Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFW8_LEIBR

TriTrypDb:

LbrM.27.2090 , LBRM2903_270027700

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.529
CLV_NRD_NRD_1	186	188	PF00675	0.560
CLV_NRD_NRD_1	195	197	PF00675	0.775
CLV_PCSK_KEX2_1	151	153	PF00082	0.529
CLV_PCSK_KEX2_1	186	188	PF00082	0.569
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DEG_SIAH_1	70	78	PF03145	0.539
DEG_SPOP_SBC_1	53	57	PF00917	0.534
DEG_SPOP_SBC_1	81	85	PF00917	0.618
DOC_USP7_MATH_1	53	57	PF00917	0.699
DOC_USP7_MATH_1	60	64	PF00917	0.629
DOC_USP7_MATH_1	71	75	PF00917	0.511
DOC_USP7_MATH_1	81	85	PF00917	0.611
DOC_WW_Pin1_4	65	70	PF00397	0.698
LIG_14-3-3_CanoR_1	240	250	PF00244	0.600
LIG_FHA_1	249	255	PF00498	0.640
LIG_LIR_Gen_1	244	254	PF02991	0.603
LIG_LIR_Nem_3	244	250	PF02991	0.604
LIG_NRP_CendR_1	253	255	PF00754	0.419
LIG_SH2_CRK	247	251	PF00017	0.500
LIG_SH2_SRC	33	36	PF00017	0.495
LIG_SH2_STAP1	212	216	PF00017	0.573
LIG_SH2_STAT5	212	215	PF00017	0.587
LIG_SH2_STAT5	86	89	PF00017	0.525
LIG_SH3_1	33	39	PF00018	0.652
LIG_SH3_3	33	39	PF00018	0.652
LIG_SH3_3	98	104	PF00018	0.702
LIG_TRFH_1	9	13	PF08558	0.640
LIG_TYR_ITIM	14	19	PF00017	0.645
LIG_WW_1	30	33	PF00397	0.555
MOD_CK1_1	46	52	PF00069	0.612
MOD_CK1_1	62	68	PF00069	0.620
MOD_CK1_1	84	90	PF00069	0.578
MOD_GlcNHglycan	119	122	PF01048	0.773
MOD_GlcNHglycan	43	46	PF01048	0.662
MOD_GSK3_1	55	62	PF00069	0.746
MOD_GSK3_1	63	70	PF00069	0.639
MOD_GSK3_1	71	78	PF00069	0.513
MOD_GSK3_1	80	87	PF00069	0.506
MOD_N-GLC_1	242	247	PF02516	0.605
MOD_N-GLC_1	46	51	PF02516	0.552
MOD_NEK2_1	173	178	PF00069	0.559
MOD_NEK2_1	59	64	PF00069	0.709
MOD_NEK2_2	71	76	PF00069	0.544
MOD_Plk_1	136	142	PF00069	0.417
MOD_Plk_1	46	52	PF00069	0.699
MOD_Plk_1	71	77	PF00069	0.542
MOD_ProDKin_1	65	71	PF00069	0.697
MOD_SUMO_rev_2	215	221	PF00179	0.374
TRG_ENDOCYTIC_2	16	19	PF00928	0.733
TRG_ENDOCYTIC_2	247	250	PF00928	0.505
TRG_ER_diArg_1	186	188	PF00400	0.628
TRG_ER_diArg_1	227	230	PF00400	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NR64	Trypanosomatidae	29%	100%
A0A3S7X0W4	Leishmania donovani	74%	98%
A4I301	Leishmania infantum	73%	98%
E9ADH3	Leishmania major	73%	100%
E9AZ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	98%