Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HFW0_LEIBR

TriTrypDb:

LbrM.27.2000 , LBRM2903_270026500

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	830	834	PF00656	0.540
CLV_C14_Caspase3-7	869	873	PF00656	0.552
CLV_NRD_NRD_1	142	144	PF00675	0.779
CLV_NRD_NRD_1	18	20	PF00675	0.595
CLV_NRD_NRD_1	241	243	PF00675	0.571
CLV_NRD_NRD_1	248	250	PF00675	0.478
CLV_NRD_NRD_1	322	324	PF00675	0.426
CLV_NRD_NRD_1	552	554	PF00675	0.546
CLV_NRD_NRD_1	698	700	PF00675	0.574
CLV_PCSK_FUR_1	246	250	PF00082	0.433
CLV_PCSK_KEX2_1	142	144	PF00082	0.608
CLV_PCSK_KEX2_1	18	20	PF00082	0.595
CLV_PCSK_KEX2_1	241	243	PF00082	0.564
CLV_PCSK_KEX2_1	248	250	PF00082	0.465
CLV_PCSK_KEX2_1	309	311	PF00082	0.456
CLV_PCSK_KEX2_1	322	324	PF00082	0.375
CLV_PCSK_KEX2_1	458	460	PF00082	0.576
CLV_PCSK_KEX2_1	552	554	PF00082	0.546
CLV_PCSK_KEX2_1	698	700	PF00082	0.775
CLV_PCSK_KEX2_1	864	866	PF00082	0.633
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.456
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.576
CLV_PCSK_PC1ET2_1	864	866	PF00082	0.556
CLV_PCSK_SKI1_1	142	146	PF00082	0.642
CLV_PCSK_SKI1_1	18	22	PF00082	0.567
CLV_PCSK_SKI1_1	248	252	PF00082	0.420
CLV_PCSK_SKI1_1	654	658	PF00082	0.565
CLV_Separin_Metazoa	635	639	PF03568	0.598
DEG_APCC_DBOX_1	247	255	PF00400	0.414
DEG_Kelch_Keap1_1	688	693	PF01344	0.562
DEG_SCF_FBW7_1	361	368	PF00400	0.626
DEG_SCF_FBW7_1	38	45	PF00400	0.573
DEG_SCF_TRCP1_1	854	860	PF00400	0.552
DEG_SPOP_SBC_1	705	709	PF00917	0.554
DOC_CKS1_1	531	536	PF01111	0.583
DOC_CKS1_1	799	804	PF01111	0.531
DOC_CYCLIN_RxL_1	242	255	PF00134	0.429
DOC_MAPK_FxFP_2	807	810	PF00069	0.552
DOC_MAPK_gen_1	319	327	PF00069	0.433
DOC_PP2B_LxvP_1	717	720	PF13499	0.525
DOC_PP4_FxxP_1	807	810	PF00568	0.552
DOC_USP7_MATH_1	124	128	PF00917	0.613
DOC_USP7_MATH_1	159	163	PF00917	0.621
DOC_USP7_MATH_1	208	212	PF00917	0.518
DOC_USP7_MATH_1	232	236	PF00917	0.612
DOC_USP7_MATH_1	42	46	PF00917	0.571
DOC_USP7_MATH_1	579	583	PF00917	0.597
DOC_USP7_MATH_1	685	689	PF00917	0.635
DOC_USP7_MATH_1	703	707	PF00917	0.555
DOC_USP7_MATH_1	79	83	PF00917	0.581
DOC_USP7_MATH_1	852	856	PF00917	0.557
DOC_USP7_MATH_1	877	881	PF00917	0.549
DOC_USP7_MATH_1	9	13	PF00917	0.618
DOC_WW_Pin1_4	128	133	PF00397	0.549
DOC_WW_Pin1_4	20	25	PF00397	0.603
