Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane adaptor Erv26, putative

Species:

Leishmania braziliensis

UniProt:

A4HFY1_LEIBR

TriTrypDb:

LbrM.27.2220 , LBRM2903_270029300

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HFY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFY1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	10
GO:0009987	cellular process	1	10
GO:0016192	vesicle-mediated transport	4	10
GO:0046907	intracellular transport	3	10
GO:0048193	Golgi vesicle transport	5	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10

Molecular functions
Term	Name	Level	Count
GO:0038024	cargo receptor activity	1	10
GO:0097020	COPII receptor activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.657
CLV_NRD_NRD_1	214	216	PF00675	0.427
CLV_PCSK_FUR_1	212	216	PF00082	0.488
CLV_PCSK_KEX2_1	212	214	PF00082	0.462
CLV_PCSK_KEX2_1	22	24	PF00082	0.474
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.504
CLV_PCSK_SKI1_1	215	219	PF00082	0.412
CLV_PCSK_SKI1_1	96	100	PF00082	0.369
DEG_APCC_DBOX_1	214	222	PF00400	0.662
DOC_MAPK_MEF2A_6	32	41	PF00069	0.422
DOC_MAPK_MEF2A_6	96	105	PF00069	0.472
DOC_MAPK_NFAT4_5	96	104	PF00069	0.464
DOC_PP1_RVXF_1	71	78	PF00149	0.366
DOC_PP2B_LxvP_1	194	197	PF13499	0.211
DOC_USP7_MATH_1	115	119	PF00917	0.322
DOC_USP7_MATH_1	24	28	PF00917	0.592
DOC_WW_Pin1_4	199	204	PF00397	0.470
LIG_14-3-3_CanoR_1	109	115	PF00244	0.281
LIG_14-3-3_CanoR_1	212	218	PF00244	0.554
LIG_14-3-3_CanoR_1	23	29	PF00244	0.622
LIG_14-3-3_CanoR_1	32	38	PF00244	0.443
LIG_14-3-3_CanoR_1	67	73	PF00244	0.317
LIG_14-3-3_CanoR_1	96	102	PF00244	0.386
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_CSL_BTD_1	17	20	PF09270	0.518
LIG_eIF4E_1	148	154	PF01652	0.569
LIG_FHA_1	148	154	PF00498	0.492
LIG_FHA_1	34	40	PF00498	0.359
LIG_LIR_Apic_2	15	21	PF02991	0.622
LIG_LIR_Gen_1	100	110	PF02991	0.298
LIG_LIR_Nem_3	100	105	PF02991	0.331
LIG_LIR_Nem_3	113	117	PF02991	0.333
LIG_LIR_Nem_3	136	142	PF02991	0.346
LIG_LIR_Nem_3	27	31	PF02991	0.500
LIG_LIR_Nem_3	93	98	PF02991	0.496
LIG_Pex14_2	159	163	PF04695	0.378
LIG_PTB_Apo_2	101	108	PF02174	0.347
LIG_PTB_Phospho_1	101	107	PF10480	0.347
LIG_SH2_GRB2like	6	9	PF00017	0.547
LIG_SH2_STAP1	149	153	PF00017	0.517
LIG_SH2_STAT5	107	110	PF00017	0.309
LIG_SH2_STAT5	142	145	PF00017	0.469
LIG_SH2_STAT5	149	152	PF00017	0.508
LIG_SUMO_SIM_anti_2	128	136	PF11976	0.464
LIG_SUMO_SIM_anti_2	150	157	PF11976	0.472
LIG_SUMO_SIM_par_1	122	128	PF11976	0.425
LIG_TYR_ITIM	105	110	PF00017	0.347
LIG_WRC_WIRS_1	25	30	PF05994	0.527
MOD_CK1_1	192	198	PF00069	0.359
MOD_CK1_1	97	103	PF00069	0.323
MOD_Cter_Amidation	210	213	PF01082	0.468
MOD_GlcNHglycan	117	120	PF01048	0.572
MOD_GlcNHglycan	135	138	PF01048	0.275
MOD_GlcNHglycan	150	153	PF01048	0.193
MOD_GlcNHglycan	191	194	PF01048	0.341
MOD_GSK3_1	188	195	PF00069	0.357
MOD_GSK3_1	90	97	PF00069	0.469
MOD_N-GLC_1	13	18	PF02516	0.330
MOD_NEK2_1	133	138	PF00069	0.370
MOD_NEK2_1	147	152	PF00069	0.388
MOD_NEK2_1	169	174	PF00069	0.376
MOD_NEK2_1	189	194	PF00069	0.337
MOD_NEK2_2	68	73	PF00069	0.311
MOD_PKA_1	213	219	PF00069	0.635
MOD_PKA_2	213	219	PF00069	0.658
MOD_Plk_1	13	19	PF00069	0.565
MOD_Plk_4	125	131	PF00069	0.360
MOD_Plk_4	13	19	PF00069	0.702
MOD_Plk_4	33	39	PF00069	0.133
MOD_Plk_4	82	88	PF00069	0.360
MOD_Plk_4	90	96	PF00069	0.484
MOD_Plk_4	97	103	PF00069	0.223
MOD_ProDKin_1	199	205	PF00069	0.474
TRG_ENDOCYTIC_2	107	110	PF00928	0.309
TRG_ENDOCYTIC_2	140	143	PF00928	0.305
TRG_ENDOCYTIC_2	25	28	PF00928	0.616
TRG_ER_diArg_1	212	215	PF00400	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBA4	Leptomonas seymouri	60%	100%
A0A0S4IJ23	Bodo saltans	30%	100%
A0A1X0NR52	Trypanosomatidae	35%	100%
A0A3Q8IDL3	Leishmania donovani	76%	100%
A0A3R7RES4	Trypanosoma rangeli	38%	100%
A4I2W9	Leishmania infantum	76%	100%
E9ADI4	Leishmania major	74%	100%
E9AZB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q58DA4	Bos taurus	22%	100%
Q5BJW3	Rattus norvegicus	22%	100%
Q5RFE0	Pongo abelii	22%	100%
Q62302	Mus musculus	22%	100%
Q6UWH6	Homo sapiens	22%	100%