LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HFY3_LEIBR
TriTrypDb:
LbrM.27.2240 , LBRM2903_270029500
Length:
385

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: bmtom@gate.sinica.edu.tw
Publication title: Identification of macrosialin (CD68) on the surface of host macrophages as the receptor for the intercellular adhesive molecule (ICAM-L) of Leishmania amazonensis
Publication 1st author(s): Ng
Publication Identifier(s): 19540239
Host organism: -1
Interaction detection method(s): anti bait coimmunoprecipitation
Interaction type: physical association
Identification method participant A: western blot
Identification method participant B: western blot
ID(s) interactor A: Q9NGK0
ID(s) interactor B: P31996
Taxid interactor A: Leishmania amazonensis
Taxid interactor B: Mus musculus
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: prey

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HFY3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFY3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 104 108 PF00656 0.743
CLV_C14_Caspase3-7 210 214 PF00656 0.527
CLV_C14_Caspase3-7 225 229 PF00656 0.598
CLV_C14_Caspase3-7 36 40 PF00656 0.568
CLV_NRD_NRD_1 329 331 PF00675 0.747
CLV_NRD_NRD_1 348 350 PF00675 0.670
CLV_NRD_NRD_1 370 372 PF00675 0.774
CLV_PCSK_KEX2_1 328 330 PF00082 0.706
CLV_PCSK_KEX2_1 348 350 PF00082 0.673
CLV_PCSK_KEX2_1 376 378 PF00082 0.719
CLV_PCSK_PC1ET2_1 328 330 PF00082 0.706
CLV_PCSK_PC1ET2_1 376 378 PF00082 0.719
CLV_PCSK_SKI1_1 59 63 PF00082 0.482
CLV_PCSK_SKI1_1 68 72 PF00082 0.412
DEG_SPOP_SBC_1 115 119 PF00917 0.670
DEG_SPOP_SBC_1 312 316 PF00917 0.542
DOC_CYCLIN_RxL_1 63 74 PF00134 0.417
DOC_MAPK_MEF2A_6 143 152 PF00069 0.538
DOC_USP7_MATH_1 102 106 PF00917 0.737
DOC_USP7_MATH_1 115 119 PF00917 0.621
DOC_USP7_MATH_1 165 169 PF00917 0.482
DOC_USP7_MATH_1 172 176 PF00917 0.477
DOC_USP7_MATH_1 19 23 PF00917 0.604
DOC_USP7_MATH_1 207 211 PF00917 0.526
DOC_USP7_MATH_1 229 233 PF00917 0.799
DOC_USP7_MATH_1 312 316 PF00917 0.548
DOC_USP7_MATH_1 331 335 PF00917 0.772
DOC_USP7_MATH_1 378 382 PF00917 0.610
DOC_USP7_MATH_1 9 13 PF00917 0.760
DOC_USP7_UBL2_3 372 376 PF12436 0.766
DOC_WW_Pin1_4 111 116 PF00397 0.719
DOC_WW_Pin1_4 117 122 PF00397 0.634
DOC_WW_Pin1_4 168 173 PF00397 0.590
DOC_WW_Pin1_4 232 237 PF00397 0.649
DOC_WW_Pin1_4 305 310 PF00397 0.532
DOC_WW_Pin1_4 323 328 PF00397 0.482
DOC_WW_Pin1_4 342 347 PF00397 0.751
LIG_14-3-3_CanoR_1 261 267 PF00244 0.544
LIG_14-3-3_CanoR_1 335 342 PF00244 0.663
LIG_14-3-3_CanoR_1 377 383 PF00244 0.564
LIG_FHA_1 118 124 PF00498 0.620
LIG_FHA_1 18 24 PF00498 0.578
LIG_FHA_1 210 216 PF00498 0.756
LIG_FHA_1 36 42 PF00498 0.454
LIG_FHA_2 34 40 PF00498 0.539
LIG_Integrin_RGD_1 143 145 PF01839 0.615
LIG_LIR_Apic_2 107 112 PF02991 0.527
LIG_LIR_Gen_1 119 130 PF02991 0.588
LIG_LIR_Nem_3 119 125 PF02991 0.594
LIG_NBox_RRM_1 37 47 PF00076 0.315
LIG_NRBOX 66 72 PF00104 0.514
LIG_REV1ctd_RIR_1 301 308 PF16727 0.659
LIG_SH2_CRK 109 113 PF00017 0.715
LIG_SH2_NCK_1 109 113 PF00017 0.519
LIG_SH2_PTP2 122 125 PF00017 0.559
LIG_SH2_SRC 122 125 PF00017 0.559
