Putative glycosomal phosphoenolpyruvate carboxykinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphoenolpyruvate carboxykinase [ATP], glycosomal

Species:

Leishmania braziliensis

UniProt:

A4HFV4_LEIBR

TriTrypDb:

LbrM.27.1940 , LBRM2903_270025700

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFV4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0005996	monosaccharide metabolic process	3	3
GO:0006006	glucose metabolic process	5	3
GO:0006094	gluconeogenesis	6	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016051	carbohydrate biosynthetic process	4	3
GO:0016310	phosphorylation	5	3
GO:0019318	hexose metabolic process	4	3
GO:0019319	hexose biosynthetic process	5	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046364	monosaccharide biosynthetic process	4	3
GO:0071704	organic substance metabolic process	2	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	3
GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	6	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	3
GO:0016831	carboxy-lyase activity	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.673
CLV_PCSK_KEX2_1	162	164	PF00082	0.674
CLV_PCSK_KEX2_1	87	89	PF00082	0.483
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.674
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.500
CLV_PCSK_SKI1_1	140	144	PF00082	0.706
CLV_PCSK_SKI1_1	36	40	PF00082	0.416
CLV_PCSK_SKI1_1	50	54	PF00082	0.300
CLV_PCSK_SKI1_1	61	65	PF00082	0.325
CLV_PCSK_SKI1_1	84	88	PF00082	0.500
DOC_MAPK_gen_1	81	91	PF00069	0.700
DOC_MAPK_MEF2A_6	84	93	PF00069	0.700
DOC_PP2B_LxvP_1	119	122	PF13499	0.700
DOC_PP4_FxxP_1	43	46	PF00568	0.616
DOC_USP7_MATH_1	171	175	PF00917	0.666
DOC_WW_Pin1_4	5	10	PF00397	0.616
LIG_14-3-3_CanoR_1	50	55	PF00244	0.616
LIG_APCC_ABBA_1	153	158	PF00400	0.580
LIG_BRCT_BRCA1_1	39	43	PF00533	0.616
LIG_FHA_1	19	25	PF00498	0.616
LIG_FHA_1	92	98	PF00498	0.700
LIG_FHA_2	146	152	PF00498	0.660
LIG_LIR_Apic_2	40	46	PF02991	0.616
LIG_LIR_LC3C_4	151	154	PF02991	0.576
LIG_LIR_Nem_3	109	114	PF02991	0.700
LIG_OCRL_FandH_1	46	58	PF00620	0.616
LIG_Pex14_2	156	160	PF04695	0.651
LIG_Pex14_2	39	43	PF04695	0.616
LIG_PTB_Apo_2	71	78	PF02174	0.700
LIG_PTB_Phospho_1	71	77	PF10480	0.700
LIG_SH2_STAP1	20	24	PF00017	0.616
LIG_SH2_STAT3	55	58	PF00017	0.616
LIG_SH2_STAT5	111	114	PF00017	0.700
LIG_SH2_STAT5	179	182	PF00017	0.673
LIG_SH2_STAT5	20	23	PF00017	0.616
LIG_SH3_3	31	37	PF00018	0.616
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.572
MOD_CK1_1	166	172	PF00069	0.632
MOD_CK2_1	145	151	PF00069	0.659
MOD_GlcNHglycan	173	176	PF01048	0.679
MOD_GlcNHglycan	39	42	PF01048	0.361
MOD_N-GLC_1	145	150	PF02516	0.656
MOD_NEK2_1	145	150	PF00069	0.656
MOD_NEK2_1	18	23	PF00069	0.616
MOD_NEK2_1	72	77	PF00069	0.647
MOD_NEK2_1	91	96	PF00069	0.515
MOD_PKA_1	61	67	PF00069	0.616
MOD_Plk_4	50	56	PF00069	0.616
MOD_ProDKin_1	5	11	PF00069	0.616
TRG_PTS1	182	185	PF00515	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFV3	Leishmania braziliensis	93%	100%