DOC_WW_Pin1_4	204	209	PF00397	0.599
DOC_WW_Pin1_4	213	218	PF00397	0.559
DOC_WW_Pin1_4	230	235	PF00397	0.519
DOC_WW_Pin1_4	34	39	PF00397	0.541
DOC_WW_Pin1_4	361	366	PF00397	0.625
DOC_WW_Pin1_4	385	390	PF00397	0.609
DOC_WW_Pin1_4	530	535	PF00397	0.617
DOC_WW_Pin1_4	55	60	PF00397	0.492
DOC_WW_Pin1_4	572	577	PF00397	0.596
DOC_WW_Pin1_4	581	586	PF00397	0.628
DOC_WW_Pin1_4	603	608	PF00397	0.570
DOC_WW_Pin1_4	655	660	PF00397	0.575
DOC_WW_Pin1_4	720	725	PF00397	0.593
DOC_WW_Pin1_4	798	803	PF00397	0.603
DOC_WW_Pin1_4	859	864	PF00397	0.642
LIG_14-3-3_CanoR_1	156	166	PF00244	0.534
LIG_14-3-3_CanoR_1	18	23	PF00244	0.516
LIG_14-3-3_CanoR_1	322	326	PF00244	0.620
LIG_14-3-3_CanoR_1	516	521	PF00244	0.554
LIG_14-3-3_CanoR_1	654	659	PF00244	0.556
LIG_14-3-3_CanoR_1	727	732	PF00244	0.684
LIG_14-3-3_CanoR_1	812	818	PF00244	0.573
LIG_14-3-3_CanoR_1	876	883	PF00244	0.549
LIG_AP2alpha_1	62	66	PF02296	0.491
LIG_AP2alpha_2	108	110	PF02296	0.564
LIG_BIR_III_2	231	235	PF00653	0.558
LIG_BRCT_BRCA1_1	115	119	PF00533	0.484
LIG_BRCT_BRCA1_1	434	438	PF00533	0.537
LIG_BRCT_BRCA1_1	805	809	PF00533	0.552
LIG_BRCT_BRCA1_2	115	121	PF00533	0.487
LIG_deltaCOP1_diTrp_1	482	490	PF00928	0.583
LIG_FHA_1	222	228	PF00498	0.606
LIG_FHA_1	273	279	PF00498	0.493
LIG_FHA_1	313	319	PF00498	0.427
LIG_FHA_1	322	328	PF00498	0.504
LIG_FHA_1	526	532	PF00498	0.546
LIG_FHA_1	600	606	PF00498	0.818
LIG_FHA_1	625	631	PF00498	0.495
LIG_FHA_1	645	651	PF00498	0.649
LIG_FHA_1	664	670	PF00498	0.567
LIG_FHA_1	794	800	PF00498	0.547
LIG_FHA_1	846	852	PF00498	0.538
LIG_FHA_2	352	358	PF00498	0.652
LIG_FHA_2	481	487	PF00498	0.643
LIG_FHA_2	655	661	PF00498	0.553
LIG_FHA_2	679	685	PF00498	0.635
LIG_FHA_2	828	834	PF00498	0.544
LIG_GBD_Chelix_1	629	637	PF00786	0.501
LIG_GSK3_LRP6_1	365	370	PF00069	0.524
LIG_Integrin_RGD_1	180	182	PF01839	0.537
LIG_LIR_Apic_2	482	488	PF02991	0.583
LIG_LIR_Apic_2	806	810	PF02991	0.552
LIG_LIR_Gen_1	224	232	PF02991	0.521
LIG_LIR_Gen_1	277	287	PF02991	0.441
LIG_LIR_Gen_1	45	54	PF02991	0.519
LIG_LIR_Gen_1	462	469	PF02991	0.514
LIG_LIR_Gen_1	840	851	PF02991	0.610
LIG_LIR_Nem_3	108	113	PF02991	0.500
LIG_LIR_Nem_3	277	282	PF02991	0.449
LIG_LIR_Nem_3	45	49	PF02991	0.591
LIG_LIR_Nem_3	462	466	PF02991	0.513
LIG_LIR_Nem_3	840	846	PF02991	0.603
