Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFY7_LEIBR

TriTrypDb:

LbrM.27.2280 , LBRM2903_270029800

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0016607	nuclear speck	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFY7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.671
CLV_C14_Caspase3-7	222	226	PF00656	0.640
CLV_NRD_NRD_1	131	133	PF00675	0.652
CLV_NRD_NRD_1	223	225	PF00675	0.711
CLV_NRD_NRD_1	241	243	PF00675	0.406
CLV_NRD_NRD_1	322	324	PF00675	0.492
CLV_NRD_NRD_1	352	354	PF00675	0.625
CLV_NRD_NRD_1	367	369	PF00675	0.595
CLV_NRD_NRD_1	378	380	PF00675	0.506
CLV_NRD_NRD_1	388	390	PF00675	0.682
CLV_NRD_NRD_1	400	402	PF00675	0.555
CLV_NRD_NRD_1	410	412	PF00675	0.587
CLV_PCSK_FUR_1	348	352	PF00082	0.597
CLV_PCSK_FUR_1	361	365	PF00082	0.468
CLV_PCSK_FUR_1	376	380	PF00082	0.587
CLV_PCSK_FUR_1	398	402	PF00082	0.756
CLV_PCSK_FUR_1	408	412	PF00082	0.677
CLV_PCSK_KEX2_1	131	133	PF00082	0.635
CLV_PCSK_KEX2_1	223	225	PF00082	0.665
CLV_PCSK_KEX2_1	240	242	PF00082	0.437
CLV_PCSK_KEX2_1	296	298	PF00082	0.390
CLV_PCSK_KEX2_1	322	324	PF00082	0.492
CLV_PCSK_KEX2_1	350	352	PF00082	0.618
CLV_PCSK_KEX2_1	363	365	PF00082	0.643
CLV_PCSK_KEX2_1	366	368	PF00082	0.487
CLV_PCSK_KEX2_1	376	378	PF00082	0.568
CLV_PCSK_KEX2_1	387	389	PF00082	0.647
CLV_PCSK_KEX2_1	398	400	PF00082	0.663
CLV_PCSK_KEX2_1	410	412	PF00082	0.581
CLV_PCSK_KEX2_1	416	418	PF00082	0.593
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.455
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.291
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.519
CLV_PCSK_PC7_1	348	354	PF00082	0.570
CLV_PCSK_PC7_1	361	367	PF00082	0.441
CLV_PCSK_PC7_1	394	400	PF00082	0.540
CLV_PCSK_SKI1_1	159	163	PF00082	0.271
CLV_PCSK_SKI1_1	191	195	PF00082	0.332
CLV_PCSK_SKI1_1	241	245	PF00082	0.427
CLV_PCSK_SKI1_1	259	263	PF00082	0.244
DOC_CYCLIN_RxL_1	189	199	PF00134	0.514
DOC_MAPK_gen_1	138	146	PF00069	0.528
DOC_MAPK_gen_1	240	248	PF00069	0.514
DOC_MAPK_gen_1	310	319	PF00069	0.640
DOC_MAPK_MEF2A_6	240	248	PF00069	0.514
DOC_MAPK_MEF2A_6	279	286	PF00069	0.514
DOC_PP2B_PxIxI_1	279	285	PF00149	0.491
DOC_PP4_FxxP_1	265	268	PF00568	0.514
DOC_PP4_FxxP_1	58	61	PF00568	0.514
DOC_USP7_MATH_1	124	128	PF00917	0.644
DOC_USP7_MATH_1	234	238	PF00917	0.485
DOC_USP7_MATH_1	288	292	PF00917	0.514
DOC_USP7_UBL2_3	191	195	PF12436	0.394
DOC_WW_Pin1_4	201	206	PF00397	0.394
DOC_WW_Pin1_4	264	269	PF00397	0.491
DOC_WW_Pin1_4	392	397	PF00397	0.701
DOC_WW_Pin1_4	402	407	PF00397	0.591
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BIR_III_4	106	110	PF00653	0.592
LIG_BIR_III_4	160	164	PF00653	0.440
LIG_FHA_1	3	9	PF00498	0.276
LIG_FHA_1	45	51	PF00498	0.394
LIG_FHA_2	101	107	PF00498	0.639
LIG_FHA_2	14	20	PF00498	0.449
LIG_FHA_2	288	294	PF00498	0.556
LIG_LIR_Apic_2	274	280	PF02991	0.514
LIG_LIR_Apic_2	55	61	PF02991	0.491
LIG_LIR_Gen_1	18	27	PF02991	0.460
LIG_LIR_Nem_3	18	24	PF02991	0.460
LIG_MAD2	143	151	PF02301	0.374
LIG_REV1ctd_RIR_1	21	30	PF16727	0.447
LIG_SH2_PTP2	277	280	PF00017	0.432
LIG_SH2_STAT5	184	187	PF00017	0.528
LIG_SH2_STAT5	277	280	PF00017	0.432
LIG_SH2_STAT5	7	10	PF00017	0.449
LIG_SH2_STAT5	82	85	PF00017	0.489
LIG_SH3_3	118	124	PF00018	0.523
LIG_SH3_3	204	210	PF00018	0.606
LIG_SH3_3	30	36	PF00018	0.514
