ABC transporter domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFU5_LEIBR

TriTrypDb:

LbrM.27.1840 , LBRM2903_270024200

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HFU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFU5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005215	transporter activity	1	5
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0015399	primary active transmembrane transporter activity	4	5
GO:0017076	purine nucleotide binding	4	10
GO:0022804	active transmembrane transporter activity	3	5
GO:0022857	transmembrane transporter activity	2	5
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0042626	ATPase-coupled transmembrane transporter activity	2	5
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140657	ATP-dependent activity	1	5
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0140359	ABC-type transporter activity	3	4
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.462
CLV_C14_Caspase3-7	60	64	PF00656	0.678
CLV_NRD_NRD_1	105	107	PF00675	0.363
CLV_NRD_NRD_1	14	16	PF00675	0.386
CLV_NRD_NRD_1	168	170	PF00675	0.254
CLV_NRD_NRD_1	205	207	PF00675	0.416
CLV_NRD_NRD_1	209	211	PF00675	0.269
CLV_NRD_NRD_1	233	235	PF00675	0.339
CLV_NRD_NRD_1	83	85	PF00675	0.417
CLV_PCSK_FUR_1	166	170	PF00082	0.354
CLV_PCSK_KEX2_1	105	107	PF00082	0.366
CLV_PCSK_KEX2_1	14	16	PF00082	0.386
CLV_PCSK_KEX2_1	168	170	PF00082	0.275
CLV_PCSK_KEX2_1	233	235	PF00082	0.337
CLV_PCSK_KEX2_1	83	85	PF00082	0.379
CLV_PCSK_SKI1_1	136	140	PF00082	0.273
CLV_PCSK_SKI1_1	234	238	PF00082	0.278
CLV_PCSK_SKI1_1	353	357	PF00082	0.229
CLV_PCSK_SKI1_1	415	419	PF00082	0.239
CLV_PCSK_SKI1_1	450	454	PF00082	0.383
DEG_APCC_DBOX_1	135	143	PF00400	0.432
DEG_APCC_DBOX_1	232	240	PF00400	0.534
DEG_APCC_DBOX_1	449	457	PF00400	0.235
DOC_CYCLIN_RxL_1	350	357	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.506
DOC_MAPK_DCC_7	415	424	PF00069	0.348
DOC_MAPK_gen_1	233	239	PF00069	0.478
DOC_MAPK_gen_1	359	367	PF00069	0.507
DOC_MAPK_gen_1	83	89	PF00069	0.482
DOC_MAPK_HePTP_8	412	424	PF00069	0.348
DOC_MAPK_MEF2A_6	233	241	PF00069	0.495
DOC_MAPK_MEF2A_6	415	424	PF00069	0.437
DOC_MAPK_MEF2A_6	450	457	PF00069	0.200
DOC_MAPK_MEF2A_6	482	489	PF00069	0.586
DOC_MAPK_MEF2A_6	499	507	PF00069	0.228
DOC_MAPK_MEF2A_6	83	91	PF00069	0.437
DOC_MAPK_NFAT4_5	234	242	PF00069	0.448
DOC_MAPK_NFAT4_5	450	458	PF00069	0.200
DOC_MAPK_NFAT4_5	84	92	PF00069	0.422
DOC_PP1_RVXF_1	448	455	PF00149	0.154
