Putative eukaryotic translation initiation factor eIF-4E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-1

Species:

Leishmania braziliensis

UniProt:

A4HFT8_LEIBR

TriTrypDb:

LbrM.27.1750 , LBRM2903_270023200

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFT8

PDB structure(s): 5wb5_A

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000339	RNA cap binding	5	1
GO:0000340	RNA 7-methylguanosine cap binding	6	1
GO:0000342	RNA cap 4 binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.412
CLV_NRD_NRD_1	165	167	PF00675	0.270
CLV_PCSK_KEX2_1	165	167	PF00082	0.270
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.283
CLV_PCSK_SKI1_1	189	193	PF00082	0.340
CLV_PCSK_SKI1_1	58	62	PF00082	0.364
DOC_MAPK_gen_1	165	174	PF00069	0.470
DOC_MAPK_gen_1	89	100	PF00069	0.529
DOC_MAPK_MEF2A_6	167	176	PF00069	0.470
DOC_MAPK_MEF2A_6	89	98	PF00069	0.483
DOC_USP7_MATH_1	117	121	PF00917	0.608
DOC_USP7_MATH_1	200	204	PF00917	0.652
DOC_USP7_UBL2_3	190	194	PF12436	0.483
DOC_USP7_UBL2_3	89	93	PF12436	0.470
DOC_WW_Pin1_4	25	30	PF00397	0.539
LIG_14-3-3_CanoR_1	20	25	PF00244	0.501
LIG_14-3-3_CanoR_1	67	75	PF00244	0.475
LIG_Actin_WH2_2	53	69	PF00022	0.564
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BRCT_BRCA1_1	202	206	PF00533	0.688
LIG_BRCT_BRCA1_2	202	208	PF00533	0.685
LIG_CaM_NSCaTE_8	132	139	PF13499	0.564
LIG_FHA_1	157	163	PF00498	0.564
LIG_FHA_1	180	186	PF00498	0.564
LIG_FHA_2	124	130	PF00498	0.480
LIG_FHA_2	137	143	PF00498	0.449
LIG_Integrin_isoDGR_2	104	106	PF01839	0.324
LIG_LIR_Apic_2	23	29	PF02991	0.564
LIG_LIR_Gen_1	129	140	PF02991	0.485
LIG_LIR_Gen_1	51	62	PF02991	0.470
LIG_LIR_Gen_1	69	79	PF02991	0.470
LIG_LIR_Nem_3	129	135	PF02991	0.490
LIG_LIR_Nem_3	51	57	PF02991	0.470
LIG_LIR_Nem_3	69	75	PF02991	0.470
LIG_PCNA_PIPBox_1	137	146	PF02747	0.483
LIG_Pex14_1	22	26	PF04695	0.470
LIG_Rb_LxCxE_1	139	159	PF01857	0.412
LIG_SH2_CRK	26	30	PF00017	0.470
LIG_SH2_CRK	59	63	PF00017	0.470
LIG_SH2_GRB2like	168	171	PF00017	0.483
LIG_SH2_NCK_1	26	30	PF00017	0.483
LIG_SH2_STAT5	143	146	PF00017	0.488
LIG_SUMO_SIM_anti_2	182	189	PF11976	0.412
LIG_TRAF2_1	49	52	PF00917	0.526
LIG_UBA3_1	56	61	PF00899	0.564
MOD_CK1_1	108	114	PF00069	0.537
MOD_CK1_1	177	183	PF00069	0.564
MOD_CK1_1	2	8	PF00069	0.714
MOD_CK1_1	28	34	PF00069	0.480
MOD_CK2_1	117	123	PF00069	0.526
MOD_CK2_1	136	142	PF00069	0.393
MOD_CK2_1	46	52	PF00069	0.520
MOD_CMANNOS	22	25	PF00535	0.270
MOD_GlcNHglycan	1	4	PF01048	0.720
MOD_GlcNHglycan	112	115	PF01048	0.319
MOD_GlcNHglycan	118	122	PF01048	0.331
MOD_GlcNHglycan	151	155	PF01048	0.281
MOD_GlcNHglycan	178	182	PF01048	0.301
MOD_GlcNHglycan	5	8	PF01048	0.740
MOD_GSK3_1	100	107	PF00069	0.571
MOD_GSK3_1	190	197	PF00069	0.541
MOD_GSK3_1	200	207	PF00069	0.528
MOD_GSK3_1	27	34	PF00069	0.483
MOD_N-GLC_1	108	113	PF02516	0.308
MOD_NEK2_1	136	141	PF00069	0.524
MOD_NEK2_1	66	71	PF00069	0.476
MOD_NEK2_1	98	103	PF00069	0.581
MOD_NEK2_2	43	48	PF00069	0.564
MOD_PIKK_1	67	73	PF00454	0.564
MOD_PKA_2	105	111	PF00069	0.564
MOD_PKA_2	66	72	PF00069	0.476
MOD_Plk_1	194	200	PF00069	0.524
MOD_Plk_1	37	43	PF00069	0.482
MOD_Plk_2-3	123	129	PF00069	0.481
MOD_Plk_4	200	206	PF00069	0.685
MOD_Plk_4	37	43	PF00069	0.470
