LeishMANIAdb
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V-type proton ATPase subunit a

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
V-type proton ATPase subunit a
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4HFY5_LEIBR
TriTrypDb:
LbrM.27.2260
Length:
70

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFY5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFY5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 7 9 PF00675 0.505
CLV_PCSK_KEX2_1 7 9 PF00082 0.409
CLV_PCSK_SKI1_1 59 63 PF00082 0.407
DEG_APCC_DBOX_1 37 45 PF00400 0.633
DEG_Nend_UBRbox_2 1 3 PF02207 0.763
DOC_MAPK_gen_1 4 14 PF00069 0.610
DOC_MAPK_MEF2A_6 7 14 PF00069 0.648
DOC_WW_Pin1_4 59 64 PF00397 0.699
LIG_14-3-3_CanoR_1 33 38 PF00244 0.639
LIG_FHA_2 37 43 PF00498 0.440
LIG_FHA_2 4 10 PF00498 0.651
LIG_PCNA_yPIPBox_3 20 33 PF02747 0.621
LIG_PDZ_Class_1 65 70 PF00595 0.463
LIG_SH2_CRK 28 32 PF00017 0.623
LIG_SH2_GRB2like 27 30 PF00017 0.629
LIG_SH2_STAT5 43 46 PF00017 0.529
LIG_SUMO_SIM_anti_2 9 14 PF11976 0.585
LIG_TRAF2_1 15 18 PF00917 0.625
LIG_TYR_ITIM 26 31 PF00017 0.626
LIG_UBA3_1 50 59 PF00899 0.358
MOD_CK1_1 3 9 PF00069 0.390
MOD_CK2_1 3 9 PF00069 0.674
MOD_GlcNHglycan 67 70 PF01048 0.461
MOD_NEK2_1 64 69 PF00069 0.728
MOD_PKA_2 3 9 PF00069 0.390
MOD_ProDKin_1 59 65 PF00069 0.706
TRG_ENDOCYTIC_2 27 30 PF00928 0.629
TRG_ER_diArg_1 32 35 PF00400 0.639

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X0Y8 Leishmania donovani 91% 85%
A4I2X8 Leishmania infantum 91% 85%
E9ADI8 Leishmania major 90% 100%
E9AZB4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 85%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS