Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFW2_LEIBR

TriTrypDb:

LbrM.27.2020 , LBRM2903_270026700

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HFW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.598
CLV_NRD_NRD_1	187	189	PF00675	0.576
CLV_NRD_NRD_1	313	315	PF00675	0.464
CLV_NRD_NRD_1	458	460	PF00675	0.621
CLV_NRD_NRD_1	68	70	PF00675	0.533
CLV_PCSK_FUR_1	83	87	PF00082	0.497
CLV_PCSK_KEX2_1	187	189	PF00082	0.470
CLV_PCSK_KEX2_1	313	315	PF00082	0.464
CLV_PCSK_KEX2_1	404	406	PF00082	0.445
CLV_PCSK_KEX2_1	458	460	PF00082	0.471
CLV_PCSK_KEX2_1	85	87	PF00082	0.603
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.461
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.570
CLV_PCSK_SKI1_1	262	266	PF00082	0.325
CLV_PCSK_SKI1_1	287	291	PF00082	0.584
CLV_PCSK_SKI1_1	313	317	PF00082	0.454
CLV_PCSK_SKI1_1	339	343	PF00082	0.345
CLV_PCSK_SKI1_1	346	350	PF00082	0.320
CLV_PCSK_SKI1_1	364	368	PF00082	0.294
CLV_PCSK_SKI1_1	382	386	PF00082	0.592
CLV_PCSK_SKI1_1	393	397	PF00082	0.482
CLV_PCSK_SKI1_1	417	421	PF00082	0.601
DEG_SPOP_SBC_1	212	216	PF00917	0.453
DEG_SPOP_SBC_1	274	278	PF00917	0.390
DOC_CKS1_1	101	106	PF01111	0.365
DOC_CKS1_1	142	147	PF01111	0.617
DOC_CKS1_1	175	180	PF01111	0.416
DOC_CYCLIN_RxL_1	390	399	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.640
DOC_MAPK_gen_1	7	16	PF00069	0.350
DOC_MAPK_gen_1	83	93	PF00069	0.382
DOC_MAPK_MEF2A_6	346	354	PF00069	0.436
DOC_PP2B_LxvP_1	209	212	PF13499	0.498
DOC_PP2B_LxvP_1	389	392	PF13499	0.441
DOC_PP2B_LxvP_1	465	468	PF13499	0.638
DOC_PP4_FxxP_1	107	110	PF00568	0.603
DOC_PP4_FxxP_1	140	143	PF00568	0.719
DOC_PP4_FxxP_1	3	6	PF00568	0.588
DOC_USP7_MATH_1	146	150	PF00917	0.647
DOC_USP7_MATH_1	15	19	PF00917	0.473
DOC_USP7_MATH_1	274	278	PF00917	0.510
DOC_USP7_MATH_1	48	52	PF00917	0.493
DOC_USP7_MATH_1	496	500	PF00917	0.585
DOC_USP7_MATH_1	512	516	PF00917	0.556
DOC_WW_Pin1_4	100	105	PF00397	0.553
DOC_WW_Pin1_4	106	111	PF00397	0.593
DOC_WW_Pin1_4	141	146	PF00397	0.564
DOC_WW_Pin1_4	174	179	PF00397	0.432
DOC_WW_Pin1_4	222	227	PF00397	0.519
LIG_14-3-3_CanoR_1	126	135	PF00244	0.683
LIG_14-3-3_CanoR_1	205	210	PF00244	0.451
LIG_14-3-3_CanoR_1	287	296	PF00244	0.617
LIG_14-3-3_CanoR_1	346	351	PF00244	0.413
LIG_14-3-3_CanoR_1	458	465	PF00244	0.565
LIG_Actin_WH2_1	405	423	PF00022	0.498
LIG_BIR_III_2	502	506	PF00653	0.524
LIG_BIR_III_4	163	167	PF00653	0.502
LIG_BRCT_BRCA1_1	12	16	PF00533	0.379
LIG_eIF4E_1	353	359	PF01652	0.351
LIG_FHA_1	118	124	PF00498	0.483
LIG_FHA_1	194	200	PF00498	0.416
LIG_FHA_1	206	212	PF00498	0.528
LIG_FHA_1	217	223	PF00498	0.692
LIG_FHA_1	347	353	PF00498	0.427
LIG_FHA_1	9	15	PF00498	0.411
LIG_FHA_2	117	123	PF00498	0.616
LIG_FHA_2	181	187	PF00498	0.338
LIG_FHA_2	458	464	PF00498	0.552
LIG_FHA_2	47	53	PF00498	0.445
LIG_FHA_2	79	85	PF00498	0.435
LIG_LIR_Apic_2	137	143	PF02991	0.662
LIG_LIR_Apic_2	2	6	PF02991	0.595
LIG_LIR_Apic_2	351	356	PF02991	0.350
LIG_LIR_Apic_2	368	374	PF02991	0.503
LIG_LIR_Gen_1	87	96	PF02991	0.515
LIG_LIR_Nem_3	259	264	PF02991	0.349
LIG_LIR_Nem_3	29	35	PF02991	0.534
LIG_LIR_Nem_3	383	389	PF02991	0.515
LIG_LIR_Nem_3	472	476	PF02991	0.706
LIG_LIR_Nem_3	87	91	PF02991	0.464
LIG_LYPXL_S_1	385	389	PF13949	0.483
LIG_LYPXL_yS_3	386	389	PF13949	0.485
LIG_MYND_1	387	391	PF01753	0.470
LIG_Pex14_2	12	16	PF04695	0.480
LIG_Pex14_2	362	366	PF04695	0.393
LIG_PTB_Apo_2	260	267	PF02174	0.304
LIG_PTB_Apo_2	342	349	PF02174	0.321