LIG_SH2_SRC 75 78 PF00017 0.359
LIG_SH2_STAT5 122 125 PF00017 0.505
LIG_SH3_1 109 115 PF00018 0.510
LIG_SH3_3 109 115 PF00018 0.657
LIG_SH3_3 176 182 PF00018 0.567
LIG_SH3_3 20 26 PF00018 0.622
LIG_SH3_3 46 52 PF00018 0.414
LIG_Sin3_3 200 207 PF02671 0.704
LIG_SUMO_SIM_par_1 277 283 PF11976 0.522
LIG_SUMO_SIM_par_1 349 354 PF11976 0.714
LIG_TRAF2_1 83 86 PF00917 0.605
LIG_TRAF2_1 88 91 PF00917 0.682
LIG_TYR_ITSM 118 125 PF00017 0.611
LIG_WW_3 293 297 PF00397 0.555
MOD_CDK_SPK_2 323 328 PF00069 0.548
MOD_CDK_SPxK_1 323 329 PF00069 0.549
MOD_CDK_SPxK_1 342 348 PF00069 0.749
MOD_CDK_SPxxK_3 323 330 PF00069 0.550
MOD_CDK_SPxxK_3 342 349 PF00069 0.745
MOD_CK1_1 101 107 PF00069 0.637
MOD_CK1_1 114 120 PF00069 0.661
MOD_CK1_1 168 174 PF00069 0.561
MOD_CK1_1 232 238 PF00069 0.759
MOD_CK1_1 311 317 PF00069 0.541
MOD_CK1_1 334 340 PF00069 0.681
MOD_CK2_1 85 91 PF00069 0.670
MOD_Cter_Amidation 5 8 PF01082 0.806
MOD_GlcNHglycan 128 131 PF01048 0.603
MOD_GlcNHglycan 13 16 PF01048 0.636
MOD_GlcNHglycan 209 212 PF01048 0.546
MOD_GlcNHglycan 225 228 PF01048 0.709
MOD_GlcNHglycan 231 234 PF01048 0.791
MOD_GlcNHglycan 310 313 PF01048 0.736
MOD_GlcNHglycan 315 318 PF01048 0.773
MOD_GlcNHglycan 336 339 PF01048 0.786
MOD_GlcNHglycan 76 80 PF01048 0.580
MOD_GlcNHglycan 99 103 PF01048 0.692
MOD_GSK3_1 110 117 PF00069 0.666
MOD_GSK3_1 168 175 PF00069 0.498
MOD_GSK3_1 205 212 PF00069 0.709
MOD_GSK3_1 308 315 PF00069 0.690
MOD_GSK3_1 334 341 PF00069 0.717
MOD_GSK3_1 377 384 PF00069 0.737
MOD_GSK3_1 71 78 PF00069 0.372
MOD_GSK3_1 98 105 PF00069 0.678
MOD_LATS_1 375 381 PF00433 0.560
MOD_LATS_1 55 61 PF00433 0.448
MOD_N-GLC_1 213 218 PF02516 0.767
MOD_NEK2_1 260 265 PF00069 0.485
MOD_NEK2_1 62 67 PF00069 0.508
MOD_NMyristoyl 1 7 PF02799 0.558
MOD_PIKK_1 213 219 PF00454 0.804
MOD_PIKK_1 85 91 PF00454 0.665
MOD_PK_1 45 51 PF00069 0.512
MOD_PK_1 57 63 PF00069 0.546
MOD_PKA_1 371 377 PF00069 0.556
MOD_PKA_2 260 266 PF00069 0.536
MOD_PKA_2 331 337 PF00069 0.744
MOD_PKA_2 378 384 PF00069 0.564
MOD_Plk_1 268 274 PF00069 0.385
MOD_Plk_1 57 63 PF00069 0.399
MOD_Plk_4 150 156 PF00069 0.457
MOD_Plk_4 19 25 PF00069 0.484
MOD_Plk_4 268 274 PF00069 0.472
MOD_Plk_4 45 51 PF00069 0.528
MOD_Plk_4 62 68 PF00069 0.459
MOD_ProDKin_1 111 117 PF00069 0.716
MOD_ProDKin_1 168 174 PF00069 0.602
MOD_ProDKin_1 232 238 PF00069 0.648
MOD_ProDKin_1 305 311 PF00069 0.535
MOD_ProDKin_1 323 329 PF00069 0.483
MOD_ProDKin_1 342 348 PF00069 0.749
MOD_SUMO_rev_2 213 222 PF00179 0.766
TRG_ENDOCYTIC_2 122 125 PF00928 0.505
TRG_ER_diArg_1 329 332 PF00400 0.549
TRG_ER_diArg_1 348 350 PF00400 0.673
TRG_NLS_MonoCore_2 375 380 PF00514 0.560
TRG_NLS_MonoExtC_3 327 332 PF00514 0.797
TRG_NLS_MonoExtN_4 327 332 PF00514 0.743
TRG_Pf-PMV_PEXEL_1 265 269 PF00026 0.548

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMI6 Leptomonas seymouri 48% 100%
A0A0S4IML8 Bodo saltans 26% 100%
A0A1X0NRR0 Trypanosomatidae 32% 100%
A0A3S7X0X4 Leishmania donovani 74% 100%
A4I2X6 Leishmania infantum 74% 100%
E9ADI6 Leishmania major 74% 99%
E9AZB2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS