BRO1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRO1-like domain/ALIX V-shaped domain binding to HIV, putative

Species:

Leishmania braziliensis

UniProt:

A4HFU0_LEIBR

TriTrypDb:

LbrM.27.1770 , LBRM2903_270023500

Length:

1023

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFU0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0071985	multivesicular body sorting pathway	5	11
GO:0006886	intracellular protein transport	4	1
GO:0007034	vacuolar transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	5	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072665	protein localization to vacuole	6	1
GO:0072666	establishment of protein localization to vacuole	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	642	646	PF00656	0.555
CLV_C14_Caspase3-7	654	658	PF00656	0.391
CLV_C14_Caspase3-7	67	71	PF00656	0.261
CLV_C14_Caspase3-7	754	758	PF00656	0.373
CLV_NRD_NRD_1	298	300	PF00675	0.383
CLV_NRD_NRD_1	414	416	PF00675	0.483
CLV_NRD_NRD_1	779	781	PF00675	0.472
CLV_PCSK_KEX2_1	194	196	PF00082	0.364
CLV_PCSK_KEX2_1	254	256	PF00082	0.228
CLV_PCSK_KEX2_1	778	780	PF00082	0.469
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.386
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.249
CLV_PCSK_SKI1_1	107	111	PF00082	0.397
CLV_PCSK_SKI1_1	13	17	PF00082	0.442
CLV_PCSK_SKI1_1	299	303	PF00082	0.448
CLV_PCSK_SKI1_1	736	740	PF00082	0.281
CLV_Separin_Metazoa	446	450	PF03568	0.510
DEG_APCC_DBOX_1	194	202	PF00400	0.315
DOC_CKS1_1	830	835	PF01111	0.459
DOC_CYCLIN_RxL_1	101	115	PF00134	0.331
DOC_MAPK_gen_1	274	283	PF00069	0.383
DOC_MAPK_gen_1	299	308	PF00069	0.315
DOC_MAPK_gen_1	333	343	PF00069	0.383
DOC_MAPK_gen_1	397	406	PF00069	0.274
DOC_MAPK_MEF2A_6	274	283	PF00069	0.332
DOC_MAPK_NFAT4_5	276	284	PF00069	0.328
DOC_PP1_RVXF_1	105	112	PF00149	0.328
DOC_PP1_RVXF_1	566	572	PF00149	0.415
DOC_PP1_RVXF_1	995	1001	PF00149	0.394
DOC_PP2B_LxvP_1	892	895	PF13499	0.390
DOC_USP7_MATH_1	337	341	PF00917	0.274
DOC_USP7_MATH_1	447	451	PF00917	0.561
DOC_USP7_MATH_1	465	469	PF00917	0.357
DOC_USP7_MATH_1	51	55	PF00917	0.383
DOC_USP7_MATH_1	75	79	PF00917	0.293
DOC_USP7_MATH_1	762	766	PF00917	0.455
DOC_USP7_MATH_1	825	829	PF00917	0.590
DOC_USP7_MATH_1	880	884	PF00917	0.423
DOC_USP7_MATH_1	935	939	PF00917	0.410
DOC_USP7_MATH_1	99	103	PF00917	0.383
DOC_USP7_UBL2_3	160	164	PF12436	0.250
DOC_USP7_UBL2_3	190	194	PF12436	0.383
DOC_USP7_UBL2_3	661	665	PF12436	0.544
DOC_WW_Pin1_4	1013	1018	PF00397	0.443
