Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFT4_LEIBR

TriTrypDb:

LbrM.27.1710 , LBRM2903_270022700

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.618
CLV_C14_Caspase3-7	262	266	PF00656	0.625
CLV_C14_Caspase3-7	285	289	PF00656	0.776
CLV_NRD_NRD_1	107	109	PF00675	0.494
CLV_NRD_NRD_1	11	13	PF00675	0.509
CLV_NRD_NRD_1	163	165	PF00675	0.696
CLV_NRD_NRD_1	3	5	PF00675	0.616
CLV_NRD_NRD_1	365	367	PF00675	0.451
CLV_NRD_NRD_1	443	445	PF00675	0.591
CLV_PCSK_FUR_1	105	109	PF00082	0.457
CLV_PCSK_KEX2_1	107	109	PF00082	0.493
CLV_PCSK_KEX2_1	11	13	PF00082	0.509
CLV_PCSK_KEX2_1	163	165	PF00082	0.686
CLV_PCSK_KEX2_1	3	5	PF00082	0.616
CLV_PCSK_KEX2_1	364	366	PF00082	0.456
CLV_PCSK_KEX2_1	443	445	PF00082	0.591
CLV_PCSK_SKI1_1	108	112	PF00082	0.542
CLV_PCSK_SKI1_1	121	125	PF00082	0.413
CLV_PCSK_SKI1_1	133	137	PF00082	0.393
CLV_PCSK_SKI1_1	139	143	PF00082	0.309
DEG_APCC_DBOX_1	95	103	PF00400	0.493
DEG_Nend_Nbox_1	1	3	PF02207	0.707
DEG_SCF_FBW7_1	307	312	PF00400	0.545
DEG_SPOP_SBC_1	294	298	PF00917	0.570
DOC_CDC14_PxL_1	264	272	PF14671	0.575
DOC_CYCLIN_RxL_1	194	208	PF00134	0.501
DOC_MAPK_gen_1	3	9	PF00069	0.710
DOC_PP1_RVXF_1	119	125	PF00149	0.552
DOC_PP2B_LxvP_1	270	273	PF13499	0.461
DOC_PP4_FxxP_1	271	274	PF00568	0.679
DOC_USP7_MATH_1	169	173	PF00917	0.478
DOC_USP7_MATH_1	282	286	PF00917	0.696
DOC_USP7_MATH_1	294	298	PF00917	0.754
DOC_USP7_MATH_1	314	318	PF00917	0.625
DOC_USP7_MATH_1	346	350	PF00917	0.486
DOC_USP7_MATH_1	48	52	PF00917	0.346
DOC_WW_Pin1_4	17	22	PF00397	0.546
DOC_WW_Pin1_4	305	310	PF00397	0.670
DOC_WW_Pin1_4	342	347	PF00397	0.501
DOC_WW_Pin1_4	434	439	PF00397	0.574
LIG_14-3-3_CanoR_1	152	157	PF00244	0.441
LIG_14-3-3_CanoR_1	295	304	PF00244	0.677
LIG_14-3-3_CanoR_1	365	371	PF00244	0.491
LIG_14-3-3_CanoR_1	75	85	PF00244	0.508
LIG_Actin_WH2_2	390	408	PF00022	0.439
LIG_AP2alpha_1	149	153	PF02296	0.396
LIG_APCC_ABBA_1	63	68	PF00400	0.461
LIG_BIR_III_2	265	269	PF00653	0.671
LIG_BIR_III_2	288	292	PF00653	0.795
LIG_BIR_III_2	329	333	PF00653	0.538
LIG_BRCT_BRCA1_1	136	140	PF00533	0.533
LIG_BRCT_BRCA1_1	171	175	PF00533	0.450
LIG_CaM_IQ_9	150	166	PF13499	0.558
LIG_CSL_BTD_1	18	21	PF09270	0.568
LIG_CtBP_PxDLS_1	433	437	PF00389	0.669
LIG_FHA_1	130	136	PF00498	0.486
LIG_FHA_1	29	35	PF00498	0.571
LIG_FHA_1	352	358	PF00498	0.420
LIG_FHA_1	77	83	PF00498	0.361
LIG_FHA_2	129	135	PF00498	0.479
LIG_FHA_2	229	235	PF00498	0.652
LIG_FHA_2	33	39	PF00498	0.590
LIG_FHA_2	358	364	PF00498	0.526
LIG_FHA_2	381	387	PF00498	0.475
LIG_FHA_2	408	414	PF00498	0.466
LIG_FHA_2	437	443	PF00498	0.604
LIG_LIR_Gen_1	151	161	PF02991	0.428
LIG_LIR_Gen_1	195	206	PF02991	0.439
LIG_LIR_Gen_1	301	311	PF02991	0.552
LIG_LIR_Gen_1	377	387	PF02991	0.466
LIG_LIR_Nem_3	151	156	PF02991	0.413
LIG_LIR_Nem_3	172	178	PF02991	0.515
LIG_LIR_Nem_3	195	201	PF02991	0.384
LIG_LIR_Nem_3	301	307	PF02991	0.558
LIG_LIR_Nem_3	377	382	PF02991	0.550
LIG_LIR_Nem_3	399	405	PF02991	0.439
LIG_MLH1_MIPbox_1	171	175	PF16413	0.341
LIG_MYND_1	268	272	PF01753	0.668
LIG_Pex14_2	149	153	PF04695	0.396
LIG_REV1ctd_RIR_1	154	164	PF16727	0.486
LIG_REV1ctd_RIR_1	400	410	PF16727	0.436
LIG_SH2_NCK_1	87	91	PF00017	0.487
