NADH-u_ox-rdase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFY6_LEIBR

TriTrypDb:

LbrM.27.2270 , LBRM2903_270029700

Length:

148

Annotations

LeishMANIAdb annotations

Relatively conserved in Kinetoplastids but not seen beyond.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HFY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.319
CLV_NRD_NRD_1	26	28	PF00675	0.391
CLV_NRD_NRD_1	42	44	PF00675	0.250
CLV_NRD_NRD_1	68	70	PF00675	0.539
CLV_NRD_NRD_1	9	11	PF00675	0.498
CLV_PCSK_FUR_1	40	44	PF00082	0.356
CLV_PCSK_KEX2_1	111	113	PF00082	0.319
CLV_PCSK_KEX2_1	26	28	PF00082	0.401
CLV_PCSK_KEX2_1	42	44	PF00082	0.250
CLV_PCSK_KEX2_1	67	69	PF00082	0.546
CLV_PCSK_SKI1_1	10	14	PF00082	0.376
DOC_MAPK_gen_1	40	48	PF00069	0.526
DOC_MAPK_gen_1	67	76	PF00069	0.339
DOC_PP1_RVXF_1	109	116	PF00149	0.520
DOC_USP7_UBL2_3	117	121	PF12436	0.537
LIG_14-3-3_CanoR_1	132	138	PF00244	0.620
LIG_14-3-3_CanoR_1	43	49	PF00244	0.442
LIG_14-3-3_CanoR_1	67	73	PF00244	0.415
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_FHA_1	45	51	PF00498	0.471
LIG_FHA_1	69	75	PF00498	0.303
LIG_LIR_Gen_1	124	131	PF02991	0.583
LIG_LIR_Gen_1	71	79	PF02991	0.271
LIG_LIR_Gen_1	80	89	PF02991	0.319
LIG_LIR_Nem_3	124	128	PF02991	0.586
LIG_LIR_Nem_3	61	65	PF02991	0.314
LIG_LIR_Nem_3	71	76	PF02991	0.219
LIG_LIR_Nem_3	77	82	PF02991	0.208
LIG_Pex14_1	133	137	PF04695	0.574
LIG_Pex14_1	35	39	PF04695	0.569
LIG_SH2_CRK	125	129	PF00017	0.597
LIG_SH2_GRB2like	98	101	PF00017	0.551
LIG_SH2_NCK_1	125	129	PF00017	0.597
LIG_SH2_NCK_1	98	102	PF00017	0.587
LIG_SH2_SRC	98	101	PF00017	0.526
LIG_SH2_STAP1	98	102	PF00017	0.546
LIG_SH2_STAT5	63	66	PF00017	0.362
LIG_SH2_STAT5	72	75	PF00017	0.262
LIG_TYR_ITIM	96	101	PF00017	0.358
LIG_WRC_WIRS_1	76	81	PF05994	0.294
MOD_CK1_1	53	59	PF00069	0.355
MOD_CK1_1	77	83	PF00069	0.353
MOD_Cter_Amidation	8	11	PF01082	0.414
MOD_GlcNHglycan	1	4	PF01048	0.381
MOD_GlcNHglycan	52	55	PF01048	0.358
MOD_GlcNHglycan	79	82	PF01048	0.389
MOD_GSK3_1	44	51	PF00069	0.458
MOD_GSK3_1	54	61	PF00069	0.283
MOD_N-GLC_1	3	8	PF02516	0.463
MOD_NEK2_1	48	53	PF00069	0.322
MOD_NEK2_1	58	63	PF00069	0.313
MOD_NEK2_1	75	80	PF00069	0.223
MOD_PIKK_1	123	129	PF00454	0.556
MOD_PKA_1	68	74	PF00069	0.338
MOD_PKA_2	68	74	PF00069	0.356
MOD_Plk_1	105	111	PF00069	0.507
MOD_Plk_1	123	129	PF00069	0.556
MOD_Plk_4	105	111	PF00069	0.516
MOD_Plk_4	54	60	PF00069	0.294
MOD_Plk_4	68	74	PF00069	0.295
TRG_ENDOCYTIC_2	125	128	PF00928	0.570
TRG_ENDOCYTIC_2	63	66	PF00928	0.441
TRG_ENDOCYTIC_2	72	75	PF00928	0.301
TRG_ENDOCYTIC_2	98	101	PF00928	0.497
TRG_ER_diArg_1	110	112	PF00400	0.515
TRG_ER_diArg_1	25	27	PF00400	0.604
TRG_ER_diArg_1	39	42	PF00400	0.457
TRG_ER_diArg_1	66	69	PF00400	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ2	Leptomonas seymouri	82%	100%
A0A0S4IJ67	Bodo saltans	50%	100%
A0A1X0NST1	Trypanosomatidae	74%	100%
A0A3S5IQM8	Trypanosoma rangeli	68%	100%
A0A3S7X0X5	Leishmania donovani	89%	100%
A4I2X9	Leishmania infantum	89%	100%
C9ZJG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	98%
E9ADI9	Leishmania major	91%	100%
E9AZB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%