DOC_WW_Pin1_4	458	463	PF00397	0.539
DOC_WW_Pin1_4	524	529	PF00397	0.510
DOC_WW_Pin1_4	7	12	PF00397	0.468
DOC_WW_Pin1_4	71	76	PF00397	0.366
DOC_WW_Pin1_4	829	834	PF00397	0.483
DOC_WW_Pin1_4	840	845	PF00397	0.484
DOC_WW_Pin1_4	869	874	PF00397	0.475
DOC_WW_Pin1_4	931	936	PF00397	0.400
LIG_14-3-3_CanoR_1	1013	1017	PF00244	0.440
LIG_14-3-3_CanoR_1	310	319	PF00244	0.291
LIG_14-3-3_CanoR_1	371	380	PF00244	0.291
LIG_14-3-3_CanoR_1	415	422	PF00244	0.487
LIG_14-3-3_CanoR_1	837	842	PF00244	0.439
LIG_14-3-3_CterR_2	1018	1023	PF00244	0.443
LIG_AP2alpha_2	379	381	PF02296	0.268
LIG_APCC_ABBA_1	549	554	PF00400	0.461
LIG_APCC_ABBA_1	579	584	PF00400	0.446
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BRCT_BRCA1_1	339	343	PF00533	0.271
LIG_BRCT_BRCA1_1	434	438	PF00533	0.497
LIG_CSL_BTD_1	909	912	PF09270	0.405
LIG_Dynein_DLC8_1	414	420	PF01221	0.429
LIG_FHA_1	175	181	PF00498	0.440
LIG_FHA_1	311	317	PF00498	0.328
LIG_FHA_1	360	366	PF00498	0.253
LIG_FHA_1	422	428	PF00498	0.449
LIG_FHA_1	43	49	PF00498	0.267
LIG_FHA_1	464	470	PF00498	0.442
LIG_FHA_1	687	693	PF00498	0.510
LIG_FHA_1	723	729	PF00498	0.353
LIG_FHA_1	897	903	PF00498	0.397
LIG_FHA_1	937	943	PF00498	0.385
LIG_FHA_2	119	125	PF00498	0.372
LIG_FHA_2	187	193	PF00498	0.409
LIG_FHA_2	327	333	PF00498	0.319
LIG_FHA_2	373	379	PF00498	0.358
LIG_FHA_2	44	50	PF00498	0.383
LIG_FHA_2	640	646	PF00498	0.420
LIG_FHA_2	65	71	PF00498	0.348
LIG_FHA_2	72	78	PF00498	0.263
LIG_FHA_2	732	738	PF00498	0.353
LIG_FHA_2	741	747	PF00498	0.430
LIG_FHA_2	872	878	PF00498	0.436
LIG_LIR_Gen_1	12	21	PF02991	0.268
LIG_LIR_Gen_1	142	151	PF02991	0.250
LIG_LIR_Gen_1	340	351	PF02991	0.297
LIG_LIR_Gen_1	527	537	PF02991	0.487
LIG_LIR_Gen_1	708	718	PF02991	0.415
LIG_LIR_Nem_3	12	17	PF02991	0.324
LIG_LIR_Nem_3	142	148	PF02991	0.250
LIG_LIR_Nem_3	161	166	PF02991	0.419
LIG_LIR_Nem_3	340	346	PF02991	0.297
LIG_LIR_Nem_3	378	384	PF02991	0.265
LIG_LIR_Nem_3	514	520	PF02991	0.496
LIG_LIR_Nem_3	527	533	PF02991	0.455
LIG_LIR_Nem_3	708	713	PF02991	0.415
LIG_LIR_Nem_3	716	720	PF02991	0.415
LIG_LIR_Nem_3	926	931	PF02991	0.514
LIG_MLH1_MIPbox_1	339	343	PF16413	0.268
LIG_PDZ_Class_1	1018	1023	PF00595	0.443
LIG_Pex14_1	113	117	PF04695	0.250
LIG_SH2_CRK	143	147	PF00017	0.198
LIG_SH2_CRK	530	534	PF00017	0.437
LIG_SH2_CRK	801	805	PF00017	0.611
LIG_SH2_CRK	87	91	PF00017	0.268
LIG_SH2_GRB2like	58	61	PF00017	0.315
LIG_SH2_NCK_1	137	141	PF00017	0.250
LIG_SH2_NCK_1	173	177	PF00017	0.250