DOC_PP1_RVXF_1	502	508	PF00149	0.344
DOC_PP1_SILK_1	586	591	PF00149	0.328
DOC_PP2B_LxvP_1	117	120	PF13499	0.481
DOC_PP2B_LxvP_1	330	333	PF13499	0.611
DOC_PP2B_LxvP_1	500	503	PF13499	0.211
DOC_USP7_MATH_1	184	188	PF00917	0.370
DOC_USP7_MATH_1	24	28	PF00917	0.732
DOC_USP7_MATH_1	477	481	PF00917	0.381
DOC_USP7_MATH_1	510	514	PF00917	0.162
DOC_USP7_MATH_1	523	527	PF00917	0.299
DOC_USP7_MATH_1	532	536	PF00917	0.212
DOC_USP7_UBL2_3	207	211	PF12436	0.498
DOC_WW_Pin1_4	487	492	PF00397	0.474
DOC_WW_Pin1_4	609	614	PF00397	0.443
DOC_WW_Pin1_4	629	634	PF00397	0.443
DOC_WW_Pin1_4	74	79	PF00397	0.613
LIG_14-3-3_CanoR_1	15	21	PF00244	0.663
LIG_14-3-3_CanoR_1	225	229	PF00244	0.564
LIG_14-3-3_CanoR_1	353	359	PF00244	0.458
LIG_14-3-3_CanoR_1	476	482	PF00244	0.474
LIG_14-3-3_CanoR_1	58	62	PF00244	0.625
LIG_14-3-3_CanoR_1	602	607	PF00244	0.376
LIG_14-3-3_CanoR_1	625	633	PF00244	0.484
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	569	573	PF00533	0.162
LIG_EH1_1	491	499	PF00400	0.471
LIG_FHA_1	160	166	PF00498	0.583
LIG_FHA_1	217	223	PF00498	0.476
LIG_FHA_1	346	352	PF00498	0.535
LIG_FHA_1	414	420	PF00498	0.387
LIG_FHA_1	482	488	PF00498	0.527
LIG_FHA_1	669	675	PF00498	0.328
LIG_FHA_2	183	189	PF00498	0.431
LIG_FHA_2	291	297	PF00498	0.564
LIG_FHA_2	383	389	PF00498	0.633
LIG_FHA_2	436	442	PF00498	0.438
LIG_FHA_2	58	64	PF00498	0.675
LIG_GBD_Chelix_1	426	434	PF00786	0.286
LIG_HP1_1	247	251	PF01393	0.452
LIG_IRF3_LxIS_1	481	488	PF10401	0.483
LIG_LIR_Gen_1	219	229	PF02991	0.445
LIG_LIR_Gen_1	289	298	PF02991	0.512
LIG_LIR_Gen_1	380	387	PF02991	0.510
LIG_LIR_Gen_1	553	562	PF02991	0.525
LIG_LIR_Gen_1	570	580	PF02991	0.260
LIG_LIR_Gen_1	671	678	PF02991	0.317
LIG_LIR_Nem_3	219	224	PF02991	0.483
LIG_LIR_Nem_3	289	295	PF02991	0.488
LIG_LIR_Nem_3	380	386	PF02991	0.525
LIG_LIR_Nem_3	553	557	PF02991	0.443
LIG_LIR_Nem_3	570	576	PF02991	0.174
LIG_MLH1_MIPbox_1	569	573	PF16413	0.162
LIG_NRBOX	452	458	PF00104	0.271
LIG_Pex14_1	548	552	PF04695	0.491
LIG_PTB_Apo_2	357	364	PF02174	0.483
LIG_PTB_Apo_2	556	563	PF02174	0.258
LIG_PTB_Phospho_1	357	363	PF10480	0.486
LIG_PTB_Phospho_1	556	562	PF10480	0.258
LIG_SH2_CRK	565	569	PF00017	0.255
LIG_SH2_CRK	593	597	PF00017	0.242
LIG_SH2_NCK_1	61	65	PF00017	0.568
LIG_SH2_SRC	221	224	PF00017	0.442
LIG_SH2_SRC	61	64	PF00017	0.568
LIG_SH2_STAP1	134	138	PF00017	0.526
LIG_SH2_STAT3	167	170	PF00017	0.548
LIG_SH2_STAT3	363	366	PF00017	0.485
LIG_SH2_STAT3	638	641	PF00017	0.284
LIG_SH2_STAT5	173	176	PF00017	0.541
