LeishMANIAdb
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GMP_PDE_delta domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GMP_PDE_delta domain-containing protein
Gene product:
GMP-PDE, delta subunit, putative
Species:
Leishmania braziliensis
UniProt:
A4HFX7_LEIBR
TriTrypDb:
LbrM.27.2180 , LBRM2903_270028900
Length:
197

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 3
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005929 cilium 4 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
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Expansion

Sequence features

A4HFX7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFX7

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 1
GO:0006996 organelle organization 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0033036 macromolecule localization 2 1
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Molecular functions
TermNameLevelCount
GO:0005488 binding 1 1
GO:0008289 lipid binding 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 93 95 PF00675 0.348
CLV_PCSK_SKI1_1 101 105 PF00082 0.283
CLV_PCSK_SKI1_1 124 128 PF00082 0.326
CLV_PCSK_SKI1_1 46 50 PF00082 0.283
CLV_PCSK_SKI1_1 64 68 PF00082 0.270
DOC_CYCLIN_RxL_1 40 53 PF00134 0.564
DOC_PP1_RVXF_1 44 50 PF00149 0.470
DOC_PP1_RVXF_1 99 105 PF00149 0.483
DOC_PP4_FxxP_1 137 140 PF00568 0.470
DOC_PP4_FxxP_1 14 17 PF00568 0.388
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PF99 Leptomonas seymouri 83% 100%
A0A0S4IN63 Bodo saltans 63% 92%
A0A1X0NR59 Trypanosomatidae 60% 100%
A0A3Q8IHR5 Leishmania donovani 90% 100%
A0A3R7R7R0 Trypanosoma rangeli 66% 100%
A4I307 Leishmania infantum 90% 100%
A6NIH7 Homo sapiens 47% 78%
C9ZJG1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9ADI0 Leishmania major 88% 100%
E9AZA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS