Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFW4_LEIBR

TriTrypDb:

LbrM.27.2040 , LBRM2903_270026900

Length:

1154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFW4

PDB structure(s): 7ane_ab

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.587
CLV_C14_Caspase3-7	308	312	PF00656	0.629
CLV_C14_Caspase3-7	826	830	PF00656	0.438
CLV_C14_Caspase3-7	85	89	PF00656	0.395
CLV_C14_Caspase3-7	990	994	PF00656	0.525
CLV_NRD_NRD_1	1003	1005	PF00675	0.445
CLV_NRD_NRD_1	305	307	PF00675	0.615
CLV_NRD_NRD_1	316	318	PF00675	0.510
CLV_NRD_NRD_1	337	339	PF00675	0.626
CLV_NRD_NRD_1	361	363	PF00675	0.474
CLV_NRD_NRD_1	374	376	PF00675	0.437
CLV_NRD_NRD_1	393	395	PF00675	0.445
CLV_NRD_NRD_1	486	488	PF00675	0.384
CLV_NRD_NRD_1	509	511	PF00675	0.396
CLV_NRD_NRD_1	665	667	PF00675	0.412
CLV_NRD_NRD_1	71	73	PF00675	0.500
CLV_NRD_NRD_1	841	843	PF00675	0.429
CLV_NRD_NRD_1	917	919	PF00675	0.454
CLV_NRD_NRD_1	925	927	PF00675	0.456
CLV_NRD_NRD_1	961	963	PF00675	0.571
CLV_PCSK_FUR_1	663	667	PF00082	0.483
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.446
CLV_PCSK_KEX2_1	305	307	PF00082	0.622
CLV_PCSK_KEX2_1	337	339	PF00082	0.515
CLV_PCSK_KEX2_1	361	363	PF00082	0.573
CLV_PCSK_KEX2_1	374	376	PF00082	0.446
CLV_PCSK_KEX2_1	393	395	PF00082	0.445
CLV_PCSK_KEX2_1	486	488	PF00082	0.382
CLV_PCSK_KEX2_1	509	511	PF00082	0.396
CLV_PCSK_KEX2_1	665	667	PF00082	0.417
CLV_PCSK_KEX2_1	71	73	PF00082	0.499
CLV_PCSK_KEX2_1	841	843	PF00082	0.426
CLV_PCSK_KEX2_1	917	919	PF00082	0.467
CLV_PCSK_KEX2_1	925	927	PF00082	0.445
CLV_PCSK_KEX2_1	961	963	PF00082	0.513
CLV_PCSK_SKI1_1	102	106	PF00082	0.578
CLV_PCSK_SKI1_1	1070	1074	PF00082	0.448
CLV_PCSK_SKI1_1	1133	1137	PF00082	0.494
CLV_PCSK_SKI1_1	116	120	PF00082	0.603
CLV_PCSK_SKI1_1	338	342	PF00082	0.536
CLV_PCSK_SKI1_1	510	514	PF00082	0.479
CLV_PCSK_SKI1_1	595	599	PF00082	0.385
CLV_PCSK_SKI1_1	608	612	PF00082	0.412
CLV_PCSK_SKI1_1	750	754	PF00082	0.568
CLV_PCSK_SKI1_1	878	882	PF00082	0.399
CLV_PCSK_SKI1_1	976	980	PF00082	0.439
DEG_APCC_DBOX_1	1069	1077	PF00400	0.533
DEG_APCC_DBOX_1	485	493	PF00400	0.449
DEG_APCC_DBOX_1	509	517	PF00400	0.397
DEG_SPOP_SBC_1	154	158	PF00917	0.594
DEG_SPOP_SBC_1	726	730	PF00917	0.517
DOC_CKS1_1	751	756	PF01111	0.314
DOC_CYCLIN_RxL_1	506	514	PF00134	0.530
DOC_CYCLIN_RxL_1	591	600	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	248	251	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	777	783	PF00134	0.536
DOC_MAPK_MEF2A_6	750	759	PF00069	0.432
DOC_PP1_RVXF_1	593	600	PF00149	0.507
DOC_PP2B_LxvP_1	248	251	PF13499	0.416
DOC_PP2B_LxvP_1	743	746	PF13499	0.346
DOC_PP2B_LxvP_1	777	780	PF13499	0.527
DOC_PP4_FxxP_1	1103	1106	PF00568	0.488
DOC_PP4_FxxP_1	872	875	PF00568	0.434
DOC_USP7_MATH_1	154	158	PF00917	0.595
DOC_USP7_MATH_1	293	297	PF00917	0.531
DOC_USP7_MATH_1	719	723	PF00917	0.727
DOC_USP7_MATH_1	726	730	PF00917	0.714
DOC_USP7_MATH_1	938	942	PF00917	0.691
DOC_USP7_MATH_1	944	948	PF00917	0.697
DOC_USP7_UBL2_3	1083	1087	PF12436	0.451
DOC_USP7_UBL2_3	1127	1131	PF12436	0.518
DOC_WW_Pin1_4	1013	1018	PF00397	0.404
DOC_WW_Pin1_4	1077	1082	PF00397	0.459
DOC_WW_Pin1_4	11	16	PF00397	0.615
DOC_WW_Pin1_4	135	140	PF00397	0.375
DOC_WW_Pin1_4	517	522	PF00397	0.414
DOC_WW_Pin1_4	549	554	PF00397	0.360
DOC_WW_Pin1_4	750	755	PF00397	0.563
DOC_WW_Pin1_4	820	825	PF00397	0.433
DOC_WW_Pin1_4	936	941	PF00397	0.692
LIG_14-3-3_CanoR_1	114	121	PF00244	0.445
LIG_14-3-3_CanoR_1	262	269	PF00244	0.543
LIG_14-3-3_CanoR_1	276	280	PF00244	0.414
LIG_14-3-3_CanoR_1	305	310	PF00244	0.603
LIG_14-3-3_CanoR_1	337	341	PF00244	0.648
LIG_14-3-3_CanoR_1	361	371	PF00244	0.519
LIG_14-3-3_CanoR_1	374	381	PF00244	0.415
LIG_14-3-3_CanoR_1	727	737	PF00244	0.547
LIG_14-3-3_CanoR_1	878	883	PF00244	0.477
LIG_14-3-3_CanoR_1	90	96	PF00244	0.565
LIG_ActinCP_TwfCPI_2	1103	1112	PF01115	0.488
LIG_BIR_II_1	1	5	PF00653	0.369
LIG_BRCT_BRCA1_1	1042	1046	PF00533	0.462
LIG_Clathr_ClatBox_1	596	600	PF01394	0.426
LIG_deltaCOP1_diTrp_1	472	476	PF00928	0.368
LIG_deltaCOP1_diTrp_1	982	987	PF00928	0.493
LIG_eIF4E_1	592	598	PF01652	0.412
LIG_FHA_1	1035	1041	PF00498	0.579
LIG_FHA_1	1127	1133	PF00498	0.565
LIG_FHA_1	131	137	PF00498	0.545
LIG_FHA_1	14	20	PF00498	0.430
LIG_FHA_1	166	172	PF00498	0.536
LIG_FHA_1	263	269	PF00498	0.526
LIG_FHA_1	293	299	PF00498	0.479
LIG_FHA_1	609	615	PF00498	0.510
LIG_FHA_1	692	698	PF00498	0.481
LIG_FHA_1	766	772	PF00498	0.481
LIG_FHA_1	804	810	PF00498	0.316
LIG_FHA_1	973	979	PF00498	0.441
LIG_FHA_2	1014	1020	PF00498	0.408
LIG_FHA_2	1088	1094	PF00498	0.465
LIG_FHA_2	172	178	PF00498	0.499
LIG_FHA_2	281	287	PF00498	0.532
LIG_FHA_2	342	348	PF00498	0.511
LIG_FHA_2	361	367	PF00498	0.325
LIG_FHA_2	518	524	PF00498	0.521
LIG_FHA_2	552	558	PF00498	0.403
LIG_FHA_2	824	830	PF00498	0.442
LIG_FHA_2	909	915	PF00498	0.437
LIG_FHA_2	977	983	PF00498	0.458
LIG_LIR_Apic_2	26	31	PF02991	0.442
LIG_LIR_Apic_2	410	416	PF02991	0.533
LIG_LIR_Apic_2	438	442	PF02991	0.412
LIG_LIR_Gen_1	1016	1026	PF02991	0.454
LIG_LIR_Gen_1	459	468	PF02991	0.398
LIG_LIR_Gen_1	472	481	PF02991	0.344
