Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inner dynein arm I1 intermediate chain, axonemal

Species:

Leishmania braziliensis

UniProt:

A4HFT9_LEIBR

TriTrypDb:

LbrM.27.1760 , LBRM2903_270023300 , LBRM2903_270023400

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036156	inner dynein arm	5	1
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	1
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HFT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFT9

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036159	inner dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060294	cilium movement involved in cell motility	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.563
CLV_C14_Caspase3-7	462	466	PF00656	0.518
CLV_C14_Caspase3-7	555	559	PF00656	0.332
CLV_C14_Caspase3-7	733	737	PF00656	0.733
CLV_NRD_NRD_1	111	113	PF00675	0.551
CLV_NRD_NRD_1	123	125	PF00675	0.426
CLV_NRD_NRD_1	212	214	PF00675	0.534
CLV_NRD_NRD_1	225	227	PF00675	0.574
CLV_NRD_NRD_1	248	250	PF00675	0.592
CLV_NRD_NRD_1	33	35	PF00675	0.662
CLV_NRD_NRD_1	437	439	PF00675	0.451
CLV_NRD_NRD_1	510	512	PF00675	0.565
CLV_NRD_NRD_1	641	643	PF00675	0.451
CLV_NRD_NRD_1	685	687	PF00675	0.337
CLV_NRD_NRD_1	745	747	PF00675	0.701
CLV_PCSK_KEX2_1	111	113	PF00082	0.641
CLV_PCSK_KEX2_1	123	125	PF00082	0.623
CLV_PCSK_KEX2_1	224	226	PF00082	0.565
CLV_PCSK_KEX2_1	248	250	PF00082	0.483
CLV_PCSK_KEX2_1	510	512	PF00082	0.525
CLV_PCSK_KEX2_1	641	643	PF00082	0.557
CLV_PCSK_KEX2_1	685	687	PF00082	0.404
CLV_PCSK_KEX2_1	745	747	PF00082	0.701
CLV_PCSK_PC7_1	221	227	PF00082	0.505
CLV_PCSK_SKI1_1	154	158	PF00082	0.524
CLV_PCSK_SKI1_1	163	167	PF00082	0.548
CLV_PCSK_SKI1_1	267	271	PF00082	0.350
CLV_PCSK_SKI1_1	438	442	PF00082	0.503
CLV_PCSK_SKI1_1	474	478	PF00082	0.527
CLV_PCSK_SKI1_1	677	681	PF00082	0.368
CLV_PCSK_SKI1_1	746	750	PF00082	0.726
CLV_Separin_Metazoa	346	350	PF03568	0.569
CLV_Separin_Metazoa	96	100	PF03568	0.559
DEG_APCC_DBOX_1	153	161	PF00400	0.300
DEG_APCC_DBOX_1	590	598	PF00400	0.442
DEG_APCC_DBOX_1	779	787	PF00400	0.373
DEG_APCC_KENBOX_2	731	735	PF00400	0.459
DEG_COP1_1	509	519	PF00400	0.518
DOC_CYCLIN_RxL_1	159	169	PF00134	0.416
DOC_CYCLIN_RxL_1	264	274	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.427
DOC_MAPK_gen_1	224	232	PF00069	0.369
DOC_MAPK_gen_1	248	256	PF00069	0.418
DOC_MAPK_gen_1	510	516	PF00069	0.629
DOC_MAPK_gen_1	562	572	PF00069	0.456
DOC_MAPK_gen_1	641	649	PF00069	0.385
DOC_MAPK_MEF2A_6	50	57	PF00069	0.531
DOC_PP1_RVXF_1	393	399	PF00149	0.357
DOC_PP2B_LxvP_1	270	273	PF13499	0.358
DOC_PP2B_LxvP_1	568	571	PF13499	0.380
DOC_USP7_MATH_1	290	294	PF00917	0.521
DOC_USP7_MATH_1	626	630	PF00917	0.464
