Adenylyltransferase and sulfurtransferase MOCS3 homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

molybdopterin synthase sulphurylase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFU1_LEIBR

TriTrypDb:

LbrM.27.1800 , LBRM2903_270023800

Length:

455

Annotations

LeishMANIAdb annotations

Homlogous to mammalian MOCS3. Non-TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	4

Expansion

Sequence features

A4HFU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFU1

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	10
GO:0002098	tRNA wobble uridine modification	8	10
GO:0002143	tRNA wobble position uridine thiolation	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006400	tRNA modification	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034227	tRNA thio-modification	7	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004792	thiosulfate sulfurtransferase activity	5	10
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0016782	transferase activity, transferring sulphur-containing groups	3	10
GO:0016783	sulfurtransferase activity	4	10
GO:0016874	ligase activity	2	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0042292	URM1 activating enzyme activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.246
CLV_C14_Caspase3-7	205	209	PF00656	0.351
CLV_C14_Caspase3-7	4	8	PF00656	0.546
CLV_NRD_NRD_1	398	400	PF00675	0.246
CLV_PCSK_KEX2_1	398	400	PF00082	0.246
CLV_PCSK_SKI1_1	191	195	PF00082	0.440
CLV_PCSK_SKI1_1	229	233	PF00082	0.510
CLV_PCSK_SKI1_1	241	245	PF00082	0.293
CLV_PCSK_SKI1_1	253	257	PF00082	0.264
CLV_PCSK_SKI1_1	32	36	PF00082	0.298
CLV_PCSK_SKI1_1	327	331	PF00082	0.338
CLV_PCSK_SKI1_1	411	415	PF00082	0.303
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DEG_SPOP_SBC_1	297	301	PF00917	0.539
DOC_PP4_FxxP_1	194	197	PF00568	0.246
DOC_USP7_MATH_1	108	112	PF00917	0.296
DOC_USP7_MATH_1	14	18	PF00917	0.583
DOC_USP7_MATH_1	166	170	PF00917	0.246
DOC_USP7_MATH_1	202	206	PF00917	0.188
DOC_USP7_MATH_1	297	301	PF00917	0.662
DOC_USP7_MATH_1	3	7	PF00917	0.668
DOC_USP7_MATH_1	303	307	PF00917	0.572
DOC_USP7_MATH_1	351	355	PF00917	0.551
DOC_WW_Pin1_4	126	131	PF00397	0.307
DOC_WW_Pin1_4	273	278	PF00397	0.604
DOC_WW_Pin1_4	298	303	PF00397	0.698
LIG_14-3-3_CanoR_1	135	144	PF00244	0.338
LIG_14-3-3_CanoR_1	305	312	PF00244	0.547
LIG_14-3-3_CanoR_1	327	332	PF00244	0.535
LIG_14-3-3_CanoR_1	399	405	PF00244	0.447
LIG_14-3-3_CanoR_1	423	429	PF00244	0.498
LIG_Actin_WH2_2	215	231	PF00022	0.351
LIG_Actin_WH2_2	389	407	PF00022	0.462
LIG_BIR_III_2	274	278	PF00653	0.548
LIG_EVH1_1	194	198	PF00568	0.246
LIG_FHA_1	137	143	PF00498	0.315
LIG_FHA_1	145	151	PF00498	0.243
LIG_FHA_1	249	255	PF00498	0.450
LIG_FHA_1	328	334	PF00498	0.505
LIG_FHA_1	405	411	PF00498	0.442
LIG_FHA_1	61	67	PF00498	0.298
LIG_FHA_1	95	101	PF00498	0.282
LIG_FHA_2	385	391	PF00498	0.433
LIG_FHA_2	75	81	PF00498	0.351
LIG_FXI_DFP_1	78	82	PF00024	0.457
LIG_GBD_Chelix_1	364	372	PF00786	0.332
LIG_LIR_Gen_1	80	89	PF02991	0.246
LIG_LIR_Nem_3	449	455	PF02991	0.550
LIG_LIR_Nem_3	80	84	PF02991	0.246
LIG_SH2_CRK	190	194	PF00017	0.271
LIG_SH2_STAP1	312	316	PF00017	0.623
LIG_SH2_STAT3	432	435	PF00017	0.516
LIG_SH2_STAT5	154	157	PF00017	0.256
LIG_SH2_STAT5	289	292	PF00017	0.597
LIG_SH2_STAT5	298	301	PF00017	0.651
LIG_SH2_STAT5	394	397	PF00017	0.507
LIG_SH2_STAT5	432	435	PF00017	0.551
LIG_SH2_STAT5	67	70	PF00017	0.336
LIG_SH3_3	192	198	PF00018	0.237
LIG_SH3_3	208	214	PF00018	0.234
LIG_SH3_3	345	351	PF00018	0.457
LIG_SH3_3	97	103	PF00018	0.231
LIG_Sin3_3	406	413	PF02671	0.462
LIG_SUMO_SIM_anti_2	280	285	PF11976	0.454
LIG_TRAF2_1	413	416	PF00917	0.474
MOD_CDK_SPxxK_3	298	305	PF00069	0.528
MOD_CK2_1	128	134	PF00069	0.253
MOD_CK2_1	305	311	PF00069	0.574
MOD_CK2_1	384	390	PF00069	0.532
MOD_GlcNHglycan	106	109	PF01048	0.454
MOD_GlcNHglycan	16	19	PF01048	0.383
MOD_GlcNHglycan	168	171	PF01048	0.444
MOD_GlcNHglycan	208	211	PF01048	0.544
MOD_GlcNHglycan	238	241	PF01048	0.273
MOD_GlcNHglycan	267	270	PF01048	0.389
MOD_GlcNHglycan	307	310	PF01048	0.363
MOD_GlcNHglycan	379	382	PF01048	0.333
MOD_GlcNHglycan	437	440	PF01048	0.351
