BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flabarin, putative

Species:

Leishmania braziliensis

UniProt:

A4HFU7_LEIBR

TriTrypDb:

LbrM.27.1860 , LBRM2903_270024400

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.507
CLV_NRD_NRD_1	246	248	PF00675	0.578
CLV_NRD_NRD_1	249	251	PF00675	0.569
CLV_NRD_NRD_1	282	284	PF00675	0.589
CLV_NRD_NRD_1	68	70	PF00675	0.500
CLV_PCSK_KEX2_1	160	162	PF00082	0.587
CLV_PCSK_KEX2_1	246	248	PF00082	0.578
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.508
CLV_PCSK_SKI1_1	112	116	PF00082	0.475
CLV_PCSK_SKI1_1	118	122	PF00082	0.486
CLV_PCSK_SKI1_1	172	176	PF00082	0.540
CLV_PCSK_SKI1_1	187	191	PF00082	0.512
CLV_PCSK_SKI1_1	27	31	PF00082	0.619
CLV_PCSK_SKI1_1	44	48	PF00082	0.371
CLV_PCSK_SKI1_1	80	84	PF00082	0.515
DOC_MAPK_gen_1	111	122	PF00069	0.458
DOC_PP2B_PxIxI_1	330	336	PF00149	0.593
DOC_USP7_MATH_1	113	117	PF00917	0.489
DOC_USP7_MATH_1	142	146	PF00917	0.462
DOC_USP7_UBL2_3	107	111	PF12436	0.490
DOC_USP7_UBL2_3	121	125	PF12436	0.444
DOC_USP7_UBL2_3	152	156	PF12436	0.505
LIG_14-3-3_CanoR_1	250	258	PF00244	0.564
LIG_14-3-3_CanoR_1	44	53	PF00244	0.465
LIG_Actin_WH2_2	96	113	PF00022	0.453
LIG_FHA_1	15	21	PF00498	0.613
LIG_FHA_1	184	190	PF00498	0.538
LIG_FHA_1	97	103	PF00498	0.529
LIG_FHA_2	215	221	PF00498	0.648
LIG_FHA_2	46	52	PF00498	0.525
LIG_LIR_Gen_1	126	134	PF02991	0.457
LIG_LIR_Gen_1	48	57	PF02991	0.471
LIG_LIR_Nem_3	126	130	PF02991	0.598
LIG_LIR_Nem_3	42	46	PF02991	0.455
LIG_LIR_Nem_3	48	53	PF02991	0.460
LIG_SH2_CRK	127	131	PF00017	0.465
LIG_SH2_CRK	43	47	PF00017	0.482
LIG_SH2_CRK	57	61	PF00017	0.488
LIG_SH2_GRB2like	318	321	PF00017	0.666
LIG_SH2_NCK_1	318	322	PF00017	0.604
LIG_SH2_SRC	168	171	PF00017	0.371
LIG_SH2_SRC	318	321	PF00017	0.643
LIG_SH2_STAT5	197	200	PF00017	0.491
LIG_SH2_STAT5	21	24	PF00017	0.418
LIG_SH3_3	268	274	PF00018	0.625
LIG_SH3_3	99	105	PF00018	0.473
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.450
LIG_SUMO_SIM_par_1	97	104	PF11976	0.449
LIG_WRC_WIRS_1	88	93	PF05994	0.482
MOD_CK1_1	116	122	PF00069	0.356
MOD_CK1_1	35	41	PF00069	0.453
MOD_CK2_1	98	104	PF00069	0.573
MOD_GlcNHglycan	291	294	PF01048	0.878
MOD_GlcNHglycan	300	303	PF01048	0.625
MOD_GlcNHglycan	307	310	PF01048	0.600
MOD_GlcNHglycan	96	99	PF01048	0.383
MOD_GSK3_1	142	149	PF00069	0.505
MOD_GSK3_1	164	171	PF00069	0.463
MOD_GSK3_1	245	252	PF00069	0.481
MOD_GSK3_1	3	10	PF00069	0.555
MOD_GSK3_1	30	37	PF00069	0.656
MOD_GSK3_1	305	312	PF00069	0.605
MOD_GSK3_1	94	101	PF00069	0.601
MOD_N-GLC_1	266	271	PF02516	0.836
MOD_N-GLC_1	30	35	PF02516	0.520
MOD_N-GLC_1	319	324	PF02516	0.630
MOD_NEK2_1	148	153	PF00069	0.612
MOD_NEK2_1	182	187	PF00069	0.555
MOD_NEK2_1	190	195	PF00069	0.461
MOD_NEK2_1	198	203	PF00069	0.464
MOD_NEK2_1	208	213	PF00069	0.541
MOD_NEK2_1	266	271	PF00069	0.591
MOD_NEK2_1	3	8	PF00069	0.554
MOD_NEK2_1	32	37	PF00069	0.589
MOD_NEK2_2	113	118	PF00069	0.450
MOD_PIKK_1	245	251	PF00454	0.540
MOD_PIKK_1	283	289	PF00454	0.611
MOD_PKA_1	283	289	PF00069	0.692
MOD_PKA_2	245	251	PF00069	0.526
MOD_Plk_1	137	143	PF00069	0.522
MOD_Plk_1	208	214	PF00069	0.492
MOD_Plk_1	309	315	PF00069	0.687
MOD_Plk_4	185	191	PF00069	0.495
MOD_Plk_4	309	315	PF00069	0.596
MOD_SUMO_rev_2	173	182	PF00179	0.461
TRG_DiLeu_BaEn_1	67	72	PF01217	0.400
TRG_DiLeu_BaEn_4	177	183	PF01217	0.416
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.594
TRG_ENDOCYTIC_2	127	130	PF00928	0.530
TRG_ENDOCYTIC_2	43	46	PF00928	0.494
TRG_ENDOCYTIC_2	57	60	PF00928	0.604
TRG_NLS_MonoExtC_3	142	147	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG41	Leptomonas seymouri	60%	100%
A0A3Q8IKU7	Leishmania donovani	25%	100%
A0A3S5H792	Leishmania donovani	22%	100%
A0A3S5H7I1	Leishmania donovani	74%	100%
A4HZL5	Leishmania infantum	22%	100%
A4HZL6	Leishmania infantum	26%	100%
A4I2W4	Leishmania infantum	74%	100%
E9ADF0	Leishmania major	73%	100%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QCL3	Leishmania major	22%	100%
Q4QCL4	Leishmania major	27%	100%