Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFV2_LEIBR

TriTrypDb:

LbrM.27.1910 , LBRM2903_270025500

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.539
CLV_C14_Caspase3-7	753	757	PF00656	0.596
CLV_NRD_NRD_1	165	167	PF00675	0.435
CLV_NRD_NRD_1	300	302	PF00675	0.585
CLV_NRD_NRD_1	441	443	PF00675	0.614
CLV_NRD_NRD_1	459	461	PF00675	0.563
CLV_NRD_NRD_1	475	477	PF00675	0.513
CLV_NRD_NRD_1	505	507	PF00675	0.667
CLV_NRD_NRD_1	612	614	PF00675	0.498
CLV_NRD_NRD_1	699	701	PF00675	0.393
CLV_NRD_NRD_1	761	763	PF00675	0.658
CLV_PCSK_FUR_1	163	167	PF00082	0.418
CLV_PCSK_FUR_1	503	507	PF00082	0.681
CLV_PCSK_KEX2_1	165	167	PF00082	0.435
CLV_PCSK_KEX2_1	300	302	PF00082	0.585
CLV_PCSK_KEX2_1	441	443	PF00082	0.614
CLV_PCSK_KEX2_1	459	461	PF00082	0.563
CLV_PCSK_KEX2_1	475	477	PF00082	0.513
CLV_PCSK_KEX2_1	505	507	PF00082	0.667
CLV_PCSK_KEX2_1	612	614	PF00082	0.477
CLV_PCSK_KEX2_1	761	763	PF00082	0.658
CLV_PCSK_SKI1_1	181	185	PF00082	0.569
CLV_PCSK_SKI1_1	195	199	PF00082	0.432
CLV_PCSK_SKI1_1	612	616	PF00082	0.508
CLV_PCSK_SKI1_1	683	687	PF00082	0.406
CLV_PCSK_SKI1_1	696	700	PF00082	0.440
CLV_PCSK_SKI1_1	80	84	PF00082	0.371
DEG_APCC_DBOX_1	134	142	PF00400	0.493
DEG_APCC_DBOX_1	458	466	PF00400	0.448
DEG_APCC_DBOX_1	658	666	PF00400	0.440
DEG_Nend_UBRbox_4	1	3	PF02207	0.509
DEG_SCF_FBW7_1	816	823	PF00400	0.541
DEG_SPOP_SBC_1	389	393	PF00917	0.572
DEG_SPOP_SBC_1	815	819	PF00917	0.574
DEG_SPOP_SBC_1	820	824	PF00917	0.626
DOC_CKS1_1	220	225	PF01111	0.522
DOC_CKS1_1	549	554	PF01111	0.528
DOC_CKS1_1	711	716	PF01111	0.507
DOC_CYCLIN_RxL_1	178	188	PF00134	0.448
DOC_CYCLIN_RxL_1	680	690	PF00134	0.406
DOC_MAPK_FxFP_2	825	828	PF00069	0.674
DOC_MAPK_gen_1	163	170	PF00069	0.426
DOC_MAPK_gen_1	66	75	PF00069	0.411
DOC_MAPK_gen_1	733	743	PF00069	0.525
DOC_MAPK_gen_1	77	85	PF00069	0.361
DOC_MAPK_MEF2A_6	532	541	PF00069	0.461
DOC_MAPK_MEF2A_6	77	85	PF00069	0.359
DOC_PP1_RVXF_1	681	688	PF00149	0.405
DOC_PP2B_PxIxI_1	128	134	PF00149	0.419
DOC_PP4_FxxP_1	595	598	PF00568	0.481
DOC_PP4_FxxP_1	825	828	PF00568	0.674
DOC_USP7_MATH_1	116	120	PF00917	0.482
DOC_USP7_MATH_1	270	274	PF00917	0.643
DOC_USP7_MATH_1	311	315	PF00917	0.623
DOC_USP7_MATH_1	323	327	PF00917	0.598
DOC_USP7_MATH_1	330	334	PF00917	0.559
DOC_USP7_MATH_1	447	451	PF00917	0.565
DOC_USP7_MATH_1	458	462	PF00917	0.597
