Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Intraflagellar transport protein 43, putative

Species:

Leishmania braziliensis

UniProt:

A4HFX1_LEIBR

TriTrypDb:

LbrM.27.2120 , LBRM2903_270028000

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	2
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0031514	motile cilium	5	1

Expansion

Sequence features

A4HFX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.581
CLV_C14_Caspase3-7	256	260	PF00656	0.573
CLV_NRD_NRD_1	128	130	PF00675	0.707
CLV_NRD_NRD_1	132	134	PF00675	0.644
CLV_NRD_NRD_1	288	290	PF00675	0.779
CLV_NRD_NRD_1	414	416	PF00675	0.588
CLV_NRD_NRD_1	418	420	PF00675	0.651
CLV_PCSK_KEX2_1	128	130	PF00082	0.689
CLV_PCSK_KEX2_1	132	134	PF00082	0.626
CLV_PCSK_KEX2_1	290	292	PF00082	0.804
CLV_PCSK_KEX2_1	328	330	PF00082	0.558
CLV_PCSK_KEX2_1	414	416	PF00082	0.588
CLV_PCSK_KEX2_1	418	420	PF00082	0.659
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.698
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.558
CLV_PCSK_PC7_1	128	134	PF00082	0.538
CLV_PCSK_PC7_1	414	420	PF00082	0.580
CLV_PCSK_SKI1_1	39	43	PF00082	0.565
DOC_PP2B_LxvP_1	305	308	PF13499	0.556
DOC_PP2B_LxvP_1	59	62	PF13499	0.569
DOC_USP7_MATH_1	113	117	PF00917	0.642
DOC_USP7_MATH_1	119	123	PF00917	0.622
DOC_USP7_MATH_1	210	214	PF00917	0.432
DOC_USP7_MATH_1	27	31	PF00917	0.732
DOC_USP7_MATH_1	301	305	PF00917	0.562
DOC_USP7_MATH_1	322	326	PF00917	0.576
DOC_USP7_MATH_1	390	394	PF00917	0.660
DOC_USP7_MATH_1	49	53	PF00917	0.792
DOC_USP7_MATH_1	82	86	PF00917	0.728
DOC_USP7_MATH_1	90	94	PF00917	0.778
DOC_USP7_UBL2_3	290	294	PF12436	0.651
DOC_USP7_UBL2_3	328	332	PF12436	0.725
DOC_USP7_UBL2_3	348	352	PF12436	0.733
DOC_USP7_UBL2_3	434	438	PF12436	0.706
DOC_WW_Pin1_4	115	120	PF00397	0.563
DOC_WW_Pin1_4	15	20	PF00397	0.730
DOC_WW_Pin1_4	334	339	PF00397	0.729
DOC_WW_Pin1_4	34	39	PF00397	0.541
DOC_WW_Pin1_4	379	384	PF00397	0.575
DOC_WW_Pin1_4	68	73	PF00397	0.679
LIG_14-3-3_CanoR_1	219	227	PF00244	0.545
LIG_14-3-3_CanoR_1	91	95	PF00244	0.741
LIG_BRCT_BRCA1_1	135	139	PF00533	0.674
LIG_EVH1_2	338	342	PF00568	0.560
LIG_FHA_1	229	235	PF00498	0.579
LIG_FHA_2	109	115	PF00498	0.595
LIG_FHA_2	281	287	PF00498	0.755
LIG_FHA_2	79	85	PF00498	0.579
LIG_LIR_Gen_1	211	221	PF02991	0.557
LIG_LIR_Gen_1	71	82	PF02991	0.564
LIG_LIR_Nem_3	211	217	PF02991	0.568
LIG_LIR_Nem_3	269	274	PF02991	0.647
LIG_LIR_Nem_3	71	77	PF02991	0.556
LIG_SH2_PTP2	271	274	PF00017	0.646
LIG_SH2_SRC	271	274	PF00017	0.646
