Putative glycosomal phosphoenolpyruvate carboxykinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphoenolpyruvate carboxykinase [ATP], glycosomal

Species:

Leishmania braziliensis

UniProt:

A4HFV3_LEIBR

TriTrypDb:

LbrM.27.1930 , LBRM2903_270025800

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFV3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0005996	monosaccharide metabolic process	3	3
GO:0006006	glucose metabolic process	5	3
GO:0006094	gluconeogenesis	6	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016051	carbohydrate biosynthetic process	4	3
GO:0016310	phosphorylation	5	3
GO:0019318	hexose metabolic process	4	3
GO:0019319	hexose biosynthetic process	5	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046364	monosaccharide biosynthetic process	4	3
GO:0071704	organic substance metabolic process	2	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	3
GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	6	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	3
GO:0016831	carboxy-lyase activity	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.372
CLV_NRD_NRD_1	73	75	PF00675	0.529
CLV_PCSK_KEX2_1	100	102	PF00082	0.539
CLV_PCSK_KEX2_1	19	21	PF00082	0.351
CLV_PCSK_KEX2_1	25	27	PF00082	0.373
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.539
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.382
CLV_PCSK_SKI1_1	22	26	PF00082	0.423
CLV_PCSK_SKI1_1	78	82	PF00082	0.545
DOC_MAPK_gen_1	19	29	PF00069	0.582
DOC_MAPK_MEF2A_6	22	31	PF00069	0.582
DOC_PP2B_LxvP_1	57	60	PF13499	0.582
DOC_USP7_MATH_1	109	113	PF00917	0.628
LIG_APCC_ABBA_1	91	96	PF00400	0.468
LIG_FHA_1	30	36	PF00498	0.582
LIG_FHA_2	84	90	PF00498	0.502
LIG_LIR_LC3C_4	89	92	PF02991	0.458
LIG_LIR_Nem_3	47	52	PF02991	0.590
LIG_Pex14_2	94	98	PF04695	0.509
LIG_PTB_Apo_2	9	16	PF02174	0.582
LIG_PTB_Phospho_1	9	15	PF10480	0.582
LIG_SH2_STAT5	117	120	PF00017	0.571
LIG_SH2_STAT5	49	52	PF00017	0.617
LIG_SH3_3	10	16	PF00018	0.479
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.466
MOD_CK1_1	104	110	PF00069	0.645
MOD_CK2_1	83	89	PF00069	0.554
MOD_Cter_Amidation	17	20	PF01082	0.279
MOD_GlcNHglycan	111	114	PF01048	0.559
MOD_N-GLC_1	83	88	PF02516	0.494
MOD_NEK2_1	29	34	PF00069	0.484
MOD_NEK2_1	83	88	PF00069	0.494
TRG_PTS1	120	123	PF00515	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFV4	Leishmania braziliensis	93%	66%