DOC_USP7_MATH_1	488	492	PF00917	0.578
DOC_USP7_MATH_1	729	733	PF00917	0.730
DOC_USP7_MATH_1	821	825	PF00917	0.784
DOC_USP7_MATH_2	479	485	PF00917	0.661
DOC_WW_Pin1_4	172	177	PF00397	0.486
DOC_WW_Pin1_4	219	224	PF00397	0.600
DOC_WW_Pin1_4	226	231	PF00397	0.611
DOC_WW_Pin1_4	260	265	PF00397	0.633
DOC_WW_Pin1_4	277	282	PF00397	0.646
DOC_WW_Pin1_4	336	341	PF00397	0.637
DOC_WW_Pin1_4	342	347	PF00397	0.639
DOC_WW_Pin1_4	396	401	PF00397	0.628
DOC_WW_Pin1_4	533	538	PF00397	0.495
DOC_WW_Pin1_4	548	553	PF00397	0.607
DOC_WW_Pin1_4	555	560	PF00397	0.703
DOC_WW_Pin1_4	59	64	PF00397	0.436
DOC_WW_Pin1_4	594	599	PF00397	0.481
DOC_WW_Pin1_4	707	712	PF00397	0.623
DOC_WW_Pin1_4	721	726	PF00397	0.521
DOC_WW_Pin1_4	811	816	PF00397	0.603
LIG_14-3-3_CanoR_1	135	145	PF00244	0.410
LIG_14-3-3_CanoR_1	213	223	PF00244	0.585
LIG_14-3-3_CanoR_1	276	282	PF00244	0.696
LIG_14-3-3_CanoR_1	292	297	PF00244	0.483
LIG_14-3-3_CanoR_1	459	463	PF00244	0.566
LIG_14-3-3_CanoR_1	532	537	PF00244	0.435
LIG_14-3-3_CanoR_1	653	659	PF00244	0.457
LIG_14-3-3_CanoR_1	66	71	PF00244	0.433
LIG_14-3-3_CanoR_1	792	796	PF00244	0.646
LIG_14-3-3_CanoR_1	96	101	PF00244	0.357
LIG_APCC_ABBAyCdc20_2	683	689	PF00400	0.406
LIG_BRCT_BRCA1_1	557	561	PF00533	0.524
LIG_BRCT_BRCA1_1	654	658	PF00533	0.370
LIG_BRCT_BRCA1_1	683	687	PF00533	0.406
LIG_BRCT_BRCA1_1	821	825	PF00533	0.821
LIG_CSL_BTD_1	708	711	PF09270	0.622
LIG_CtBP_PxDLS_1	340	344	PF00389	0.700
LIG_CtBP_PxDLS_1	552	556	PF00389	0.519
LIG_CtBP_PxDLS_1	835	839	PF00389	0.621
LIG_DLG_GKlike_1	96	104	PF00625	0.366
LIG_FHA_1	311	317	PF00498	0.518
LIG_FHA_1	423	429	PF00498	0.536
LIG_FHA_1	534	540	PF00498	0.570
LIG_FHA_1	60	66	PF00498	0.445
LIG_FHA_1	649	655	PF00498	0.464
LIG_FHA_1	828	834	PF00498	0.558
LIG_FHA_2	11	17	PF00498	0.520
LIG_FHA_2	2	8	PF00498	0.504
LIG_FHA_2	563	569	PF00498	0.521
LIG_FHA_2	639	645	PF00498	0.509
LIG_FHA_2	751	757	PF00498	0.627
LIG_FHA_2	781	787	PF00498	0.675
LIG_LIR_Apic_2	125	129	PF02991	0.539
LIG_LIR_Apic_2	472	477	PF02991	0.643
LIG_LIR_Apic_2	548	552	PF02991	0.534
LIG_LIR_Apic_2	822	828	PF02991	0.676
LIG_LIR_Gen_1	558	568	PF02991	0.523
LIG_LIR_Gen_1	69	79	PF02991	0.286
LIG_LIR_Nem_3	280	285	PF02991	0.613
LIG_LIR_Nem_3	468	474	PF02991	0.525
LIG_LIR_Nem_3	558	564	PF02991	0.528
LIG_LIR_Nem_3	69	75	PF02991	0.430
