Putative eukaryotic translation release factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation release factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HFU6_LEIBR

TriTrypDb:

LbrM.27.1850 , LBRM2903_270024300

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HFU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003747	translation release factor activity	5	11
GO:0005488	binding	1	11
GO:0008079	translation termination factor activity	4	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.428
CLV_C14_Caspase3-7	6	10	PF00656	0.657
CLV_NRD_NRD_1	139	141	PF00675	0.328
CLV_NRD_NRD_1	199	201	PF00675	0.296
CLV_NRD_NRD_1	204	206	PF00675	0.296
CLV_NRD_NRD_1	356	358	PF00675	0.228
CLV_PCSK_KEX2_1	139	141	PF00082	0.337
CLV_PCSK_KEX2_1	199	201	PF00082	0.296
CLV_PCSK_SKI1_1	110	114	PF00082	0.296
CLV_PCSK_SKI1_1	139	143	PF00082	0.329
CLV_PCSK_SKI1_1	235	239	PF00082	0.296
CLV_PCSK_SKI1_1	286	290	PF00082	0.307
CLV_PCSK_SKI1_1	5	9	PF00082	0.722
DOC_CKS1_1	40	45	PF01111	0.507
DOC_CYCLIN_RxL_1	107	117	PF00134	0.513
DOC_CYCLIN_RxL_1	120	130	PF00134	0.453
DOC_CYCLIN_RxL_1	281	291	PF00134	0.405
DOC_MAPK_gen_1	108	116	PF00069	0.506
DOC_MAPK_gen_1	247	255	PF00069	0.496
DOC_MAPK_gen_1	418	426	PF00069	0.592
DOC_MAPK_MEF2A_6	108	116	PF00069	0.520
DOC_MAPK_MEF2A_6	247	255	PF00069	0.507
DOC_PP1_RVXF_1	233	240	PF00149	0.582
DOC_PP1_SILK_1	414	419	PF00149	0.537
DOC_USP7_MATH_2	43	49	PF00917	0.430
DOC_WW_Pin1_4	39	44	PF00397	0.507
LIG_Actin_WH2_2	236	251	PF00022	0.557
LIG_Actin_WH2_2	70	87	PF00022	0.557
LIG_AP2alpha_1	448	452	PF02296	0.594
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_BRCT_BRCA1_1	230	234	PF00533	0.496
LIG_BRCT_BRCA1_1	240	244	PF00533	0.496
LIG_BRCT_BRCA1_1	374	378	PF00533	0.521
LIG_Clathr_ClatBox_1	322	326	PF01394	0.537
LIG_EH1_1	16	24	PF00400	0.447
LIG_eIF4E_1	17	23	PF01652	0.442
LIG_FHA_1	111	117	PF00498	0.507
LIG_FHA_1	133	139	PF00498	0.496
LIG_FHA_1	173	179	PF00498	0.507
LIG_FHA_1	32	38	PF00498	0.496
LIG_FHA_1	390	396	PF00498	0.537
LIG_FHA_1	402	408	PF00498	0.495
LIG_FHA_1	66	72	PF00498	0.501
LIG_FHA_1	76	82	PF00498	0.486
LIG_FHA_1	90	96	PF00498	0.496
LIG_FHA_2	289	295	PF00498	0.582
LIG_FHA_2	350	356	PF00498	0.557
LIG_FHA_2	367	373	PF00498	0.537
LIG_FHA_2	40	46	PF00498	0.507
LIG_FHA_2	6	12	PF00498	0.668
LIG_LIR_Apic_2	38	43	PF02991	0.496
LIG_LIR_Gen_1	159	167	PF02991	0.496
LIG_LIR_Gen_1	291	298	PF02991	0.537
LIG_LIR_Nem_3	117	122	PF02991	0.488
LIG_LIR_Nem_3	145	151	PF02991	0.348
LIG_LIR_Nem_3	159	163	PF02991	0.496
LIG_LIR_Nem_3	231	237	PF02991	0.507
LIG_LIR_Nem_3	291	296	PF02991	0.537
LIG_Pex14_2	448	452	PF04695	0.594
LIG_Rb_LxCxE_1	320	329	PF01857	0.502
LIG_SH2_CRK	40	44	PF00017	0.507
LIG_SH2_PTP2	333	336	PF00017	0.599
LIG_SH2_SRC	333	336	PF00017	0.599
LIG_SH2_STAT5	127	130	PF00017	0.496
LIG_SH2_STAT5	203	206	PF00017	0.496
LIG_SH2_STAT5	214	217	PF00017	0.496
LIG_SH2_STAT5	303	306	PF00017	0.489
LIG_SH2_STAT5	333	336	PF00017	0.496
LIG_SH3_1	85	91	PF00018	0.582
LIG_SH3_3	173	179	PF00018	0.496
