Casein kinase I-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I-like protein

Species:

Leishmania braziliensis

UniProt:

A4HFV0_LEIBR

TriTrypDb:

LbrM.27.1900 , LBRM2903_270025200

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HFV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFV0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0036211	protein modification process	4	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043412	macromolecule modification	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:0007165	signal transduction	2	3
GO:0018105	peptidyl-serine phosphorylation	6	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018209	peptidyl-serine modification	6	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0065007	biological regulation	1	3
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0016192	vesicle-mediated transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004672	protein kinase activity	3	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0004674	protein serine/threonine kinase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.342
CLV_C14_Caspase3-7	485	489	PF00656	0.532
CLV_NRD_NRD_1	325	327	PF00675	0.320
CLV_PCSK_KEX2_1	325	327	PF00082	0.320
CLV_PCSK_KEX2_1	359	361	PF00082	0.408
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.408
CLV_PCSK_SKI1_1	382	386	PF00082	0.327
CLV_TASPASE1	486	492	PF01112	0.525
DOC_ANK_TNKS_1	451	458	PF00023	0.491
DOC_CKS1_1	307	312	PF01111	0.238
DOC_CKS1_1	539	544	PF01111	0.437
DOC_MAPK_DCC_7	116	124	PF00069	0.230
DOC_MAPK_MEF2A_6	365	372	PF00069	0.262
DOC_MAPK_NFAT4_5	365	373	PF00069	0.253
DOC_PP2B_LxvP_1	23	26	PF13499	0.474
DOC_PP2B_LxvP_1	79	82	PF13499	0.495
DOC_PP4_FxxP_1	539	542	PF00568	0.506
DOC_USP7_MATH_1	136	140	PF00917	0.238
DOC_USP7_MATH_1	27	31	PF00917	0.524
DOC_WW_Pin1_4	306	311	PF00397	0.238
DOC_WW_Pin1_4	538	543	PF00397	0.498
DOC_WW_Pin1_4	549	554	PF00397	0.439
DOC_WW_Pin1_4	60	65	PF00397	0.520
LIG_14-3-3_CanoR_1	128	136	PF00244	0.304
LIG_14-3-3_CanoR_1	234	238	PF00244	0.297
LIG_14-3-3_CanoR_1	311	316	PF00244	0.315
LIG_14-3-3_CanoR_1	95	99	PF00244	0.333
LIG_Actin_WH2_2	397	412	PF00022	0.303
LIG_BIR_III_2	523	527	PF00653	0.535
LIG_BIR_III_4	510	514	PF00653	0.536
LIG_BRCT_BRCA1_1	103	107	PF00533	0.238
LIG_BRCT_BRCA1_1	138	142	PF00533	0.238
LIG_BRCT_BRCA1_1	286	290	PF00533	0.257
LIG_eIF4E_1	334	340	PF01652	0.238
LIG_EVH1_1	23	27	PF00568	0.475
LIG_EVH1_1	539	543	PF00568	0.436
LIG_FHA_1	238	244	PF00498	0.238
LIG_FHA_1	427	433	PF00498	0.498
LIG_FHA_1	443	449	PF00498	0.481
LIG_FHA_1	475	481	PF00498	0.527
LIG_FHA_1	539	545	PF00498	0.438
LIG_FHA_1	67	73	PF00498	0.492
LIG_FHA_2	95	101	PF00498	0.260
LIG_LIR_Apic_2	536	542	PF02991	0.447
LIG_LIR_Gen_1	236	244	PF02991	0.243
LIG_LIR_Gen_1	309	319	PF02991	0.251
LIG_LIR_Gen_1	396	406	PF02991	0.356
LIG_LIR_Gen_1	97	107	PF02991	0.187
LIG_LIR_Nem_3	104	110	PF02991	0.306
LIG_LIR_Nem_3	236	241	PF02991	0.275
LIG_LIR_Nem_3	309	315	PF02991	0.295
LIG_LIR_Nem_3	379	384	PF02991	0.365
LIG_LIR_Nem_3	396	402	PF02991	0.454
LIG_LIR_Nem_3	97	102	PF02991	0.307
LIG_NRBOX	401	407	PF00104	0.294
LIG_PCNA_yPIPBox_3	203	216	PF02747	0.257
LIG_Pex14_2	92	96	PF04695	0.390
LIG_PTB_Apo_2	300	307	PF02174	0.257
LIG_SH2_CRK	312	316	PF00017	0.251
LIG_SH2_CRK	399	403	PF00017	0.456
LIG_SH2_PTP2	334	337	PF00017	0.257
LIG_SH2_SRC	259	262	PF00017	0.273
LIG_SH2_STAP1	387	391	PF00017	0.338
LIG_SH2_STAT3	206	209	PF00017	0.257