LIG_MYND_1	716	720	PF01753	0.609
LIG_NRBOX	632	638	PF00104	0.593
LIG_Pex14_2	62	66	PF04695	0.491
LIG_RPA_C_Fungi	317	329	PF08784	0.345
LIG_SH2_CRK	279	283	PF00017	0.443
LIG_SH2_SRC	331	334	PF00017	0.335
LIG_SH2_STAP1	113	117	PF00017	0.525
LIG_SH2_STAP1	505	509	PF00017	0.569
LIG_SH2_STAT5	331	334	PF00017	0.425
LIG_SH2_STAT5	838	841	PF00017	0.518
LIG_SH3_1	363	369	PF00018	0.530
LIG_SH3_3	363	369	PF00018	0.604
LIG_SH3_3	386	392	PF00018	0.612
LIG_SH3_3	454	460	PF00018	0.551
LIG_SH3_3	573	579	PF00018	0.557
LIG_SH3_3	582	588	PF00018	0.529
LIG_SH3_3	759	765	PF00018	0.586
LIG_SH3_3	796	802	PF00018	0.539
LIG_Sin3_3	614	621	PF02671	0.523
LIG_SUMO_SIM_anti_2	324	329	PF11976	0.430
LIG_SUMO_SIM_anti_2	613	619	PF11976	0.526
LIG_SUMO_SIM_anti_2	632	639	PF11976	0.593
LIG_SUMO_SIM_par_1	336	343	PF11976	0.392
LIG_WRC_WIRS_1	222	227	PF05994	0.516
LIG_WW_3	809	813	PF00397	0.546
MOD_CDC14_SPxK_1	216	219	PF00782	0.586
MOD_CDC14_SPxK_1	233	236	PF00782	0.509
MOD_CDC14_SPxK_1	388	391	PF00782	0.556
MOD_CDC14_SPxK_1	862	865	PF00782	0.643
MOD_CDK_SPK_2	603	608	PF00069	0.528
MOD_CDK_SPK_2	859	864	PF00069	0.553
MOD_CDK_SPxK_1	213	219	PF00069	0.590
MOD_CDK_SPxK_1	230	236	PF00069	0.508
MOD_CDK_SPxK_1	385	391	PF00069	0.560
MOD_CDK_SPxK_1	859	865	PF00069	0.643
MOD_CDK_SPxxK_3	20	27	PF00069	0.607
MOD_CDK_SPxxK_3	720	727	PF00069	0.535
MOD_CK1_1	126	132	PF00069	0.605
MOD_CK1_1	157	163	PF00069	0.532
MOD_CK1_1	207	213	PF00069	0.568
MOD_CK1_1	237	243	PF00069	0.498
MOD_CK1_1	343	349	PF00069	0.485
MOD_CK1_1	353	359	PF00069	0.602
MOD_CK1_1	396	402	PF00069	0.554
MOD_CK1_1	4	10	PF00069	0.530
MOD_CK1_1	417	423	PF00069	0.516
MOD_CK1_1	441	447	PF00069	0.526
MOD_CK1_1	473	479	PF00069	0.520
MOD_CK1_1	555	561	PF00069	0.614
MOD_CK1_1	584	590	PF00069	0.614
MOD_CK1_1	639	645	PF00069	0.608
MOD_CK1_1	658	664	PF00069	0.679
MOD_CK1_1	688	694	PF00069	0.650
MOD_CK1_1	706	712	PF00069	0.529
MOD_CK1_1	743	749	PF00069	0.611
MOD_CK1_1	773	779	PF00069	0.608
MOD_CK1_1	803	809	PF00069	0.581
MOD_CK1_1	827	833	PF00069	0.549
MOD_CK1_1	845	851	PF00069	0.530
MOD_CK1_1	855	861	PF00069	0.611
MOD_CK2_1	629	635	PF00069	0.606
MOD_CK2_1	654	660	PF00069	0.558
MOD_CK2_1	678	684	PF00069	0.633
MOD_CK2_1	687	693	PF00069	0.599
MOD_CK2_1	838	844	PF00069	0.510
MOD_GlcNHglycan	115	118	PF01048	0.601