LIG_SH2_STAT5	271	274	PF00017	0.646
LIG_SH3_3	144	150	PF00018	0.516
LIG_TYR_ITIM	161	166	PF00017	0.474
MOD_CDC14_SPxK_1	118	121	PF00782	0.563
MOD_CDK_SPK_2	34	39	PF00069	0.559
MOD_CDK_SPxK_1	115	121	PF00069	0.566
MOD_CK1_1	100	106	PF00069	0.738
MOD_CK1_1	228	234	PF00069	0.576
MOD_CK1_1	341	347	PF00069	0.575
MOD_CK1_1	382	388	PF00069	0.692
MOD_CK1_1	45	51	PF00069	0.736
MOD_CK1_1	52	58	PF00069	0.630
MOD_CK1_1	93	99	PF00069	0.755
MOD_CK2_1	280	286	PF00069	0.738
MOD_CK2_1	70	76	PF00069	0.597
MOD_CK2_1	78	84	PF00069	0.690
MOD_Cter_Amidation	126	129	PF01082	0.690
MOD_GlcNHglycan	123	126	PF01048	0.684
MOD_GlcNHglycan	23	27	PF01048	0.680
MOD_GlcNHglycan	266	269	PF01048	0.512
MOD_GlcNHglycan	388	391	PF01048	0.746
MOD_GlcNHglycan	409	412	PF01048	0.730
MOD_GlcNHglycan	47	50	PF01048	0.628
MOD_GlcNHglycan	59	62	PF01048	0.598
MOD_GlcNHglycan	84	88	PF01048	0.601
MOD_GSK3_1	103	110	PF00069	0.742
MOD_GSK3_1	113	120	PF00069	0.574
MOD_GSK3_1	15	22	PF00069	0.609
MOD_GSK3_1	225	232	PF00069	0.577
MOD_GSK3_1	296	303	PF00069	0.649
MOD_GSK3_1	334	341	PF00069	0.615
MOD_GSK3_1	342	349	PF00069	0.612
MOD_GSK3_1	377	384	PF00069	0.714
MOD_GSK3_1	386	393	PF00069	0.646
MOD_GSK3_1	403	410	PF00069	0.677
MOD_GSK3_1	45	52	PF00069	0.616
MOD_GSK3_1	68	75	PF00069	0.657
MOD_GSK3_1	78	85	PF00069	0.653
MOD_GSK3_1	93	100	PF00069	0.803
MOD_N-GLC_1	386	391	PF02516	0.697
MOD_N-GLC_1	406	411	PF02516	0.672
MOD_N-GLC_1	62	67	PF02516	0.573
MOD_N-GLC_1	9	14	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.735
MOD_NEK2_1	107	112	PF00069	0.578
MOD_NEK2_1	208	213	PF00069	0.546
MOD_NEK2_1	296	301	PF00069	0.564
MOD_NEK2_1	342	347	PF00069	0.578
MOD_NEK2_1	42	47	PF00069	0.635
MOD_PIKK_1	52	58	PF00454	0.562
MOD_PKA_2	322	328	PF00069	0.574
MOD_PKA_2	90	96	PF00069	0.739
MOD_Plk_1	225	231	PF00069	0.685
MOD_Plk_1	240	246	PF00069	0.472
MOD_Plk_1	49	55	PF00069	0.558
MOD_ProDKin_1	115	121	PF00069	0.566
MOD_ProDKin_1	15	21	PF00069	0.732
MOD_ProDKin_1	334	340	PF00069	0.726
MOD_ProDKin_1	34	40	PF00069	0.539
MOD_ProDKin_1	379	385	PF00069	0.575
MOD_ProDKin_1	68	74	PF00069	0.679
TRG_ENDOCYTIC_2	163	166	PF00928	0.506
TRG_ENDOCYTIC_2	271	274	PF00928	0.646
TRG_ENDOCYTIC_2	74	77	PF00928	0.556
TRG_ER_diArg_1	413	415	PF00400	0.585
TRG_ER_diArg_1	77	80	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE97	Leishmania donovani	60%	100%
A4I303	Leishmania infantum	60%	100%
E9ADH6	Leishmania major	60%	98%
E9AZA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%