D-lactate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-lactate dehydrogenase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HFX9_LEIBR

TriTrypDb:

LbrM.27.2200 , LBRM2903_270029100

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HFX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFX9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006089	lactate metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016054	organic acid catabolic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901616	organic hydroxy compound catabolic process	4	2
GO:1903457	lactate catabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0050660	flavin adenine dinucleotide binding	4	13
GO:0071949	FAD binding	5	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004457	lactate dehydrogenase activity	4	2
GO:0004458	D-lactate dehydrogenase (cytochrome) activity	5	2
GO:0008720	D-lactate dehydrogenase activity	5	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0016898	oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.395
CLV_C14_Caspase3-7	300	304	PF00656	0.244
CLV_NRD_NRD_1	201	203	PF00675	0.510
CLV_NRD_NRD_1	29	31	PF00675	0.426
CLV_NRD_NRD_1	345	347	PF00675	0.343
CLV_NRD_NRD_1	42	44	PF00675	0.525
CLV_PCSK_KEX2_1	310	312	PF00082	0.412
CLV_PCSK_KEX2_1	345	347	PF00082	0.343
CLV_PCSK_KEX2_1	427	429	PF00082	0.357
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.331
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.387
CLV_PCSK_SKI1_1	135	139	PF00082	0.411
CLV_PCSK_SKI1_1	145	149	PF00082	0.442
CLV_PCSK_SKI1_1	18	22	PF00082	0.413
CLV_PCSK_SKI1_1	186	190	PF00082	0.343
CLV_PCSK_SKI1_1	30	34	PF00082	0.415
CLV_PCSK_SKI1_1	424	428	PF00082	0.444
CLV_PCSK_SKI1_1	466	470	PF00082	0.308
DEG_SCF_FBW7_1	86	93	PF00400	0.231
DEG_SIAH_1	61	69	PF03145	0.343
DOC_CKS1_1	187	192	PF01111	0.346
DOC_CKS1_1	87	92	PF01111	0.343
DOC_CYCLIN_yCln2_LP_2	405	411	PF00134	0.231
DOC_MAPK_gen_1	202	210	PF00069	0.471
DOC_MAPK_gen_1	424	432	PF00069	0.464
DOC_MAPK_gen_1	43	49	PF00069	0.432
DOC_MAPK_MEF2A_6	179	187	PF00069	0.343
DOC_PP2B_LxvP_1	405	408	PF13499	0.395
DOC_USP7_MATH_1	244	248	PF00917	0.480
DOC_USP7_MATH_1	280	284	PF00917	0.424
DOC_USP7_MATH_1	344	348	PF00917	0.404
DOC_USP7_UBL2_3	310	314	PF12436	0.320
DOC_USP7_UBL2_3	321	325	PF12436	0.418
DOC_USP7_UBL2_3	387	391	PF12436	0.400
DOC_WW_Pin1_4	186	191	PF00397	0.372
DOC_WW_Pin1_4	86	91	PF00397	0.343
LIG_14-3-3_CanoR_1	202	210	PF00244	0.471
LIG_14-3-3_CanoR_1	305	313	PF00244	0.508
LIG_14-3-3_CanoR_1	345	353	PF00244	0.438
LIG_14-3-3_CanoR_1	373	380	PF00244	0.239
LIG_BRCT_BRCA1_1	346	350	PF00533	0.530
LIG_FHA_1	110	116	PF00498	0.343
LIG_FHA_1	195	201	PF00498	0.431
LIG_FHA_1	218	224	PF00498	0.357
LIG_FHA_1	373	379	PF00498	0.361
LIG_FHA_1	421	427	PF00498	0.395
LIG_FHA_2	114	120	PF00498	0.381
LIG_FHA_2	12	18	PF00498	0.496
LIG_FHA_2	175	181	PF00498	0.343
LIG_FHA_2	204	210	PF00498	0.467
LIG_FHA_2	298	304	PF00498	0.335
LIG_FHA_2	379	385	PF00498	0.387