LIG_LIR_Gen_1	741	746	PF02991	0.339
LIG_LIR_Gen_1	982	992	PF02991	0.481
LIG_LIR_LC3C_4	741	745	PF02991	0.328
LIG_LIR_Nem_3	1016	1021	PF02991	0.429
LIG_LIR_Nem_3	1043	1048	PF02991	0.477
LIG_LIR_Nem_3	1090	1094	PF02991	0.538
LIG_LIR_Nem_3	438	443	PF02991	0.425
LIG_LIR_Nem_3	459	464	PF02991	0.459
LIG_LIR_Nem_3	472	476	PF02991	0.281
LIG_LIR_Nem_3	49	55	PF02991	0.522
LIG_LIR_Nem_3	672	677	PF02991	0.550
LIG_LIR_Nem_3	741	745	PF02991	0.483
LIG_LIR_Nem_3	769	775	PF02991	0.470
LIG_LIR_Nem_3	982	987	PF02991	0.467
LIG_LYPXL_yS_3	52	55	PF13949	0.563
LIG_MAD2	863	871	PF02301	0.551
LIG_MLH1_MIPbox_1	1042	1046	PF16413	0.462
LIG_MYND_1	246	250	PF01753	0.426
LIG_NRBOX	592	598	PF00104	0.347
LIG_PCNA_yPIPBox_3	418	432	PF02747	0.407
LIG_PDZ_Class_2	1149	1154	PF00595	0.473
LIG_Pex14_1	544	548	PF04695	0.372
LIG_Pex14_1	606	610	PF04695	0.512
LIG_Pex14_1	901	905	PF04695	0.410
LIG_Pex14_2	602	606	PF04695	0.484
LIG_RPA_C_Fungi	586	598	PF08784	0.308
LIG_SH2_CRK	413	417	PF00017	0.521
LIG_SH2_CRK	625	629	PF00017	0.518
LIG_SH2_GRB2like	1065	1068	PF00017	0.580
LIG_SH2_NCK_1	186	190	PF00017	0.344
LIG_SH2_NCK_1	625	629	PF00017	0.588
LIG_SH2_NCK_1	919	923	PF00017	0.530
LIG_SH2_PTP2	548	551	PF00017	0.474
LIG_SH2_PTP2	927	930	PF00017	0.460
LIG_SH2_SRC	927	930	PF00017	0.444
LIG_SH2_STAP1	1065	1069	PF00017	0.549
LIG_SH2_STAP1	167	171	PF00017	0.420
LIG_SH2_STAP1	186	190	PF00017	0.597
LIG_SH2_STAP1	65	69	PF00017	0.495
LIG_SH2_STAP1	959	963	PF00017	0.559
LIG_SH2_STAT3	1006	1009	PF00017	0.535
LIG_SH2_STAT3	35	38	PF00017	0.442
LIG_SH2_STAT3	646	649	PF00017	0.512
LIG_SH2_STAT3	867	870	PF00017	0.432
LIG_SH2_STAT5	1006	1009	PF00017	0.449
LIG_SH2_STAT5	1011	1014	PF00017	0.402
LIG_SH2_STAT5	1015	1018	PF00017	0.400
LIG_SH2_STAT5	1044	1047	PF00017	0.460
LIG_SH2_STAT5	1061	1064	PF00017	0.403
LIG_SH2_STAT5	167	170	PF00017	0.617
LIG_SH2_STAT5	372	375	PF00017	0.487
LIG_SH2_STAT5	439	442	PF00017	0.415
LIG_SH2_STAT5	548	551	PF00017	0.438
LIG_SH2_STAT5	592	595	PF00017	0.258
LIG_SH2_STAT5	634	637	PF00017	0.484
LIG_SH2_STAT5	646	649	PF00017	0.374
LIG_SH2_STAT5	667	670	PF00017	0.581
LIG_SH2_STAT5	742	745	PF00017	0.550
LIG_SH2_STAT5	803	806	PF00017	0.371
LIG_SH2_STAT5	927	930	PF00017	0.444
LIG_SH3_2	521	526	PF14604	0.540
LIG_SH3_2	833	838	PF14604	0.530
LIG_SH3_3	1143	1149	PF00018	0.395
LIG_SH3_3	12	18	PF00018	0.497
LIG_SH3_3	244	250	PF00018	0.619
LIG_SH3_3	518	524	PF00018	0.473
LIG_SH3_3	830	836	PF00018	0.470
LIG_SH3_3	927	933	PF00018	0.459
LIG_SUMO_SIM_anti_2	488	493	PF11976	0.524
LIG_SUMO_SIM_par_1	696	701	PF11976	0.508