MOD_GlcNHglycan	128	131	PF01048	0.542
MOD_GlcNHglycan	156	159	PF01048	0.622
MOD_GlcNHglycan	161	164	PF01048	0.600
MOD_GlcNHglycan	184	187	PF01048	0.543
MOD_GlcNHglycan	3	6	PF01048	0.539
MOD_GlcNHglycan	306	309	PF01048	0.438
MOD_GlcNHglycan	347	350	PF01048	0.478
MOD_GlcNHglycan	369	372	PF01048	0.566
MOD_GlcNHglycan	374	377	PF01048	0.555
MOD_GlcNHglycan	385	388	PF01048	0.535
MOD_GlcNHglycan	395	398	PF01048	0.566
MOD_GlcNHglycan	416	419	PF01048	0.585
MOD_GlcNHglycan	475	478	PF01048	0.526
MOD_GlcNHglycan	547	550	PF01048	0.734
MOD_GlcNHglycan	554	557	PF01048	0.716
MOD_GlcNHglycan	608	611	PF01048	0.566
MOD_GlcNHglycan	690	693	PF01048	0.564
MOD_GlcNHglycan	710	713	PF01048	0.599
MOD_GlcNHglycan	772	775	PF01048	0.642
MOD_GlcNHglycan	853	857	PF01048	0.546
MOD_GlcNHglycan	917	920	PF01048	0.576
MOD_GSK3_1	122	129	PF00069	0.557
MOD_GSK3_1	204	211	PF00069	0.592
MOD_GSK3_1	230	237	PF00069	0.545
MOD_GSK3_1	263	270	PF00069	0.489
MOD_GSK3_1	300	307	PF00069	0.399
MOD_GSK3_1	34	41	PF00069	0.618
MOD_GSK3_1	343	350	PF00069	0.545
MOD_GSK3_1	361	368	PF00069	0.520
MOD_GSK3_1	402	409	PF00069	0.507
MOD_GSK3_1	414	421	PF00069	0.481
MOD_GSK3_1	434	441	PF00069	0.504
MOD_GSK3_1	468	475	PF00069	0.513
MOD_GSK3_1	579	586	PF00069	0.600
MOD_GSK3_1	595	602	PF00069	0.602
MOD_GSK3_1	625	632	PF00069	0.584
MOD_GSK3_1	636	643	PF00069	0.611
MOD_GSK3_1	654	661	PF00069	0.645
MOD_GSK3_1	683	690	PF00069	0.647
MOD_GSK3_1	703	710	PF00069	0.525
MOD_GSK3_1	743	750	PF00069	0.583
MOD_GSK3_1	812	819	PF00069	0.592
MOD_GSK3_1	838	845	PF00069	0.532
MOD_GSK3_1	852	859	PF00069	0.610
MOD_LATS_1	502	508	PF00433	0.516
MOD_LATS_1	652	658	PF00433	0.568
MOD_LATS_1	822	828	PF00433	0.655
MOD_LATS_1	874	880	PF00433	0.604
MOD_N-GLC_1	663	668	PF02516	0.596
MOD_N-GLC_1	886	891	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.542
MOD_NEK2_1	278	283	PF00069	0.375
MOD_NEK2_1	300	305	PF00069	0.601
MOD_NEK2_1	372	377	PF00069	0.569
MOD_NEK2_1	406	411	PF00069	0.562
MOD_NEK2_1	704	709	PF00069	0.651
MOD_NEK2_1	747	752	PF00069	0.540
MOD_NEK2_1	818	823	PF00069	0.564
MOD_NEK2_1	95	100	PF00069	0.541
MOD_PIKK_1	175	181	PF00454	0.670
MOD_PIKK_1	208	214	PF00454	0.528
MOD_PIKK_1	351	357	PF00454	0.620
MOD_PIKK_1	641	647	PF00454	0.544
MOD_PIKK_1	683	689	PF00454	0.569