LIG_SH2_STAT3	49	52	PF00017	0.593
LIG_SH2_STAT5	259	262	PF00017	0.301
LIG_SH2_STAT5	280	283	PF00017	0.320
LIG_SH2_STAT5	321	324	PF00017	0.269
LIG_SH2_STAT5	334	337	PF00017	0.397
LIG_SH2_STAT5	338	341	PF00017	0.450
LIG_SH3_3	18	24	PF00018	0.524
LIG_SH3_3	537	543	PF00018	0.463
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.187
LIG_SUMO_SIM_par_1	239	245	PF11976	0.286
LIG_TRAF2_1	194	197	PF00917	0.230
LIG_TYR_ITIM	332	337	PF00017	0.238
MOD_CDK_SPK_2	306	311	PF00069	0.238
MOD_CDK_SPxxK_3	549	556	PF00069	0.487
MOD_CK1_1	314	320	PF00069	0.286
MOD_CK1_1	419	425	PF00069	0.470
MOD_CK1_1	499	505	PF00069	0.589
MOD_CK1_1	538	544	PF00069	0.440
MOD_CK2_1	246	252	PF00069	0.186
MOD_GlcNHglycan	103	106	PF01048	0.254
MOD_GlcNHglycan	178	181	PF01048	0.268
MOD_GlcNHglycan	346	349	PF01048	0.238
MOD_GlcNHglycan	424	427	PF01048	0.507
MOD_GlcNHglycan	453	456	PF01048	0.537
MOD_GlcNHglycan	480	483	PF01048	0.512
MOD_GlcNHglycan	517	520	PF01048	0.559
MOD_GlcNHglycan	527	530	PF01048	0.500
MOD_GlcNHglycan	64	67	PF01048	0.498
MOD_GSK3_1	158	165	PF00069	0.217
MOD_GSK3_1	233	240	PF00069	0.267
MOD_GSK3_1	302	309	PF00069	0.349
MOD_GSK3_1	405	412	PF00069	0.356
MOD_GSK3_1	415	422	PF00069	0.464
MOD_GSK3_1	474	481	PF00069	0.651
MOD_GSK3_1	495	502	PF00069	0.738
MOD_GSK3_1	515	522	PF00069	0.524
MOD_GSK3_1	62	69	PF00069	0.503
MOD_N-GLC_1	302	307	PF02516	0.257
MOD_N-GLC_1	519	524	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.568
MOD_NEK2_1	216	221	PF00069	0.240
MOD_NEK2_1	237	242	PF00069	0.266
MOD_NEK2_1	284	289	PF00069	0.238
MOD_NEK2_1	319	324	PF00069	0.273
MOD_NEK2_1	405	410	PF00069	0.353
MOD_NEK2_1	415	420	PF00069	0.540
MOD_NEK2_1	495	500	PF00069	0.683
MOD_NEK2_2	94	99	PF00069	0.285
MOD_PIKK_1	158	164	PF00454	0.198
MOD_PIKK_1	51	57	PF00454	0.672
MOD_PKA_2	127	133	PF00069	0.257
MOD_PKA_2	233	239	PF00069	0.286
MOD_PKA_2	409	415	PF00069	0.364
MOD_PKA_2	451	457	PF00069	0.547
MOD_PKA_2	495	501	PF00069	0.553
MOD_PKA_2	94	100	PF00069	0.338
MOD_Plk_1	136	142	PF00069	0.238
MOD_Plk_1	302	308	PF00069	0.257
MOD_Plk_1	535	541	PF00069	0.452
MOD_Plk_4	136	142	PF00069	0.238
MOD_Plk_4	233	239	PF00069	0.280
MOD_Plk_4	302	308	PF00069	0.257
MOD_Plk_4	87	93	PF00069	0.420
MOD_ProDKin_1	306	312	PF00069	0.238
MOD_ProDKin_1	538	544	PF00069	0.498
MOD_ProDKin_1	549	555	PF00069	0.435
MOD_ProDKin_1	60	66	PF00069	0.518
MOD_SUMO_for_1	124	127	PF00179	0.320
MOD_SUMO_for_1	264	267	PF00179	0.370
MOD_SUMO_rev_2	139	148	PF00179	0.280
TRG_DiLeu_BaEn_1	277	282	PF01217	0.238
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.230
TRG_ENDOCYTIC_2	312	315	PF00928	0.295
TRG_ENDOCYTIC_2	334	337	PF00928	0.238
TRG_ENDOCYTIC_2	399	402	PF00928	0.365
TRG_ER_diArg_1	340	343	PF00400	0.238
TRG_NES_CRM1_1	233	245	PF08389	0.187
TRG_NES_CRM1_1	277	292	PF08389	0.238
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB0	Leptomonas seymouri	60%	98%
A0A3Q8ISA0	Leishmania donovani	33%	100%
A0A3S7WZA2	Leishmania donovani	31%	100%
A0A3S7X0V1	Leishmania donovani	76%	98%
A4HEI6	Leishmania braziliensis	31%	100%
A4HIT6	Leishmania braziliensis	32%	100%
A4I1K4	Leishmania infantum	31%	100%
A4I2Y4	Leishmania infantum	76%	98%
A4I638	Leishmania infantum	33%	100%
E9ADF5	Leishmania major	77%	100%
E9AXN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
P42158	Arabidopsis thaliana	27%	100%
Q4Q6U1	Leishmania major	31%	100%
Q4Q9T3	Leishmania major	32%	100%
Q8LPI7	Arabidopsis thaliana	28%	100%