LIG_SH3_3	255	261	PF00018	0.496
LIG_SH3_3	85	91	PF00018	0.582
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.537
LIG_SUMO_SIM_par_1	112	117	PF11976	0.520
LIG_SUMO_SIM_par_1	391	398	PF11976	0.520
LIG_SUMO_SIM_par_1	422	428	PF11976	0.500
LIG_WRC_WIRS_1	171	176	PF05994	0.507
LIG_WRC_WIRS_1	289	294	PF05994	0.537
MOD_CDK_SPK_2	39	44	PF00069	0.507
MOD_CK1_1	156	162	PF00069	0.496
MOD_CK1_1	210	216	PF00069	0.428
MOD_CK1_1	35	41	PF00069	0.496
MOD_CK1_1	397	403	PF00069	0.582
MOD_CK1_1	72	78	PF00069	0.487
MOD_CK2_1	366	372	PF00069	0.520
MOD_CK2_1	39	45	PF00069	0.507
MOD_CK2_1	5	11	PF00069	0.541
MOD_GlcNHglycan	1	4	PF01048	0.740
MOD_GlcNHglycan	154	158	PF01048	0.286
MOD_GlcNHglycan	209	212	PF01048	0.228
MOD_GlcNHglycan	230	233	PF01048	0.296
MOD_GlcNHglycan	27	30	PF01048	0.296
MOD_GlcNHglycan	271	275	PF01048	0.328
MOD_GlcNHglycan	277	280	PF01048	0.377
MOD_GlcNHglycan	47	50	PF01048	0.165
MOD_GlcNHglycan	74	77	PF01048	0.307
MOD_GlcNHglycan	98	101	PF01048	0.382
MOD_GSK3_1	210	217	PF00069	0.582
MOD_GSK3_1	31	38	PF00069	0.496
MOD_GSK3_1	397	404	PF00069	0.496
MOD_GSK3_1	59	66	PF00069	0.546
MOD_NEK2_1	153	158	PF00069	0.525
MOD_NEK2_1	25	30	PF00069	0.499
MOD_NEK2_1	288	293	PF00069	0.537
MOD_NEK2_1	32	37	PF00069	0.490
MOD_NEK2_1	96	101	PF00069	0.582
MOD_PIKK_1	297	303	PF00454	0.496
MOD_PIKK_1	366	372	PF00454	0.537
MOD_PIKK_1	397	403	PF00454	0.496
MOD_PKA_1	110	116	PF00069	0.496
MOD_Plk_1	10	16	PF00069	0.588
MOD_Plk_4	210	216	PF00069	0.582
MOD_Plk_4	288	294	PF00069	0.537
MOD_Plk_4	318	324	PF00069	0.496
MOD_Plk_4	32	38	PF00069	0.496
MOD_Plk_4	98	104	PF00069	0.492
MOD_ProDKin_1	39	45	PF00069	0.507
MOD_SUMO_rev_2	106	113	PF00179	0.497
MOD_SUMO_rev_2	125	133	PF00179	0.496
MOD_SUMO_rev_2	143	148	PF00179	0.461
MOD_SUMO_rev_2	231	237	PF00179	0.496
TRG_DiLeu_BaEn_1	402	407	PF01217	0.582
TRG_DiLeu_BaEn_2	373	379	PF01217	0.507
TRG_DiLeu_BaEn_3	136	142	PF01217	0.496
TRG_ENDOCYTIC_2	333	336	PF00928	0.543
TRG_ENDOCYTIC_2	386	389	PF00928	0.496
TRG_ER_diArg_1	138	140	PF00400	0.537
TRG_ER_diArg_1	194	197	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ2	Leptomonas seymouri	90%	100%
A0A0S4IRW3	Bodo saltans	76%	100%
A0A1X0P4B3	Trypanosomatidae	84%	100%
A0A3Q8IQ17	Leishmania donovani	97%	100%
A0A422NCC7	Trypanosoma rangeli	82%	100%
A4FX39	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	28%	100%
A4I2W3	Leishmania infantum	97%	100%
A5ULL8	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	31%	100%
A6UPD8	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	29%	100%
A6VG76	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	27%	100%
A9AAH5	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	28%	100%
B0R748	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	29%	100%
B6YU52	Thermococcus onnurineus (strain NA1)	31%	100%
B9LRF2	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	29%	100%
C5ZZZ5	Thermococcus sibiricus (strain DSM 12597 / MM 739)	31%	100%
D0A637	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
