Putative glycosomal phosphoenolpyruvate carboxykinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal phosphoenolpyruvate carboxykinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFV5_LEIBR

TriTrypDb:

LbrM.27.1950 , LBRM2903_270025700

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFV5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0005996	monosaccharide metabolic process	3	2
GO:0006006	glucose metabolic process	5	2
GO:0006094	gluconeogenesis	6	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0016051	carbohydrate biosynthetic process	4	2
GO:0016310	phosphorylation	5	2
GO:0019318	hexose metabolic process	4	2
GO:0019319	hexose biosynthetic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046364	monosaccharide biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	2
GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	6	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016829	lyase activity	2	2
GO:0016830	carbon-carbon lyase activity	3	2
GO:0016831	carboxy-lyase activity	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	46	50	PF00082	0.500
CLV_PCSK_KEX2_1	48	50	PF00082	0.500
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.500
CLV_PCSK_SKI1_1	109	113	PF00082	0.500
CLV_PCSK_SKI1_1	186	190	PF00082	0.500
CLV_PCSK_SKI1_1	7	11	PF00082	0.500
DEG_APCC_DBOX_1	29	37	PF00400	0.700
DOC_MAPK_gen_1	103	110	PF00069	0.700
DOC_MAPK_gen_1	185	191	PF00069	0.700
DOC_MAPK_gen_1	76	84	PF00069	0.700
DOC_MAPK_MEF2A_6	103	110	PF00069	0.700
DOC_MAPK_MEF2A_6	161	168	PF00069	0.700
DOC_PP2B_LxvP_1	9	12	PF13499	0.700
DOC_PP4_FxxP_1	136	139	PF00568	0.700
DOC_USP7_MATH_1	151	155	PF00917	0.700
DOC_WW_Pin1_4	41	46	PF00397	0.700
LIG_14-3-3_CanoR_1	109	116	PF00244	0.700
LIG_14-3-3_CanoR_1	7	12	PF00244	0.700
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BRCT_BRCA1_1	164	168	PF00533	0.700
LIG_FHA_1	30	36	PF00498	0.700
LIG_FHA_1	51	57	PF00498	0.700
LIG_FHA_2	127	133	PF00498	0.700
LIG_FHA_2	168	174	PF00498	0.700
LIG_FHA_2	8	14	PF00498	0.700
LIG_LIR_Apic_2	134	139	PF02991	0.700
LIG_LIR_Nem_3	138	144	PF02991	0.700
LIG_LIR_Nem_3	61	65	PF02991	0.700
LIG_SH2_CRK	116	120	PF00017	0.700
LIG_SH2_CRK	122	126	PF00017	0.625
LIG_SH2_STAT5	141	144	PF00017	0.700
LIG_SH3_3	147	153	PF00018	0.700
LIG_SUMO_SIM_par_1	187	194	PF11976	0.700
LIG_TRAF2_1	170	173	PF00917	0.700
