TAP-C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFU3_LEIBR

TriTrypDb:

LbrM.27.1820 , LBRM2903_270024000

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	18
GO:0042995	cell projection	2	18
GO:0043226	organelle	2	18
GO:0043227	membrane-bounded organelle	3	18
GO:0110165	cellular anatomical entity	1	18
GO:0120025	plasma membrane bounded cell projection	3	18
GO:0005634	nucleus	5	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

A4HFU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFU3

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	3
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	3
GO:0016973	poly(A)+ mRNA export from nucleus	7	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	3
GO:0050658	RNA transport	4	3
GO:0051028	mRNA transport	5	3
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051236	establishment of RNA localization	3	3
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	489	491	PF00675	0.488
CLV_PCSK_KEX2_1	124	126	PF00082	0.605
CLV_PCSK_KEX2_1	198	200	PF00082	0.481
CLV_PCSK_KEX2_1	488	490	PF00082	0.500
CLV_PCSK_KEX2_1	539	541	PF00082	0.584
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.605
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.526
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.447
CLV_PCSK_SKI1_1	160	164	PF00082	0.464
CLV_PCSK_SKI1_1	176	180	PF00082	0.353
CLV_PCSK_SKI1_1	240	244	PF00082	0.598
CLV_PCSK_SKI1_1	30	34	PF00082	0.685
CLV_PCSK_SKI1_1	539	543	PF00082	0.608
CLV_PCSK_SKI1_1	86	90	PF00082	0.450
CLV_Separin_Metazoa	139	143	PF03568	0.532
DOC_CYCLIN_RxL_1	144	158	PF00134	0.537
DOC_CYCLIN_RxL_1	83	90	PF00134	0.568
DOC_CYCLIN_yClb1_LxF_4	188	194	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.423
DOC_MAPK_DCC_7	222	232	PF00069	0.609
DOC_MAPK_gen_1	142	151	PF00069	0.468
DOC_MAPK_MEF2A_6	225	232	PF00069	0.490
DOC_MAPK_MEF2A_6	370	378	PF00069	0.564
DOC_MAPK_MEF2A_6	514	522	PF00069	0.603
DOC_MAPK_MEF2A_6	86	93	PF00069	0.540
DOC_MAPK_NFAT4_5	86	94	PF00069	0.553
DOC_PP2B_LxvP_1	243	246	PF13499	0.559
DOC_PP2B_LxvP_1	521	524	PF13499	0.582
DOC_USP7_MATH_1	248	252	PF00917	0.621
DOC_USP7_MATH_1	32	36	PF00917	0.700
DOC_USP7_MATH_1	341	345	PF00917	0.663
DOC_USP7_MATH_1	506	510	PF00917	0.567
DOC_USP7_MATH_1	530	534	PF00917	0.601
DOC_USP7_MATH_2	355	361	PF00917	0.418
DOC_WW_Pin1_4	113	118	PF00397	0.542
DOC_WW_Pin1_4	467	472	PF00397	0.587
DOC_WW_Pin1_4	477	482	PF00397	0.582
DOC_WW_Pin1_4	493	498	PF00397	0.442
DOC_WW_Pin1_4	55	60	PF00397	0.539
LIG_14-3-3_CanoR_1	332	340	PF00244	0.521
LIG_Actin_WH2_2	317	334	PF00022	0.492
LIG_APCC_ABBAyCdc20_2	462	468	PF00400	0.677