LIG_SUMO_SIM_par_1	996	1001	PF11976	0.428
LIG_TRAF2_1	1022	1025	PF00917	0.408
LIG_TRAF2_1	253	256	PF00917	0.518
LIG_TRAF2_1	816	819	PF00917	0.528
LIG_TRAF2_2	222	227	PF00917	0.459
LIG_TYR_ITIM	1030	1035	PF00017	0.362
LIG_TYR_ITIM	50	55	PF00017	0.462
LIG_WRPW_2	440	443	PF00400	0.445
MOD_CDC14_SPxK_1	138	141	PF00782	0.368
MOD_CDK_SPxK_1	1077	1083	PF00069	0.475
MOD_CDK_SPxK_1	135	141	PF00069	0.370
MOD_CK1_1	117	123	PF00069	0.429
MOD_CK1_1	157	163	PF00069	0.697
MOD_CK1_1	722	728	PF00069	0.766
MOD_CK1_1	729	735	PF00069	0.546
MOD_CK1_1	761	767	PF00069	0.536
MOD_CK1_1	823	829	PF00069	0.444
MOD_CK1_1	939	945	PF00069	0.704
MOD_CK2_1	1013	1019	PF00069	0.421
MOD_CK2_1	1087	1093	PF00069	0.462
MOD_CK2_1	171	177	PF00069	0.589
MOD_CK2_1	249	255	PF00069	0.509
MOD_CK2_1	280	286	PF00069	0.554
MOD_CK2_1	341	347	PF00069	0.484
MOD_CK2_1	361	367	PF00069	0.292
MOD_CK2_1	527	533	PF00069	0.355
MOD_CK2_1	551	557	PF00069	0.392
MOD_CK2_1	95	101	PF00069	0.531
MOD_Cter_Amidation	663	666	PF01082	0.511
MOD_GlcNHglycan	116	119	PF01048	0.614
MOD_GlcNHglycan	133	136	PF01048	0.387
MOD_GlcNHglycan	159	162	PF01048	0.640
MOD_GlcNHglycan	57	60	PF01048	0.684
MOD_GlcNHglycan	700	703	PF01048	0.493
MOD_GlcNHglycan	724	727	PF01048	0.685
MOD_GlcNHglycan	760	763	PF01048	0.468
MOD_GlcNHglycan	772	775	PF01048	0.396
MOD_GlcNHglycan	781	784	PF01048	0.484
MOD_GlcNHglycan	946	949	PF01048	0.658
MOD_GlcNHglycan	968	971	PF01048	0.630
MOD_GSK3_1	1040	1047	PF00069	0.444
MOD_GSK3_1	1122	1129	PF00069	0.455
MOD_GSK3_1	117	124	PF00069	0.428
MOD_GSK3_1	131	138	PF00069	0.512
MOD_GSK3_1	153	160	PF00069	0.575
MOD_GSK3_1	403	410	PF00069	0.503
MOD_GSK3_1	551	558	PF00069	0.512
MOD_GSK3_1	57	64	PF00069	0.622
MOD_GSK3_1	587	594	PF00069	0.300
MOD_GSK3_1	721	728	PF00069	0.750
MOD_GSK3_1	761	768	PF00069	0.563
MOD_GSK3_1	90	97	PF00069	0.635
MOD_GSK3_1	972	979	PF00069	0.447
MOD_LATS_1	303	309	PF00433	0.638
MOD_N-GLC_1	121	126	PF02516	0.507
MOD_N-GLC_1	281	286	PF02516	0.601
MOD_N-GLC_1	499	504	PF02516	0.450
MOD_NEK2_1	131	136	PF00069	0.528
MOD_NEK2_1	163	168	PF00069	0.680
MOD_NEK2_1	215	220	PF00069	0.540
MOD_NEK2_1	261	266	PF00069	0.526
MOD_NEK2_1	55	60	PF00069	0.669
MOD_NEK2_1	698	703	PF00069	0.506
MOD_NEK2_1	705	710	PF00069	0.541
MOD_NEK2_1	987	992	PF00069	0.477
MOD_NEK2_1	998	1003	PF00069	0.413
MOD_PIKK_1	803	809	PF00454	0.376
MOD_PIKK_1	83	89	PF00454	0.509
MOD_PK_1	996	1002	PF00069	0.432
MOD_PKA_1	305	311	PF00069	0.642
MOD_PKA_1	341	347	PF00069	0.501
MOD_PKA_1	361	367	PF00069	0.292
MOD_PKA_1	374	380	PF00069	0.519