LIG_WRC_WIRS_1	133	138	PF05994	0.600
MOD_CDK_SPK_2	41	46	PF00069	0.600
MOD_CDK_SPxxK_3	41	48	PF00069	0.600
MOD_CK1_1	160	166	PF00069	0.600
MOD_CK1_1	70	76	PF00069	0.600
MOD_CK2_1	126	132	PF00069	0.600
MOD_CK2_1	167	173	PF00069	0.600
MOD_CK2_1	7	13	PF00069	0.600
MOD_GlcNHglycan	27	30	PF01048	0.600
MOD_GSK3_1	156	163	PF00069	0.600
MOD_GSK3_1	187	194	PF00069	0.600
MOD_GSK3_1	25	32	PF00069	0.600
MOD_GSK3_1	34	41	PF00069	0.442
MOD_N-GLC_1	7	12	PF02516	0.600
MOD_NEK2_2	139	144	PF00069	0.600
MOD_PIKK_1	126	132	PF00454	0.600
MOD_PIKK_1	167	173	PF00454	0.600
MOD_PKA_2	126	132	PF00069	0.600
MOD_PKA_2	29	35	PF00069	0.600
MOD_Plk_1	139	145	PF00069	0.600
MOD_Plk_1	7	13	PF00069	0.600
MOD_Plk_1	70	76	PF00069	0.600
MOD_Plk_2-3	132	138	PF00069	0.600
MOD_Plk_4	139	145	PF00069	0.600
MOD_Plk_4	187	193	PF00069	0.600
MOD_Plk_4	22	28	PF00069	0.600
MOD_ProDKin_1	41	47	PF00069	0.600
MOD_SUMO_for_1	19	22	PF00179	0.600
TRG_ENDOCYTIC_2	116	119	PF00928	0.600
TRG_ENDOCYTIC_2	122	125	PF00928	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0KRH2	SHESA	34%	38%
A0LXJ9	GRAFK	33%	36%
A0RJZ8	BACAH	39%	37%
A1AGS9	ECOK1	35%	36%
A1AV24	PELPD	38%	37%
A1B5Z2	PARDP	37%	36%
A1JSE7	YERE8	35%	36%
A1RPC2	SHESW	33%	38%
A1S1X0	SHEAM	34%	38%
A1U754	MARN8	28%	38%
A1VZR5	CAMJJ	35%	37%
A3DAB2	SHEB5	33%	38%
A3N0G0	ACTP2	31%	36%
A3PGG3	CERS1	36%	36%
A3QJ41	SHELP	32%	38%
A4IRZ2	GEOTN	37%	37%
A4TGS8	YERPP	34%	36%
A4WFJ1	ENT38	34%	36%
A4WVP0	CERS5	38%	36%
A4XP75	PSEMY	29%	38%
A4YBE7	SHEPC	33%	38%
A4YL90	BRASO	37%	36%
A5EST5	BRASB	37%	36%
A5F4Q4	VIBC3	32%	36%
A5FK68	FLAJ1	38%	36%
A5GBF9	GEOUR	35%	37%
A5ITV7	STAA9	39%	37%
A5UDR5	HAEIE	35%	36%
A5UHW1	HAEIG	35%	36%
A5VX32	PSEP1	30%	38%
A6LFQ4	PARD8	40%	36%
A6Q102	NITSB	32%	37%
A6QHX1	STAAE	39%	37%
A6U2Q2	STAA2	39%	37%
A6UEJ7	SINMW	34%	36%
A6VDW7	PSEA7	30%	38%
A6VKV4	ACTSZ	32%	36%
A6WHM7	SHEB8	33%	38%
A6WX47	BRUA4	37%	36%
A7FNU8	YERP3	34%	36%
A7GU41	BACCN	38%	37%
A7H3B9	CAMJD	36%	37%
A7HP99	PARL1	34%	36%
A7MGC5	CROS8	35%	36%
A7MZB2	VIBC1	32%	36%
A7X3N3	STAA1	39%	37%
A7Z7Z0	BACVZ	37%	37%
A7ZST1	ECO24	35%	36%
A8A5L1	ECOHS	35%	36%
A8AQV7	CITK8	35%	36%
A8FGH8	BACP2	38%	37%
A8FLY1	CAMJ8	35%	37%
A8G1J1	SHESH	32%	38%
A8GYT2	SHEPA	30%	38%
A8ILP8	AZOC5	35%	36%
A8LLF2	DINSH	41%	36%
A8MEV2	ALKOO	37%	37%
A8Z4L3	STAAT	39%	37%
A9KDE5	COXBN	31%	38%
A9KVC7	SHEB9	33%	38%
A9M9S3	BRUC2	37%	36%