LIG_SH2_STAP1	55	59	PF00017	0.469
LIG_SH2_STAT5	174	177	PF00017	0.418
LIG_SH2_STAT5	337	340	PF00017	0.446
LIG_SH3_2	438	443	PF14604	0.560
LIG_SH3_3	266	272	PF00018	0.658
LIG_SH3_3	304	310	PF00018	0.764
LIG_SH3_3	435	441	PF00018	0.523
LIG_TRAF2_1	231	234	PF00917	0.559
LIG_TRAF2_1	298	301	PF00917	0.713
LIG_TRAF2_1	35	38	PF00917	0.480
LIG_TYR_ITIM	85	90	PF00017	0.461
LIG_WRC_WIRS_1	153	158	PF05994	0.465
LIG_WW_3	272	276	PF00397	0.607
MOD_CK1_1	316	322	PF00069	0.538
MOD_CK1_1	424	430	PF00069	0.638
MOD_CK1_1	80	86	PF00069	0.532
MOD_CK2_1	111	117	PF00069	0.573
MOD_CK2_1	128	134	PF00069	0.414
MOD_CK2_1	174	180	PF00069	0.385
MOD_CK2_1	228	234	PF00069	0.553
MOD_CK2_1	294	300	PF00069	0.673
MOD_CK2_1	309	315	PF00069	0.659
MOD_CK2_1	32	38	PF00069	0.501
MOD_CK2_1	357	363	PF00069	0.478
MOD_CK2_1	380	386	PF00069	0.501
MOD_CK2_1	407	413	PF00069	0.444
MOD_CK2_1	436	442	PF00069	0.658
MOD_CK2_1	48	54	PF00069	0.349
MOD_CK2_1	85	91	PF00069	0.462
MOD_GlcNHglycan	113	116	PF01048	0.584
MOD_GlcNHglycan	136	139	PF01048	0.474
MOD_GlcNHglycan	25	28	PF01048	0.615
MOD_GlcNHglycan	254	257	PF01048	0.626
MOD_GlcNHglycan	284	287	PF01048	0.695
MOD_GlcNHglycan	297	300	PF01048	0.571
MOD_GlcNHglycan	315	319	PF01048	0.674
MOD_GlcNHglycan	424	427	PF01048	0.563
MOD_GlcNHglycan	81	85	PF01048	0.497
MOD_GSK3_1	17	24	PF00069	0.543
MOD_GSK3_1	28	35	PF00069	0.536
MOD_GSK3_1	280	287	PF00069	0.598
MOD_GSK3_1	305	312	PF00069	0.550
MOD_GSK3_1	313	320	PF00069	0.497
MOD_GSK3_1	342	349	PF00069	0.458
MOD_GSK3_1	69	76	PF00069	0.537
MOD_LATS_1	293	299	PF00433	0.569
MOD_N-GLC_1	21	26	PF02516	0.662
MOD_NEK2_1	111	116	PF00069	0.631
MOD_NEK2_1	242	247	PF00069	0.660
MOD_NEK2_1	357	362	PF00069	0.338
MOD_NEK2_1	69	74	PF00069	0.538
MOD_PKA_2	228	234	PF00069	0.558
MOD_PKA_2	294	300	PF00069	0.569
MOD_PKA_2	419	425	PF00069	0.525
MOD_PKA_2	76	82	PF00069	0.420
MOD_PKB_1	364	372	PF00069	0.493
MOD_PKB_1	75	83	PF00069	0.586
MOD_Plk_1	169	175	PF00069	0.366
MOD_Plk_1	350	356	PF00069	0.471
MOD_Plk_1	80	86	PF00069	0.527
MOD_Plk_2-3	205	211	PF00069	0.447
MOD_Plk_4	152	158	PF00069	0.463
MOD_ProDKin_1	17	23	PF00069	0.548
MOD_ProDKin_1	305	311	PF00069	0.684
MOD_ProDKin_1	342	348	PF00069	0.497
MOD_ProDKin_1	434	440	PF00069	0.570
MOD_SUMO_rev_2	129	138	PF00179	0.560
TRG_AP2beta_CARGO_1	151	160	PF09066	0.481
TRG_DiLeu_BaEn_1	413	418	PF01217	0.502
TRG_ENDOCYTIC_2	198	201	PF00928	0.410
TRG_ENDOCYTIC_2	379	382	PF00928	0.442
TRG_ENDOCYTIC_2	44	47	PF00928	0.465
TRG_ENDOCYTIC_2	87	90	PF00928	0.466
TRG_ER_diArg_1	2	4	PF00400	0.628
TRG_ER_diArg_1	226	229	PF00400	0.561
TRG_ER_diArg_1	364	366	PF00400	0.456
TRG_ER_diArg_1	443	445	PF00400	0.591
TRG_ER_diArg_1	75	78	PF00400	0.577
TRG_NES_CRM1_1	396	409	PF08389	0.441
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE13	Leptomonas seymouri	61%	92%
A0A1X0P4A4	Trypanosomatidae	49%	94%
A0A381ML35	Leishmania infantum	84%	100%
A0A3Q8IGD4	Leishmania donovani	84%	100%
A0A3Q8IQ02	Leishmania donovani	84%	100%
A0A3R7LRX2	Trypanosoma rangeli	51%	100%
D0A626	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADD6	Leishmania major	84%	97%
E9AZ61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%