TBCC domain-containing protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin cofactor C domain-containing protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HFU9_LEIBR

TriTrypDb:

LbrM.27.1880 , LBRM2903_270024600

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	2
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HFU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFU9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.389
CLV_NRD_NRD_1	178	180	PF00675	0.568
CLV_NRD_NRD_1	3	5	PF00675	0.721
CLV_NRD_NRD_1	504	506	PF00675	0.453
CLV_PCSK_KEX2_1	177	179	PF00082	0.543
CLV_PCSK_KEX2_1	3	5	PF00082	0.721
CLV_PCSK_KEX2_1	504	506	PF00082	0.453
CLV_PCSK_SKI1_1	136	140	PF00082	0.417
DEG_APCC_DBOX_1	135	143	PF00400	0.421
DEG_SCF_FBW7_1	113	120	PF00400	0.536
DEG_SPOP_SBC_1	29	33	PF00917	0.631
DOC_CKS1_1	114	119	PF01111	0.557
DOC_CKS1_1	388	393	PF01111	0.426
DOC_MAPK_DCC_7	158	167	PF00069	0.348
DOC_MAPK_DCC_7	488	496	PF00069	0.346
DOC_MAPK_gen_1	82	91	PF00069	0.524
DOC_MAPK_MEF2A_6	158	167	PF00069	0.348
DOC_MAPK_MEF2A_6	84	93	PF00069	0.452
DOC_MAPK_RevD_3	165	179	PF00069	0.479
DOC_PP2B_LxvP_1	494	497	PF13499	0.592
DOC_PP2B_LxvP_1	54	57	PF13499	0.496
DOC_USP7_MATH_1	152	156	PF00917	0.417
DOC_USP7_MATH_1	208	212	PF00917	0.345
DOC_USP7_MATH_1	29	33	PF00917	0.647
DOC_USP7_MATH_1	409	413	PF00917	0.669
DOC_USP7_MATH_1	430	434	PF00917	0.362
DOC_USP7_MATH_1	5	9	PF00917	0.722
DOC_USP7_MATH_2	467	473	PF00917	0.548
DOC_WW_Pin1_4	113	118	PF00397	0.541
DOC_WW_Pin1_4	299	304	PF00397	0.540
DOC_WW_Pin1_4	387	392	PF00397	0.299
DOC_WW_Pin1_4	445	450	PF00397	0.435
LIG_14-3-3_CanoR_1	124	128	PF00244	0.601
LIG_14-3-3_CanoR_1	158	163	PF00244	0.361
LIG_14-3-3_CanoR_1	213	217	PF00244	0.442
LIG_14-3-3_CanoR_1	266	274	PF00244	0.483
LIG_14-3-3_CanoR_1	313	321	PF00244	0.426
LIG_14-3-3_CanoR_1	538	543	PF00244	0.509
LIG_Actin_WH2_2	509	526	PF00022	0.565
LIG_Actin_WH2_2	532	550	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BIR_III_4	518	522	PF00653	0.342
LIG_BRCT_BRCA1_1	239	243	PF00533	0.389
LIG_BRCT_BRCA1_1	471	475	PF00533	0.555
LIG_BRCT_BRCA1_1	5	9	PF00533	0.719
LIG_EVH1_2	466	470	PF00568	0.427
LIG_FHA_1	249	255	PF00498	0.378
LIG_FHA_1	296	302	PF00498	0.319
LIG_FHA_1	345	351	PF00498	0.311
LIG_FHA_1	381	387	PF00498	0.324
LIG_FHA_1	388	394	PF00498	0.333
LIG_FHA_1	518	524	PF00498	0.564
LIG_FHA_1	558	564	PF00498	0.594
LIG_FHA_1	60	66	PF00498	0.406
LIG_FHA_2	213	219	PF00498	0.388
LIG_FHA_2	548	554	PF00498	0.567
LIG_IRF3_LxIS_1	315	322	PF10401	0.435
LIG_LIR_Gen_1	258	267	PF02991	0.489
LIG_LIR_Gen_1	302	312	PF02991	0.559
LIG_LIR_Gen_1	383	393	PF02991	0.426
LIG_LIR_Gen_1	468	477	PF02991	0.561