LIG_PTB_Phospho_1	260	266	PF10480	0.303
LIG_SH2_CRK	261	265	PF00017	0.300
LIG_SH2_CRK	473	477	PF00017	0.699
LIG_SH2_GRB2like	114	117	PF00017	0.437
LIG_SH2_NCK_1	266	270	PF00017	0.260
LIG_SH2_PTP2	353	356	PF00017	0.320
LIG_SH2_SRC	353	356	PF00017	0.349
LIG_SH2_STAT5	182	185	PF00017	0.486
LIG_SH2_STAT5	353	356	PF00017	0.343
LIG_SH3_3	142	148	PF00018	0.543
LIG_SH3_3	169	175	PF00018	0.706
LIG_SH3_3	298	304	PF00018	0.329
LIG_SH3_3	465	471	PF00018	0.629
LIG_SH3_3	490	496	PF00018	0.785
LIG_SH3_3	89	95	PF00018	0.393
LIG_SH3_3	98	104	PF00018	0.435
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.453
LIG_SUMO_SIM_par_1	33	38	PF11976	0.547
LIG_SUMO_SIM_par_1	89	94	PF11976	0.323
LIG_TRAF2_1	446	449	PF00917	0.641
LIG_TYR_ITIM	264	269	PF00017	0.277
LIG_WW_3	390	394	PF00397	0.433
MOD_CK1_1	149	155	PF00069	0.596
MOD_CK1_1	213	219	PF00069	0.700
MOD_CK1_1	225	231	PF00069	0.426
MOD_CK1_1	276	282	PF00069	0.670
MOD_CK1_1	38	44	PF00069	0.504
MOD_CK2_1	116	122	PF00069	0.703
MOD_CK2_1	457	463	PF00069	0.537
MOD_CK2_1	46	52	PF00069	0.453
MOD_CK2_1	508	514	PF00069	0.619
MOD_CK2_1	78	84	PF00069	0.348
MOD_Cter_Amidation	311	314	PF01082	0.449
MOD_Cter_Amidation	402	405	PF01082	0.442
MOD_GlcNHglycan	200	203	PF01048	0.428
MOD_GlcNHglycan	258	261	PF01048	0.419
MOD_GlcNHglycan	278	281	PF01048	0.701
MOD_GlcNHglycan	496	499	PF01048	0.818
MOD_GlcNHglycan	510	513	PF01048	0.502
MOD_GlcNHglycan	514	517	PF01048	0.462
MOD_GSK3_1	144	151	PF00069	0.655
MOD_GSK3_1	193	200	PF00069	0.450
MOD_GSK3_1	210	217	PF00069	0.574
MOD_GSK3_1	275	282	PF00069	0.640
MOD_GSK3_1	411	418	PF00069	0.445
MOD_GSK3_1	508	515	PF00069	0.582
MOD_N-GLC_1	344	349	PF02516	0.467
MOD_NEK2_1	180	185	PF00069	0.510
MOD_NEK2_1	198	203	PF00069	0.475
MOD_NEK2_1	275	280	PF00069	0.647
MOD_NEK2_1	344	349	PF00069	0.459
MOD_PIKK_1	126	132	PF00454	0.550
MOD_PIKK_1	216	222	PF00454	0.453
MOD_PIKK_1	23	29	PF00454	0.454
MOD_PIKK_1	287	293	PF00454	0.575
MOD_PIKK_1	411	417	PF00454	0.523
MOD_PKA_2	125	131	PF00069	0.655
MOD_PKA_2	204	210	PF00069	0.458
MOD_PKA_2	332	338	PF00069	0.373
MOD_PKA_2	457	463	PF00069	0.559
MOD_PKA_2	8	14	PF00069	0.518
MOD_PKB_1	285	293	PF00069	0.460
MOD_Plk_1	194	200	PF00069	0.395
MOD_Plk_1	344	350	PF00069	0.454
MOD_Plk_1	35	41	PF00069	0.522
MOD_Plk_1	78	84	PF00069	0.552
MOD_Plk_4	194	200	PF00069	0.398
MOD_Plk_4	35	41	PF00069	0.522
MOD_Plk_4	415	421	PF00069	0.600
MOD_ProDKin_1	100	106	PF00069	0.563
MOD_ProDKin_1	141	147	PF00069	0.564
MOD_ProDKin_1	174	180	PF00069	0.423
MOD_ProDKin_1	222	228	PF00069	0.508
MOD_SUMO_rev_2	335	341	PF00179	0.372
TRG_DiLeu_BaEn_3	448	454	PF01217	0.616
TRG_DiLeu_BaEn_4	433	439	PF01217	0.560
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.544
TRG_ENDOCYTIC_2	261	264	PF00928	0.305
TRG_ENDOCYTIC_2	266	269	PF00928	0.310
TRG_ENDOCYTIC_2	32	35	PF00928	0.532
TRG_ENDOCYTIC_2	386	389	PF00928	0.485
TRG_ENDOCYTIC_2	473	476	PF00928	0.693
TRG_ER_diArg_1	19	22	PF00400	0.349
TRG_ER_diArg_1	284	287	PF00400	0.669
TRG_ER_diArg_1	313	315	PF00400	0.571
TRG_ER_diArg_1	6	9	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J3	Leptomonas seymouri	67%	85%
A0A1X0NRT0	Trypanosomatidae	40%	100%
A0A3S7X0V2	Leishmania donovani	82%	97%
A0A422NJS3	Trypanosoma rangeli	37%	100%
A4I2Z4	Leishmania infantum	82%	97%
C9ZJE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ADG6	Leishmania major	82%	100%
E9AZ90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
V5DEY5	Trypanosoma cruzi	45%	100%