D2K759	Brassica oleracea var. botrytis	55%	100%
D2K760	Brassica oleracea var. botrytis	56%	100%
D5LHJ0	Brassica oleracea var. botrytis	54%	100%
E9AZ73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O16520	Caenorhabditis elegans	55%	76%
O26964	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	32%	100%
O29048	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	32%	100%
O59264	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O59948	Podospora anserina	55%	100%
P12385	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	55%	100%
P35614	Arabidopsis thaliana	55%	100%
P35615	Xenopus laevis	54%	100%
P58227	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	30%	100%
P61731	Methanococcus maripaludis (strain S2 / LL)	28%	100%
P62495	Homo sapiens	54%	100%
P62496	Mesocricetus auratus	54%	100%
P62497	Oryctolagus cuniculus	54%	100%
P62498	Xenopus tropicalis	55%	100%
P79063	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
Q0VCX5	Bos taurus	54%	100%
Q12V98	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	29%	100%
Q18FC0	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	30%	100%
Q2NEL3	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	30%	100%
Q39097	Arabidopsis thaliana	55%	100%
Q58239	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	30%	100%
Q5CD84	Loxodes striatus	44%	100%
Q5CD95	Blepharisma musculus	50%	100%
Q5CD96	Dileptus margaritifer	48%	100%
Q5CD97	Didinium nasutum	45%	100%
Q5CG95	Cryptosporidium hominis	53%	100%
Q5JGK6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	100%
Q5R4C7	Pongo abelii	54%	100%
Q5U2Q7	Rattus norvegicus	54%	100%
Q5UXY3	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	31%	100%
Q6KZ24	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	27%	100%
Q8BWY3	Mus musculus	54%	100%
Q8PX75	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	27%	100%
Q8TS00	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	28%	100%
Q8TUM4	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	28%	100%
Q8TXB5	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	34%	100%
Q8U0J4	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
Q8ZU81	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	26%	100%
Q97W96	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	100%
Q9BMM0	Stylonychia lemnae	50%	100%
Q9BMM1	Stylonychia mytilus	50%	100%
Q9BMM3	Blepharisma americanum	51%	100%
Q9BMX0	Dictyostelium discoideum	50%	100%
Q9BMX3	Oxytricha trifallax	49%	100%
Q9GR88	Polyandrocarpa misakiensis	57%	100%
Q9HKR2	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	30%	100%
Q9HNF0	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	29%	100%
Q9LPV8	Arabidopsis thaliana	55%	100%
Q9NAX8	Trypanosoma brucei brucei	80%	100%
Q9NCP1	Giardia intestinalis	47%	99%
Q9U8U5	Tetrahymena thermophila	48%	100%
Q9V151	Pyrococcus abyssi (strain GE5 / Orsay)	31%	100%
Q9VPH7	Drosophila melanogaster	56%	100%
Q9YAF1	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	24%	100%
V5BGE7	Trypanosoma cruzi	82%	100%