0.644
MOD_ProDKin_1	288	294	PF00069	0.537
MOD_ProDKin_1	325	331	PF00069	0.460
MOD_ProDKin_1	397	403	PF00069	0.652
MOD_ProDKin_1	624	630	PF00069	0.434
MOD_ProDKin_1	635	641	PF00069	0.402
MOD_ProDKin_1	66	72	PF00069	0.797
MOD_ProDKin_1	741	747	PF00069	0.650
MOD_ProDKin_1	87	93	PF00069	0.647
TRG_DiLeu_BaEn_3	555	561	PF01217	0.249
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.429
TRG_ENDOCYTIC_2	673	676	PF00928	0.399
TRG_ENDOCYTIC_2	729	732	PF00928	0.542
TRG_ER_diArg_1	243	246	PF00400	0.732
TRG_ER_diArg_1	318	320	PF00400	0.665
TRG_ER_diArg_1	337	340	PF00400	0.311
TRG_ER_diArg_1	595	598	PF00400	0.316
TRG_ER_diArg_1	602	604	PF00400	0.266
TRG_ER_diArg_1	818	821	PF00400	0.503
TRG_ER_diArg_1	852	855	PF00400	0.561
TRG_ER_diArg_1	91	93	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEF4	Leishmania donovani	61%	86%
A4I310	Leishmania infantum	64%	77%
E9ADJ4	Leishmania major	64%	100%
E9AZC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	85%