MSP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFY9_LEIBR

TriTrypDb:

LbrM.27.2300 , LBRM2903_270030000

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	4
GO:0020016	ciliary pocket	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HFY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFY9

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	6
GO:0006612	protein targeting to membrane	5	6
GO:0006613	cotranslational protein targeting to membrane	6	6
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	6
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0033365	protein localization to organelle	5	6
GO:0045047	protein targeting to ER	6	6
GO:0045184	establishment of protein localization	3	6
GO:0046907	intracellular transport	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0051668	localization within membrane	3	6
GO:0070727	cellular macromolecule localization	3	6
GO:0070972	protein localization to endoplasmic reticulum	6	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0072594	establishment of protein localization to organelle	4	6
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	6
GO:0072657	protein localization to membrane	4	6
GO:0090150	establishment of protein localization to membrane	4	6
GO:0016043	cellular component organization	3	1
GO:0022406	membrane docking	2	1
GO:0051640	organelle localization	2	1
GO:0051643	endoplasmic reticulum localization	3	1
GO:0061024	membrane organization	4	1
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090158	endoplasmic reticulum membrane organization	5	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0017076	purine nucleotide binding	4	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.604
CLV_PCSK_SKI1_1	165	169	PF00082	0.426
CLV_PCSK_SKI1_1	295	299	PF00082	0.412
CLV_PCSK_SKI1_1	87	91	PF00082	0.376
DEG_APCC_DBOX_1	160	168	PF00400	0.551
DEG_SPOP_SBC_1	205	209	PF00917	0.775
DEG_SPOP_SBC_1	272	276	PF00917	0.607
DOC_CYCLIN_yClb5_NLxxxL_5	1	10	PF00134	0.510
DOC_CYCLIN_yClb5_NLxxxL_5	324	333	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.519
DOC_MAPK_HePTP_8	56	68	PF00069	0.559
DOC_MAPK_MEF2A_6	103	110	PF00069	0.511
DOC_MAPK_MEF2A_6	309	317	PF00069	0.403
DOC_MAPK_MEF2A_6	59	68	PF00069	0.527
DOC_MAPK_NFAT4_5	103	111	PF00069	0.445
DOC_PP4_FxxP_1	17	20	PF00568	0.509
DOC_PP4_FxxP_1	269	272	PF00568	0.608
DOC_USP7_MATH_1	205	209	PF00917	0.810
DOC_USP7_MATH_1	233	237	PF00917	0.695
DOC_USP7_MATH_1	252	256	PF00917	0.624
DOC_USP7_MATH_1	272	276	PF00917	0.743
DOC_WW_Pin1_4	153	158	PF00397	0.645
DOC_WW_Pin1_4	213	218	PF00397	0.642
DOC_WW_Pin1_4	229	234	PF00397	0.751
DOC_WW_Pin1_4	268	273	PF00397	0.695
LIG_14-3-3_CanoR_1	282	288	PF00244	0.616
LIG_14-3-3_CanoR_1	309	314	PF00244	0.280
LIG_14-3-3_CanoR_1	59	63	PF00244	0.600
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.555
