Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HFW7_LEIBR

TriTrypDb:

LbrM.27.2080 , LBRM2903_270027600

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HFW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.590
CLV_NRD_NRD_1	144	146	PF00675	0.347
CLV_PCSK_KEX2_1	113	115	PF00082	0.590
CLV_PCSK_KEX2_1	144	146	PF00082	0.347
CLV_PCSK_SKI1_1	158	162	PF00082	0.450
CLV_PCSK_SKI1_1	250	254	PF00082	0.563
CLV_PCSK_SKI1_1	61	65	PF00082	0.435
CLV_PCSK_SKI1_1	94	98	PF00082	0.583
DEG_APCC_DBOX_1	286	294	PF00400	0.549
DEG_APCC_DBOX_1	60	68	PF00400	0.634
DEG_SCF_FBW7_1	84	90	PF00400	0.516
DEG_SPOP_SBC_1	308	312	PF00917	0.625
DOC_CKS1_1	84	89	PF01111	0.558
DOC_CYCLIN_RxL_1	155	162	PF00134	0.613
DOC_MAPK_gen_1	113	119	PF00069	0.232
DOC_MAPK_gen_1	284	293	PF00069	0.556
DOC_MAPK_MEF2A_6	33	40	PF00069	0.587
DOC_MAPK_NFAT4_5	33	41	PF00069	0.544
DOC_PP4_FxxP_1	133	136	PF00568	0.245
DOC_USP7_MATH_1	100	104	PF00917	0.402
DOC_USP7_MATH_1	149	153	PF00917	0.625
DOC_USP7_MATH_1	227	231	PF00917	0.299
DOC_USP7_MATH_1	292	296	PF00917	0.618
DOC_USP7_MATH_1	308	312	PF00917	0.660
DOC_USP7_UBL2_3	317	321	PF12436	0.617
DOC_WW_Pin1_4	112	117	PF00397	0.388
DOC_WW_Pin1_4	52	57	PF00397	0.555
DOC_WW_Pin1_4	83	88	PF00397	0.549
LIG_14-3-3_CanoR_1	150	156	PF00244	0.618
LIG_14-3-3_CanoR_1	22	27	PF00244	0.681
LIG_14-3-3_CanoR_1	237	241	PF00244	0.413
LIG_14-3-3_CanoR_1	94	100	PF00244	0.388
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BRCT_BRCA1_1	119	123	PF00533	0.272
LIG_BRCT_BRCA1_1	84	88	PF00533	0.416
LIG_BRCT_BRCA1_1	92	96	PF00533	0.361
LIG_Clathr_ClatBox_1	69	73	PF01394	0.335
LIG_FHA_1	113	119	PF00498	0.232
LIG_FHA_1	124	130	PF00498	0.224
LIG_FHA_1	4	10	PF00498	0.663
LIG_FHA_1	84	90	PF00498	0.561
LIG_GBD_Chelix_1	74	82	PF00786	0.312
LIG_LIR_Apic_2	132	136	PF02991	0.245
LIG_LIR_Gen_1	126	134	PF02991	0.288
LIG_LIR_Gen_1	43	52	PF02991	0.623
LIG_LIR_LC3C_4	115	119	PF02991	0.229
LIG_LIR_LC3C_4	43	48	PF02991	0.618
LIG_LIR_Nem_3	126	130	PF02991	0.288
LIG_LIR_Nem_3	43	48	PF02991	0.618
LIG_LIR_Nem_3	93	99	PF02991	0.394
LIG_NRBOX	67	73	PF00104	0.380
LIG_NRBOX	77	83	PF00104	0.290
LIG_Pex14_2	123	127	PF04695	0.292
LIG_Pex14_2	248	252	PF04695	0.392
LIG_SH2_CRK	23	27	PF00017	0.582
LIG_SH2_CRK	269	273	PF00017	0.245
LIG_SH2_CRK	274	278	PF00017	0.531
LIG_SH2_CRK	282	286	PF00017	0.560
LIG_SH2_STAP1	59	63	PF00017	0.585