LIG_SH2_PTP2	145	148	PF00017	0.300
LIG_SH2_SRC	143	146	PF00017	0.364
LIG_SH2_SRC	239	242	PF00017	0.268
LIG_SH2_SRC	508	511	PF00017	0.510
LIG_SH2_SRC	801	804	PF00017	0.592
LIG_SH2_STAP1	143	147	PF00017	0.198
LIG_SH2_STAP1	239	243	PF00017	0.268
LIG_SH2_STAP1	862	866	PF00017	0.441
LIG_SH2_STAT5	145	148	PF00017	0.312
LIG_SH2_STAT5	214	217	PF00017	0.297
LIG_SH2_STAT5	342	345	PF00017	0.252
LIG_SH2_STAT5	35	38	PF00017	0.373
LIG_SH2_STAT5	508	511	PF00017	0.463
LIG_SH2_STAT5	530	533	PF00017	0.503
LIG_SH2_STAT5	741	744	PF00017	0.569
LIG_SH2_STAT5	87	90	PF00017	0.250
LIG_SH2_STAT5	945	948	PF00017	0.395
LIG_SH3_3	347	353	PF00018	0.254
LIG_SH3_3	441	447	PF00018	0.328
LIG_SH3_3	827	833	PF00018	0.486
LIG_SH3_3	838	844	PF00018	0.511
LIG_SH3_3	926	932	PF00018	0.411
LIG_SUMO_SIM_par_1	688	695	PF11976	0.353
LIG_SUMO_SIM_par_1	899	905	PF11976	0.402
LIG_SxIP_EBH_1	908	917	PF03271	0.409
LIG_TRAF2_1	155	158	PF00917	0.163
LIG_TRAF2_1	285	288	PF00917	0.163
LIG_TRAF2_1	329	332	PF00917	0.186
LIG_TRAF2_1	375	378	PF00917	0.163
LIG_TRAF2_1	617	620	PF00917	0.447
LIG_TYR_ITIM	85	90	PF00017	0.383
LIG_UBA3_1	452	460	PF00899	0.383
LIG_WRC_WIRS_1	114	119	PF05994	0.287
LIG_WRC_WIRS_1	243	248	PF05994	0.315
MOD_CDC14_SPxK_1	10	13	PF00782	0.239
MOD_CDK_SPK_2	1013	1018	PF00069	0.443
MOD_CDK_SPxK_1	7	13	PF00069	0.399
MOD_CK1_1	1011	1017	PF00069	0.436
MOD_CK1_1	125	131	PF00069	0.384
MOD_CK1_1	229	235	PF00069	0.293
MOD_CK1_1	30	36	PF00069	0.330
MOD_CK1_1	322	328	PF00069	0.297
MOD_CK1_1	359	365	PF00069	0.330
MOD_CK1_1	417	423	PF00069	0.475
MOD_CK1_1	42	48	PF00069	0.253
MOD_CK1_1	463	469	PF00069	0.376
MOD_CK1_1	475	481	PF00069	0.263
MOD_CK1_1	524	530	PF00069	0.245
MOD_CK1_1	635	641	PF00069	0.373
MOD_CK1_1	71	77	PF00069	0.315
MOD_CK1_1	740	746	PF00069	0.178
MOD_CK1_1	840	846	PF00069	0.478
MOD_CK1_1	882	888	PF00069	0.413
MOD_CK1_1	968	974	PF00069	0.429
MOD_CK2_1	118	124	PF00069	0.364
MOD_CK2_1	125	131	PF00069	0.358
MOD_CK2_1	152	158	PF00069	0.256
MOD_CK2_1	282	288	PF00069	0.163
MOD_CK2_1	326	332	PF00069	0.191
MOD_CK2_1	371	377	PF00069	0.315
MOD_CK2_1	535	541	PF00069	0.465
MOD_CK2_1	634	640	PF00069	0.268
MOD_CK2_1	71	77	PF00069	0.255
MOD_CK2_1	731	737	PF00069	0.334
MOD_CK2_1	740	746	PF00069	0.193
MOD_CK2_1	871	877	PF00069	0.438
MOD_CMANNOS	992	995	PF00535	0.391
MOD_GlcNHglycan	1	4	PF01048	0.687
MOD_GlcNHglycan	101	104	PF01048	0.383
MOD_GlcNHglycan	160	163	PF01048	0.327
MOD_GlcNHglycan	325	328	PF01048	0.315
MOD_GlcNHglycan	385	388	PF01048	0.465
