Putative GTP binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFV7_LEIBR

TriTrypDb:

LbrM.27.1970 , LBRM2903_270026200

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFV7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.364
CLV_NRD_NRD_1	11	13	PF00675	0.357
CLV_NRD_NRD_1	150	152	PF00675	0.445
CLV_PCSK_FUR_1	8	12	PF00082	0.433
CLV_PCSK_KEX2_1	10	12	PF00082	0.401
CLV_PCSK_KEX2_1	150	152	PF00082	0.454
CLV_PCSK_KEX2_1	170	172	PF00082	0.524
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.440
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.490
CLV_PCSK_SKI1_1	157	161	PF00082	0.578
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DOC_CKS1_1	124	129	PF01111	0.417
DOC_MAPK_gen_1	10	19	PF00069	0.271
DOC_MAPK_MEF2A_6	105	113	PF00069	0.364
DOC_MAPK_MEF2A_6	72	80	PF00069	0.430
DOC_MAPK_RevD_3	135	151	PF00069	0.355
DOC_PP4_FxxP_1	124	127	PF00568	0.402
DOC_USP7_MATH_1	327	331	PF00917	0.301
DOC_USP7_MATH_1	49	53	PF00917	0.525
DOC_USP7_MATH_1	88	92	PF00917	0.504
DOC_WW_Pin1_4	123	128	PF00397	0.426
LIG_14-3-3_CanoR_1	3	7	PF00244	0.596
LIG_14-3-3_CanoR_1	326	336	PF00244	0.182
LIG_BRCT_BRCA1_1	24	28	PF00533	0.428
LIG_DCNL_PONY_1	1	4	PF03556	0.517
LIG_FHA_1	104	110	PF00498	0.402
LIG_FHA_1	238	244	PF00498	0.359
LIG_FHA_1	249	255	PF00498	0.396
LIG_FHA_1	49	55	PF00498	0.526
LIG_FHA_2	179	185	PF00498	0.416
LIG_FHA_2	190	196	PF00498	0.440
LIG_FHA_2	66	72	PF00498	0.553
LIG_LIR_Apic_2	122	127	PF02991	0.427
LIG_LIR_Gen_1	163	172	PF02991	0.487
LIG_LIR_Gen_1	201	210	PF02991	0.411
LIG_LIR_Gen_1	25	36	PF02991	0.526
LIG_LIR_Gen_1	330	339	PF02991	0.320
LIG_LIR_Nem_3	163	169	PF02991	0.486
LIG_LIR_Nem_3	201	205	PF02991	0.417
LIG_LIR_Nem_3	25	31	PF02991	0.430
LIG_LIR_Nem_3	289	293	PF02991	0.283
LIG_LIR_Nem_3	330	335	PF02991	0.320
LIG_MYND_3	338	342	PF01753	0.182
LIG_PCNA_yPIPBox_3	273	282	PF02747	0.431
LIG_Pex14_2	320	324	PF04695	0.363
LIG_PTB_Apo_2	349	356	PF02174	0.182
LIG_PTB_Phospho_1	349	355	PF10480	0.182
LIG_SH2_CRK	166	170	PF00017	0.476
LIG_SH2_CRK	202	206	PF00017	0.327
LIG_SH2_CRK	282	286	PF00017	0.341
LIG_SH2_STAT3	355	358	PF00017	0.363
LIG_SH2_STAT5	355	358	PF00017	0.346
LIG_SH3_3	14	20	PF00018	0.494
LIG_SH3_3	333	339	PF00018	0.182
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.453
LIG_TRAF2_1	246	249	PF00917	0.362
LIG_TRAF2_1	256	259	PF00917	0.399
LIG_WRC_WIRS_1	287	292	PF05994	0.271
MOD_CK1_1	289	295	PF00069	0.271
MOD_CK2_1	140	146	PF00069	0.403
MOD_CK2_1	189	195	PF00069	0.419
MOD_CK2_1	243	249	PF00069	0.327
MOD_CK2_1	253	259	PF00069	0.457
MOD_CK2_1	315	321	PF00069	0.296
MOD_CK2_1	65	71	PF00069	0.512
MOD_GlcNHglycan	243	246	PF01048	0.263
MOD_GlcNHglycan	329	332	PF01048	0.371
MOD_GlcNHglycan	342	345	PF01048	0.396
MOD_GSK3_1	237	244	PF00069	0.351
MOD_N-GLC_1	49	54	PF02516	0.271
MOD_NEK2_1	2	7	PF00069	0.562
MOD_NEK2_1	31	36	PF00069	0.450
MOD_NEK2_1	334	339	PF00069	0.412
MOD_NEK2_2	23	28	PF00069	0.428
MOD_NEK2_2	43	48	PF00069	0.364
MOD_PIKK_1	31	37	PF00454	0.439
MOD_PIKK_1	366	372	PF00454	0.574
MOD_PKA_2	161	167	PF00069	0.435
MOD_PKA_2	2	8	PF00069	0.593
MOD_PKA_2	241	247	PF00069	0.345
