Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFY4_LEIBR

TriTrypDb:

LbrM.27.2250 , LBRM2903_270029600

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HFY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.627
CLV_C14_Caspase3-7	380	384	PF00656	0.761
CLV_C14_Caspase3-7	386	390	PF00656	0.678
CLV_MEL_PAP_1	50	56	PF00089	0.227
CLV_NRD_NRD_1	134	136	PF00675	0.614
CLV_NRD_NRD_1	200	202	PF00675	0.594
CLV_NRD_NRD_1	25	27	PF00675	0.324
CLV_NRD_NRD_1	261	263	PF00675	0.343
CLV_NRD_NRD_1	418	420	PF00675	0.638
CLV_NRD_NRD_1	535	537	PF00675	0.486
CLV_NRD_NRD_1	547	549	PF00675	0.512
CLV_PCSK_FUR_1	416	420	PF00082	0.574
CLV_PCSK_KEX2_1	134	136	PF00082	0.614
CLV_PCSK_KEX2_1	200	202	PF00082	0.594
CLV_PCSK_KEX2_1	260	262	PF00082	0.341
CLV_PCSK_KEX2_1	418	420	PF00082	0.638
CLV_PCSK_KEX2_1	516	518	PF00082	0.519
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.519
CLV_PCSK_SKI1_1	334	338	PF00082	0.563
DEG_MDM2_SWIB_1	74	81	PF02201	0.278
DOC_MAPK_gen_1	11	20	PF00069	0.664
DOC_MAPK_gen_1	164	174	PF00069	0.546
DOC_MAPK_gen_1	216	225	PF00069	0.266
DOC_MAPK_gen_1	41	50	PF00069	0.593
DOC_MAPK_gen_1	533	543	PF00069	0.715
DOC_MAPK_HePTP_8	50	62	PF00069	0.618
DOC_MAPK_MEF2A_6	167	176	PF00069	0.546
DOC_MAPK_MEF2A_6	53	62	PF00069	0.411
DOC_MAPK_MEF2A_6	536	545	PF00069	0.577
DOC_MAPK_NFAT4_5	53	61	PF00069	0.274
DOC_PP1_RVXF_1	109	115	PF00149	0.348
DOC_PP2B_LxvP_1	560	563	PF13499	0.274
DOC_PP4_FxxP_1	587	590	PF00568	0.388
DOC_SPAK_OSR1_1	53	57	PF12202	0.512
DOC_USP7_MATH_1	165	169	PF00917	0.603
DOC_USP7_MATH_1	269	273	PF00917	0.682
DOC_USP7_MATH_1	322	326	PF00917	0.671
DOC_USP7_MATH_1	470	474	PF00917	0.700
DOC_USP7_MATH_1	488	492	PF00917	0.674
DOC_USP7_MATH_1	509	513	PF00917	0.800
DOC_USP7_MATH_1	599	603	PF00917	0.504
DOC_WW_Pin1_4	276	281	PF00397	0.557
DOC_WW_Pin1_4	295	300	PF00397	0.574
DOC_WW_Pin1_4	381	386	PF00397	0.793
DOC_WW_Pin1_4	484	489	PF00397	0.754
DOC_WW_Pin1_4	526	531	PF00397	0.618
DOC_WW_Pin1_4	603	608	PF00397	0.420
LIG_14-3-3_CanoR_1	13	19	PF00244	0.616
LIG_14-3-3_CanoR_1	200	208	PF00244	0.410
LIG_14-3-3_CanoR_1	249	257	PF00244	0.635
LIG_14-3-3_CanoR_1	26	30	PF00244	0.621
LIG_14-3-3_CanoR_1	303	307	PF00244	0.735
LIG_14-3-3_CanoR_1	334	339	PF00244	0.699
LIG_14-3-3_CanoR_1	369	377	PF00244	0.661
LIG_14-3-3_CanoR_1	483	488	PF00244	0.678
LIG_14-3-3_CanoR_1	517	523	PF00244	0.637
LIG_Actin_WH2_2	184	202	PF00022	0.318
LIG_APCC_ABBA_1	37	42	PF00400	0.592
LIG_BRCT_BRCA1_1	128	132	PF00533	0.395
LIG_BRCT_BRCA1_1	575	579	PF00533	0.292
LIG_Clathr_ClatBox_1	173	177	PF01394	0.512
LIG_EH1_1	53	61	PF00400	0.512
LIG_FHA_1	143	149	PF00498	0.472
LIG_FHA_1	194	200	PF00498	0.362
LIG_FHA_1	280	286	PF00498	0.748