LIG_SH2_STAT5	221	224	PF00017	0.561
LIG_SH2_STAT5	235	238	PF00017	0.480
LIG_SH2_STAT5	312	315	PF00017	0.546
LIG_SH2_STAT5	396	399	PF00017	0.490
LIG_SH2_STAT5	492	495	PF00017	0.404
LIG_SH2_STAT5	554	557	PF00017	0.286
LIG_SH2_STAT5	565	568	PF00017	0.180
LIG_SH2_STAT5	638	641	PF00017	0.251
LIG_SH2_STAT5	643	646	PF00017	0.246
LIG_SH3_3	17	23	PF00018	0.586
LIG_SH3_3	241	247	PF00018	0.440
LIG_SH3_5	550	554	PF00018	0.457
LIG_SUMO_SIM_anti_2	246	254	PF11976	0.555
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.438
LIG_SUMO_SIM_anti_2	335	342	PF11976	0.570
LIG_SUMO_SIM_anti_2	526	531	PF11976	0.211
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.508
LIG_SUMO_SIM_anti_2	657	663	PF11976	0.288
LIG_SUMO_SIM_par_1	246	254	PF11976	0.458
LIG_SUMO_SIM_par_1	433	439	PF11976	0.431
LIG_SUMO_SIM_par_1	523	528	PF11976	0.358
LIG_SxIP_EBH_1	572	581	PF03271	0.360
LIG_TYR_ITIM	591	596	PF00017	0.402
LIG_TYR_ITSM	217	224	PF00017	0.339
LIG_WRC_WIRS_1	355	360	PF05994	0.245
LIG_WRC_WIRS_1	533	538	PF05994	0.334
LIG_WW_1	393	396	PF00397	0.485
MOD_CK1_1	129	135	PF00069	0.395
MOD_CK1_1	286	292	PF00069	0.322
MOD_CK1_1	38	44	PF00069	0.756
MOD_CK1_1	575	581	PF00069	0.363
MOD_CK1_1	612	618	PF00069	0.567
MOD_CK1_1	621	627	PF00069	0.523
MOD_CK1_1	650	656	PF00069	0.361
MOD_CK1_1	8	14	PF00069	0.695
MOD_CK2_1	182	188	PF00069	0.358
MOD_CK2_1	382	388	PF00069	0.502
MOD_CK2_1	435	441	PF00069	0.421
MOD_CK2_1	612	618	PF00069	0.530
MOD_CK2_1	82	88	PF00069	0.415
MOD_GlcNHglycan	10	13	PF01048	0.683
MOD_GlcNHglycan	26	29	PF01048	0.425
MOD_GlcNHglycan	285	288	PF01048	0.336
MOD_GlcNHglycan	304	307	PF01048	0.389
MOD_GlcNHglycan	37	40	PF01048	0.689
MOD_GlcNHglycan	569	572	PF01048	0.299
MOD_GlcNHglycan	625	628	PF01048	0.564
MOD_GlcNHglycan	656	659	PF01048	0.241
MOD_GlcNHglycan	680	683	PF01048	0.512
MOD_GlcNHglycan	84	87	PF01048	0.419
MOD_GSK3_1	107	114	PF00069	0.468
MOD_GSK3_1	125	132	PF00069	0.236
MOD_GSK3_1	156	163	PF00069	0.523
MOD_GSK3_1	279	286	PF00069	0.408
MOD_GSK3_1	34	41	PF00069	0.721
MOD_GSK3_1	345	352	PF00069	0.419
MOD_GSK3_1	354	361	PF00069	0.316
MOD_GSK3_1	4	11	PF00069	0.684
MOD_GSK3_1	477	484	PF00069	0.301
MOD_GSK3_1	52	59	PF00069	0.512
MOD_GSK3_1	608	615	PF00069	0.571
MOD_GSK3_1	617	624	PF00069	0.577
MOD_GSK3_1	625	632	PF00069	0.415
MOD_GSK3_1	650	657	PF00069	0.386
MOD_GSK3_1	668	675	PF00069	0.240
MOD_N-GLC_1	279	284	PF02516	0.373
MOD_N-GLC_1	52	57	PF02516	0.495
MOD_N-GLC_1	621	626	PF02516	0.467
