ACT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFT6_LEIBR

TriTrypDb:

LbrM.27.1730 , LBRM2903_270022900

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.674
CLV_C14_Caspase3-7	180	184	PF00656	0.575
CLV_PCSK_SKI1_1	155	159	PF00082	0.468
CLV_PCSK_SKI1_1	211	215	PF00082	0.567
DEG_APCC_DBOX_1	163	171	PF00400	0.498
DEG_APCC_DBOX_1	210	218	PF00400	0.588
DEG_ODPH_VHL_1	55	68	PF01847	0.331
DOC_CKS1_1	83	88	PF01111	0.663
DOC_CYCLIN_RxL_1	152	161	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	81	84	PF00134	0.381
DOC_MAPK_MEF2A_6	155	162	PF00069	0.523
DOC_PP2B_LxvP_1	35	38	PF13499	0.611
DOC_PP2B_LxvP_1	81	84	PF13499	0.381
DOC_USP7_MATH_1	107	111	PF00917	0.740
DOC_USP7_MATH_1	124	128	PF00917	0.449
DOC_USP7_MATH_1	172	176	PF00917	0.521
DOC_USP7_MATH_1	28	32	PF00917	0.714
DOC_WW_Pin1_4	112	117	PF00397	0.530
DOC_WW_Pin1_4	4	9	PF00397	0.450
DOC_WW_Pin1_4	82	87	PF00397	0.545
DOC_WW_Pin1_4	95	100	PF00397	0.612
LIG_14-3-3_CanoR_1	164	172	PF00244	0.362
LIG_14-3-3_CanoR_1	46	55	PF00244	0.468
LIG_14-3-3_CanoR_1	93	99	PF00244	0.575
LIG_APCC_ABBA_1	9	14	PF00400	0.371
LIG_BIR_III_2	130	134	PF00653	0.422
LIG_BRCT_BRCA1_1	64	68	PF00533	0.549
LIG_EVH1_1	82	86	PF00568	0.397
LIG_FHA_1	34	40	PF00498	0.596
LIG_FHA_1	76	82	PF00498	0.630
LIG_FHA_2	210	216	PF00498	0.677
LIG_LIR_Gen_1	115	125	PF02991	0.504
LIG_LIR_Gen_1	145	154	PF02991	0.362
LIG_LIR_Nem_3	115	120	PF02991	0.500
LIG_LIR_Nem_3	14	19	PF02991	0.579
LIG_LIR_Nem_3	145	149	PF02991	0.558
LIG_NRBOX	153	159	PF00104	0.514
LIG_SH2_CRK	137	141	PF00017	0.325
LIG_SH2_STAT5	142	145	PF00017	0.460
LIG_SH3_3	210	216	PF00018	0.677
LIG_SH3_3	80	86	PF00018	0.570
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.619
MOD_CK1_1	110	116	PF00069	0.650
MOD_CK1_1	179	185	PF00069	0.733
MOD_CK1_1	4	10	PF00069	0.677
MOD_CK2_1	172	178	PF00069	0.528
MOD_CK2_1	181	187	PF00069	0.447
MOD_GlcNHglycan	107	110	PF01048	0.667
MOD_GlcNHglycan	111	115	PF01048	0.704
MOD_GlcNHglycan	126	129	PF01048	0.421
MOD_GlcNHglycan	3	6	PF01048	0.650
MOD_GlcNHglycan	31	34	PF01048	0.544
MOD_GlcNHglycan	73	76	PF01048	0.527
MOD_GlcNHglycan	87	90	PF01048	0.646
MOD_GSK3_1	105	112	PF00069	0.651
MOD_GSK3_1	172	179	PF00069	0.655
MOD_GSK3_1	29	36	PF00069	0.595
MOD_GSK3_1	71	78	PF00069	0.628
MOD_GSK3_1	85	92	PF00069	0.470
MOD_N-GLC_1	94	99	PF02516	0.489
MOD_NEK2_1	1	6	PF00069	0.763
MOD_NEK2_1	158	163	PF00069	0.459
MOD_NEK2_1	209	214	PF00069	0.558
MOD_NEK2_1	39	44	PF00069	0.468
MOD_NEK2_1	94	99	PF00069	0.530
MOD_PKA_2	165	171	PF00069	0.346
MOD_PKA_2	22	28	PF00069	0.739
MOD_Plk_2-3	183	189	PF00069	0.705
MOD_Plk_4	158	164	PF00069	0.497
MOD_Plk_4	77	83	PF00069	0.622
MOD_ProDKin_1	112	118	PF00069	0.536
MOD_ProDKin_1	4	10	PF00069	0.437
MOD_ProDKin_1	82	88	PF00069	0.553
MOD_ProDKin_1	95	101	PF00069	0.601
TRG_AP2beta_CARGO_1	14	23	PF09066	0.431
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.647
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.376
TRG_ENDOCYTIC_2	137	140	PF00928	0.476
TRG_ER_diArg_1	163	166	PF00400	0.455
TRG_ER_diArg_1	197	200	PF00400	0.515
TRG_NES_CRM1_1	54	67	PF08389	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S5	Leptomonas seymouri	37%	100%
A0A3S7X0S9	Leishmania donovani	71%	100%
A4I2V3	Leishmania infantum	70%	100%
E9ADD9	Leishmania major	69%	100%
E9AZ63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%