MOD_PKA_2	65	71	PF00069	0.399
MOD_Plk_1	164	170	PF00069	0.487
MOD_Plk_1	49	55	PF00069	0.364
MOD_Plk_2-3	315	321	PF00069	0.287
MOD_Plk_4	164	170	PF00069	0.409
MOD_Plk_4	189	195	PF00069	0.474
MOD_Plk_4	23	29	PF00069	0.428
MOD_Plk_4	286	292	PF00069	0.271
MOD_ProDKin_1	123	129	PF00069	0.412
MOD_SUMO_rev_2	184	192	PF00179	0.410
TRG_DiLeu_BaEn_3	258	264	PF01217	0.382
TRG_ENDOCYTIC_2	166	169	PF00928	0.465
TRG_ENDOCYTIC_2	202	205	PF00928	0.330
TRG_ENDOCYTIC_2	282	285	PF00928	0.346
TRG_ER_diArg_1	150	152	PF00400	0.405
TRG_NES_CRM1_1	131	146	PF08389	0.346
TRG_NLS_MonoExtN_4	8	14	PF00514	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD45	Leptomonas seymouri	77%	100%
A0A0N1PG70	Leptomonas seymouri	34%	95%
A0A0S4JQA1	Bodo saltans	31%	95%
A0A0S4JQX4	Bodo saltans	62%	100%
A0A1X0NR20	Trypanosomatidae	32%	94%
A0A1X0NSW3	Trypanosomatidae	64%	100%
A0A3R7MAR4	Trypanosoma rangeli	32%	94%
A0A3R7MNI8	Trypanosoma rangeli	65%	100%
A0A3S7X0V3	Leishmania donovani	87%	100%
A0A3S7X112	Leishmania donovani	34%	95%
A0JPJ7	Rattus norvegicus	35%	94%
A1SSB6	Psychromonas ingrahamii (strain 37)	28%	96%
A4HG11	Leishmania braziliensis	34%	100%
A4I2Y9	Leishmania infantum	87%	100%
A4I330	Leishmania infantum	34%	95%
B8BBN7	Oryza sativa subsp. indica	31%	94%
C9ZJD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
C9ZJK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
E9ACV1	Leishmania major	34%	100%
E9ADG1	Leishmania major	86%	100%
E9AZ85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AZE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	95%
O13998	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	95%
O14078	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	91%
P0ABU2	Escherichia coli (strain K12)	41%	100%
P0ABU3	Escherichia coli O157:H7	41%	100%
P0ABU4	Shigella flexneri	41%	100%
P37518	Bacillus subtilis (strain 168)	39%	100%
P38219	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	94%
P38746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	92%
P44681	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	42%	100%
P47270	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	37%	100%
P57288	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	34%	100%
P75088	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	36%	100%
P91917	Caenorhabditis elegans	33%	94%
Q2HJ33	Bos taurus	34%	94%
Q58728	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	95%
Q5R821	Pongo abelii	34%	94%
Q5ZM25	Gallus gallus	34%	94%
Q66JG0	Xenopus tropicalis	35%	94%
Q6Z1J6	Oryza sativa subsp. japonica	32%	94%
Q7VMI2	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	42%	100%
Q7ZU42	Danio rerio	34%	94%
Q7ZWM6	Xenopus laevis	35%	94%
Q89AR6	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	34%	100%
Q8K9V2	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	32%	100%
Q8SWU7	Drosophila melanogaster	31%	94%
Q9CP90	Pasteurella multocida (strain Pm70)	41%	100%
Q9CZ30	Mus musculus	34%	94%
Q9NTK5	Homo sapiens	34%	94%
Q9SA73	Arabidopsis thaliana	34%	94%
V5AYP1	Trypanosoma cruzi	64%	87%
V5B8C6	Trypanosoma cruzi	32%	94%