LIG_BIR_III_4	241	245	PF00653	0.625
LIG_BRCT_BRCA1_1	13	17	PF00533	0.520
LIG_EVH1_2	64	68	PF00568	0.586
LIG_FHA_1	138	144	PF00498	0.498
LIG_FHA_1	194	200	PF00498	0.766
LIG_FHA_1	329	335	PF00498	0.457
LIG_FHA_2	214	220	PF00498	0.742
LIG_LIR_Apic_2	14	20	PF02991	0.518
LIG_LIR_Gen_1	109	118	PF02991	0.549
LIG_LIR_Nem_3	109	113	PF02991	0.531
LIG_LIR_Nem_3	13	19	PF02991	0.518
LIG_LIR_Nem_3	307	311	PF02991	0.526
LIG_LIR_Nem_3	49	53	PF02991	0.579
LIG_MLH1_MIPbox_1	13	17	PF16413	0.520
LIG_NRBOX	319	325	PF00104	0.373
LIG_NRP_CendR_1	336	337	PF00754	0.553
LIG_PCNA_yPIPBox_3	119	133	PF02747	0.611
LIG_PCNA_yPIPBox_3	23	33	PF02747	0.589
LIG_PCNA_yPIPBox_3	326	337	PF02747	0.453
LIG_Pex14_2	17	21	PF04695	0.585
LIG_SH2_CRK	308	312	PF00017	0.592
LIG_SH3_3	164	170	PF00018	0.463
LIG_SH3_3	59	65	PF00018	0.598
LIG_SUMO_SIM_par_1	312	318	PF11976	0.246
LIG_TYR_ITIM	306	311	PF00017	0.632
LIG_UBA3_1	329	336	PF00899	0.472
LIG_WRC_WIRS_1	47	52	PF05994	0.570
LIG_WRC_WIRS_1	78	83	PF05994	0.579
MOD_CDK_SPxxK_3	273	280	PF00069	0.693
MOD_CK1_1	11	17	PF00069	0.523
MOD_CK1_1	117	123	PF00069	0.595
MOD_CK1_1	129	135	PF00069	0.639
MOD_CK1_1	156	162	PF00069	0.594
MOD_CK1_1	271	277	PF00069	0.710
MOD_CK2_1	213	219	PF00069	0.740
MOD_GlcNHglycan	241	245	PF01048	0.495
MOD_GlcNHglycan	254	257	PF01048	0.494
MOD_GSK3_1	189	196	PF00069	0.718
MOD_GSK3_1	229	236	PF00069	0.743
MOD_GSK3_1	268	275	PF00069	0.798
MOD_GSK3_1	324	331	PF00069	0.621
MOD_GSK3_1	73	80	PF00069	0.588
MOD_N-GLC_1	213	218	PF02516	0.520
MOD_N-GLC_1	22	27	PF02516	0.396
MOD_NEK2_1	206	211	PF00069	0.695
MOD_NEK2_1	315	320	PF00069	0.403
MOD_NEK2_1	324	329	PF00069	0.506
MOD_NEK2_1	6	11	PF00069	0.538
MOD_NEK2_2	290	295	PF00069	0.714
MOD_PIKK_1	207	213	PF00454	0.776
MOD_PIKK_1	275	281	PF00454	0.758
MOD_PIKK_1	8	14	PF00454	0.515
MOD_PK_1	309	315	PF00069	0.213
MOD_PKA_2	189	195	PF00069	0.714
MOD_PKA_2	223	229	PF00069	0.743
MOD_PKA_2	281	287	PF00069	0.812
MOD_PKA_2	58	64	PF00069	0.572
MOD_Plk_1	193	199	PF00069	0.634
MOD_Plk_1	22	28	PF00069	0.555
MOD_Plk_1	290	296	PF00069	0.710
MOD_Plk_4	11	17	PF00069	0.538
MOD_Plk_4	174	180	PF00069	0.597
MOD_Plk_4	309	315	PF00069	0.386
MOD_Plk_4	328	334	PF00069	0.407
MOD_Plk_4	73	79	PF00069	0.609
MOD_ProDKin_1	153	159	PF00069	0.638
MOD_ProDKin_1	213	219	PF00069	0.644
MOD_ProDKin_1	229	235	PF00069	0.751
MOD_ProDKin_1	268	274	PF00069	0.695
MOD_SUMO_for_1	182	185	PF00179	0.722
TRG_ENDOCYTIC_2	308	311	PF00928	0.592
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF53	Leptomonas seymouri	66%	100%
A0A3Q8IEI8	Leishmania donovani	74%	100%
A0A422N827	Trypanosoma rangeli	29%	96%
A4I2Y2	Leishmania infantum	74%	100%
C9ZJH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ADJ2	Leishmania major	74%	100%
E9AZB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
V5AYR4	Trypanosoma cruzi	28%	96%