Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF543), putative

Species:

Leishmania braziliensis

UniProt:

A4HFT1_LEIBR

TriTrypDb:

LbrM.27.1680 , LBRM2903_270022300

Length:

108

Annotations

LeishMANIAdb annotations

Likely part of the mitochondrial MICOS complex, based on homology.. It is possible that this protein only has a single TM segment as the first can also be a transit signal.. Localization: Mitochondrial inner membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0061617	MICOS complex	4	12
GO:0098796	membrane protein complex	2	12
GO:0098798	mitochondrial protein-containing complex	2	12
GO:0098800	inner mitochondrial membrane protein complex	3	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.340
CLV_PCSK_KEX2_1	84	86	PF00082	0.526
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.569
CLV_PCSK_SKI1_1	73	77	PF00082	0.328
DEG_SPOP_SBC_1	93	97	PF00917	0.493
DOC_MAPK_gen_1	30	36	PF00069	0.321
DOC_MAPK_gen_1	84	92	PF00069	0.530
DOC_MAPK_MEF2A_6	84	92	PF00069	0.530
DOC_USP7_MATH_1	11	15	PF00917	0.366
DOC_USP7_MATH_1	51	55	PF00917	0.376
DOC_WW_Pin1_4	46	51	PF00397	0.313
DOC_WW_Pin1_4	7	12	PF00397	0.350
LIG_14-3-3_CanoR_1	30	36	PF00244	0.338
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_FHA_1	10	16	PF00498	0.318
LIG_FHA_1	36	42	PF00498	0.277
LIG_SH2_STAT5	74	77	PF00017	0.330
LIG_SUMO_SIM_par_1	54	61	PF11976	0.396
LIG_TRAF2_1	97	100	PF00917	0.466
MOD_CDK_SPxxK_3	46	53	PF00069	0.298
MOD_CK1_1	24	30	PF00069	0.331
MOD_CK1_1	9	15	PF00069	0.403
MOD_CK2_1	13	19	PF00069	0.319
MOD_CK2_1	94	100	PF00069	0.456
MOD_GlcNHglycan	1	4	PF01048	0.625
MOD_GlcNHglycan	53	56	PF01048	0.338
MOD_GlcNHglycan	64	67	PF01048	0.222
MOD_GSK3_1	58	65	PF00069	0.370
MOD_GSK3_1	6	13	PF00069	0.346
MOD_N-GLC_1	100	105	PF02516	0.476
MOD_PIKK_1	100	106	PF00454	0.475
MOD_PKA_1	30	36	PF00069	0.315
MOD_PKA_2	29	35	PF00069	0.323
MOD_Plk_1	21	27	PF00069	0.310
MOD_Plk_4	24	30	PF00069	0.339
MOD_ProDKin_1	46	52	PF00069	0.313
MOD_ProDKin_1	7	13	PF00069	0.350
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD22	Leptomonas seymouri	71%	100%
A0A0S4IQE6	Bodo saltans	28%	100%
A0A3Q8IHN0	Leishmania donovani	88%	100%
A0A422NHB5	Trypanosoma rangeli	30%	94%
A4HBS0	Leishmania braziliensis	28%	100%
A4I2U5	Leishmania infantum	89%	100%
D0A621	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ADD2	Leishmania major	88%	100%
E9AV41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AZ57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%