A9MMC5	SALAR	36%	36%
A9MT72	SALPB	36%	36%
A9NBT9	COXBR	31%	38%
A9R4C2	YERPG	35%	36%
A9VLC7	BACMK	37%	37%
A9W382	METEP	35%	36%
B0BP80	ACTPJ	31%	36%
B0KI05	PSEPG	30%	38%
B0SFJ3	LEPBA	37%	37%
B0SPF0	LEPBP	37%	37%
B0TMY0	SHEHH	30%	38%
B0UFE2	METS4	36%	36%
B0UWS7	HISS2	33%	36%
B1HXZ6	LYSSC	35%	37%
B1IP62	ECOLC	35%	36%
B1JET1	PSEPW	30%	38%
B1JI04	YERPY	34%	36%
B1KN33	SHEWM	33%	38%
B1LHK1	ECOSM	35%	36%
B1M6N5	METRJ	35%	36%
B1X750	ECODH	35%	36%
B1ZG99	METPB	35%	36%
B2K5U8	YERPB	34%	36%
B2RHV8	PORG3	36%	36%
B2U3L1	SHIB3	35%	36%
B2VJU9	ERWT9	33%	36%
B3ET45	AMOA5	34%	37%
B3H1D9	ACTP7	31%	36%
B3PWH4	RHIE6	37%	36%
B3Q999	RHOPT	37%	36%
B4F025	PROMH	38%	36%
B4SVK3	SALNS	36%	36%
B4TKS6	SALHS	36%	36%
B4TY59	SALSV	36%	36%
B5BHF8	SALPK	36%	36%
B5F8L6	SALA4	36%	36%
B5FCE7	ALIFM	33%	36%
B5FJS1	SALDC	36%	36%
B5R360	SALEP	36%	36%
B5R7L4	SALG2	36%	36%
B5YTV3	ECO5E	35%	36%
B5ZV86	RHILW	37%	36%
B6EGP7	ALISL	35%	36%
B6I2W3	ECOSE	35%	36%
B6J3V5	COXB2	31%	38%
B6J6M2	COXB1	31%	38%
B6JJT0	AFIC5	36%	36%
B6YRN4	AZOPC	32%	37%
B7H9C8	BACC4	38%	37%
B7HSV7	BACC7	39%	37%
B7IL29	BACC2	38%	37%
B7JT33	BACC0	39%	37%
B7KVW8	METC4	35%	36%
B7L4T1	ECO55	35%	36%
B7LSA4	ESCF3	36%	36%
B7M1V7	ECO8A	35%	36%
B7MDM9	ECO45	35%	36%
B7N136	ECO81	35%	36%
B7NE08	ECOLU	35%	36%
B7NMG6	ECO7I	35%	36%
B7UKA7	ECO27	35%	36%
B7V3T9	PSEA8	29%	38%
B7VHF2	VIBA3	33%	36%
B8CH32	SHEPW	30%	38%
B8E3X7	SHEB2	33%	38%
B8F4W1	GLAP5	32%	36%
B8IMT2	METNO	35%	36%
B9DN20	STACT	38%	37%
B9J266	BACCQ	39%	37%
B9JG59	AGRRK	36%	36%
B9JXX4	AGRVS	33%	36%
B9KD79	CAMLR	36%	37%
C0Q0H5	SALPC	36%	36%
C0ZL09	BREBN	40%	37%
C1EW38	BACC3	39%	37%
C3K4J5	PSEFS	31%	38%
C3LSG5	VIBCM	32%	36%
C3PCC6	BACAA	39%	37%
C4K3J5	HAMD5	34%	36%
C4Z0Q6	LACE2	38%	36%
C4ZBL1	AGARV	35%	36%
C4ZUQ8	ECOBW	35%	36%
C5BGS4	EDWI9	35%	36%
C6DGE8	PECCP	35%	36%
C6E0Y2	GEOSM	36%	37%
O09460	ANASU	35%	36%
O13434	CANAX	55%	35%
O43112	KLULA	55%	36%
O83023	SELRU	34%	36%
P0A0B3	STAAM	39%	37%
P0C1S4	STAAU	39%	37%
P10963	YEAST	51%	35%
P13735	TRYBB	76%	41%
P22259	ECOLI	35%	36%
P41033	SALTY	36%	36%
P43085	RHIME	34%	36%
P43086	SINFN	34%	36%
P43923	HAEIN	35%	36%
P49292	UROPA	50%	31%
P51058	TRYCR	77%	41%
P54418	BACSU	35%	37%
P99128	STAAN	39%	37%
Q02EH2	PSEAB	30%	38%
Q07TF9	RHOP5	38%	36%
Q089V1	SHEFN	31%	38%
Q0AQP4	MARMM	33%	36%
Q0HNY4	SHESM	33%	38%
Q0I0F2	SHESR	33%	38%
Q0I554	HAES1	33%	36%
Q0SZR5	SHIF8	35%	36%