LIG_FHA_1	303	309	PF00498	0.822
LIG_FHA_1	566	572	PF00498	0.503
LIG_FHA_1	74	80	PF00498	0.513
LIG_FHA_2	113	119	PF00498	0.306
LIG_FHA_2	249	255	PF00498	0.667
LIG_FHA_2	328	334	PF00498	0.796
LIG_FHA_2	484	490	PF00498	0.647
LIG_FHA_2	554	560	PF00498	0.411
LIG_GBD_Chelix_1	171	179	PF00786	0.255
LIG_LIR_Gen_1	113	120	PF02991	0.478
LIG_LIR_Gen_1	42	51	PF02991	0.590
LIG_LIR_Gen_1	63	71	PF02991	0.471
LIG_LIR_Gen_1	86	94	PF02991	0.387
LIG_LIR_Nem_3	113	117	PF02991	0.479
LIG_LIR_Nem_3	35	40	PF02991	0.586
LIG_LIR_Nem_3	42	48	PF02991	0.586
LIG_LIR_Nem_3	576	582	PF02991	0.394
LIG_LIR_Nem_3	63	67	PF02991	0.471
LIG_LIR_Nem_3	75	81	PF02991	0.311
LIG_LIR_Nem_3	86	90	PF02991	0.375
LIG_PCNA_TLS_4	31	38	PF02747	0.479
LIG_Pex14_2	132	136	PF04695	0.474
LIG_Pex14_2	542	546	PF04695	0.701
LIG_Pex14_2	74	78	PF04695	0.350
LIG_REV1ctd_RIR_1	543	553	PF16727	0.713
LIG_REV1ctd_RIR_1	91	98	PF16727	0.458
LIG_RPA_C_Fungi	256	268	PF08784	0.402
LIG_SH2_CRK	45	49	PF00017	0.468
LIG_SH2_GRB2like	595	598	PF00017	0.475
LIG_SH2_NCK_1	45	49	PF00017	0.468
LIG_SH2_STAP1	195	199	PF00017	0.448
LIG_SH2_STAT3	40	43	PF00017	0.486
LIG_SH2_STAT5	195	198	PF00017	0.549
LIG_SH2_STAT5	244	247	PF00017	0.400
LIG_SH2_STAT5	554	557	PF00017	0.411
LIG_SH3_3	113	119	PF00018	0.325
LIG_SH3_3	17	23	PF00018	0.565
LIG_SH3_3	333	339	PF00018	0.824
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.244
LIG_SUMO_SIM_par_1	171	177	PF11976	0.298
LIG_SUMO_SIM_par_1	178	184	PF11976	0.370
LIG_SUMO_SIM_par_1	327	333	PF11976	0.545
LIG_SUMO_SIM_par_1	57	63	PF11976	0.471
LIG_TRAF2_1	602	605	PF00917	0.512
LIG_WRC_WIRS_1	34	39	PF05994	0.309
LIG_WRC_WIRS_1	579	584	PF05994	0.480
LIG_WRC_WIRS_1	61	66	PF05994	0.471
LIG_WRC_WIRS_1	71	76	PF05994	0.327
MOD_CDK_SPxxK_3	526	533	PF00069	0.504
MOD_CK1_1	106	112	PF00069	0.493
MOD_CK1_1	181	187	PF00069	0.244
MOD_CK1_1	194	200	PF00069	0.250
MOD_CK1_1	279	285	PF00069	0.628
MOD_CK1_1	425	431	PF00069	0.737
MOD_CK1_1	447	453	PF00069	0.694
MOD_CK1_1	457	463	PF00069	0.696
MOD_CK1_1	464	470	PF00069	0.694
MOD_CK1_1	512	518	PF00069	0.793
MOD_CK1_1	72	78	PF00069	0.367
MOD_CK1_1	80	86	PF00069	0.477
MOD_CK2_1	107	113	PF00069	0.432
MOD_CK2_1	483	489	PF00069	0.557
MOD_CK2_1	553	559	PF00069	0.411
MOD_CK2_1	599	605	PF00069	0.524
MOD_GlcNHglycan	129	132	PF01048	0.479
MOD_GlcNHglycan	136	139	PF01048	0.402
MOD_GlcNHglycan	167	170	PF01048	0.476
MOD_GlcNHglycan	183	186	PF01048	0.411
MOD_GlcNHglycan	317	320	PF01048	0.640
MOD_GlcNHglycan	324	327	PF01048	0.716
MOD_GlcNHglycan	356	359	PF01048	0.611
MOD_GlcNHglycan	370	373	PF01048	0.749
MOD_GlcNHglycan	379	382	PF01048	0.539
MOD_GlcNHglycan	408	411	PF01048	0.678
MOD_GlcNHglycan	449	452	PF01048	0.623
MOD_GlcNHglycan	471	475	PF01048	0.628