MOD_GlcNHglycan	393	396	PF01048	0.380
MOD_GlcNHglycan	434	437	PF01048	0.428
MOD_GlcNHglycan	462	465	PF01048	0.433
MOD_GlcNHglycan	477	480	PF01048	0.282
MOD_GlcNHglycan	493	497	PF01048	0.315
MOD_GlcNHglycan	533	536	PF01048	0.373
MOD_GlcNHglycan	591	594	PF01048	0.383
MOD_GlcNHglycan	846	849	PF01048	0.501
MOD_GlcNHglycan	852	855	PF01048	0.450
MOD_GlcNHglycan	882	885	PF01048	0.420
MOD_GlcNHglycan	967	970	PF01048	0.425
MOD_GSK3_1	1	8	PF00069	0.412
MOD_GSK3_1	1008	1015	PF00069	0.430
MOD_GSK3_1	118	125	PF00069	0.156
MOD_GSK3_1	127	134	PF00069	0.305
MOD_GSK3_1	146	153	PF00069	0.424
MOD_GSK3_1	242	249	PF00069	0.251
MOD_GSK3_1	310	317	PF00069	0.315
MOD_GSK3_1	319	326	PF00069	0.287
MOD_GSK3_1	35	42	PF00069	0.305
MOD_GSK3_1	411	418	PF00069	0.392
MOD_GSK3_1	463	470	PF00069	0.320
MOD_GSK3_1	531	538	PF00069	0.443
MOD_GSK3_1	634	641	PF00069	0.291
MOD_GSK3_1	64	71	PF00069	0.295
MOD_GSK3_1	649	656	PF00069	0.201
MOD_GSK3_1	682	689	PF00069	0.383
MOD_GSK3_1	737	744	PF00069	0.270
MOD_GSK3_1	825	832	PF00069	0.511
MOD_GSK3_1	840	847	PF00069	0.420
MOD_GSK3_1	856	863	PF00069	0.628
MOD_GSK3_1	896	903	PF00069	0.407
MOD_GSK3_1	906	913	PF00069	0.457
MOD_GSK3_1	931	938	PF00069	0.436
MOD_GSK3_1	968	975	PF00069	0.427
MOD_GSK3_1	99	106	PF00069	0.347
MOD_N-GLC_1	337	342	PF02516	0.284
MOD_N-GLC_1	42	47	PF02516	0.279
MOD_N-GLC_1	458	463	PF02516	0.383
MOD_N-GLC_1	524	529	PF02516	0.163
MOD_N-GLC_1	75	80	PF02516	0.357
MOD_N-GLC_2	269	271	PF02516	0.245
MOD_N-GLC_2	705	707	PF02516	0.268
MOD_N-GLC_2	961	963	PF02516	0.420
MOD_NEK2_1	139	144	PF00069	0.250
MOD_NEK2_1	175	180	PF00069	0.383
MOD_NEK2_1	246	251	PF00069	0.294
MOD_NEK2_1	473	478	PF00069	0.263
MOD_NEK2_1	605	610	PF00069	0.355
MOD_NEK2_1	632	637	PF00069	0.270
MOD_NEK2_1	68	73	PF00069	0.352
MOD_NEK2_1	896	901	PF00069	0.396
MOD_NEK2_2	1008	1013	PF00069	0.428
MOD_NEK2_2	217	222	PF00069	0.315
MOD_NEK2_2	337	342	PF00069	0.328
MOD_NEK2_2	361	366	PF00069	0.163
MOD_OFUCOSY	1002	1007	PF10250	0.401
MOD_PIKK_1	146	152	PF00454	0.383
MOD_PIKK_1	310	316	PF00454	0.315
MOD_PIKK_1	415	421	PF00454	0.527
MOD_PIKK_1	639	645	PF00454	0.279
MOD_PIKK_1	762	768	PF00454	0.542
MOD_PIKK_1	769	775	PF00454	0.487
MOD_PIKK_1	792	798	PF00454	0.608
MOD_PIKK_1	825	831	PF00454	0.469
MOD_PIKK_1	856	862	PF00454	0.561
MOD_PIKK_1	974	980	PF00454	0.418
MOD_PK_1	837	843	PF00069	0.436
MOD_PKA_1	194	200	PF00069	0.347
MOD_PKA_1	415	421	PF00069	0.539
MOD_PKA_2	1012	1018	PF00069	0.419
MOD_PKA_2	194	200	PF00069	0.414