LIG_FHA_2	465	471	PF00498	0.231
LIG_FHA_2	93	99	PF00498	0.378
LIG_HCF-1_HBM_1	53	56	PF13415	0.320
LIG_LIR_Gen_1	281	292	PF02991	0.241
LIG_LIR_Gen_1	382	393	PF02991	0.515
LIG_LIR_Gen_1	400	410	PF02991	0.419
LIG_LIR_Nem_3	226	232	PF02991	0.462
LIG_LIR_Nem_3	312	316	PF02991	0.343
LIG_LIR_Nem_3	317	323	PF02991	0.343
LIG_LIR_Nem_3	400	406	PF02991	0.440
LIG_MLH1_MIPbox_1	346	350	PF16413	0.338
LIG_SH2_CRK	403	407	PF00017	0.231
LIG_SH2_NCK_1	380	384	PF00017	0.424
LIG_SH2_STAP1	22	26	PF00017	0.392
LIG_SH2_STAT3	481	484	PF00017	0.421
LIG_SH2_STAT5	214	217	PF00017	0.376
LIG_SH2_STAT5	331	334	PF00017	0.407
LIG_SH2_STAT5	349	352	PF00017	0.436
LIG_SH2_STAT5	380	383	PF00017	0.395
LIG_SH3_3	184	190	PF00018	0.346
LIG_SH3_3	364	370	PF00018	0.378
LIG_SH3_3	84	90	PF00018	0.343
LIG_SUMO_SIM_anti_2	72	79	PF11976	0.345
LIG_SUMO_SIM_par_1	293	298	PF11976	0.305
LIG_TRAF2_1	14	17	PF00917	0.525
LIG_TRAF2_1	70	73	PF00917	0.395
LIG_TRFH_1	229	233	PF08558	0.419
LIG_UBA3_1	231	236	PF00899	0.440
LIG_WRC_WIRS_1	12	17	PF05994	0.407
MOD_CDK_SPK_2	86	91	PF00069	0.378
MOD_CK1_1	155	161	PF00069	0.349
MOD_CK1_1	168	174	PF00069	0.270
MOD_CK1_1	217	223	PF00069	0.358
MOD_CK1_1	285	291	PF00069	0.269
MOD_CK1_1	304	310	PF00069	0.306
MOD_CK1_1	372	378	PF00069	0.384
MOD_CK2_1	11	17	PF00069	0.516
MOD_CK2_1	174	180	PF00069	0.343
MOD_CK2_1	203	209	PF00069	0.463
MOD_CK2_1	285	291	PF00069	0.298
MOD_CK2_1	331	337	PF00069	0.409
MOD_CK2_1	378	384	PF00069	0.359
MOD_CK2_1	66	72	PF00069	0.275
MOD_CK2_1	92	98	PF00069	0.343
MOD_DYRK1A_RPxSP_1	186	190	PF00069	0.378
MOD_GlcNHglycan	165	168	PF01048	0.346
MOD_GlcNHglycan	190	193	PF01048	0.271
MOD_GlcNHglycan	237	240	PF01048	0.399
MOD_GlcNHglycan	333	336	PF01048	0.396
MOD_GlcNHglycan	436	439	PF01048	0.346
MOD_GSK3_1	109	116	PF00069	0.436
MOD_GSK3_1	161	168	PF00069	0.336
MOD_GSK3_1	278	285	PF00069	0.382
MOD_GSK3_1	297	304	PF00069	0.302
MOD_GSK3_1	340	347	PF00069	0.417
MOD_GSK3_1	48	55	PF00069	0.413
MOD_GSK3_1	86	93	PF00069	0.231
MOD_N-GLC_1	301	306	PF02516	0.243
MOD_N-GLC_2	124	126	PF02516	0.378
MOD_NEK2_1	162	167	PF00069	0.372
MOD_NEK2_1	208	213	PF00069	0.428
MOD_NEK2_1	297	302	PF00069	0.374
MOD_NEK2_1	432	437	PF00069	0.436
MOD_NEK2_2	169	174	PF00069	0.343
MOD_NEK2_2	344	349	PF00069	0.453
MOD_PIKK_1	208	214	PF00454	0.420
MOD_PKA_1	202	208	PF00069	0.482
MOD_PKA_2	201	207	PF00069	0.475
MOD_PKA_2	304	310	PF00069	0.508
MOD_PKA_2	344	350	PF00069	0.438
MOD_PKA_2	372	378	PF00069	0.293
MOD_PKA_2	90	96	PF00069	0.231
MOD_Plk_1	208	214	PF00069	0.420
MOD_Plk_1	301	307	PF00069	0.335
MOD_Plk_1	52	58	PF00069	0.360
MOD_Plk_4	263	269	PF00069	0.390
MOD_ProDKin_1	186	192	PF00069	0.372
MOD_ProDKin_1	86	92	PF00069	0.343
MOD_SUMO_rev_2	307	316	PF00179	0.231
MOD_SUMO_rev_2	417	426	PF00179	0.379
TRG_DiLeu_BaEn_4	413	419	PF01217	0.231
TRG_ENDOCYTIC_2	242	245	PF00928	0.395
TRG_ENDOCYTIC_2	284	287	PF00928	0.271
TRG_ENDOCYTIC_2	313	316	PF00928	0.436
TRG_ENDOCYTIC_2	403	406	PF00928	0.231
TRG_ER_diArg_1	258	261	PF00400	0.395