LIG_LIR_Nem_3	78	82	PF02991	0.374
LIG_LRP6_Inhibitor_1	368	374	PF00058	0.541
LIG_MYND_1	226	230	PF01753	0.535
LIG_NRBOX	149	155	PF00104	0.388
LIG_NRBOX	156	162	PF00104	0.405
LIG_PCNA_PIPBox_1	702	711	PF02747	0.447
LIG_PCNA_yPIPBox_3	696	709	PF02747	0.403
LIG_PDZ_Class_2	835	840	PF00595	0.588
LIG_RPA_C_Fungi	648	660	PF08784	0.522
LIG_SH2_CRK	239	243	PF00017	0.604
LIG_SH2_CRK	282	286	PF00017	0.518
LIG_SH2_CRK	474	478	PF00017	0.659
LIG_SH2_CRK	549	553	PF00017	0.529
LIG_SH2_CRK	67	71	PF00017	0.427
LIG_SH2_CRK	79	83	PF00017	0.350
LIG_SH2_GRB2like	72	75	PF00017	0.354
LIG_SH2_NCK_1	239	243	PF00017	0.604
LIG_SH2_PTP2	72	75	PF00017	0.276
LIG_SH2_SRC	72	75	PF00017	0.354
LIG_SH2_STAT5	302	305	PF00017	0.514
LIG_SH2_STAT5	528	531	PF00017	0.434
LIG_SH2_STAT5	72	75	PF00017	0.354
LIG_SH3_3	220	226	PF00018	0.660
LIG_SH3_3	258	264	PF00018	0.630
LIG_SH3_3	293	299	PF00018	0.628
LIG_SH3_3	379	385	PF00018	0.718
LIG_SH3_3	394	400	PF00018	0.600
LIG_SH3_3	534	540	PF00018	0.434
LIG_SH3_3	708	714	PF00018	0.515
LIG_SH3_3	719	725	PF00018	0.520
LIG_SUMO_SIM_par_1	29	35	PF11976	0.466
LIG_TRAF2_1	119	122	PF00917	0.623
LIG_TRAF2_1	144	147	PF00917	0.472
LIG_TRAF2_1	491	494	PF00917	0.557
LIG_TRAF2_1	744	747	PF00917	0.527
LIG_TRAF2_1	783	786	PF00917	0.559
LIG_TRAF2_2	402	407	PF00917	0.550
LIG_TYR_ITIM	65	70	PF00017	0.345
LIG_UBA3_1	81	89	PF00899	0.387
MOD_CDC14_SPxK_1	345	348	PF00782	0.636
MOD_CDK_SPK_2	260	265	PF00069	0.633
MOD_CDK_SPK_2	707	712	PF00069	0.623
MOD_CDK_SPxK_1	219	225	PF00069	0.530
MOD_CDK_SPxK_1	342	348	PF00069	0.641
MOD_CDK_SPxxK_3	277	284	PF00069	0.656
MOD_CDK_SPxxK_3	396	403	PF00069	0.682
MOD_CDK_SPxxK_3	59	66	PF00069	0.437
MOD_CK1_1	12	18	PF00069	0.396
MOD_CK1_1	134	140	PF00069	0.370
MOD_CK1_1	214	220	PF00069	0.683
MOD_CK1_1	23	29	PF00069	0.498
MOD_CK1_1	263	269	PF00069	0.805
MOD_CK1_1	274	280	PF00069	0.567
MOD_CK1_1	32	38	PF00069	0.395
MOD_CK1_1	335	341	PF00069	0.560
MOD_CK1_1	597	603	PF00069	0.538
MOD_CK1_1	630	636	PF00069	0.365
MOD_CK1_1	707	713	PF00069	0.605
MOD_CK1_1	801	807	PF00069	0.816
MOD_CK1_1	814	820	PF00069	0.549
MOD_CK1_1	826	832	PF00069	0.770
MOD_CK2_1	1	7	PF00069	0.490
MOD_CK2_1	10	16	PF00069	0.539
MOD_CK2_1	116	122	PF00069	0.522
MOD_CK2_1	141	147	PF00069	0.460
MOD_CK2_1	336	342	PF00069	0.701
MOD_CK2_1	488	494	PF00069	0.668
MOD_CK2_1	729	735	PF00069	0.668