Q0TC64	ECOL5	35%	36%
Q11CK2	CHESB	37%	36%
Q12T12	SHEDO	35%	38%
Q13E86	RHOPS	35%	36%
Q16AH6	ROSDO	34%	36%
Q1AY78	RUBXD	36%	36%
Q1C2M9	YERPA	34%	36%
Q1CCM6	YERPN	34%	36%
Q1GDU2	RUEST	35%	36%
Q1IGK1	PSEE4	31%	38%
Q1IZ41	DEIGD	41%	37%
Q1LU72	BAUCH	33%	36%
Q1MNG2	RHIL3	34%	36%
Q1QR12	NITHX	35%	36%
Q21BR2	RHOPB	38%	36%
Q2FFV5	STAA3	39%	37%
Q2G1W2	STAA8	39%	37%
Q2G480	NOVAD	38%	36%
Q2J2Y8	RHOP2	37%	36%
Q2KE66	RHIEC	34%	36%
Q2NQI3	SODGM	35%	36%
Q2RH96	MOOTA	40%	37%
Q2RKS7	MOOTA	38%	37%
Q2S008	SALRD	51%	37%
Q2S1I3	SALRD	36%	36%
Q2SPF9	HAHCH	30%	38%
Q2YTK0	STAAB	38%	37%
Q30PV8	SULDN	34%	37%
Q31VN1	SHIBS	35%	36%
Q32AL7	SHIDS	35%	36%
Q39QU2	GEOMG	36%	37%
Q3ILP3	PSET1	30%	38%
Q3J5V6	CERS4	36%	36%
Q3KJP4	PSEPF	30%	38%
Q3SVS4	NITWN	34%	36%
Q3YWM2	SHISS	35%	36%
Q47VD0	COLP3	36%	36%
Q48BY7	PSE14	34%	38%
Q49YL7	STAS1	38%	37%
Q4KK03	PSEF5	32%	38%
Q4L7C9	STAHJ	40%	37%
Q4QM91	HAEI8	35%	36%
Q500D1	PSEU2	34%	38%
Q57IX4	SALCH	36%	36%
Q5E1X3	ALIF1	34%	36%
Q5HEY8	STAAC	39%	37%
Q5HNB7	STAEQ	37%	37%
Q5HUM7	CAMJR	36%	37%
Q5KW01	GEOKA	38%	37%
Q5L7N5	BACFN	40%	36%
Q5LVJ2	RUEPO	33%	36%
Q5PLX8	SALPA	36%	36%
Q5QUN4	IDILO	37%	36%
Q5SLL5	THET8	39%	37%
Q5WDZ7	ALKCK	35%	37%
Q632S4	BACCZ	39%	37%
Q64MV4	BACFR	40%	36%
Q65FV7	BACLD	36%	37%
Q65Q60	MANSM	36%	36%
Q664K7	YERPS	34%	36%
Q6CZP5	PECAS	35%	36%
Q6FRR0	CANGA	56%	36%
Q6G8E2	STAAS	39%	37%
Q6GFR5	STAAR	39%	37%
Q6HCB3	BACHK	39%	37%
Q6LLS2	PHOPR	33%	37%
Q72GY7	THET2	39%	37%
Q72VT0	LEPIC	36%	37%
Q72YV4	BACC1	39%	37%
Q753M0	ASHGO	53%	36%
Q75JD5	DICDI	50%	35%
Q7MQ03	VIBVY	32%	36%
Q7MU78	PORGI	36%	36%
Q7NA45	PHOLL	35%	36%
Q7RVS9	NEUCR	52%	32%
Q7VLT3	HAEDU	34%	36%
Q816Q7	BACCR	39%	37%
Q81KH8	BACAN	39%	37%
Q83A19	COXBU	31%	38%
Q83J96	SHIFL	35%	36%
Q87TE1	VIBPA	33%	36%
Q88AZ4	PSESM	34%	38%
Q89BK7	BRADU	38%	36%
Q8A414	BACTN	38%	36%
Q8CS25	STAES	37%	37%
Q8D1X9	WIGBR	30%	36%
Q8DDS6	VIBVU	32%	36%
Q8EKD3	SHEON	33%	38%
Q8EP04	OCEIH	37%	37%
Q8F9E4	LEPIN	36%	37%
Q8FCU4	ECOL6	35%	36%
Q8FY05	BRUSU	37%	36%
Q8NVZ8	STAAW	39%	37%
Q8R943	CALS4	39%	37%
Q8REI2	FUSNN	31%	37%
Q8UJ94	AGRFC	34%	36%
Q8X733	ECO57	35%	36%
Q8YE41	BRUME	37%	36%
Q8Z216	SALTI	36%	36%
Q8ZJG9	YERPE	34%	36%
Q96UL8	EMENI	51%	32%
Q98CL7	RHILO	34%	36%
Q9CKR4	PASMU	32%	36%
Q9HTZ7	PSEAE	30%	38%
Q9K7Q7	HALH5	38%	37%
Q9KNK0	VIBCH	32%	36%
Q9PP01	CAMJE	36%	37%
Q9RVP6	DEIRA	39%	42%
Q9XFA2	UROPA	49%	31%
Q9ZNH4	RHOPA	37%	36%