MOD_N-GLC_2	113	115	PF02516	0.248
MOD_NEK2_1	156	161	PF00069	0.515
MOD_NEK2_1	182	187	PF00069	0.341
MOD_NEK2_1	358	363	PF00069	0.289
MOD_NEK2_1	455	460	PF00069	0.288
MOD_NEK2_1	481	486	PF00069	0.353
MOD_NEK2_1	493	498	PF00069	0.203
MOD_NEK2_1	52	57	PF00069	0.616
MOD_NEK2_1	531	536	PF00069	0.270
MOD_NEK2_1	572	577	PF00069	0.375
MOD_NEK2_1	6	11	PF00069	0.620
MOD_NEK2_1	617	622	PF00069	0.653
MOD_NEK2_1	636	641	PF00069	0.224
MOD_NEK2_1	662	667	PF00069	0.247
MOD_NEK2_1	672	677	PF00069	0.237
MOD_NEK2_2	126	131	PF00069	0.251
MOD_NEK2_2	354	359	PF00069	0.384
MOD_NEK2_2	477	482	PF00069	0.209
MOD_PKA_2	16	22	PF00069	0.591
MOD_PKA_2	224	230	PF00069	0.462
MOD_PKA_2	358	364	PF00069	0.366
MOD_PKA_2	57	63	PF00069	0.523
MOD_PKA_2	82	88	PF00069	0.468
MOD_PKB_1	375	383	PF00069	0.364
MOD_Plk_1	182	188	PF00069	0.287
MOD_Plk_1	52	58	PF00069	0.741
MOD_Plk_1	650	656	PF00069	0.442
MOD_Plk_1	87	93	PF00069	0.357
MOD_Plk_4	16	22	PF00069	0.608
MOD_Plk_4	224	230	PF00069	0.479
MOD_Plk_4	279	285	PF00069	0.436
MOD_Plk_4	299	305	PF00069	0.423
MOD_Plk_4	307	313	PF00069	0.406
MOD_Plk_4	462	468	PF00069	0.242
MOD_Plk_4	493	499	PF00069	0.265
MOD_Plk_4	52	58	PF00069	0.644
MOD_Plk_4	525	531	PF00069	0.190
MOD_Plk_4	584	590	PF00069	0.270
MOD_ProDKin_1	487	493	PF00069	0.335
MOD_ProDKin_1	609	615	PF00069	0.577
MOD_ProDKin_1	629	635	PF00069	0.565
MOD_ProDKin_1	74	80	PF00069	0.531
MOD_SUMO_for_1	468	471	PF00179	0.340
MOD_SUMO_rev_2	199	209	PF00179	0.241
MOD_SUMO_rev_2	305	311	PF00179	0.382
TRG_DiLeu_BaEn_1	246	251	PF01217	0.315
TRG_ENDOCYTIC_2	221	224	PF00928	0.342
TRG_ENDOCYTIC_2	396	399	PF00928	0.415
TRG_ENDOCYTIC_2	554	557	PF00928	0.308
TRG_ENDOCYTIC_2	565	568	PF00928	0.185
TRG_ENDOCYTIC_2	593	596	PF00928	0.293
TRG_ENDOCYTIC_2	643	646	PF00928	0.294
TRG_ER_diArg_1	104	106	PF00400	0.512
TRG_ER_diArg_1	13	15	PF00400	0.485
TRG_ER_diArg_1	167	169	PF00400	0.379
TRG_ER_diArg_1	233	235	PF00400	0.315
TRG_ER_diArg_1	375	378	PF00400	0.437
TRG_ER_diArg_1	601	604	PF00400	0.372
TRG_ER_diArg_1	99	102	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I194	Leptomonas seymouri	54%	83%
A0A0S4IZ09	Bodo saltans	37%	100%
A0A0S4KMF6	Bodo saltans	24%	85%
A0A1X0P4K0	Trypanosomatidae	33%	100%
A0A3Q8IDI3	Leishmania donovani	77%	100%
A0A3R7MIF6	Trypanosoma rangeli	32%	100%
A4I2W2	Leishmania infantum	77%	100%
E9ADE9	Leishmania major	75%	100%
Q4GZT4	Bos taurus	22%	100%
Q8MIB3	Sus scrofa	22%	100%
V5B0X3	Trypanosoma cruzi	34%	100%
V5BLN9	Trypanosoma cruzi	24%	99%