Paraflagellar rod protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 5, putative

Species:

Leishmania braziliensis

UniProt:

A4HFV9_LEIBR

TriTrypDb:

LbrM.27.1990 , LBRM2903_270026400

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 26

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	28
GO:0031514	motile cilium	5	28
GO:0042995	cell projection	2	28
GO:0043226	organelle	2	28
GO:0043227	membrane-bounded organelle	3	28
GO:0110165	cellular anatomical entity	1	28
GO:0120025	plasma membrane bounded cell projection	3	28
GO:0005930	axoneme	2	1
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

A4HFV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFV9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	28
GO:0005515	protein binding	2	28
GO:0005516	calmodulin binding	3	28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.270
CLV_C14_Caspase3-7	95	99	PF00656	0.440
CLV_NRD_NRD_1	129	131	PF00675	0.457
CLV_NRD_NRD_1	167	169	PF00675	0.349
CLV_NRD_NRD_1	245	247	PF00675	0.454
CLV_NRD_NRD_1	292	294	PF00675	0.272
CLV_NRD_NRD_1	348	350	PF00675	0.359
CLV_NRD_NRD_1	359	361	PF00675	0.363
CLV_NRD_NRD_1	443	445	PF00675	0.276
CLV_NRD_NRD_1	447	449	PF00675	0.255
CLV_NRD_NRD_1	88	90	PF00675	0.590
CLV_NRD_NRD_1	92	94	PF00675	0.632
CLV_PCSK_FUR_1	10	14	PF00082	0.448
CLV_PCSK_FUR_1	243	247	PF00082	0.480
CLV_PCSK_KEX2_1	12	14	PF00082	0.441
CLV_PCSK_KEX2_1	129	131	PF00082	0.441
CLV_PCSK_KEX2_1	167	169	PF00082	0.349
CLV_PCSK_KEX2_1	211	213	PF00082	0.402
CLV_PCSK_KEX2_1	243	245	PF00082	0.507
CLV_PCSK_KEX2_1	294	296	PF00082	0.345
CLV_PCSK_KEX2_1	348	350	PF00082	0.359
CLV_PCSK_KEX2_1	359	361	PF00082	0.368
CLV_PCSK_KEX2_1	447	449	PF00082	0.330
CLV_PCSK_KEX2_1	88	90	PF00082	0.495
CLV_PCSK_KEX2_1	92	94	PF00082	0.544
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.439
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.461
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.340
CLV_PCSK_PC7_1	239	245	PF00082	0.453
CLV_PCSK_PC7_1	355	361	PF00082	0.379
CLV_PCSK_PC7_1	88	94	PF00082	0.608
CLV_PCSK_SKI1_1	147	151	PF00082	0.481
CLV_PCSK_SKI1_1	167	171	PF00082	0.497
CLV_PCSK_SKI1_1	222	226	PF00082	0.372
CLV_PCSK_SKI1_1	255	259	PF00082	0.334
CLV_PCSK_SKI1_1	320	324	PF00082	0.404
CLV_PCSK_SKI1_1	463	467	PF00082	0.222
CLV_PCSK_SKI1_1	507	511	PF00082	0.366
CLV_PCSK_SKI1_1	68	72	PF00082	0.634
CLV_PCSK_SKI1_1	88	92	PF00082	0.485
CLV_Separin_Metazoa	418	422	PF03568	0.255
CLV_Separin_Metazoa	494	498	PF03568	0.226
DEG_APCC_DBOX_1	755	763	PF00400	0.255
DEG_SPOP_SBC_1	600	604	PF00917	0.457
DOC_CKS1_1	123	128	PF01111	0.539
DOC_CYCLIN_RxL_1	84	95	PF00134	0.398
DOC_CYCLIN_yClb5_NLxxxL_5	388	394	PF00134	0.183
DOC_MAPK_gen_1	167	175	PF00069	0.335