MOD_GlcNHglycan	500	503	PF01048	0.708
MOD_GSK3_1	102	109	PF00069	0.556
MOD_GSK3_1	155	162	PF00069	0.292
MOD_GSK3_1	290	297	PF00069	0.698
MOD_GSK3_1	368	375	PF00069	0.792
MOD_GSK3_1	377	384	PF00069	0.726
MOD_GSK3_1	440	447	PF00069	0.764
MOD_GSK3_1	450	457	PF00069	0.692
MOD_GSK3_1	484	491	PF00069	0.734
MOD_GSK3_1	505	512	PF00069	0.663
MOD_GSK3_1	549	556	PF00069	0.471
MOD_GSK3_1	599	606	PF00069	0.522
MOD_GSK3_1	69	76	PF00069	0.459
MOD_N-GLC_1	447	452	PF02516	0.765
MOD_N-GLC_1	83	88	PF02516	0.544
MOD_NEK2_1	112	117	PF00069	0.281
MOD_NEK2_1	14	19	PF00069	0.511
MOD_NEK2_1	155	160	PF00069	0.326
MOD_NEK2_1	178	183	PF00069	0.359
MOD_NEK2_1	191	196	PF00069	0.396
MOD_NEK2_1	377	382	PF00069	0.612
MOD_NEK2_1	412	417	PF00069	0.767
MOD_NEK2_1	493	498	PF00069	0.710
MOD_NEK2_1	60	65	PF00069	0.410
MOD_NEK2_1	69	74	PF00069	0.413
MOD_NEK2_1	92	97	PF00069	0.557
MOD_OFUCOSY	198	203	PF10250	0.470
MOD_PIKK_1	589	595	PF00454	0.591
MOD_PK_1	461	467	PF00069	0.700
MOD_PKA_1	134	140	PF00069	0.244
MOD_PKA_1	261	267	PF00069	0.446
MOD_PKA_2	134	140	PF00069	0.306
MOD_PKA_2	163	169	PF00069	0.498
MOD_PKA_2	199	205	PF00069	0.481
MOD_PKA_2	248	254	PF00069	0.522
MOD_PKA_2	25	31	PF00069	0.512
MOD_PKA_2	261	267	PF00069	0.580
MOD_PKA_2	302	308	PF00069	0.707
MOD_PKA_2	368	374	PF00069	0.640
MOD_PKA_2	412	418	PF00069	0.730
MOD_PKA_2	52	58	PF00069	0.244
MOD_PKA_2	532	538	PF00069	0.543
MOD_PKB_1	11	19	PF00069	0.348
MOD_PKB_1	481	489	PF00069	0.560
MOD_Plk_1	112	118	PF00069	0.362
MOD_Plk_1	454	460	PF00069	0.725
MOD_Plk_1	461	467	PF00069	0.723
MOD_Plk_1	488	494	PF00069	0.808
MOD_Plk_1	83	89	PF00069	0.537
MOD_Plk_2-3	383	389	PF00069	0.622
MOD_Plk_4	14	20	PF00069	0.518
MOD_Plk_4	155	161	PF00069	0.322
MOD_Plk_4	240	246	PF00069	0.345
MOD_Plk_4	269	275	PF00069	0.496
MOD_Plk_4	33	39	PF00069	0.418
MOD_Plk_4	454	460	PF00069	0.826
MOD_Plk_4	488	494	PF00069	0.731
MOD_Plk_4	83	89	PF00069	0.537
MOD_ProDKin_1	276	282	PF00069	0.433
MOD_ProDKin_1	295	301	PF00069	0.450
MOD_ProDKin_1	381	387	PF00069	0.755
MOD_ProDKin_1	484	490	PF00069	0.701
MOD_ProDKin_1	526	532	PF00069	0.506
MOD_ProDKin_1	603	609	PF00069	0.519
TRG_DiLeu_BaEn_1	151	156	PF01217	0.274
TRG_DiLeu_BaEn_1	489	494	PF01217	0.548
TRG_ENDOCYTIC_2	45	48	PF00928	0.475
TRG_ER_diArg_1	10	13	PF00400	0.495
TRG_ER_diArg_1	133	135	PF00400	0.497
TRG_ER_diArg_1	199	201	PF00400	0.469
TRG_ER_diArg_1	260	262	PF00400	0.521
TRG_ER_diArg_1	416	419	PF00400	0.817
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U4	Leptomonas seymouri	43%	75%
A0A3Q8IQ50	Leishmania donovani	63%	72%
A4I2X7	Leishmania infantum	63%	72%
E9ADI7	Leishmania major	62%	100%
E9AZB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	72%