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BIR_III_4	103	107	PF00653	0.333
LIG_BRCT_BRCA1_1	129	133	PF00533	0.426
LIG_BRCT_BRCA1_1	333	337	PF00533	0.459
LIG_BRCT_BRCA1_1	430	434	PF00533	0.449
LIG_BRCT_BRCA1_1	89	93	PF00533	0.505
LIG_BRCT_BRCA1_1	97	101	PF00533	0.493
LIG_BRCT_BRCA1_2	129	135	PF00533	0.438
LIG_BRCT_BRCA1_2	89	95	PF00533	0.550
LIG_FHA_1	311	317	PF00498	0.532
LIG_FHA_1	435	441	PF00498	0.349
LIG_FHA_1	446	452	PF00498	0.365
LIG_FHA_1	494	500	PF00498	0.510
LIG_FHA_2	430	436	PF00498	0.481
LIG_FHA_2	505	511	PF00498	0.562
LIG_IRF3_LxIS_1	289	295	PF10401	0.549
LIG_LIR_Gen_1	127	136	PF02991	0.433
LIG_LIR_Gen_1	268	278	PF02991	0.568
LIG_LIR_Gen_1	287	294	PF02991	0.555
LIG_LIR_Gen_1	94	104	PF02991	0.577
LIG_LIR_Nem_3	127	131	PF02991	0.437
LIG_LIR_Nem_3	275	281	PF02991	0.508
LIG_LIR_Nem_3	287	292	PF02991	0.534
LIG_LIR_Nem_3	327	331	PF02991	0.477
LIG_LIR_Nem_3	334	340	PF02991	0.536
LIG_LIR_Nem_3	441	445	PF02991	0.594
LIG_LIR_Nem_3	94	100	PF02991	0.574
LIG_LRP6_Inhibitor_1	154	160	PF00058	0.400
LIG_MLH1_MIPbox_1	430	434	PF16413	0.492
LIG_MYND_1	117	121	PF01753	0.494
LIG_NRBOX	87	93	PF00104	0.427
LIG_PCNA_PIPBox_1	258	267	PF02747	0.528
LIG_PDZ_Class_2	539	544	PF00595	0.374
LIG_Pex14_2	378	382	PF04695	0.598
LIG_PTB_Apo_2	376	383	PF02174	0.585
LIG_REV1ctd_RIR_1	431	440	PF16727	0.417
LIG_SH2_CRK	128	132	PF00017	0.547
LIG_SH2_CRK	200	204	PF00017	0.537
LIG_SH2_CRK	278	282	PF00017	0.491
LIG_SH2_NCK_1	128	132	PF00017	0.547
LIG_SH2_NCK_1	278	282	PF00017	0.414
LIG_SH2_NCK_1	97	101	PF00017	0.533
LIG_SH2_SRC	283	286	PF00017	0.392
LIG_SH2_STAP1	219	223	PF00017	0.434
LIG_SH2_STAP1	97	101	PF00017	0.584
LIG_SH2_STAT3	264	267	PF00017	0.566
LIG_SH2_STAT3	285	288	PF00017	0.571
LIG_SH2_STAT5	10	13	PF00017	0.604
LIG_SH2_STAT5	264	267	PF00017	0.526
LIG_SH2_STAT5	283	286	PF00017	0.529
LIG_SH2_STAT5	408	411	PF00017	0.422
LIG_SH3_3	409	415	PF00018	0.481
LIG_SH3_3	417	423	PF00018	0.420
LIG_SH3_3	468	474	PF00018	0.680
LIG_SUMO_SIM_par_1	435	441	PF11976	0.482
LIG_TRAF2_1	509	512	PF00917	0.476
LIG_TYR_ITIM	126	131	PF00017	0.544
LIG_UBA3_1	88	95	PF00899	0.424
LIG_WRC_WIRS_1	430	435	PF05994	0.536
MOD_CDK_SPxK_1	477	483	PF00069	0.629
MOD_CK1_1	16	22	PF00069	0.770
MOD_CK1_1	192	198	PF00069	0.504
MOD_CK1_1	272	278	PF00069	0.530
MOD_CK1_1	287	293	PF00069	0.524
MOD_CK1_1	344	350	PF00069	0.607
MOD_CK1_1	390	396	PF00069	0.477
MOD_CK1_1	444	450	PF00069	0.407
MOD_CK1_1	76	82	PF00069	0.618
MOD_CK2_1	505	511	PF00069	0.582
MOD_CK2_1	530	536	PF00069	0.540
MOD_Cter_Amidation	5	8	PF01082	0.639
MOD_GlcNHglycan	18	21	PF01048	0.769
MOD_GlcNHglycan	181	184	PF01048	0.410
MOD_GlcNHglycan	194	197	PF01048	0.372
MOD_GlcNHglycan	250	253	PF01048	0.709