DOC_USP7_MATH_1	737	741	PF00917	0.477
DOC_WW_Pin1_4	482	487	PF00397	0.327
DOC_WW_Pin1_4	585	590	PF00397	0.404
LIG_14-3-3_CanoR_1	445	453	PF00244	0.371
LIG_14-3-3_CanoR_1	50	56	PF00244	0.505
LIG_14-3-3_CanoR_1	510	517	PF00244	0.692
LIG_14-3-3_CanoR_1	526	532	PF00244	0.303
LIG_14-3-3_CanoR_1	641	649	PF00244	0.437
LIG_14-3-3_CanoR_1	66	76	PF00244	0.537
LIG_14-3-3_CanoR_1	693	701	PF00244	0.516
LIG_Actin_WH2_2	1	18	PF00022	0.489
LIG_Actin_WH2_2	340	357	PF00022	0.557
LIG_APCC_ABBA_1	174	179	PF00400	0.413
LIG_APCC_ABBA_1	53	58	PF00400	0.556
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	628	632	PF00533	0.468
LIG_Clathr_ClatBox_1	197	201	PF01394	0.500
LIG_CSL_BTD_1	452	455	PF09270	0.344
LIG_CSL_BTD_1	586	589	PF09270	0.447
LIG_deltaCOP1_diTrp_1	388	398	PF00928	0.519
LIG_deltaCOP1_diTrp_1	691	694	PF00928	0.521
LIG_eIF4E_1	643	649	PF01652	0.454
LIG_FHA_1	3	9	PF00498	0.512
LIG_FHA_1	37	43	PF00498	0.444
LIG_FHA_1	419	425	PF00498	0.477
LIG_FHA_1	523	529	PF00498	0.405
LIG_FHA_1	617	623	PF00498	0.515
LIG_FHA_1	642	648	PF00498	0.373
LIG_FHA_1	682	688	PF00498	0.488
LIG_FHA_1	736	742	PF00498	0.461
LIG_FHA_2	132	138	PF00498	0.585
LIG_FHA_2	191	197	PF00498	0.432
LIG_FHA_2	237	243	PF00498	0.531
LIG_FHA_2	413	419	PF00498	0.429
LIG_FHA_2	460	466	PF00498	0.582
LIG_FHA_2	493	499	PF00498	0.339
LIG_FHA_2	553	559	PF00498	0.356
LIG_IBAR_NPY_1	759	761	PF08397	0.653
LIG_LIR_Apic_2	169	175	PF02991	0.531
LIG_LIR_Gen_1	227	237	PF02991	0.405
LIG_LIR_Gen_1	410	419	PF02991	0.389
LIG_LIR_Gen_1	485	493	PF02991	0.376
LIG_LIR_Gen_1	498	506	PF02991	0.468
LIG_LIR_Gen_1	605	614	PF02991	0.516
LIG_LIR_Gen_1	768	778	PF02991	0.553
LIG_LIR_Nem_3	178	184	PF02991	0.485
LIG_LIR_Nem_3	227	232	PF02991	0.415
LIG_LIR_Nem_3	23	27	PF02991	0.409
LIG_LIR_Nem_3	340	344	PF02991	0.706
LIG_LIR_Nem_3	410	416	PF02991	0.384
LIG_LIR_Nem_3	450	456	PF02991	0.389
LIG_LIR_Nem_3	485	491	PF02991	0.316
LIG_LIR_Nem_3	605	610	PF02991	0.486
LIG_LIR_Nem_3	629	635	PF02991	0.414
LIG_LIR_Nem_3	655	661	PF02991	0.298
LIG_LIR_Nem_3	768	774	PF02991	0.394
LIG_MYND_1	368	372	PF01753	0.387
LIG_PCNA_PIPBox_1	150	159	PF02747	0.425
LIG_PCNA_yPIPBox_3	147	157	PF02747	0.476
LIG_PDZ_Class_1	787	792	PF00595	0.582
LIG_Pex14_2	473	477	PF04695	0.327
LIG_PTB_Apo_2	89	96	PF02174	0.599
LIG_PTB_Phospho_1	89	95	PF10480	0.598
LIG_SH2_CRK	172	176	PF00017	0.531
LIG_SH2_CRK	488	492	PF00017	0.232
LIG_SH2_CRK	566	570	PF00017	0.490
LIG_SH2_NCK_1	573	577	PF00017	0.439
LIG_SH2_PTP2	659	662	PF00017	0.425
LIG_SH2_STAP1	177	181	PF00017	0.532
LIG_SH2_STAP1	488	492	PF00017	0.422
LIG_SH2_STAP1	643	647	PF00017	0.465
LIG_SH2_STAP1	690	694	PF00017	0.472
LIG_SH2_STAT3	643	646	PF00017	0.472