MOD_PK_1	516	522	PF00069	0.531
MOD_PK_1	601	607	PF00069	0.526
MOD_PK_1	824	830	PF00069	0.633
MOD_PKA_1	18	24	PF00069	0.516
MOD_PKA_1	552	558	PF00069	0.550
MOD_PKA_2	18	24	PF00069	0.516
MOD_PKA_2	237	243	PF00069	0.527
MOD_PKA_2	312	318	PF00069	0.380
MOD_PKA_2	321	327	PF00069	0.410
MOD_PKA_2	343	349	PF00069	0.504
MOD_PKA_2	390	396	PF00069	0.544
MOD_PKA_2	552	558	PF00069	0.699
MOD_PKA_2	639	645	PF00069	0.619
MOD_PKA_2	726	732	PF00069	0.633
MOD_PKA_2	811	817	PF00069	0.567
MOD_PKB_1	638	646	PF00069	0.623
MOD_Plk_1	300	306	PF00069	0.565
MOD_Plk_1	356	362	PF00069	0.569
MOD_Plk_1	441	447	PF00069	0.526
MOD_Plk_2-3	47	53	PF00069	0.520
MOD_Plk_2-3	486	492	PF00069	0.582
MOD_Plk_2-3	842	848	PF00069	0.529
MOD_Plk_2-3	886	892	PF00069	0.619
MOD_Plk_4	278	284	PF00069	0.353
MOD_Plk_4	625	631	PF00069	0.517
MOD_Plk_4	747	753	PF00069	0.564
MOD_ProDKin_1	128	134	PF00069	0.551
MOD_ProDKin_1	20	26	PF00069	0.604
MOD_ProDKin_1	204	210	PF00069	0.597
MOD_ProDKin_1	213	219	PF00069	0.559
MOD_ProDKin_1	230	236	PF00069	0.519
MOD_ProDKin_1	34	40	PF00069	0.541
MOD_ProDKin_1	361	367	PF00069	0.625
MOD_ProDKin_1	385	391	PF00069	0.610
MOD_ProDKin_1	530	536	PF00069	0.613
MOD_ProDKin_1	55	61	PF00069	0.485
MOD_ProDKin_1	572	578	PF00069	0.596
MOD_ProDKin_1	581	587	PF00069	0.625
MOD_ProDKin_1	603	609	PF00069	0.570
MOD_ProDKin_1	655	661	PF00069	0.574
MOD_ProDKin_1	720	726	PF00069	0.595
MOD_ProDKin_1	798	804	PF00069	0.600
MOD_ProDKin_1	859	865	PF00069	0.643
MOD_SUMO_for_1	308	311	PF00179	0.451
MOD_SUMO_for_1	732	735	PF00179	0.589
MOD_SUMO_rev_2	184	193	PF00179	0.540
MOD_SUMO_rev_2	729	734	PF00179	0.548
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.504
TRG_DiLeu_BaLyEn_6	713	718	PF01217	0.527
TRG_ENDOCYTIC_2	279	282	PF00928	0.444
TRG_ENDOCYTIC_2	46	49	PF00928	0.521
TRG_ER_diArg_1	141	143	PF00400	0.606
TRG_ER_diArg_1	17	19	PF00400	0.561
TRG_ER_diArg_1	246	249	PF00400	0.492
TRG_ER_diArg_1	637	640	PF00400	0.606
TRG_ER_diArg_1	697	699	PF00400	0.551
TRG_ER_diArg_1	81	84	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	865	869	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDF6	Leishmania donovani	56%	100%
A4I2Z2	Leishmania infantum	56%	100%
E9ADG4	Leishmania major	55%	94%
E9AZ88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%