DOC_PP1_RVXF_1	138	145	PF00149	0.444
DOC_PP1_RVXF_1	512	519	PF00149	0.291
DOC_PP2B_PxIxI_1	525	531	PF00149	0.209
DOC_PP4_FxxP_1	123	126	PF00568	0.438
DOC_USP7_MATH_1	3	7	PF00917	0.450
DOC_USP7_MATH_1	34	38	PF00917	0.331
DOC_USP7_MATH_1	601	605	PF00917	0.609
DOC_USP7_MATH_1	625	629	PF00917	0.630
DOC_WW_Pin1_4	122	127	PF00397	0.460
DOC_WW_Pin1_4	181	186	PF00397	0.380
DOC_WW_Pin1_4	507	512	PF00397	0.366
DOC_WW_Pin1_4	655	660	PF00397	0.511
DOC_WW_Pin1_4	667	672	PF00397	0.513
DOC_WW_Pin1_4	697	702	PF00397	0.686
LIG_14-3-3_CanoR_1	222	231	PF00244	0.388
LIG_14-3-3_CanoR_1	239	247	PF00244	0.569
LIG_14-3-3_CanoR_1	320	325	PF00244	0.377
LIG_14-3-3_CanoR_1	33	39	PF00244	0.359
LIG_14-3-3_CanoR_1	388	398	PF00244	0.184
LIG_14-3-3_CanoR_1	430	436	PF00244	0.304
LIG_14-3-3_CanoR_1	447	456	PF00244	0.487
LIG_14-3-3_CanoR_1	483	487	PF00244	0.336
LIG_14-3-3_CanoR_1	537	542	PF00244	0.283
LIG_14-3-3_CanoR_1	560	568	PF00244	0.476
LIG_APCC_ABBA_1	322	327	PF00400	0.306
LIG_BRCT_BRCA1_1	119	123	PF00533	0.541
LIG_BRCT_BRCA1_1	140	144	PF00533	0.497
LIG_BRCT_BRCA1_1	27	31	PF00533	0.373
LIG_BRCT_BRCA1_1	302	306	PF00533	0.231
LIG_BRCT_BRCA1_1	514	518	PF00533	0.255
LIG_CtBP_PxDLS_1	704	708	PF00389	0.432
LIG_FHA_1	151	157	PF00498	0.523
LIG_FHA_1	164	170	PF00498	0.441
LIG_FHA_1	2	8	PF00498	0.450
LIG_FHA_1	256	262	PF00498	0.316
LIG_FHA_1	508	514	PF00498	0.366
LIG_FHA_1	560	566	PF00498	0.609
LIG_FHA_1	679	685	PF00498	0.516
LIG_FHA_2	177	183	PF00498	0.431
LIG_FHA_2	538	544	PF00498	0.311
LIG_FHA_2	93	99	PF00498	0.509
LIG_LIR_Apic_2	120	126	PF02991	0.540
LIG_LIR_Gen_1	215	224	PF02991	0.394
LIG_LIR_Gen_1	316	325	PF02991	0.352
LIG_LIR_Gen_1	536	544	PF02991	0.404
LIG_LIR_Gen_1	546	553	PF02991	0.573
LIG_LIR_Gen_1	714	723	PF02991	0.364
LIG_LIR_Nem_3	215	220	PF02991	0.394
LIG_LIR_Nem_3	225	231	PF02991	0.406
LIG_LIR_Nem_3	316	321	PF02991	0.342
LIG_LIR_Nem_3	323	328	PF02991	0.332
LIG_LIR_Nem_3	429	434	PF02991	0.361
LIG_LIR_Nem_3	515	521	PF02991	0.255
LIG_LIR_Nem_3	543	547	PF02991	0.307
LIG_LIR_Nem_3	714	718	PF02991	0.364
LIG_LIR_Nem_3	746	752	PF02991	0.275
LIG_LYPXL_yS_3	228	231	PF13949	0.389
LIG_NRBOX	415	421	PF00104	0.183
LIG_PCNA_PIPBox_1	213	222	PF02747	0.252
LIG_PCNA_yPIPBox_3	408	420	PF02747	0.275
LIG_Pex14_1	318	322	PF04695	0.255
LIG_Pex14_2	31	35	PF04695	0.419
LIG_Pex14_2	715	719	PF04695	0.366
LIG_PTB_Apo_2	316	323	PF02174	0.255
LIG_SH2_PTP2	523	526	PF00017	0.255
LIG_SH2_PTP2	764	767	PF00017	0.332
LIG_SH2_SRC	477	480	PF00017	0.306
LIG_SH2_SRC	523	526	PF00017	0.255
LIG_SH2_STAP1	217	221	PF00017	0.318
LIG_SH2_STAT3	409	412	PF00017	0.275
LIG_SH2_STAT5	15	18	PF00017	0.416
LIG_SH2_STAT5	435	438	PF00017	0.319
LIG_SH2_STAT5	441	444	PF00017	0.314
LIG_SH2_STAT5	477	480	PF00017	0.366