LIG_SH2_STAT5	177	180	PF00017	0.565
LIG_SH2_STAT5	205	208	PF00017	0.393
LIG_SH2_STAT5	268	271	PF00017	0.467
LIG_SH2_STAT5	521	524	PF00017	0.501
LIG_SH2_STAT5	541	544	PF00017	0.293
LIG_SH2_STAT5	553	556	PF00017	0.328
LIG_SH2_STAT5	643	646	PF00017	0.354
LIG_SH2_STAT5	659	662	PF00017	0.431
LIG_SH2_STAT5	675	678	PF00017	0.356
LIG_SH2_STAT5	75	78	PF00017	0.567
LIG_SH3_1	573	579	PF00018	0.327
LIG_SH3_2	45	50	PF14604	0.666
LIG_SH3_3	14	20	PF00018	0.595
LIG_SH3_3	140	146	PF00018	0.546
LIG_SH3_3	260	266	PF00018	0.382
LIG_SH3_3	280	286	PF00018	0.238
LIG_SH3_3	345	351	PF00018	0.550
LIG_SH3_3	362	368	PF00018	0.325
LIG_SH3_3	39	45	PF00018	0.690
LIG_SH3_3	449	455	PF00018	0.450
LIG_SH3_3	573	579	PF00018	0.500
LIG_SH3_3	586	592	PF00018	0.410
LIG_SH3_3	657	663	PF00018	0.270
LIG_SH3_3	87	93	PF00018	0.562
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.471
LIG_SUMO_SIM_anti_2	251	259	PF11976	0.432
LIG_SUMO_SIM_anti_2	768	776	PF11976	0.471
LIG_SUMO_SIM_par_1	195	201	PF11976	0.411
LIG_SUMO_SIM_par_1	593	599	PF11976	0.301
LIG_SUMO_SIM_par_1	602	608	PF11976	0.296
LIG_TRAF2_1	146	149	PF00917	0.504
LIG_TRAF2_1	272	275	PF00917	0.395
LIG_TRAF2_1	29	32	PF00917	0.617
LIG_TRFH_1	659	663	PF08558	0.364
LIG_WRC_WIRS_1	516	521	PF05994	0.615
LIG_WRC_WIRS_1	653	658	PF05994	0.301
MOD_CDC14_SPxK_1	588	591	PF00782	0.396
MOD_CDK_SPxK_1	585	591	PF00069	0.358
MOD_CK1_1	116	122	PF00069	0.616
MOD_CK1_1	216	222	PF00069	0.352
MOD_CK1_1	252	258	PF00069	0.528
MOD_CK1_1	26	32	PF00069	0.490
MOD_CK1_1	313	319	PF00069	0.572
MOD_CK1_1	373	379	PF00069	0.309
MOD_CK1_1	444	450	PF00069	0.377
MOD_CK1_1	46	52	PF00069	0.387
MOD_CK1_1	666	672	PF00069	0.473
MOD_CK2_1	190	196	PF00069	0.549
MOD_CK2_1	236	242	PF00069	0.443
MOD_CK2_1	26	32	PF00069	0.490
MOD_CK2_1	373	379	PF00069	0.459
MOD_CK2_1	412	418	PF00069	0.447
MOD_CK2_1	444	450	PF00069	0.461
MOD_CK2_1	492	498	PF00069	0.316
MOD_CK2_1	666	672	PF00069	0.487
MOD_Cter_Amidation	211	214	PF01082	0.491
MOD_Cter_Amidation	222	225	PF01082	0.462
MOD_GlcNHglycan	215	218	PF01048	0.387
MOD_GlcNHglycan	221	224	PF01048	0.342
MOD_GlcNHglycan	533	536	PF01048	0.363
MOD_GlcNHglycan	69	72	PF01048	0.666
MOD_GSK3_1	110	117	PF00069	0.640
MOD_GSK3_1	414	421	PF00069	0.478
MOD_GSK3_1	441	448	PF00069	0.380
MOD_GSK3_1	478	485	PF00069	0.364
MOD_GSK3_1	515	522	PF00069	0.599
MOD_GSK3_1	527	534	PF00069	0.396
MOD_GSK3_1	637	644	PF00069	0.485
MOD_GSK3_1	648	655	PF00069	0.247
MOD_GSK3_1	692	699	PF00069	0.540
MOD_GSK3_1	713	720	PF00069	0.594
MOD_LATS_1	508	514	PF00433	0.617
MOD_N-GLC_1	207	212	PF02516	0.292
MOD_N-GLC_1	313	318	PF02516	0.447
MOD_N-GLC_1	407	412	PF02516	0.505
MOD_N-GLC_2	478	480	PF02516	0.395
MOD_NEK2_1	166	171	PF00069	0.529