LIG_LIR_Gen_1	96	107	PF02991	0.374
LIG_LIR_Nem_3	103	108	PF02991	0.339
LIG_LIR_Nem_3	258	263	PF02991	0.491
LIG_LIR_Nem_3	302	307	PF02991	0.571
LIG_LIR_Nem_3	309	315	PF02991	0.549
LIG_LIR_Nem_3	383	388	PF02991	0.413
LIG_LIR_Nem_3	433	438	PF02991	0.288
LIG_LIR_Nem_3	96	102	PF02991	0.379
LIG_LYPXL_S_1	434	438	PF13949	0.504
LIG_LYPXL_yS_3	435	438	PF13949	0.501
LIG_NRBOX	165	171	PF00104	0.446
LIG_NRBOX	221	227	PF00104	0.358
LIG_Pex14_2	102	106	PF04695	0.456
LIG_Pex14_2	243	247	PF04695	0.523
LIG_SH2_CRK	304	308	PF00017	0.580
LIG_SH2_PTP2	385	388	PF00017	0.459
LIG_SH2_SRC	330	333	PF00017	0.421
LIG_SH2_STAT3	194	197	PF00017	0.518
LIG_SH2_STAT5	194	197	PF00017	0.422
LIG_SH2_STAT5	224	227	PF00017	0.464
LIG_SH2_STAT5	260	263	PF00017	0.491
LIG_SH2_STAT5	385	388	PF00017	0.426
LIG_SH2_STAT5	40	43	PF00017	0.478
LIG_SH3_3	157	163	PF00018	0.386
LIG_SH3_3	230	236	PF00018	0.399
LIG_SH3_3	385	391	PF00018	0.426
LIG_SH3_3	453	459	PF00018	0.401
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.365
LIG_SUMO_SIM_par_1	390	396	PF11976	0.245
LIG_TRAF2_1	550	553	PF00917	0.534
LIG_TRFH_1	304	308	PF08558	0.580
LIG_TYR_ITSM	381	388	PF00017	0.426
LIG_WRC_WIRS_1	431	436	PF05994	0.449
LIG_WW_3	420	424	PF00397	0.439
MOD_CK1_1	14	20	PF00069	0.738
MOD_CK1_1	212	218	PF00069	0.500
MOD_CK1_1	276	282	PF00069	0.530
MOD_CK1_1	317	323	PF00069	0.317
MOD_CK1_1	341	347	PF00069	0.459
MOD_CK1_1	377	383	PF00069	0.396
MOD_CK1_1	396	402	PF00069	0.380
MOD_CK1_1	411	417	PF00069	0.680
MOD_CK1_1	445	451	PF00069	0.414
MOD_CK1_1	484	490	PF00069	0.616
MOD_CK1_1	58	64	PF00069	0.455
MOD_CK2_1	117	123	PF00069	0.629
MOD_CK2_1	547	553	PF00069	0.519
MOD_GlcNHglycan	108	111	PF01048	0.488
MOD_GlcNHglycan	11	14	PF01048	0.716
MOD_GlcNHglycan	119	122	PF01048	0.578
MOD_GlcNHglycan	20	23	PF01048	0.659
MOD_GlcNHglycan	203	206	PF01048	0.433
MOD_GlcNHglycan	353	356	PF01048	0.353
MOD_GlcNHglycan	367	370	PF01048	0.260
MOD_GlcNHglycan	423	426	PF01048	0.377
MOD_GlcNHglycan	444	447	PF01048	0.362
MOD_GlcNHglycan	479	482	PF01048	0.595
MOD_GlcNHglycan	5	8	PF01048	0.679
MOD_GlcNHglycan	57	60	PF01048	0.480
MOD_GSK3_1	113	120	PF00069	0.534
MOD_GSK3_1	13	20	PF00069	0.719
MOD_GSK3_1	208	215	PF00069	0.460
MOD_GSK3_1	273	280	PF00069	0.570
MOD_GSK3_1	295	302	PF00069	0.522
MOD_GSK3_1	313	320	PF00069	0.233
MOD_GSK3_1	335	342	PF00069	0.426
MOD_GSK3_1	351	358	PF00069	0.371
MOD_GSK3_1	404	411	PF00069	0.749
MOD_GSK3_1	441	448	PF00069	0.450
MOD_GSK3_1	465	472	PF00069	0.492
MOD_GSK3_1	477	484	PF00069	0.525
MOD_GSK3_1	5	12	PF00069	0.675
MOD_GSK3_1	55	62	PF00069	0.445
MOD_GSK3_1	559	566	PF00069	0.605
MOD_GSK3_1	69	76	PF00069	0.440
MOD_LATS_1	536	542	PF00433	0.557