MOD_ProDKin_1	25	31	PF00069	0.539
MOD_SUMO_rev_2	118	126	PF00179	0.484
MOD_SUMO_rev_2	142	152	PF00179	0.524
TRG_DiLeu_BaEn_3	51	57	PF01217	0.526
TRG_ENDOCYTIC_2	72	75	PF00928	0.470
TRG_NLS_Bipartite_1	149	169	PF00514	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A075QQ08	Nicotiana tabacum	28%	96%
A0A0N0P8F2	Leptomonas seymouri	82%	100%
A0A0S4KG92	Bodo saltans	22%	73%
A0A1D8EJF9	Solanum pimpinellifolium	25%	92%
A0A1U8F5V2	Capsicum annuum	30%	100%
A0A1U8GR65	Capsicum annuum	25%	93%
A0A1X0P494	Trypanosomatidae	48%	83%
A0A2J6L8Y7	Lactuca sativa	27%	91%
A0A3Q7FGP1	Solanum lycopersicum	26%	96%
A0A3Q7I7R4	Solanum lycopersicum	30%	100%
A0A3Q8IE78	Leishmania donovani	95%	100%
A0A3R7N8L4	Trypanosoma rangeli	48%	81%
A0A445AGS0	Arachis hypogaea	30%	100%
A3RCV9	Triticum aestivum	27%	92%
A4HHZ6	Leishmania braziliensis	27%	70%
A4HYH8	Leishmania infantum	25%	76%
A4I2V4	Leishmania infantum	95%	100%
A6NMX2	Homo sapiens	24%	88%
A7KWF8	Cucumis zeyherii	27%	91%
C6ZJZ3	Glycine max	28%	90%
C7SG33	Citrullus lanatus	28%	91%
D0A633	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	91%
D3UW26	Solanum tuberosum	25%	92%
E9ADE1	Leishmania major	92%	100%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
K0P2S0	Arachis hypogaea	27%	92%
M1J8U6	Prunus domestica	30%	100%
M1JJT8	Prunus domestica	27%	91%
O04663	Arabidopsis thaliana	29%	100%
O23252	Arabidopsis thaliana	26%	91%
O45551	Caenorhabditis elegans	26%	100%
O60573	Homo sapiens	26%	87%
O61955	Caenorhabditis elegans	29%	85%
O74743	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	88%
O77210	Aplysia californica	27%	99%
O81481	Zea mays	28%	98%
O81482	Zea mays	30%	99%
P06730	Homo sapiens	24%	98%
P07260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P29338	Oryctolagus cuniculus	24%	98%
P29557	Triticum aestivum	27%	99%
P48597	Xenopus laevis	24%	100%
P48598	Drosophila melanogaster	28%	82%
P48599	Oryza sativa subsp. japonica	27%	94%
P48600	Oryza sativa subsp. japonica	30%	100%
P56570	Caenorhabditis elegans	24%	100%
P63073	Mus musculus	24%	98%
P63074	Rattus norvegicus	24%	98%
P78954	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	98%
Q00LS8	Cucumis melo	28%	91%
Q03389	Triticum aestivum	32%	100%
Q0GRC4	Pisum sativum	25%	93%
Q10NQ9	Oryza sativa subsp. japonica	25%	94%
Q21693	Caenorhabditis elegans	30%	93%
Q22888	Caenorhabditis elegans	26%	100%
Q3UTA9	Mus musculus	28%	87%
Q4QD60	Leishmania major	25%	76%
Q4QXS7	Hordeum vulgare subsp. vulgare	28%	99%
Q4VQY1	Solanum habrochaites	25%	92%
Q4VQY3	Solanum lycopersicum	25%	92%
Q55FE0	Dictyostelium discoideum	30%	85%
Q66UV4	Nicotiana tabacum	28%	96%
Q66WU1	Nicotiana tabacum	31%	100%
Q75AV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q8BMB3	Mus musculus	26%	87%
Q8N5X7	Homo sapiens	28%	95%
Q9C7P2	Arabidopsis thaliana	26%	89%
Q9C7P6	Arabidopsis thaliana	26%	89%
Q9DBB5	Mus musculus	28%	100%
Q9DFS6	Danio rerio	26%	99%
Q9N0T5	Bos taurus	23%	98%
Q9P974	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q9P975	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	100%
Q9PW28	Danio rerio	22%	100%
R4HYA4	Solanum etuberosum	23%	92%
V5B0X7	Trypanosoma cruzi	49%	82%
V7BSD0	Phaseolus vulgaris	27%	93%