MOD_NEK2_1	527	532	PF00069	0.473
MOD_NEK2_1	648	653	PF00069	0.412
MOD_NEK2_1	713	718	PF00069	0.520
MOD_PIKK_1	114	120	PF00454	0.496
MOD_PIKK_1	166	172	PF00454	0.527
MOD_PIKK_1	2	8	PF00454	0.362
MOD_PIKK_1	313	319	PF00454	0.516
MOD_PIKK_1	370	376	PF00454	0.289
MOD_PIKK_1	641	647	PF00454	0.516
MOD_PK_1	510	516	PF00069	0.629
MOD_PKA_1	111	117	PF00069	0.396
MOD_PKA_1	213	219	PF00069	0.488
MOD_PKA_1	510	516	PF00069	0.629
MOD_PKA_1	641	647	PF00069	0.401
MOD_PKA_2	110	116	PF00069	0.655
MOD_PKA_2	20	26	PF00069	0.406
MOD_PKA_2	284	290	PF00069	0.256
MOD_PKA_2	444	450	PF00069	0.377
MOD_PKA_2	509	515	PF00069	0.623
MOD_PKA_2	637	643	PF00069	0.514
MOD_PKA_2	666	672	PF00069	0.514
MOD_PKA_2	67	73	PF00069	0.590
MOD_PKA_2	681	687	PF00069	0.326
MOD_PKA_2	692	698	PF00069	0.383
MOD_PKA_2	713	719	PF00069	0.578
MOD_Plk_1	250	256	PF00069	0.508
MOD_Plk_2-3	696	702	PF00069	0.422
MOD_Plk_2-3	86	92	PF00069	0.566
MOD_Plk_4	131	137	PF00069	0.481
MOD_Plk_4	252	258	PF00069	0.437
MOD_Plk_4	284	290	PF00069	0.272
MOD_Plk_4	402	408	PF00069	0.543
MOD_Plk_4	418	424	PF00069	0.485
MOD_Plk_4	500	506	PF00069	0.461
MOD_Plk_4	510	516	PF00069	0.574
MOD_Plk_4	737	743	PF00069	0.460
MOD_ProDKin_1	482	488	PF00069	0.320
MOD_ProDKin_1	585	591	PF00069	0.403
MOD_SUMO_for_1	146	149	PF00179	0.554
MOD_SUMO_for_1	748	751	PF00179	0.455
MOD_SUMO_rev_2	397	405	PF00179	0.392
MOD_SUMO_rev_2	666	676	PF00179	0.427
TRG_DiLeu_BaEn_1	605	610	PF01217	0.460
TRG_DiLeu_BaEn_1	770	775	PF01217	0.466
TRG_DiLeu_BaEn_4	148	154	PF01217	0.482
TRG_DiLeu_BaEn_4	274	280	PF01217	0.378
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.359
TRG_ENDOCYTIC_2	488	491	PF00928	0.293
TRG_ENDOCYTIC_2	566	569	PF00928	0.488
TRG_ENDOCYTIC_2	95	98	PF00928	0.556
TRG_ER_diArg_1	110	112	PF00400	0.643
TRG_ER_diArg_1	123	125	PF00400	0.623
TRG_ER_diArg_1	224	226	PF00400	0.551
TRG_ER_diArg_1	641	643	PF00400	0.451
TRG_ER_diArg_1	65	68	PF00400	0.559
TRG_ER_diArg_1	685	687	PF00400	0.375
TRG_ER_diArg_1	745	747	PF00400	0.583
TRG_NLS_MonoExtN_4	436	442	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2KIZ8	Danio rerio	25%	82%
A0A0N1PF46	Leptomonas seymouri	71%	91%
A0A0S4JPP6	Bodo saltans	42%	100%
A0A1X0P495	Trypanosomatidae	47%	95%
A0A3Q8IEC3	Leishmania donovani	86%	94%
A0A3S7X5B2	Leishmania donovani	25%	100%
A0A422N9T1	Trypanosoma rangeli	48%	98%
A4I2V5	Leishmania infantum	86%	94%
A4I7S3	Leishmania infantum	25%	100%
B2RY71	Mus musculus	24%	86%
D0A634	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9ADE2	Leishmania major	86%	100%
E9AZ66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	95%
Q8IWG1	Homo sapiens	23%	89%
Q95JP0	Macaca fascicularis	22%	89%
V5BGF1	Trypanosoma cruzi	47%	98%