MOD_N-GLC_1	288	293	PF02516	0.558
MOD_N-GLC_1	317	322	PF02516	0.369
MOD_N-GLC_1	344	349	PF02516	0.314
MOD_N-GLC_1	377	382	PF02516	0.375
MOD_N-GLC_1	396	401	PF02516	0.437
MOD_N-GLC_1	481	486	PF02516	0.666
MOD_N-GLC_1	73	78	PF02516	0.372
MOD_NEK2_1	106	111	PF00069	0.313
MOD_NEK2_1	237	242	PF00069	0.344
MOD_NEK2_1	295	300	PF00069	0.423
MOD_NEK2_1	314	319	PF00069	0.186
MOD_NEK2_1	477	482	PF00069	0.655
MOD_NEK2_1	547	552	PF00069	0.502
MOD_NEK2_1	559	564	PF00069	0.607
MOD_NEK2_1	60	65	PF00069	0.341
MOD_NEK2_1	69	74	PF00069	0.471
MOD_NEK2_1	9	14	PF00069	0.694
MOD_NEK2_1	93	98	PF00069	0.417
MOD_NEK2_2	430	435	PF00069	0.437
MOD_PIKK_1	255	261	PF00454	0.369
MOD_PIKK_1	322	328	PF00454	0.333
MOD_PIKK_1	335	341	PF00454	0.210
MOD_PK_1	273	279	PF00069	0.430
MOD_PKA_1	3	9	PF00069	0.723
MOD_PKA_2	123	129	PF00069	0.610
MOD_PKA_2	209	215	PF00069	0.440
MOD_PKA_2	3	9	PF00069	0.723
MOD_PKA_2	537	543	PF00069	0.535
MOD_PKA_2	93	99	PF00069	0.400
MOD_PKB_1	264	272	PF00069	0.517
MOD_Plk_1	122	128	PF00069	0.602
MOD_Plk_1	248	254	PF00069	0.407
MOD_Plk_1	288	294	PF00069	0.562
MOD_Plk_1	295	301	PF00069	0.448
MOD_Plk_1	317	323	PF00069	0.358
MOD_Plk_1	344	350	PF00069	0.314
MOD_Plk_1	380	386	PF00069	0.392
MOD_Plk_1	396	402	PF00069	0.333
MOD_Plk_1	73	79	PF00069	0.365
MOD_Plk_1	94	100	PF00069	0.494
MOD_Plk_4	330	336	PF00069	0.339
MOD_Plk_4	344	350	PF00069	0.206
MOD_Plk_4	380	386	PF00069	0.357
MOD_Plk_4	430	436	PF00069	0.467
MOD_Plk_4	460	466	PF00069	0.551
MOD_Plk_4	538	544	PF00069	0.433
MOD_ProDKin_1	113	119	PF00069	0.541
MOD_ProDKin_1	299	305	PF00069	0.546
MOD_ProDKin_1	387	393	PF00069	0.299
MOD_ProDKin_1	445	451	PF00069	0.432
TRG_DiLeu_BaEn_1	221	226	PF01217	0.358
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.542
TRG_DiLeu_BaLyEn_6	446	451	PF01217	0.488
TRG_ENDOCYTIC_2	260	263	PF00928	0.491
TRG_ENDOCYTIC_2	304	307	PF00928	0.546
TRG_ENDOCYTIC_2	385	388	PF00928	0.409
TRG_ENDOCYTIC_2	431	434	PF00928	0.383
TRG_ENDOCYTIC_2	435	438	PF00928	0.374
TRG_ENDOCYTIC_2	99	102	PF00928	0.373
TRG_ER_diArg_1	177	179	PF00400	0.529
TRG_ER_diArg_1	261	264	PF00400	0.385
TRG_ER_diArg_1	3	5	PF00400	0.754
TRG_ER_diArg_1	504	506	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E5	Leptomonas seymouri	75%	100%
A0A1X0P3V6	Trypanosomatidae	48%	100%
A0A3Q8IEG6	Leishmania donovani	85%	100%
A0A3R7M8R7	Trypanosoma rangeli	50%	100%
A4I2W6	Leishmania infantum	85%	100%
D0A651	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADF3	Leishmania major	85%	100%
E9AZ76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q5ZKT1	Gallus gallus	21%	100%
Q640P7	Mus musculus	22%	100%
V5BYH8	Trypanosoma cruzi	51%	100%