Putative small nuclear ribonucleoprotein protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFX2_LEIBR

TriTrypDb:

LbrM.27.2130 , LBRM2903_270028100

Length:

110

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005685	U1 snRNP	5	1
GO:0005686	U2 snRNP	5	1
GO:0005687	U4 snRNP	5	1
GO:0005737	cytoplasm	2	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HFX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFX2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.697
CLV_PCSK_KEX2_1	106	108	PF00082	0.632
CLV_PCSK_KEX2_1	50	52	PF00082	0.356
CLV_PCSK_KEX2_1	60	62	PF00082	0.345
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.632
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.356
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.342
CLV_PCSK_PC7_1	46	52	PF00082	0.193
CLV_PCSK_SKI1_1	22	26	PF00082	0.251
CLV_PCSK_SKI1_1	98	102	PF00082	0.673
DOC_CYCLIN_RxL_1	22	32	PF00134	0.482
DOC_MAPK_gen_1	60	68	PF00069	0.484
DOC_MAPK_HePTP_8	66	78	PF00069	0.464
DOC_MAPK_MEF2A_6	60	67	PF00069	0.490
DOC_MAPK_MEF2A_6	69	78	PF00069	0.437
DOC_MAPK_NFAT4_5	60	68	PF00069	0.545
DOC_PP1_RVXF_1	25	32	PF00149	0.482
LIG_14-3-3_CterR_2	107	110	PF00244	0.480
LIG_Clathr_ClatBox_1	28	32	PF01394	0.507
LIG_FHA_1	23	29	PF00498	0.488
LIG_SH2_CRK	4	8	PF00017	0.538
LIG_SH2_STAT5	4	7	PF00017	0.489
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.603
LIG_SUMO_SIM_par_1	71	77	PF11976	0.457
LIG_TRAF2_1	42	45	PF00917	0.545
MOD_GlcNHglycan	86	89	PF01048	0.625
MOD_GlcNHglycan	93	96	PF01048	0.548
MOD_GlcNHglycan	98	101	PF01048	0.604
MOD_GSK3_1	96	103	PF00069	0.552
MOD_N-GLC_1	91	96	PF02516	0.430
MOD_Plk_4	2	8	PF00069	0.460
MOD_Plk_4	74	80	PF00069	0.472
TRG_ENDOCYTIC_2	4	7	PF00928	0.542
TRG_ER_diLys_1	106	110	PF00400	0.687
TRG_NLS_MonoCore_2	105	110	PF00514	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y3	Leptomonas seymouri	78%	100%
A0A0S4J6U1	Bodo saltans	49%	100%
A0A1X0NSU4	Trypanosomatidae	57%	100%
A0A3Q8IEE4	Leishmania donovani	91%	99%
A0A3R7MNH5	Trypanosoma rangeli	56%	96%
A4I304	Leishmania infantum	91%	99%
C9ZJF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ADH7	Leishmania major	92%	100%
E9AZA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
P91918	Caenorhabditis elegans	41%	69%
Q10163	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	75%