MOD_GSK3_1	104	111	PF00069	0.276
MOD_GSK3_1	14	21	PF00069	0.598
MOD_GSK3_1	202	209	PF00069	0.248
MOD_GSK3_1	303	310	PF00069	0.536
MOD_GSK3_1	400	407	PF00069	0.474
MOD_N-GLC_1	206	211	PF02516	0.446
MOD_N-GLC_1	435	440	PF02516	0.351
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	248	253	PF00069	0.519
MOD_NEK2_1	404	409	PF00069	0.374
MOD_NEK2_1	60	65	PF00069	0.298
MOD_NEK2_2	177	182	PF00069	0.236
MOD_NEK2_2	400	405	PF00069	0.497
MOD_PKA_2	422	428	PF00069	0.480
MOD_PKA_2	74	80	PF00069	0.351
MOD_Plk_4	177	183	PF00069	0.236
MOD_Plk_4	360	366	PF00069	0.537
MOD_Plk_4	60	66	PF00069	0.361
MOD_Plk_4	74	80	PF00069	0.300
MOD_ProDKin_1	126	132	PF00069	0.307
MOD_ProDKin_1	273	279	PF00069	0.604
MOD_ProDKin_1	298	304	PF00069	0.695
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.174
TRG_ENDOCYTIC_2	190	193	PF00928	0.271
TRG_ENDOCYTIC_2	352	355	PF00928	0.532
TRG_ER_diArg_1	257	260	PF00400	0.459
TRG_ER_diArg_1	333	336	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E8	Leptomonas seymouri	65%	100%
A0A0S4JY12	Bodo saltans	46%	94%
A0A1X0P4G1	Trypanosomatidae	48%	84%
A0A3Q8IDE2	Leishmania donovani	80%	98%
A0A422NC72	Trypanosoma rangeli	52%	92%
A1A4L8	Bos taurus	39%	100%
A1CAZ7	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	36%	92%
A1DED8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	36%	94%
A2BDX3	Mus musculus	39%	99%
A2R3H4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	94%
A3ACF3	Oryza sativa subsp. japonica	34%	100%
A3LQF9	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	33%	100%
A4I2V9	Leishmania infantum	80%	98%
A4RPM5	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	34%	93%
A5DMB6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	32%	100%
A5DSR2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	32%	100%
A5GFZ6	Sus scrofa	39%	100%
A6ZT19	Saccharomyces cerevisiae (strain YJM789)	33%	100%
A7F582	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	32%	100%
A7THV5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	32%	100%
A8WRE3	Caenorhabditis briggsae	35%	100%
B0W377	Culex quinquefasciatus	39%	100%
B0Y0P7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	35%	92%
B3LSM6	Saccharomyces cerevisiae (strain RM11-1a)	33%	100%
B3MLX7	Drosophila ananassae	36%	100%
B4FAT0	Zea mays	38%	94%
B4GKQ3	Drosophila persimilis	35%	100%
B4HYP0	Drosophila sechellia	36%	100%
B4JBC4	Drosophila grimshawi	35%	100%
B4KI53	Drosophila mojavensis	35%	100%
B4LRB9	Drosophila virilis	36%	100%
B4N7R4	Drosophila willistoni	35%	100%
B4NXF7	Drosophila yakuba	36%	100%
B5DS72	Drosophila pseudoobscura pseudoobscura	35%	100%
B5VK45	Saccharomyces cerevisiae (strain AWRI1631)	33%	100%
B6TNK6	Zea mays	40%	97%
D0A640	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	90%
E9ADE6	Leishmania major	77%	99%
E9AZ70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
O44510	Caenorhabditis elegans	35%	100%
O59954	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	94%
O95396	Homo sapiens	39%	99%
P38820	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P51335	Porphyra purpurea	31%	100%
Q09810	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q0CFD4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	37%	94%
Q17CA7	Aedes aegypti	38%	100%
Q1XDF1	Neopyropia yezoensis	30%	100%
Q29PG5	Drosophila pseudoobscura pseudoobscura	35%	100%
Q2TWN3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	98%
Q4WV19	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	92%
Q55FS0	Dictyostelium discoideum	34%	100%
Q58E95	Xenopus laevis	34%	100%
Q59WH7	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	100%
Q6BHZ2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	34%	100%
Q6CBK1	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	100%
Q6CMC2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	100%
Q6FR35	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	34%	100%
Q756K6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	100%
Q7PY41	Anopheles gambiae	40%	100%
Q8AWD2	Danio rerio	37%	99%
Q9VLJ8	Drosophila melanogaster	35%	100%
Q9ZNW0	Arabidopsis thaliana	38%	98%
V5B0X0	Trypanosoma cruzi	50%	92%