LIG_SH2_STAT5	523	526	PF00017	0.255
LIG_SH2_STAT5	672	675	PF00017	0.482
LIG_SH2_STAT5	721	724	PF00017	0.183
LIG_SH2_STAT5	764	767	PF00017	0.424
LIG_SH3_3	140	146	PF00018	0.535
LIG_SH3_3	61	67	PF00018	0.574
LIG_SH3_3	698	704	PF00018	0.461
LIG_SUMO_SIM_par_1	2	9	PF11976	0.421
LIG_TRAF2_1	179	182	PF00917	0.486
LIG_TRAF2_1	270	273	PF00917	0.290
LIG_TRAF2_1	733	736	PF00917	0.258
LIG_TRAF2_1	743	746	PF00917	0.258
LIG_ULM_U2AF65_1	243	248	PF00076	0.460
LIG_WRC_WIRS_1	544	549	PF05994	0.340
MOD_CDC14_SPxK_1	658	661	PF00782	0.502
MOD_CDK_SPK_2	122	127	PF00069	0.456
MOD_CDK_SPxK_1	655	661	PF00069	0.507
MOD_CDK_SPxxK_3	122	129	PF00069	0.451
MOD_CDK_SPxxK_3	507	514	PF00069	0.366
MOD_CK1_1	122	128	PF00069	0.506
MOD_CK1_1	238	244	PF00069	0.462
MOD_CK1_1	283	289	PF00069	0.183
MOD_CK1_1	333	339	PF00069	0.257
MOD_CK1_1	536	542	PF00069	0.374
MOD_CK1_1	618	624	PF00069	0.611
MOD_CK1_1	657	663	PF00069	0.559
MOD_CK1_1	680	686	PF00069	0.696
MOD_CK1_1	695	701	PF00069	0.630
MOD_CK2_1	176	182	PF00069	0.476
MOD_CK2_1	3	9	PF00069	0.558
MOD_CK2_1	358	364	PF00069	0.255
MOD_CK2_1	567	573	PF00069	0.597
MOD_Cter_Amidation	357	360	PF01082	0.255
MOD_DYRK1A_RPxSP_1	507	511	PF00069	0.366
MOD_GlcNHglycan	360	363	PF01048	0.277
MOD_GlcNHglycan	603	606	PF01048	0.664
MOD_GlcNHglycan	627	630	PF01048	0.559
MOD_GlcNHglycan	694	697	PF01048	0.776
MOD_GSK3_1	111	118	PF00069	0.503
MOD_GSK3_1	229	236	PF00069	0.387
MOD_GSK3_1	280	287	PF00069	0.375
MOD_GSK3_1	329	336	PF00069	0.378
MOD_GSK3_1	358	365	PF00069	0.275
MOD_GSK3_1	533	540	PF00069	0.304
MOD_GSK3_1	567	574	PF00069	0.505
MOD_GSK3_1	596	603	PF00069	0.662
MOD_GSK3_1	616	623	PF00069	0.593
MOD_GSK3_1	651	658	PF00069	0.730
MOD_GSK3_1	667	674	PF00069	0.613
MOD_GSK3_1	680	687	PF00069	0.605
MOD_GSK3_1	691	698	PF00069	0.597
MOD_N-GLC_1	283	288	PF02516	0.248
MOD_N-GLC_1	533	538	PF02516	0.327
MOD_N-GLC_1	654	659	PF02516	0.754
MOD_N-GLC_1	692	697	PF02516	0.639
MOD_NEK2_1	1	6	PF00069	0.710
MOD_NEK2_1	111	116	PF00069	0.426
MOD_NEK2_1	150	155	PF00069	0.541
MOD_NEK2_1	194	199	PF00069	0.387
MOD_NEK2_1	377	382	PF00069	0.374
MOD_NEK2_1	39	44	PF00069	0.355
MOD_NEK2_1	390	395	PF00069	0.350
MOD_NEK2_1	533	538	PF00069	0.380
MOD_NEK2_1	71	76	PF00069	0.510
MOD_NEK2_1	8	13	PF00069	0.396
MOD_NEK2_2	3	8	PF00069	0.526
MOD_PIKK_1	41	47	PF00454	0.501
MOD_PIKK_1	447	453	PF00454	0.199
MOD_PIKK_1	571	577	PF00454	0.546
MOD_PK_1	313	319	PF00069	0.296
MOD_PKA_1	447	453	PF00069	0.199
MOD_PKA_1	92	98	PF00069	0.446
MOD_PKA_2	238	244	PF00069	0.454
MOD_PKA_2	358	364	PF00069	0.256
MOD_PKA_2	429	435	PF00069	0.265
MOD_PKA_2	447	453	PF00069	0.384
MOD_PKA_2	482	488	PF00069	0.328
MOD_PKA_2	536	542	PF00069	0.335
MOD_PKA_2	559	565	PF00069	0.526
MOD_PKA_2	651	657	PF00069	0.649