TRG_ER_diArg_1	353	356	PF00400	0.277
TRG_NLS_Bipartite_1	30	47	PF00514	0.331
TRG_NLS_MonoExtC_3	42	48	PF00514	0.342
TRG_PTS1	490	493	PF00515	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q0	Leptomonas seymouri	26%	95%
A0A0N1PE88	Leptomonas seymouri	76%	99%
A0A0N1PEY1	Leptomonas seymouri	25%	79%
A0A0S4IT80	Bodo saltans	24%	100%
A0A0S4JD99	Bodo saltans	53%	100%
A0A0S4JV88	Bodo saltans	25%	78%
A0A1X0NXE7	Trypanosomatidae	25%	95%
A0A1X0P026	Trypanosomatidae	67%	100%
A0A1X0P2J0	Trypanosomatidae	23%	80%
A0A3Q8IDH3	Leishmania donovani	61%	100%
A0A3Q8IDH5	Leishmania donovani	86%	100%
A0A3Q8IEJ5	Leishmania donovani	25%	95%
A0A3Q8IRN9	Leishmania donovani	23%	79%
A0A422N649	Trypanosoma rangeli	23%	80%
A0A422N8Z9	Trypanosoma rangeli	26%	95%
A1L258	Danio rerio	24%	92%
A4HCV1	Leishmania braziliensis	26%	100%
A4HHV7	Leishmania braziliensis	22%	79%
A4I0D2	Leishmania infantum	25%	95%
A4I309	Leishmania infantum	87%	100%
A4I481	Leishmania infantum	61%	100%
A4I507	Leishmania infantum	23%	79%
A4VGK4	Pseudomonas stutzeri (strain A1501)	27%	100%
B8B7X6	Oryza sativa subsp. indica	26%	88%
D4MUV9	Anaerostipes hadrus	31%	100%
E9ADI2	Leishmania major	87%	100%
E9ADN0	Leishmania major	61%	100%
E9AM50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AW96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	95%
E9AZA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B0D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	79%
F1QXM5	Danio rerio	36%	99%
H6LBS1	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	29%	100%
O23240	Arabidopsis thaliana	24%	88%
O29853	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	31%	100%
O45218	Caenorhabditis elegans	25%	83%
O96759	Dictyostelium discoideum	24%	81%
P09788	Pseudomonas putida	22%	95%
P0AEP9	Escherichia coli (strain K12)	30%	99%
P0AEQ0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	99%
P0DV35	Xanthomonas citri pv. viticola (strain LMG 965 / NCPPB 2475 / ICMP 3867 / CFBP 7660)	29%	100%
P32891	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	84%
P39976	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	99%
P46681	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	93%
P84850	Rattus norvegicus	24%	92%
P94535	Bacillus subtilis (strain 168)	30%	100%
P9WIT0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	100%
P9WIT1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
Q12627	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	86%
Q1JPD3	Bos taurus	25%	91%
Q46911	Escherichia coli (strain K12)	24%	100%
Q4QB82	Leishmania major	25%	100%
Q7TNG8	Mus musculus	37%	100%
Q7XI14	Oryza sativa subsp. japonica	26%	88%
Q7YWB6	Leishmania major	24%	100%
Q86WU2	Homo sapiens	34%	97%
Q8CIM3	Mus musculus	25%	92%
Q8N465	Homo sapiens	27%	95%
Q94AX4	Arabidopsis thaliana	34%	87%
Q9C1X2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	94%
Q9V778	Drosophila melanogaster	24%	78%
V5BCB2	Trypanosoma cruzi	23%	80%
V5D7M3	Trypanosoma cruzi	24%	98%