MOD_PKA_2	309	315	PF00069	0.291
MOD_PKA_2	414	420	PF00069	0.493
MOD_PKA_2	501	507	PF00069	0.186
MOD_PKA_2	856	862	PF00069	0.414
MOD_PKA_2	965	971	PF00069	0.431
MOD_PKA_2	993	999	PF00069	0.389
MOD_Plk_1	217	223	PF00069	0.299
MOD_Plk_1	27	33	PF00069	0.328
MOD_Plk_1	337	343	PF00069	0.250
MOD_Plk_1	43	49	PF00069	0.128
MOD_Plk_1	731	737	PF00069	0.383
MOD_Plk_1	75	81	PF00069	0.286
MOD_Plk_4	175	181	PF00069	0.383
MOD_Plk_4	246	252	PF00069	0.323
MOD_Plk_4	314	320	PF00069	0.390
MOD_Plk_4	337	343	PF00069	0.354
MOD_Plk_4	58	64	PF00069	0.299
MOD_Plk_4	705	711	PF00069	0.268
MOD_Plk_4	75	81	PF00069	0.250
MOD_Plk_4	937	943	PF00069	0.385
MOD_ProDKin_1	1013	1019	PF00069	0.444
MOD_ProDKin_1	458	464	PF00069	0.423
MOD_ProDKin_1	524	530	PF00069	0.383
MOD_ProDKin_1	7	13	PF00069	0.467
MOD_ProDKin_1	71	77	PF00069	0.366
MOD_ProDKin_1	829	835	PF00069	0.484
MOD_ProDKin_1	840	846	PF00069	0.484
MOD_ProDKin_1	869	875	PF00069	0.473
MOD_ProDKin_1	931	937	PF00069	0.399
MOD_SUMO_for_1	215	218	PF00179	0.250
MOD_SUMO_for_1	283	286	PF00179	0.221
MOD_SUMO_rev_2	155	162	PF00179	0.302
MOD_SUMO_rev_2	326	334	PF00179	0.443
MOD_SUMO_rev_2	457	462	PF00179	0.315
MOD_SUMO_rev_2	482	491	PF00179	0.393
MOD_SUMO_rev_2	613	623	PF00179	0.246
MOD_SUMO_rev_2	69	74	PF00179	0.220
MOD_SUMO_rev_2	732	740	PF00179	0.163
TRG_DiLeu_BaEn_1	628	633	PF01217	0.195
TRG_DiLeu_BaEn_4	618	624	PF01217	0.268
TRG_DiLeu_BaLyEn_6	892	897	PF01217	0.393
TRG_ENDOCYTIC_2	114	117	PF00928	0.245
TRG_ENDOCYTIC_2	143	146	PF00928	0.328
TRG_ENDOCYTIC_2	163	166	PF00928	0.128
TRG_ENDOCYTIC_2	172	175	PF00928	0.214
TRG_ENDOCYTIC_2	239	242	PF00928	0.268
TRG_ENDOCYTIC_2	530	533	PF00928	0.257
TRG_ENDOCYTIC_2	710	713	PF00928	0.250
TRG_ENDOCYTIC_2	87	90	PF00928	0.250
TRG_ENDOCYTIC_2	945	948	PF00928	0.414
TRG_ER_diArg_1	441	444	PF00400	0.511
TRG_ER_diArg_1	609	612	PF00400	0.237
TRG_ER_diArg_1	778	780	PF00400	0.541
TRG_NES_CRM1_1	196	208	PF08389	0.355
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	670	675	PF00026	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T8	Leptomonas seymouri	73%	100%
A0A1X0P4J9	Trypanosomatidae	50%	100%
A0A3S7X0S6	Leishmania donovani	86%	100%
A0A422N9P5	Trypanosoma rangeli	48%	100%
A4I2V6	Leishmania infantum	86%	100%
D0A635	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ADE3	Leishmania major	86%	100%
E9AZ67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q8T7K0	Dictyostelium discoideum	21%	100%
V5BQH3	Trypanosoma cruzi	50%	100%