Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFW2_LEIBR

TriTrypDb:

LbrM.27.2020 , LBRM2903_270026700

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HFW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFW2

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.598
CLV_NRD_NRD_1	187	189	PF00675	0.576
CLV_NRD_NRD_1	313	315	PF00675	0.464
CLV_NRD_NRD_1	458	460	PF00675	0.621
CLV_NRD_NRD_1	68	70	PF00675	0.533
CLV_PCSK_FUR_1	83	87	PF00082	0.497
CLV_PCSK_KEX2_1	187	189	PF00082	0.470
CLV_PCSK_KEX2_1	313	315	PF00082	0.464
CLV_PCSK_KEX2_1	404	406	PF00082	0.445
CLV_PCSK_KEX2_1	458	460	PF00082	0.471

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J3	Leptomonas seymouri	67%	85%
A0A1X0NRT0	Trypanosomatidae	40%	100%
A0A3S7X0V2	Leishmania donovani	82%	97%
A0A422NJS3	Trypanosoma rangeli	37%	100%
A4I2Z4	Leishmania infantum	82%	97%
C9ZJE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ADG6	Leishmania major	82%	100%
E9AZ90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
V5DEY5	Trypanosoma cruzi	45%	100%

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