LIG_SH2_STAT5	269	272	PF00017	0.370
LIG_SH2_STAT5	45	48	PF00017	0.605
LIG_SH2_STAT5	62	65	PF00017	0.519
LIG_SH3_3	171	177	PF00018	0.561
LIG_SH3_3	44	50	PF00018	0.614
LIG_SUMO_SIM_anti_2	218	224	PF11976	0.266
LIG_SUMO_SIM_anti_2	255	261	PF11976	0.245
LIG_SUMO_SIM_par_1	115	121	PF11976	0.235
LIG_SUMO_SIM_par_1	224	231	PF11976	0.258
LIG_SUMO_SIM_par_1	67	73	PF11976	0.335
LIG_TRAF2_1	184	187	PF00917	0.623
LIG_TRFH_1	52	56	PF08558	0.547
LIG_TYR_ITIM	21	26	PF00017	0.457
LIG_TYR_ITIM	267	272	PF00017	0.245
LIG_WRC_WIRS_1	124	129	PF05994	0.288
LIG_WRC_WIRS_1	130	135	PF05994	0.302
LIG_WRC_WIRS_1	96	101	PF05994	0.475
MOD_CDK_SPK_2	52	57	PF00069	0.418
MOD_CK1_1	103	109	PF00069	0.468
MOD_CK1_1	24	30	PF00069	0.469
MOD_CK1_1	3	9	PF00069	0.484
MOD_CK1_1	325	331	PF00069	0.485
MOD_CK1_1	95	101	PF00069	0.470
MOD_CK2_1	292	298	PF00069	0.505
MOD_CK2_1	307	313	PF00069	0.590
MOD_GlcNHglycan	102	105	PF01048	0.485
MOD_GlcNHglycan	120	123	PF01048	0.202
MOD_GlcNHglycan	18	21	PF01048	0.483
MOD_GSK3_1	21	28	PF00069	0.414
MOD_GSK3_1	3	10	PF00069	0.481
MOD_GSK3_1	83	90	PF00069	0.513
MOD_NEK2_1	117	122	PF00069	0.290
MOD_NEK2_1	123	128	PF00069	0.317
MOD_NEK2_1	129	134	PF00069	0.344
MOD_NEK2_1	252	257	PF00069	0.284
MOD_NEK2_1	77	82	PF00069	0.312
MOD_NEK2_2	292	297	PF00069	0.436
MOD_OFUCOSY	323	329	PF10250	0.485
MOD_PKA_2	149	155	PF00069	0.470
MOD_PKA_2	21	27	PF00069	0.521
MOD_PKA_2	236	242	PF00069	0.523
MOD_Plk_1	199	205	PF00069	0.422
MOD_Plk_1	7	13	PF00069	0.462
MOD_Plk_4	103	109	PF00069	0.535
MOD_Plk_4	123	129	PF00069	0.312
MOD_Plk_4	7	13	PF00069	0.462
MOD_Plk_4	77	83	PF00069	0.267
MOD_ProDKin_1	112	118	PF00069	0.456
MOD_ProDKin_1	52	58	PF00069	0.416
MOD_ProDKin_1	83	89	PF00069	0.555
MOD_SUMO_for_1	184	187	PF00179	0.634
TRG_DiLeu_BaEn_1	200	205	PF01217	0.434
TRG_DiLeu_BaEn_2	72	78	PF01217	0.380
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.398
TRG_DiLeu_LyEn_5	200	205	PF01217	0.434
TRG_ENDOCYTIC_2	23	26	PF00928	0.456
TRG_ENDOCYTIC_2	269	272	PF00928	0.380
TRG_ENDOCYTIC_2	274	277	PF00928	0.478
TRG_ENDOCYTIC_2	282	285	PF00928	0.480
TRG_ENDOCYTIC_2	45	48	PF00928	0.488
TRG_ER_diArg_1	143	145	PF00400	0.471
TRG_ER_diArg_1	277	280	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQ36	Leishmania donovani	52%	99%
A4I300	Leishmania infantum	52%	99%
E9ADH2	Leishmania major	47%	100%
E9AZ96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	99%