MOD_CK2_1	741	747	PF00069	0.740
MOD_CK2_1	780	786	PF00069	0.673
MOD_CK2_1	801	807	PF00069	0.684
MOD_DYRK1A_RPxSP_1	721	725	PF00069	0.532
MOD_GlcNHglycan	118	121	PF01048	0.483
MOD_GlcNHglycan	214	217	PF01048	0.490
MOD_GlcNHglycan	242	245	PF01048	0.551
MOD_GlcNHglycan	277	280	PF01048	0.604
MOD_GlcNHglycan	324	328	PF01048	0.570
MOD_GlcNHglycan	353	356	PF01048	0.586
MOD_GlcNHglycan	368	371	PF01048	0.777
MOD_GlcNHglycan	375	378	PF01048	0.641
MOD_GlcNHglycan	386	389	PF01048	0.493
MOD_GlcNHglycan	407	411	PF01048	0.835
MOD_GlcNHglycan	413	416	PF01048	0.646
MOD_GlcNHglycan	417	420	PF01048	0.595
MOD_GlcNHglycan	629	632	PF01048	0.362
MOD_GlcNHglycan	7	10	PF01048	0.509
MOD_GlcNHglycan	717	720	PF01048	0.627
MOD_GlcNHglycan	750	753	PF01048	0.567
MOD_GlcNHglycan	768	771	PF01048	0.756
MOD_GlcNHglycan	800	803	PF01048	0.548
MOD_GSK3_1	1	8	PF00069	0.420
MOD_GSK3_1	137	144	PF00069	0.448
MOD_GSK3_1	175	182	PF00069	0.608
MOD_GSK3_1	240	247	PF00069	0.796
MOD_GSK3_1	270	277	PF00069	0.654
MOD_GSK3_1	318	325	PF00069	0.637
MOD_GSK3_1	32	39	PF00069	0.398
MOD_GSK3_1	332	339	PF00069	0.676
MOD_GSK3_1	347	354	PF00069	0.570
MOD_GSK3_1	384	391	PF00069	0.526
MOD_GSK3_1	411	418	PF00069	0.701
MOD_GSK3_1	428	435	PF00069	0.568
MOD_GSK3_1	551	558	PF00069	0.665
MOD_GSK3_1	576	583	PF00069	0.679
MOD_GSK3_1	597	604	PF00069	0.578
MOD_GSK3_1	648	655	PF00069	0.382
MOD_GSK3_1	750	757	PF00069	0.569
MOD_GSK3_1	776	783	PF00069	0.689
MOD_GSK3_1	811	818	PF00069	0.604
MOD_GSK3_1	819	826	PF00069	0.621
MOD_GSK3_1	96	103	PF00069	0.504
MOD_LATS_1	430	436	PF00433	0.550
MOD_N-GLC_1	244	249	PF02516	0.550
MOD_N-GLC_2	678	680	PF02516	0.400
MOD_NEK2_1	1	6	PF00069	0.419
MOD_NEK2_1	100	105	PF00069	0.376
MOD_NEK2_1	20	25	PF00069	0.498
MOD_NEK2_1	36	41	PF00069	0.363
MOD_NEK2_1	465	470	PF00069	0.462
MOD_NEK2_1	48	53	PF00069	0.433
MOD_NEK2_1	638	643	PF00069	0.497
MOD_NEK2_1	648	653	PF00069	0.423
MOD_NEK2_1	654	659	PF00069	0.367
MOD_NEK2_1	681	686	PF00069	0.405
MOD_NEK2_2	750	755	PF00069	0.510
MOD_NEK2_2	776	781	PF00069	0.539
MOD_PIKK_1	148	154	PF00454	0.531
MOD_PIKK_1	175	181	PF00454	0.618
MOD_PIKK_1	20	26	PF00454	0.381
MOD_PIKK_1	271	277	PF00454	0.566
MOD_PIKK_1	330	336	PF00454	0.644
MOD_PIKK_1	432	438	PF00454	0.551
MOD_PIKK_1	447	453	PF00454	0.580
MOD_PIKK_1	49	55	PF00454	0.498
MOD_PIKK_1	580	586	PF00454	0.670