MOD_PKA_2	216	222	PF00069	0.509
MOD_PKA_2	261	267	PF00069	0.541
MOD_PKA_2	275	281	PF00069	0.400
MOD_PKA_2	305	311	PF00069	0.522
MOD_PKA_2	336	342	PF00069	0.654
MOD_PKA_2	360	366	PF00069	0.499
MOD_PKA_2	374	380	PF00069	0.409
MOD_PKA_2	407	413	PF00069	0.523
MOD_PKA_2	726	732	PF00069	0.609
MOD_PKA_2	812	818	PF00069	0.328
MOD_PKA_2	89	95	PF00069	0.525
MOD_PKA_2	972	978	PF00069	0.440
MOD_Plk_1	121	127	PF00069	0.501
MOD_Plk_1	705	711	PF00069	0.386
MOD_Plk_1	908	914	PF00069	0.452
MOD_Plk_4	1040	1046	PF00069	0.465
MOD_Plk_4	551	557	PF00069	0.367
MOD_Plk_4	730	736	PF00069	0.607
MOD_ProDKin_1	1013	1019	PF00069	0.405
MOD_ProDKin_1	1077	1083	PF00069	0.459
MOD_ProDKin_1	11	17	PF00069	0.615
MOD_ProDKin_1	135	141	PF00069	0.374
MOD_ProDKin_1	517	523	PF00069	0.418
MOD_ProDKin_1	549	555	PF00069	0.360
MOD_ProDKin_1	750	756	PF00069	0.567
MOD_ProDKin_1	820	826	PF00069	0.437
MOD_ProDKin_1	936	942	PF00069	0.701
MOD_SUMO_rev_2	1120	1129	PF00179	0.504
MOD_SUMO_rev_2	208	215	PF00179	0.567
MOD_SUMO_rev_2	285	290	PF00179	0.636
MOD_SUMO_rev_2	530	536	PF00179	0.537
TRG_DiLeu_BaEn_1	459	464	PF01217	0.389
TRG_DiLeu_BaEn_2	100	106	PF01217	0.373
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.428
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.549
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.425
TRG_ENDOCYTIC_2	1032	1035	PF00928	0.624
TRG_ENDOCYTIC_2	1091	1094	PF00928	0.460
TRG_ENDOCYTIC_2	455	458	PF00928	0.392
TRG_ENDOCYTIC_2	52	55	PF00928	0.563
TRG_ENDOCYTIC_2	674	677	PF00928	0.416
TRG_ENDOCYTIC_2	742	745	PF00928	0.515
TRG_ENDOCYTIC_2	927	930	PF00928	0.467
TRG_ER_diArg_1	360	362	PF00400	0.584
TRG_ER_diArg_1	373	375	PF00400	0.452
TRG_ER_diArg_1	509	511	PF00400	0.446
TRG_ER_diArg_1	663	666	PF00400	0.431
TRG_ER_diArg_1	70	72	PF00400	0.470
TRG_ER_diArg_1	841	843	PF00400	0.429
TRG_ER_diArg_1	861	864	PF00400	0.528
TRG_ER_diArg_1	917	919	PF00400	0.467
TRG_ER_diArg_1	924	926	PF00400	0.430
TRG_ER_diArg_1	961	963	PF00400	0.571
TRG_NLS_Bipartite_1	305	321	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	595	600	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K9	Leptomonas seymouri	74%	92%
A0A0S4JLH0	Bodo saltans	46%	98%
A0A1X0NRH4	Trypanosomatidae	58%	96%
A0A3S7X0V6	Leishmania donovani	89%	98%
A0A422NJT2	Trypanosoma rangeli	60%	99%
A4I2Z6	Leishmania infantum	89%	87%
C9ZJE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	98%
E9ADG8	Leishmania major	88%	100%
E9AZ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
V5BN80	Trypanosoma cruzi	61%	98%