MOD_GlcNHglycan	289	292	PF01048	0.496
MOD_GlcNHglycan	307	310	PF01048	0.467
MOD_GlcNHglycan	34	37	PF01048	0.826
MOD_GlcNHglycan	343	346	PF01048	0.652
MOD_GlcNHglycan	43	46	PF01048	0.738
MOD_GlcNHglycan	50	53	PF01048	0.558
MOD_GlcNHglycan	75	78	PF01048	0.711
MOD_GSK3_1	217	224	PF00069	0.605
MOD_GSK3_1	248	255	PF00069	0.622
MOD_GSK3_1	265	272	PF00069	0.442
MOD_GSK3_1	326	333	PF00069	0.602
MOD_GSK3_1	414	421	PF00069	0.505
MOD_GSK3_1	434	441	PF00069	0.390
MOD_GSK3_1	443	450	PF00069	0.420
MOD_GSK3_1	64	71	PF00069	0.771
MOD_N-GLC_1	108	113	PF02516	0.468
MOD_N-GLC_1	13	18	PF02516	0.574
MOD_N-GLC_1	504	509	PF02516	0.592
MOD_N-GLC_1	68	73	PF02516	0.756
MOD_N-GLC_2	364	366	PF02516	0.347
MOD_NEK2_1	108	113	PF00069	0.475
MOD_NEK2_1	265	270	PF00069	0.437
MOD_NEK2_1	284	289	PF00069	0.491
MOD_NEK2_1	292	297	PF00069	0.430
MOD_NEK2_1	387	392	PF00069	0.558
MOD_NEK2_1	429	434	PF00069	0.426
MOD_NEK2_1	93	98	PF00069	0.476
MOD_NEK2_2	398	403	PF00069	0.425
MOD_PIKK_1	252	258	PF00454	0.532
MOD_PIKK_1	284	290	PF00454	0.595
MOD_PIKK_1	331	337	PF00454	0.640
MOD_PK_1	370	376	PF00069	0.392
MOD_PKA_2	221	227	PF00069	0.545
MOD_PKA_2	331	337	PF00069	0.559
MOD_PKA_2	48	54	PF00069	0.672
MOD_Plk_1	155	161	PF00069	0.533
MOD_Plk_1	189	195	PF00069	0.485
MOD_Plk_1	265	271	PF00069	0.552
MOD_Plk_1	387	393	PF00069	0.472
MOD_Plk_1	434	440	PF00069	0.396
MOD_Plk_1	93	99	PF00069	0.583
MOD_Plk_4	189	195	PF00069	0.510
MOD_Plk_4	257	263	PF00069	0.537
MOD_Plk_4	265	271	PF00069	0.404
MOD_Plk_4	429	435	PF00069	0.503
MOD_Plk_4	87	93	PF00069	0.432
MOD_ProDKin_1	113	119	PF00069	0.536
MOD_ProDKin_1	467	473	PF00069	0.590
MOD_ProDKin_1	477	483	PF00069	0.576
MOD_ProDKin_1	493	499	PF00069	0.433
MOD_ProDKin_1	55	61	PF00069	0.541
MOD_SUMO_rev_2	508	516	PF00179	0.610
TRG_ENDOCYTIC_2	128	131	PF00928	0.543
TRG_ENDOCYTIC_2	200	203	PF00928	0.454
TRG_ENDOCYTIC_2	278	281	PF00928	0.495
TRG_ENDOCYTIC_2	97	100	PF00928	0.574
TRG_ER_diArg_1	148	151	PF00400	0.552
TRG_ER_diArg_1	487	490	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	24%	87%
A0A0N0P8S6	Leptomonas seymouri	73%	100%
A0A0S4IRU5	Bodo saltans	26%	100%
A0A0S4IW66	Bodo saltans	27%	100%
A0A1X0P4A3	Trypanosomatidae	45%	100%
A0A1X0P4L1	Trypanosomatidae	25%	93%
A0A3R7NID6	Trypanosoma rangeli	25%	93%
A0A3S7X0T0	Leishmania donovani	87%	100%
A4HFU4	Leishmania braziliensis	23%	88%
A4I2W0	Leishmania infantum	87%	100%
D0A641	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A644	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ADE7	Leishmania major	88%	98%
E9AZ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
V5B0W6	Trypanosoma cruzi	26%	94%
V5BQG4	Trypanosoma cruzi	43%	100%