MOD_PKA_2	92	98	PF00069	0.446
MOD_Plk_1	171	177	PF00069	0.505
MOD_Plk_1	194	200	PF00069	0.397
MOD_Plk_1	255	261	PF00069	0.294
MOD_Plk_1	333	339	PF00069	0.256
MOD_Plk_1	39	45	PF00069	0.434
MOD_Plk_1	533	539	PF00069	0.453
MOD_Plk_1	554	560	PF00069	0.466
MOD_Plk_1	727	733	PF00069	0.255
MOD_Plk_2-3	727	733	PF00069	0.255
MOD_Plk_4	119	125	PF00069	0.492
MOD_Plk_4	138	144	PF00069	0.488
MOD_Plk_4	171	177	PF00069	0.511
MOD_Plk_4	3	9	PF00069	0.446
MOD_Plk_4	313	319	PF00069	0.296
MOD_Plk_4	34	40	PF00069	0.355
MOD_Plk_4	362	368	PF00069	0.275
MOD_Plk_4	482	488	PF00069	0.251
MOD_Plk_4	537	543	PF00069	0.255
MOD_Plk_4	55	61	PF00069	0.406
MOD_Plk_4	554	560	PF00069	0.433
MOD_Plk_4	603	609	PF00069	0.649
MOD_Plk_4	680	686	PF00069	0.661
MOD_ProDKin_1	122	128	PF00069	0.459
MOD_ProDKin_1	181	187	PF00069	0.372
MOD_ProDKin_1	507	513	PF00069	0.366
MOD_ProDKin_1	655	661	PF00069	0.511
MOD_ProDKin_1	667	673	PF00069	0.511
MOD_ProDKin_1	697	703	PF00069	0.685
MOD_SUMO_rev_2	133	142	PF00179	0.436
MOD_SUMO_rev_2	17	22	PF00179	0.414
TRG_DiLeu_BaEn_1	145	150	PF01217	0.476
TRG_DiLeu_BaEn_1	418	423	PF01217	0.265
TRG_DiLeu_BaEn_2	301	307	PF01217	0.366
TRG_DiLeu_BaEn_4	17	23	PF01217	0.520
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.475
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.719
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.425
TRG_ENDOCYTIC_2	217	220	PF00928	0.335
TRG_ENDOCYTIC_2	228	231	PF00928	0.420
TRG_ENDOCYTIC_2	544	547	PF00928	0.306
TRG_ER_diArg_1	129	131	PF00400	0.459
TRG_ER_diArg_1	167	169	PF00400	0.349
TRG_ER_diArg_1	243	246	PF00400	0.455
TRG_ER_diArg_1	293	296	PF00400	0.279
TRG_ER_diArg_1	348	350	PF00400	0.353
TRG_ER_diArg_1	447	449	PF00400	0.255
TRG_ER_diArg_1	496	499	PF00400	0.254
TRG_ER_diArg_1	88	90	PF00400	0.584
TRG_ER_diArg_1	91	93	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	24%	100%
A0A0N0P5J5	Leptomonas seymouri	70%	98%
A0A0N1IFZ5	Leptomonas seymouri	25%	100%
A0A1X0NYU4	Trypanosomatidae	26%	100%
A0A381MH18	Leishmania infantum	25%	100%
A0A381MN58	Leishmania infantum	24%	100%
A0A3Q8IAP5	Leishmania donovani	25%	100%
A0A3Q8IEH2	Leishmania donovani	24%	100%
A0A3R7KDB9	Trypanosoma rangeli	26%	100%
A0A3S7X0V5	Leishmania donovani	85%	99%
A0A3S7X2K1	Leishmania donovani	24%	100%
A0A422NJR9	Trypanosoma rangeli	56%	100%
A4H8S1	Leishmania braziliensis	24%	100%
A4HIY0	Leishmania braziliensis	25%	100%
A4I2Z1	Leishmania infantum	85%	99%
C9ZJD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ADG3	Leishmania major	85%	100%
E9AE36	Leishmania major	24%	100%
E9AE37	Leishmania major	24%	100%
E9AHJ2	Leishmania infantum	24%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QEM2	Leishmania major	25%	100%
V5BIN9	Trypanosoma cruzi	56%	100%