MOD_PK_1	292	298	PF00069	0.488
MOD_PKA_2	134	140	PF00069	0.375
MOD_PKA_2	212	218	PF00069	0.543
MOD_PKA_2	275	281	PF00069	0.697
MOD_PKA_2	330	336	PF00069	0.637
MOD_PKA_2	347	353	PF00069	0.599
MOD_PKA_2	373	379	PF00069	0.530
MOD_PKA_2	458	464	PF00069	0.530
MOD_PKA_2	531	537	PF00069	0.451
MOD_PKA_2	568	574	PF00069	0.542
MOD_PKA_2	652	658	PF00069	0.387
MOD_PKA_2	670	676	PF00069	0.572
MOD_PKA_2	720	726	PF00069	0.683
MOD_PKA_2	729	735	PF00069	0.559
MOD_PKA_2	754	760	PF00069	0.552
MOD_PKA_2	791	797	PF00069	0.639
MOD_Plk_1	179	185	PF00069	0.479
MOD_Plk_1	586	592	PF00069	0.520
MOD_Plk_1	689	695	PF00069	0.468
MOD_Plk_1	755	761	PF00069	0.632
MOD_Plk_1	776	782	PF00069	0.539
MOD_Plk_2-3	122	128	PF00069	0.450
MOD_Plk_4	122	128	PF00069	0.486
MOD_Plk_4	29	35	PF00069	0.529
MOD_Plk_4	568	574	PF00069	0.514
MOD_Plk_4	681	687	PF00069	0.406
MOD_Plk_4	689	695	PF00069	0.406
MOD_Plk_4	704	710	PF00069	0.433
MOD_Plk_4	755	761	PF00069	0.520
MOD_ProDKin_1	172	178	PF00069	0.487
MOD_ProDKin_1	219	225	PF00069	0.607
MOD_ProDKin_1	226	232	PF00069	0.611
MOD_ProDKin_1	260	266	PF00069	0.633
MOD_ProDKin_1	277	283	PF00069	0.639
MOD_ProDKin_1	336	342	PF00069	0.639
MOD_ProDKin_1	396	402	PF00069	0.622
MOD_ProDKin_1	533	539	PF00069	0.496
MOD_ProDKin_1	548	554	PF00069	0.606
MOD_ProDKin_1	555	561	PF00069	0.635
MOD_ProDKin_1	59	65	PF00069	0.431
MOD_ProDKin_1	594	600	PF00069	0.479
MOD_ProDKin_1	707	713	PF00069	0.626
MOD_ProDKin_1	721	727	PF00069	0.523
MOD_ProDKin_1	811	817	PF00069	0.606
MOD_SUMO_rev_2	617	627	PF00179	0.505
MOD_SUMO_rev_2	744	751	PF00179	0.657
TRG_DiLeu_BaEn_1	194	199	PF01217	0.499
TRG_DiLeu_BaEn_1	78	83	PF01217	0.364
TRG_DiLeu_BaEn_3	689	695	PF01217	0.328
TRG_ENDOCYTIC_2	282	285	PF00928	0.523
TRG_ENDOCYTIC_2	67	70	PF00928	0.437
TRG_ENDOCYTIC_2	72	75	PF00928	0.356
TRG_ENDOCYTIC_2	79	82	PF00928	0.354
TRG_ER_diArg_1	249	252	PF00400	0.559
TRG_ER_diArg_1	299	301	PF00400	0.579
TRG_ER_diArg_1	474	476	PF00400	0.654
TRG_ER_diArg_1	503	506	PF00400	0.658
TRG_ER_diArg_1	612	614	PF00400	0.477
TRG_ER_diArg_1	760	762	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P552	Leptomonas seymouri	35%	87%
A0A3Q8IED4	Leishmania donovani	69%	100%
A4I2Y5	Leishmania infantum	69%	100%
E9ADF6	Leishmania major	67%	100%
E9AZ79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%