LIG_WW_3	211	215	PF00397	0.575
LIG_WW_3	395	399	PF00397	0.673
MOD_CDC14_SPxK_1	395	398	PF00782	0.739
MOD_CDC14_SPxK_1	405	408	PF00782	0.539
MOD_CDK_SPxK_1	392	398	PF00069	0.706
MOD_CDK_SPxK_1	402	408	PF00069	0.591
MOD_CDK_SPxxK_3	392	399	PF00069	0.539
MOD_CK1_1	133	139	PF00069	0.602
MOD_CK1_1	2	8	PF00069	0.497
MOD_CK1_1	255	261	PF00069	0.426
MOD_CK1_1	302	308	PF00069	0.478
MOD_CK1_1	338	344	PF00069	0.587
MOD_CK1_1	354	360	PF00069	0.421
MOD_CK1_1	66	72	PF00069	0.510
MOD_CK2_1	11	17	PF00069	0.517
MOD_CK2_1	287	293	PF00069	0.503
MOD_DYRK1A_RPxSP_1	392	396	PF00069	0.699
MOD_GlcNHglycan	1	4	PF01048	0.555
MOD_GlcNHglycan	13	16	PF01048	0.319
MOD_GlcNHglycan	132	135	PF01048	0.761
MOD_GlcNHglycan	215	220	PF01048	0.754
MOD_GlcNHglycan	236	239	PF01048	0.630
MOD_GlcNHglycan	290	293	PF01048	0.296
MOD_GlcNHglycan	301	304	PF01048	0.240
MOD_GlcNHglycan	47	50	PF01048	0.387
MOD_GlcNHglycan	65	68	PF01048	0.230
MOD_GlcNHglycan	70	73	PF01048	0.550
MOD_GlcNHglycan	83	86	PF01048	0.568
MOD_GSK3_1	133	140	PF00069	0.568
MOD_GSK3_1	2	9	PF00069	0.497
MOD_GSK3_1	215	222	PF00069	0.749
MOD_GSK3_1	302	309	PF00069	0.394
MOD_GSK3_1	338	345	PF00069	0.565
MOD_GSK3_1	351	358	PF00069	0.595
MOD_GSK3_1	388	395	PF00069	0.778
MOD_GSK3_1	400	407	PF00069	0.687
MOD_GSK3_1	66	73	PF00069	0.624
MOD_LATS_1	349	355	PF00433	0.461
MOD_LATS_1	402	408	PF00433	0.522
MOD_N-GLC_1	113	118	PF02516	0.526
MOD_N-GLC_1	201	206	PF02516	0.194
MOD_NEK2_1	145	150	PF00069	0.483
MOD_NEK2_1	196	201	PF00069	0.452
MOD_NEK2_1	306	311	PF00069	0.483
MOD_NEK2_1	99	104	PF00069	0.513
MOD_PIKK_1	338	344	PF00454	0.451
MOD_PKA_1	351	357	PF00069	0.541
MOD_PKA_1	366	372	PF00069	0.572
MOD_PKA_1	377	383	PF00069	0.584
MOD_PKA_1	388	394	PF00069	0.774
MOD_PKA_1	400	406	PF00069	0.687
MOD_PKA_2	130	136	PF00069	0.627
MOD_PKA_2	137	143	PF00069	0.517
MOD_PKA_2	338	344	PF00069	0.604
MOD_PKA_2	351	357	PF00069	0.646
MOD_PKA_2	366	372	PF00069	0.572
MOD_PKA_2	377	383	PF00069	0.584
MOD_PKA_2	388	394	PF00069	0.774
MOD_PKA_2	400	406	PF00069	0.687
MOD_PKB_1	350	358	PF00069	0.585
MOD_PKB_1	364	372	PF00069	0.442
MOD_PKB_1	377	385	PF00069	0.590
MOD_PKB_1	398	406	PF00069	0.654
MOD_Plk_4	145	151	PF00069	0.579
MOD_Plk_4	2	8	PF00069	0.497
MOD_Plk_4	302	308	PF00069	0.394
MOD_ProDKin_1	201	207	PF00069	0.394
MOD_ProDKin_1	264	270	PF00069	0.491
MOD_ProDKin_1	392	398	PF00069	0.706
MOD_ProDKin_1	402	408	PF00069	0.591
MOD_SUMO_for_1	278	281	PF00179	0.514
MOD_SUMO_for_1	311	314	PF00179	0.402
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.509
TRG_ER_diArg_1	130	132	PF00400	0.644
TRG_ER_diArg_1	348	351	PF00400	0.636
TRG_ER_diArg_1	363	366	PF00400	0.556
TRG_ER_diArg_1	376	379	PF00400	0.598
TRG_ER_diArg_1	387	389	PF00400	0.599
TRG_ER_diArg_1	397	400	PF00400	0.584
TRG_ER_diArg_1	408	411	PF00400	0.583
TRG_NLS_Bipartite_1	223	244	PF00514	0.482
TRG_NLS_MonoExtC_3	239	245	PF00514	0.421
TRG_NLS_MonoExtN_4	239	244	PF00514	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB5	Leptomonas seymouri	48%	100%
A0A1X0NSK5	Trypanosomatidae	28%	91%
A0A3R7LQ31	Trypanosoma rangeli	29%	95%
A0A3S7X0Y2	Leishmania donovani	81%	92%
A4I2Y0	Leishmania infantum	81%	93%
E9ADJ0	Leishmania major	81%	100%
E9AZB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%